Prof Chris Probert MD FRCP FHEA

Professor of Gastroenterology Cellular and Molecular Physiology

    Research

    Metabolomics

    Recently, most of my research has be directed towards volatile organic compounds and their use as biomarkers of IBS, IBD and various cancers.


    The intestinal microbiome and mycobiome

    My group also looks at the microbiome and mycobiome of the intestine in humans, mice and equines.

    Clinical interests

    I have an ongoing-interest in IBD and IBS.

    Research Grants

    Mechanisms Affecting the Gut of Preterm Infants in Enteral feeding trials (MAGPIE)

    DEPARTMENT OF HEALTH (UK) (NIHR)

    February 2016 - September 2019

    VOID-bladder cancer

    CANCER RESEARCH UK (UK)

    January 2017 - April 2019

    IASO: A phase II randomised placebo controlled double blind trial of Interleukin 1 blockade in Acute Severe Colitis

    DEPARTMENT OF HEALTH (UK) (NIHR)

    March 2017 - October 2022

    Characterization of the gut mycobiome in an inception cohort of paediatric inflammatory bowel disease patients

    GUTS (UK CHARITY)

    April 2018 - March 2019

    Understanding the mechanisms for the variation in beneficial effects of dietary fibre in IBS: an old concept in new light

    DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY (BEIS) (UK)

    August 2016 - January 2020

    MECNUT: Impact of dietary exposure to emulsifiers on the intestinal mucosa - implications for inflammatory bowel disease and metabolic syndrome

    MEDICAL RESEARCH COUNCIL (MRC)

    November 2017 - March 2021

    Volatile Organic compounds for the DEtection of Colorectal cAncer: VODECA

    CANCER RESEARCH UK (UK)

    November 2018 - October 2021

    Investigation of octen-3-ol, a fungal metabolite, in faeces of people with Parkinson’s disease

    WELLCOME TRUST (UK)

    July 2015 - August 2015

    Study to determine the effect of ferric maltol on gut microbiota in inflammatory bowel disease patients with iron deficiency

    SHIELD THERAPEUTICS PLC (UK)

    January 2018 - January 2019

    Peripheral blood gene expression profiling as predictors of response to biological therapy in ulcerative colitis

    CROHN'S AND COLITIS UK (UK)

    September 2016 - October 2020

    Diarrhoea Diagnostic Device: From Bench to Bedside

    WELLCOME TRUST (UK)

    October 2014 - December 2015

    Impact Acceleration Account - University of Liverpool 2012

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    October 2012 - March 2017

    Examination of the fungal microbiome in Crohn’s disease and an investigation of the impact of fungi on bacterial microbiota and their interaction with phagocytic leucocytes

    NAT ASSOC FOR COLITIS & CROHNS DISEASE (UK)

    September 2015 - August 2017

    Evaluation of faecal volatile organic compounds in the diagnosis of paediatric inflammatory bowel disease

    DEPARTMENT OF HEALTH (UK) (NIHR)

    April 2017 - June 2020

    The role of faecal and urinary Volatile Organic Compounds (VOCs) as a non-invasive diagnostic biomarker of colorectal cancer

    SHIRE PHARMACEUTICALS LIMITED (UK)

    May 2015 - April 2017

    The role of urinary volatile organic compounds as a biomarker for hepatocellular carcinoma

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    August 2015 - July 2016

    Can Volatile Organic Compounds be used to detect Campylobacter infection in Poultry Houses?

    ROBOSCIENTIFIC LIMITED (UK)

    October 2012 - March 2013

    Systems medicine of chronic inflammatory bowel disease (SysmedIBD)

    EUROPEAN COMMISSION

    December 2012 - November 2017

    Faecal Microbiota in Preterm Infants Developing Necrotising Enterocolitis (NEC) - The DOVEtail Study.

    ACTION MEDICAL RESEARCH (UK), BIRMINGHAM CHILDREN'S HOSPITAL (UK)

    September 2012 - October 2015

    The role of faecal Volatile Organic Compounds (VOCs) as a non-invasive diagnostic biomarker of colorectal cancer (pilot study)

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    January 2014 - June 2015

    Influence of iron supplementation on gut flora and the natural history of Inflammatory Bowel Disease

    LIBYAN EMBASSY IN LONDON

    April 2013 - March 2015

    Analysis of volatile organic compounds (VOCs) emitted from the faeces of preterm infants as a predictor of preclinical necrotising enterocolitis (NEC).

    ACTION MEDICAL RESEARCH (UK)

    October 2012 - February 2016

    Trial of antibiotics and hydroxychloroquine in Crohn's disease

    NAT ASSOC FOR COLITIS & CROHNS DISEASE (UK)

    October 2013 - March 2020