IMPACT SEMINAR: Prof Patrick Sung, Yale University - Title: 'Role of the BRCA2-DSS1 complex in homologous recombination'
12:00pm - 1:00pm /
Friday 27th November 2015
Type: Seminar /
Category: Department
- Dr Nigel Jones
- Admission: Free
- Book now
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University of Liverpool alumnus Prof Patrick Sung has gone on to have an illustrious and distinguished career with genuine impact. Patrick has been Chair of the Department of Molecular Biophysics & Biochemistry at Yale University since 2009. Patrick graduated from Liverpool University with a 1st Class honours degree in Biochemistry in 1981. His research has provided crucial and compelling evidence for a key role of homologous recombination in cancer avoidance. The topic of Patrick’s seminar: “Role of the BRCA2-DSS1 Complex in Homologous Recombination”, featured on the front cover of Molecular Cell in July 2015.
Abstract:
The exchange of the DNA binding protein RPA for the RAD51 recombinase on single-stranded DNA is a critical step in DNA break repair by homologous recombination. This RPA-RAD51 handoff is dependent on the tumour suppressor BRCA2. Importantly, our work has shown that the BRCA2-associated DSS1, a small, highly acidic protein, is also needed for this handoff process. Mechanistically, DSS1 acts as a DNA mimic to attenuate the affinity of RPA for DNA. Thus, by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance and cancer avoidance.
Abstract:
The exchange of the DNA binding protein RPA for the RAD51 recombinase on single-stranded DNA is a critical step in DNA break repair by homologous recombination. This RPA-RAD51 handoff is dependent on the tumour suppressor BRCA2. Importantly, our work has shown that the BRCA2-associated DSS1, a small, highly acidic protein, is also needed for this handoff process. Mechanistically, DSS1 acts as a DNA mimic to attenuate the affinity of RPA for DNA. Thus, by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance and cancer avoidance.