Department of Cellular and Molecular Physiology Seminar Series: Mechanisms and functions of lysosome positioning
1:00pm - 2:00pm /
Friday 8th July 2016
/ Venue: Physiology Seminar Room Nuffield Wing
Type: Seminar /
Category: Department
- Sylvie Urbe
- Admission: Free
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On Friday 8th July 2016, Juan Bonifacino from the National Institute of Health, Bethesda, USA, will be giving a seminar in the Physiology Seminar Room at the University of Liverpool entitled 'Mechanisms and functions of lysosome positioning'
Abstract: "Lysosomes are membrane-bound organelles whose main function is the degradation of biomacromolecules in the endomembrane system of eukaryotic cells. In addition, lysosomes participate in many other cellular processes, including lipid homeostasis, cell adhesion and migration, tumor invasion, plasma membrane repair, detoxification, apoptosis, metabolic signalling and gene regulation. In my presentation I will discuss an emerging property of lysosomes that influences many of the aforementioned functions: their positioning and motility within the cytoplasm. In the course of studies on the BLOC-1 complex that is defective in some types of Hermansky-Pudlak syndrome, we discovered a related eight-subunit complex named BORC (for BLOC-one-related complex). We found that BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a chain of interactions that promotes kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the cell periphery. Further studies showed that BORC regulates members of both the kinesin-1 and -3 subfamilies to drive regional movement of lysosomes along different microtubule tracks. These studies thus uncovered novel aspects of the molecular machinery involved in moving lysosomes to the cell periphery, and highlighted the importance of this machinery for the regulation many critical cellular processes"
To register, please contact Sylvie Urbé via email: urbe@liv.ac.uk
Abstract: "Lysosomes are membrane-bound organelles whose main function is the degradation of biomacromolecules in the endomembrane system of eukaryotic cells. In addition, lysosomes participate in many other cellular processes, including lipid homeostasis, cell adhesion and migration, tumor invasion, plasma membrane repair, detoxification, apoptosis, metabolic signalling and gene regulation. In my presentation I will discuss an emerging property of lysosomes that influences many of the aforementioned functions: their positioning and motility within the cytoplasm. In the course of studies on the BLOC-1 complex that is defective in some types of Hermansky-Pudlak syndrome, we discovered a related eight-subunit complex named BORC (for BLOC-one-related complex). We found that BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a chain of interactions that promotes kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the cell periphery. Further studies showed that BORC regulates members of both the kinesin-1 and -3 subfamilies to drive regional movement of lysosomes along different microtubule tracks. These studies thus uncovered novel aspects of the molecular machinery involved in moving lysosomes to the cell periphery, and highlighted the importance of this machinery for the regulation many critical cellular processes"
To register, please contact Sylvie Urbé via email: urbe@liv.ac.uk