Institute meeting and seminar with Professor Udo Oppermann: Epigenetic mechanisms regulating mesenchymal stem cell properties and differentiation
12:45pm - 1:45pm /
Wednesday 8th June 2016
/ Venue: G12-G15 Ground floor Apex Building
- 0151 794 9003
- Brenda Smith
- Suitable for: All staff and students
- Admission: Free to all staff and students
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Epigenetic mechanisms regulating mesenchymal stem cell properties and differentiation
Host: Mandy Peffers.
Udo Oppermann is Professor of Molecular Biology at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), holds the chair in Musculoskeletal Sciences, is Director of Laboratory Sciences at the Botnar Research Centre, and Deputy Director of the Institute of Musculoskeletal Sciences, Botnar Research Centre, University of Oxford.
Furthermore, he is Principal Investigator of the Structural Genomics Consortium (SGC) in Oxford since its inception in 2003, and investigator at the Oxford Stem Cell Institute (http://www.stemcells.ox.ac.uk/). He obtained his PhD (1994) in Toxicology and Pharmacology from Philipps University, Marburg, Germany, after receiving his Diploma (MSc equivalent) in Human Biology from the same university (1990). He went for his post-doc training to the Karolinska Institute (Stockholm, Sweden), where he became Associate Professor at the Department of Medical Biochemistry and Biophysics, before joining the Oxford Structural Genomics Consortium in 2003 as Principal Investigator, leading a research team centred around “Metabolic Enzymes and Epigenetics”.
His research interests were – already starting during his undergraduate studies – analysis of structure-function relationships of human protein families as well as using this knowledge for drug target identification by various molecular biology and informatics methods. Major accomplishments comprise elucidation of chemical mechanisms in oxidoreductases, culminating in establishment of a systematic nomenclature for e.g. short-chain dehydrogenases/reductases; advancing pre-clinical target validation in insulin resistance with Biovitrum AB (previously Pharmacia & Upjohn, Stockholm) (development of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors); establishing metabolic enzyme structural biology as platform for understanding of human disease biology; elucidation of molecular mechanisms of drug action in human disease such as osteoporosis; as well as epigenetic target discovery and validation.
Trained in toxicology, protein chemistry and molecular biology with over 20 years of experience more than 140 research publications, his research continues on the biology and structure-activity relationships of human metabolic protein families of all types. The use of chemical biology to understand human biology is a major focus of the group and is applied to the field of epigenetic mechanisms in musculoskeletal biology comprising stem cell biology, bone oncology as well as chronic inflammatory and metabolic diseases.
He is member of the editorial board for the Journal of Steroid Biochemistry and Molecular Biology, as well as The Journal of Epigenetic Diagnosis & Therapy.
All IACD students are expected to attend.
Host: Mandy Peffers.
Udo Oppermann is Professor of Molecular Biology at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), holds the chair in Musculoskeletal Sciences, is Director of Laboratory Sciences at the Botnar Research Centre, and Deputy Director of the Institute of Musculoskeletal Sciences, Botnar Research Centre, University of Oxford.
Furthermore, he is Principal Investigator of the Structural Genomics Consortium (SGC) in Oxford since its inception in 2003, and investigator at the Oxford Stem Cell Institute (http://www.stemcells.ox.ac.uk/). He obtained his PhD (1994) in Toxicology and Pharmacology from Philipps University, Marburg, Germany, after receiving his Diploma (MSc equivalent) in Human Biology from the same university (1990). He went for his post-doc training to the Karolinska Institute (Stockholm, Sweden), where he became Associate Professor at the Department of Medical Biochemistry and Biophysics, before joining the Oxford Structural Genomics Consortium in 2003 as Principal Investigator, leading a research team centred around “Metabolic Enzymes and Epigenetics”.
His research interests were – already starting during his undergraduate studies – analysis of structure-function relationships of human protein families as well as using this knowledge for drug target identification by various molecular biology and informatics methods. Major accomplishments comprise elucidation of chemical mechanisms in oxidoreductases, culminating in establishment of a systematic nomenclature for e.g. short-chain dehydrogenases/reductases; advancing pre-clinical target validation in insulin resistance with Biovitrum AB (previously Pharmacia & Upjohn, Stockholm) (development of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors); establishing metabolic enzyme structural biology as platform for understanding of human disease biology; elucidation of molecular mechanisms of drug action in human disease such as osteoporosis; as well as epigenetic target discovery and validation.
Trained in toxicology, protein chemistry and molecular biology with over 20 years of experience more than 140 research publications, his research continues on the biology and structure-activity relationships of human metabolic protein families of all types. The use of chemical biology to understand human biology is a major focus of the group and is applied to the field of epigenetic mechanisms in musculoskeletal biology comprising stem cell biology, bone oncology as well as chronic inflammatory and metabolic diseases.
He is member of the editorial board for the Journal of Steroid Biochemistry and Molecular Biology, as well as The Journal of Epigenetic Diagnosis & Therapy.
All IACD students are expected to attend.