Photo of Prof Azzam Taktak

Prof Azzam Taktak BEng(Hons), PhD, CEng, CSci, MIPEM

Honorary Professor Physics

    Publications

    2021

    Small High-Risk Uveal Melanomas Have a Lower Mortality Rate (Journal article)

    Hussain, R. N., Coupland, S. E., Kalirai, H., Taktak, A. F. G., Eleuteri, A., Damato, B. E., . . . Heimann, H. (2021). Small High-Risk Uveal Melanomas Have a Lower Mortality Rate. CANCERS, 13(9). doi:10.3390/cancers13092267

    DOI: 10.3390/cancers13092267

    Cost-utility analysis of a decade of liver screening for metastases using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO) (Journal article)

    Eleuteri, A., Rola, A. C., Kalirai, H., Hussain, R., Sacco, J., Damato, B. E., . . . Taktak, A. F. G. (2021). Cost-utility analysis of a decade of liver screening for metastases using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO). COMPUTERS IN BIOLOGY AND MEDICINE, 130. doi:10.1016/j.compbiomed.2021.104221

    DOI: 10.1016/j.compbiomed.2021.104221

    2020

    MORTALITY OF PATIENTS WITH UVEAL MELANOMA DETECTED BY DIABETIC RETINOPATHY SCREENING (Journal article)

    Hussain, R., Czanner, G., Taktak, A., Damato, B., Praidou, A., & Heimann, H. (2020). MORTALITY OF PATIENTS WITH UVEAL MELANOMA DETECTED BY DIABETIC RETINOPATHY SCREENING. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 40(11), 2198-2206. doi:10.1097/IAE.0000000000002763

    DOI: 10.1097/IAE.0000000000002763

    Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis (Journal article)

    Thornton, S., Coupland, S. E., Heimann, H., Hussain, R., Groenewald, C., Kacperek, A., . . . Kalirai, H. (2020). Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis. BRITISH JOURNAL OF OPHTHALMOLOGY, 104(10), 1462-1466. doi:10.1136/bjophthalmol-2019-315363

    DOI: 10.1136/bjophthalmol-2019-315363

    Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma (Journal article)

    Thornton, S., Coupland, S. E., Olohan, L., Sibbring, J. S., Kenny, J. G., Hertz-Fowler, C., . . . Kalirai, H. (2020). Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma. CANCERS, 12(4). doi:10.3390/cancers12041039

    DOI: 10.3390/cancers12041039

    Parsimonious Models for Predicting Mortality from Choroidal Melanoma. (Journal article)

    Damato, B., Eleuteri, A., Hussain, R., Kalirai, H., Thornton, S., Taktak, A., . . . Coupland, S. E. (2020). Parsimonious Models for Predicting Mortality from Choroidal Melanoma.. Investigative ophthalmology & visual science, 61(4), 35. doi:10.1167/iovs.61.4.35

    DOI: 10.1167/iovs.61.4.35

    Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study (Journal article)

    Rola, A. C., Taktak, A., Eleuteri, A., Kalirai, H., Heimann, H., Hussain, R., . . . Coupland, S. E. (2020). Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study. CANCERS, 12(2). doi:10.3390/cancers12020477

    DOI: 10.3390/cancers12020477

    2019

    Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features and clinical outcome. (Journal article)

    Kenawy, N., Kalirai, H., Sacco, J. J., Lake, S. L., Heegaard, S., Larsen, A. -C., . . . Coupland, S. E. (2019). Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features and clinical outcome.. Pigment cell & melanoma research, 32(4), 564-575. doi:10.1111/pcmr.12767

    DOI: 10.1111/pcmr.12767

    2018

    Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model (Journal article)

    Eleuteri, A., Taktak, A. F. G., Coupland, S. E., Heimann, H., Kalirai, H., & Damato, B. (2018). Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model. COMPUTERS IN BIOLOGY AND MEDICINE, 102, 151-156. doi:10.1016/j.compbiomed.2018.09.024

    DOI: 10.1016/j.compbiomed.2018.09.024

    Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma (Journal article)

    Farquhar, N., Thornton, S., Coupland, S. E., Coulson, J., Sacco, J. J., Krishna, Y., . . . Kalirai, H. (2018). Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma. The Journal of Pathology: Clinical Research, 4(1), 26-38. doi:10.1002/cjp2.86

    DOI: 10.1002/cjp2.86

    2017

    Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach (Journal article)

    Angi, M., Kalirai, H., Taktak, A., Hussain, R., Groenewald, C., Damato, B. E., . . . Coupland, S. E. (2017). Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach. BRITISH JOURNAL OF OPHTHALMOLOGY, 101(8), 1143-1146. doi:10.1136/bjophthalmol-2017-310361

    DOI: 10.1136/bjophthalmol-2017-310361

    Incorporating Clinical, Histological, and Genetic Parameters for Choroidal Melanoma Prognostication (Journal article)

    Coupland, S. E., Taktak, A., & Damato, B. (2017). Incorporating Clinical, Histological, and Genetic Parameters for Choroidal Melanoma Prognostication. JAMA OPHTHALMOLOGY, 135(7), 818-819. doi:10.1001/jamaophthalmol.2017.1391

    DOI: 10.1001/jamaophthalmol.2017.1391

    2016

    Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors (Journal article)

    Ireland, L., Santos, A., Ahmed, M. S., Rainer, C., Nielsen, S. R., Quaranta, V., . . . Mielgo, A. (2016). Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors. Cancer Research, 76(23), 6851-6863. doi:10.1158/0008-5472.CAN-16-1201

    DOI: 10.1158/0008-5472.CAN-16-1201

    Variations in the anatomy of the vertebral artery cervical loop segment - a potential predisposing factor for traumatic basal subarachnoid hemorrhage? (Journal article)

    Medcalf, J. E., Johnson, C. P., Taktak, A., & Grabherr, S. (2016). Variations in the anatomy of the vertebral artery cervical loop segment - a potential predisposing factor for traumatic basal subarachnoid hemorrhage?. FORENSIC SCIENCE MEDICINE AND PATHOLOGY, 12(4), 444-450. doi:10.1007/s12024-016-9819-4

    DOI: 10.1007/s12024-016-9819-4

    External Validation of the Liverpool Uveal Melanoma Prognosticator Online (Journal article)

    DeParis, S. W., Taktak, A., Eleuteri, A., Enanoria, W., Heimann, H., Coupland, S. E., & Damato, B. (2016). External Validation of the Liverpool Uveal Melanoma Prognosticator Online. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(14), 6116-6122. doi:10.1167/iovs.16-19654

    DOI: 10.1167/iovs.16-19654

    Does Proton Beam Radiotherapy Diminish the Reliability of Prognostic Genetic Analysis of Choroidal Melanoma? (Conference Paper)

    Damato, B. E., Hussein, R. N., Taktak, A. F. G., Kalirai, H., Thornton, S., Heimann, H., & Coupland, S. E. (2016). Does Proton Beam Radiotherapy Diminish the Reliability of Prognostic Genetic Analysis of Choroidal Melanoma?. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 57. Retrieved from http://gateway.webofknowledge.com/

    2015

    Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins. (Journal article)

    Middle, S., Coupland, S. E., Taktak, A., Kidgell, V., Slupsky, J. R., Pettitt, A. R., & Till, K. J. (2015). Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins.. Experimental hematology & oncology, 4, 10. doi:10.1186/s40164-015-0004-3

    DOI: 10.1186/s40164-015-0004-3

    Cluster analysis of multiplex ligation-dependent probe amplification data in choroidal melanoma (Journal article)

    Caines, R., Eleuteri, A., Kalirai, H., Fisher, A. C., Heimann, H., Damato, B. E., . . . Taktak, A. F. G. (2015). Cluster analysis of multiplex ligation-dependent probe amplification data in choroidal melanoma. MOLECULAR VISION, 21, 1-11. Retrieved from http://gateway.webofknowledge.com/

    2014

    Prognostication in Choroidal Melanoma (Chapter)

    Coupland, S. E., Taktak, A., Eleuteri, A., Kalirai, H., & Damato, B. (2014). Prognostication in Choroidal Melanoma. In Clinical Ophthalmic Oncology (pp. 249-261). Springer Berlin Heidelberg. doi:10.1007/978-3-642-54255-8_20

    DOI: 10.1007/978-3-642-54255-8_20

    2013

    Genomic Amplification Is Not a Frequent Event in Uveal Melanomas Reply (Journal article)

    Lake, S. L., Kalirai, H., Dodson, A. R., Coupland, S. E., Lloyd, B. H., Damato, B. E., & Taktak, A. F. G. (2013). Genomic Amplification Is Not a Frequent Event in Uveal Melanomas Reply. AMERICAN JOURNAL OF PATHOLOGY, 183(2), 638-640. Retrieved from http://gateway.webofknowledge.com/

    Single Nucleotide Polymorphism Array Analysis of Uveal Melanomas Reveals That Amplification of CNKSR3 Is Correlated With Improved Patient Survival (Journal article)

    Lake, S. L., Damato, B. E., Kalirai, H., Dodson, A. R., Taktak, A. F. G., Lloyd, B. H., & Coupland, S. E. (2013). Single Nucleotide Polymorphism Array Analysis of Uveal Melanomas Reveals That Amplification of CNKSR3 Is Correlated With Improved Patient Survival. AMERICAN JOURNAL OF PATHOLOGY, 182(3), 678-687. doi:10.1016/j.ajpath.2012.11.036

    DOI: 10.1016/j.ajpath.2012.11.036

    Anatomy and Physiology (Chapter)

    Rhodes, N. P. (2014). Anatomy and Physiology. In Clinical Engineering (pp. 3-20). Elsevier. doi:10.1016/b978-0-12-396961-3.00001-9

    DOI: 10.1016/b978-0-12-396961-3.00001-9

    2012

    HSP-27 protein expression in uveal melanoma: correlation with predicted survival (Journal article)

    Jmor, F., Kalirai, H., Taktak, A., Damato, B., & Coupland, S. E. (2012). HSP-27 protein expression in uveal melanoma: correlation with predicted survival. ACTA OPHTHALMOLOGICA, 90(6), 534-539. doi:10.1111/j.1755-3768.2010.02038.x

    DOI: 10.1111/j.1755-3768.2010.02038.x

    Enhancing survival prognostication in patients with choroidal melanoma by integrating pathologic, clinical and genetic predictors of metastasis (Journal article)

    Eleuteri, A., Damato, B., Coupland, S. E., & Taktak, A. F. G. (2012). Enhancing survival prognostication in patients with choroidal melanoma by integrating pathologic, clinical and genetic predictors of metastasis. International Journal of Biomedical Engineering and Technology, 8(1), 18. doi:10.1504/ijbet.2012.045355

    DOI: 10.1504/ijbet.2012.045355

    2011

    Estimating prognosis for survival after treatment of choroidal melanoma (Journal article)

    Damato, B., Eleuteri, A., Taktak, A. F. G., & Coupland, S. E. (2011). Estimating prognosis for survival after treatment of choroidal melanoma. PROGRESS IN RETINAL AND EYE RESEARCH, 30(5), 285-295. doi:10.1016/j.preteyeres.2011.05.003

    DOI: 10.1016/j.preteyeres.2011.05.003

    Multiplex Ligation-Dependent Probe Amplification Analysis of Uveal Melanoma with Extraocular Extension Demonstrates Heterogeneity of Gross Chromosomal Abnormalities (Journal article)

    Lake, S. L., Damato, B. E., Dopierala, J., Baudo, M. M., Taktak, A. F. G., & Coupland, S. E. (2011). Multiplex Ligation-Dependent Probe Amplification Analysis of Uveal Melanoma with Extraocular Extension Demonstrates Heterogeneity of Gross Chromosomal Abnormalities. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(8), 5559-5564. doi:10.1167/iovs.10-6845

    DOI: 10.1167/iovs.10-6845

    Multiplex Ligation-Dependent Probe Amplification of Conjunctival Melanoma Reveals Common BRAF V600E Gene Mutation and Gene Copy Number Changes (Journal article)

    Lake, S. L., Jmor, F., Dopierala, J., Taktak, A. F. G., Coupland, S. E., & Damato, B. E. (2011). Multiplex Ligation-Dependent Probe Amplification of Conjunctival Melanoma Reveals Common BRAF V600E Gene Mutation and Gene Copy Number Changes. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(8), 5598-5604. doi:10.1167/iovs.10-6934

    DOI: 10.1167/iovs.10-6934

    Immunohistochemical assessment of mitotic count in uveal melanoma (Journal article)

    Angi, M., Damato, B., Kalirai, H., Dodson, A., Taktak, A., & Coupland, S. E. (2011). Immunohistochemical assessment of mitotic count in uveal melanoma. ACTA OPHTHALMOLOGICA, 89(2), E155-E160. doi:10.1111/j.1755-3768.2009.01769.x

    DOI: 10.1111/j.1755-3768.2009.01769.x

    2010

    Genetic Heterogeneity in Uveal Melanoma Assessed by Multiplex Ligation-Dependent Probe Amplification (Journal article)

    Dopierala, J., Damato, B. E., Lake, S. L., Taktak, A. F. G., & Coupland, S. E. (2010). Genetic Heterogeneity in Uveal Melanoma Assessed by Multiplex Ligation-Dependent Probe Amplification. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(10), 4898-4905. doi:10.1167/iovs.09-5004

    DOI: 10.1167/iovs.09-5004

    Whole-Genome Microarray Detects Deletions and Loss of Heterozygosity of Chromosome 3 Occurring Exclusively in Metastasizing Uveal Melanoma (Journal article)

    Lake, S. L., Coupland, S. E., Taktak, A. F. G., & Damato, B. E. (2010). Whole-Genome Microarray Detects Deletions and Loss of Heterozygosity of Chromosome 3 Occurring Exclusively in Metastasizing Uveal Melanoma. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(10), 4884-4891. doi:10.1167/iovs.09-5083

    DOI: 10.1167/iovs.09-5083

    2008

    Artifficial neural networks estimating survival probability after treatment of choroidal melanoma (Journal article)

    Damato, B., Eleuteri, A., Fisher, A. C., Coupland, S. E., & Taktak, A. F. G. (2008). Artifficial neural networks estimating survival probability after treatment of choroidal melanoma. OPHTHALMOLOGY, 115(9), 1598-1607. doi:10.1016/j.ophtha.2008.01.032

    DOI: 10.1016/j.ophtha.2008.01.032

    2007

    Towards the integration of a bioprofile in ocular melanoma (Chapter)

    Taktak, A., Eleuteri, A., Setzkorn, C., Douglas, A., Coupland, S., Hiscott, P., & Damato, B. (2007). Towards the integration of a bioprofile in ocular melanoma. In Unknown Book (Vol. 4507, pp. 980-+). Retrieved from http://gateway.webofknowledge.com/

    2006

    An artificial neural network improves prediction of observed survival in patients with laryngeal squamous carcinoma (Journal article)

    Jones, A. S., Taktak, A. G. F., Helliwell, T. R., Fenton, J. E., Birchall, M. A., Husband, D. J., & Fisher, A. C. (2006). An artificial neural network improves prediction of observed survival in patients with laryngeal squamous carcinoma. European Archives of Oto-Rhino-Laryngology, 263(6), 541-547. doi:10.1007/s00405-006-0021-2

    DOI: 10.1007/s00405-006-0021-2

    2005

    Artificial neural networks and survival prediction in laryngeal cancer (Journal article)

    Helliwell, T. R., Jones, A. S., Taktak, A. G. F., Fenton, J. E., & Fisher, A. C. (2005). Artificial neural networks and survival prediction in laryngeal cancer. Journal of Pathology, 205, 4A.