Prof Christian Hedrich MD, PhD

Professor of Child Health Women's and Children's Health

Biography

Personal Statement

Professor Christian Hedrich is a Paediatric Rheumatologist with special interest in molecular mechanisms of cytokine dysregulation in autoimmune/inflammatory disease, their potential applicability as disease biomarkers, and the resolution of pathological inflammatory responses by individualized and target-directed therapeutic approaches. In August 2017, he was appointed Professor of Child Health at the University of Liverpool, Faculty of Health and Life Sciences, Department of Women's and Children's Health. Previously, he served as Head of Paediatric Rheumatology and Immunology at the Faculty of Medicine Carl Gustav Carus, TU Dresden, Germany.

Christian Hedrich completed his medical training and doctoral degree (Dr. med.) at the University of Ulm Medical School, Ulm, Germany. He undertook a residency program in General Paediatrics, followed by a sub-specialty fellowship in Paediatric Rheumatology in the Department of Paediatrics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. He received his scientific training in Germany (University of Ulm, and TU Dresden) and the United States, where he completed a research fellowship at the Johns Hopkins School of Public Health in Baltimore, MD, USA, followed by a research fellowship and appointment as Instructor in Medicine at Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA. In 2014, Christian Hedrich received his teaching license (Habilitation; Dr. med. habil.) from the Faculty of Medicine Carl Gustav Carus, TU Dresden based on his his thesis entitled "Molecular mechanisms of cytokine dysregulation and their contribution to the pathophysiology of autoimmune/inflammatory disorders".

Christian Hedrich's core research interests are molecular mechanisms of cytokine regulation and their effects on disease expression in the spectrum from autoinflammation to autoimmunity. Special foci include the autoinflammatory bone disorder chronic nonbacterial osteomyelitis (CNO), the mixed-pattern disease psoriasis, and the prototypical autoimmune disorder systemic lupus erythematosus (SLE). Christian Hedrich is actively involved with consensus treatment plan initiatives of the North American CARRA group (CNO) and treat to target (T2T) initiatives of the German Society of Pediatric Rheumatology (GKJR) (SLE, systemic JIA, CNO). Both initiatives aim at translating knowledge from small patient cohorts, daily clinical experience, and laboratory studies into routine patient care, and back to the laboratory bench.

Personal Distinctions

  • Grant for a Postdoctoral Research Fellowship at the W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA (Competitive Fellowship, German Research Foundation (DFG) 2007)
  • Scholarship to the CIS School in Systemic Autoimmune Diseases (Clinical Immunology Society (CIS) 2008)
  • Young Investigator Award (German Pediatric Rheumatology Society (GKJR) 2010)
  • BIDMC Lupus Symposium, Harvard Medical School, Boston, MA, USA: CREM promotes effector T cell phenotypes in SLE (Invitation to Speak, Beth Israel Deaconess Medical Center, Department of Medicine, Dividion of Rheumatology 2012)
  • German Rheumatology Society (DGRh), Annual Meeting, Bochum, Germany: SLE in Children (Invitation to Speak, German Rheumatology Society (DGRh) 2012)
  • International Symposium on Epigenetics and Autoimmunity, Changsha, China: CREM and the dysregulation of IL-2 expression (Invitation to Speak, Changsha University, China 2012)
  • EULAR Conference, Berlin, Germany: Immunological Background of CRMO (Invitation to Speak, European League Against Rheumatism (EULAR) 2012)
  • Young Investigator Award (American Association of Immunologists (AAI) 2012)
  • BIDMC Lupus Symposium, Harvard Medical School, Boston, MA, USA: Disrupted transcription factor networks mediate epigenetic remodeling in T cells from SLE patients (Invitation to Speak, Beth Israel Deaconess Medical Center, Department of Medicine, Division of Rheumatology 2013)
  • German Rheumatology Society (DGRh), Annual Meeting, Mannheim, Germany: IL-10 and CRMO (Invitation to Speak, German Rheumatology Society (DGRh) 2013)
  • Pre-Conference Meeting to the American College of Rheumatology Annual Meeting 2013, San Diego, CA, USA: CREM regulates CD8 expression and contributes to the generation of TCR+CD3+CD4-CD8- “double negative” T cells in SLE (Invitation to Speak, American College of Rheumatology (ACR) 2013)
  • 2nd International Meeting on Chronic Nonbacterial Osteomyelitis, Munich, Germany: IL-10 Dysregulation in CRMO (Invitation to Perform, CNO Expert Group, represented by Annette Jansson, LMU Munich 2013)
  • Postgraduate Research Award (Competitive Fellowship, Novartis Foundation for Therapeutic Research 2013)
  • German Society for Pediatric Nephrology, Frankfurt: What’s new in the pathophysiology of SLE (Invitation to Speak, German Society for Pediatric Nephrology 2014)
  • German Pediatric Society (DGKJ), Annual Meeting, Munich, Germany: Diagnosis and Treatment of Childhood CNS Vasculitis (Invitation to Speak, German Pediatric Society (DGKJ) 2015)
  • Award for best abstract presentation (oral) in session “New aspects in pathophysiology of auto-inflammation” (International Society of Systemic Autoinflammatory Syndromes (ISSAID) 2015)
  • 8th International Congress of Familial Mediterranean Fever and Systemic Auto-Inflammatory Diseases, International Society of Systemic Autoinflammatory Syndromes (ISSAID), Dresden, Germany: From Autoinflammation to Autoimmunity – Bridging the Gap (Invitation to Speak, International Society of Systemic Autoinflammatory Syndromes (ISSAID) 2015)
  • 3rd International Meeting on Chronic Nonbacterial Osteomyelitis, Dresden, Germany: Biomarkers for the diagnosis of CRMO (Invitation to Speak, International Society of Systemic Autoinflammatory Syndromes (ISSAID) 2015)
  • Award for best abstract presentation (oral) (German Pediatric Immunology Society (API) 2015)
  • German Rheumatology Society (DGRh), Annual Meeting, Frankfurt, Germany: The Inflammatory Spectrum - from Autoinflammation to Autoimmunity (Invitation to Speak, German Rheumatology Society (DGRh) 2016)
  • German Rheumatology Society (DGRh), Annual Meeting, Frankfurt, Germany: Jahrestagung: Chronic Recurrent Multifocal Osteomyelitis (Invitation to Speak, German Rheumatology Society (DGRh) 2016)
  • German Society for Maxillofacial Surgery (AKOPOM) Annual Meeting, Bad Homburg, Germany: Osteomyelitis of the jaw (Invitation to Speak, German Society for Maxillofacial Surgery (AKOPOM) 2016)
  • DSAI – Immunodeficiency in Children and Adults – What to do?: Chronic Nonbacterial Osteitis (CNO/CRMO) vs. Bacterial Osteomyelitis (Invitation to Speak, DSAI 2016)
  • American College of Rheumatology Annual Meeting 2016, Washington, DC, USA: Pediatric Rheumatology – A year in Review (Invitation to Speak, Americal College of Rheumatology 2016)
  • Pediatric commission of the German Society for Thombosis and Hemostasis Research (Ständige Kommission Pädiatrie der GTH); annual Meeting 2016, Würzburg, Germany: CNS-Vasculopathy (Invitation to Speak, Pediatric commission of the German Society for Thombosis and Hemostasis Research (Ständige Kommission Pädiatrie der GTH) 2016)
  • EpiBrest, Brest, France: Epigenetic control of cytokine regulation (Invitation to Speak, University of Bretagne, Brest 2016)
  • Abstract Award for “Serum biomarkers for the diagnosis and monitoring of CRMO” (Childhood Arthritis and Rheumatism Research Alliance (CARRA) 2016)
  • Wörlitz consensus meetings, Wörlitz, Germany: Treat to target - Chronic Recurrent Multifocal Osteomyelitis (CRMO): Evidence treatment goals (Invitation to Speak, Initiative for the Child with Rheumatic Disease 2017)
  • German Rheumatology Society (DGRh), Annual Meeting, Stuttgart, Germany: Pediatric systemic lupus erythematosus (SLE) (Invitation to Speak, German Rheumatology Society (DGRh) 2017)
  • German Rheumatology Societ (DGRh), Annual Meeting, Stuttgart, Germany: Differential Diagnoses of CRMO (Invitation to Speak, German Rheumatology Society (DGRh) 2017)
  • 9th International Congress of Familial Mediterranean Fever and Systemic Auto-Inflammatory Diseases, International Society of Systemic Autoinflammatory Syndromes (ISSAID), Northern Cyprus, Turkish Republic: Chronic Recurrent Multifocal Osteomyelitis (Invitation to Speak, International Society of Systemic Autoinflammatory Syndromes (ISSAID) 2017)
  • New concepts on the mechanisms of inflammation, autoimmunity and tumor genesis, Kazan, Russia: The inflammatory spectrum from Autoinflammation to Autoimmunity (Invitation to Speak, State Medical Academy, Kazan, Russia 2017)
  • Differential Diagnoses of CRMO (Invitation to Speak, German Rheumatology Society (DGRh) 2017)
  • Complications in juvenile SLE (Invitation to Speak, German Rheumatology Society (DGRh) 2017)
  • Targeted vs. "Classical" Immunosupprossive Treatment in juvenile SLE (Invitation to Speak, German Pediatric Rheumatology Society (GKJR) - Paediatric Rheumatology School 2017)

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