Publications
2024
Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy.
Sun, L., Zhao, Q., Ao, S., Liu, T., Wang, Z., You, J., . . . Zhang, F. (2024). Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy.. Allergy. doi:10.1111/all.16393
Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris.
Shi, P., Chen, W., Lyu, X., Wang, Z., Li, W., Jia, F., . . . Zhang, F. (2024). Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris.. Nature communications, 15(1), 6259. doi:10.1038/s41467-024-50481-z
Lymphocyte transformation tests predict delayed-type allergy to piperacillin/tazobactam in patients with cystic fibrosis.
Roehmel, J. F., Rohrbach, A., Staab, D., Mall, M. A., Ogese, M., Doerfler, F., & Naisbitt, D. (2024). Lymphocyte transformation tests predict delayed-type allergy to piperacillin/tazobactam in patients with cystic fibrosis.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 23(3), 573-578. doi:10.1016/j.jcf.2023.12.003
2023
Basophil activation test in diagnosis of immediate hypersensitivity reactions to IL-17A inhibitors.
Zhao, Q., Liu, T., Sun, L., Ogese, M. O., Liu, G., Liu, H., & Zhang, F. (2023). Basophil activation test in diagnosis of immediate hypersensitivity reactions to IL-17A inhibitors.. Journal of the European Academy of Dermatology and Venereology : JEADV. doi:10.1111/jdv.19631
A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment
Ogese, M. O., Lister, A., Farrell, L., Gardner, J., Kafu, L., Ali, S. -E., . . . Naisbitt, D. J. (2023). A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment. TOXICOLOGICAL SCIENCES. doi:10.1093/toxsci/kfad101
Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System
Ali, S. -E., Meng, X., Kafu, L., Hammond, S., Zhao, Q., Ogese, M., . . . Naisbitt, D. J. (2023). Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System. CHEMICAL RESEARCH IN TOXICOLOGY, 36(3), 390-401. doi:10.1021/acs.chemrestox.2c00343
2022
Lymphocyte transformation tests offer improved sensitivity over skin tests for lymphocytic sensitization in CF patients with allergy to antibiotics
Roehmel, J., Doerfler, F., Rohrbach, A., Mall, M., Ogese, M., & Naisbitt, D. (2022). Lymphocyte transformation tests offer improved sensitivity over skin tests for lymphocytic sensitization in CF patients with allergy to antibiotics. In KLINISCHE PADIATRIE Vol. 234 (pp. 340). doi:10.1055/s-0042-1754510
Pathomechanisms of Drug Hypersensitivity Targeting the Liver and Skin
Thomson, P., Naisbitt, D., & Ogese, M. (2022). Pathomechanisms of Drug Hypersensitivity Targeting the Liver and Skin. In Cutaneous Drug Hypersensitivity (pp. 47-57). Springer International Publishing. doi:10.1007/978-3-030-82743-4_6
T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis
Semic-Jusufagic, A., Ogese, M. O., Edwards, C., Wilkinson, M., Nissenbaum, C., Lee, T., . . . Naisbitt, D. J. (2022). T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis. PEDIATRIC ALLERGY AND IMMUNOLOGY, 33(6). doi:10.1111/pai.13815
T CELL-MEDIATED HYPERSENSITIVITY TO LUMACAFTOR AND IVACAFTOR IN CYSTIC FIBROSIS
Semic-Jusufagic, A., Ogese, M., Edwards, C., Wilkinson, M., Nissenbaum, C., Lee, T., . . . Naisbitt, D. (2022). T CELL-MEDIATED HYPERSENSITIVITY TO LUMACAFTOR AND IVACAFTOR IN CYSTIC FIBROSIS. doi:10.22541/au.164672762.25283352/v1
Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.
Gardner, J., Ogese, M., Betts, C. J., Pirmohamed, M., & Naisbitt, D. J. (2022). Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.. Chemical research in toxicology, 35(2), 199-202. doi:10.1021/acs.chemrestox.1c00425
2021
HLA Class-II. Restricted CD8<SUP>+</SUP> T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients
Zhao, Q., Almutairi, M., Tailor, A., Lister, A., Harper, N., Line, J., . . . Naisbitt, D. J. (2021). HLA Class-II. Restricted CD8<SUP>+</SUP> T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(10), 2412-+. doi:10.1016/j.jid.2021.03.014
Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084
Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK
Vaselli, N. M., Setiabudi, W., Subramaniam, K., Adams, E. R., Turtle, L., Iturriza-Gomara, M., . . . Hungerford, D. (2021). Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06443-7
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
Ogbe, A., Kronsteiner, B., Skelly, D. T., Pace, M., Brown, A., Adland, E., . . . Dunachie, S. (2021). T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21856-3
Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol
Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317
Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4<SUP>+</SUP> T lymphocytes
Roehmel, J. F., Ogese, M. O., Rohrbach, A., Mall, M. A., & Naisbitt, D. J. (2021). Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4<SUP>+</SUP> T lymphocytes. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), 753-+. doi:10.1016/j.jaci.2020.05.041
2020
Characterization of Clozapine-Responsive Human T Cells
Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646
Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity
Ariza, A., Fernandez-Santamaria, R., Meng, X., Salas, M., Ogese, M. O., Tailor, A., . . . Naisbitt, D. J. (2020). Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity. ALLERGY, 75(10), 2562-2573. doi:10.1111/all.14298
Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.
Ogese, M. O., Watkinson, J., Lister, A., Faulkner, L., Gibson, A., Hillegas, A., . . . Naisbitt, D. J. (2020). Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.. Toxicological sciences : an official journal of the Society of Toxicology, 175(2), 266-278. doi:10.1093/toxsci/kfaa034
P206 Drug allergy to CFTR modulator therapy associated with lumacaftorspecific CD4+ T lymphocytes
Roehmel, J., Ogese, M., Manuel, E., Farell, J., Alexander, R., Mall, M., & Naisbitt, D. (2020). P206 Drug allergy to CFTR modulator therapy associated with lumacaftorspecific CD4+ T lymphocytes. Journal of Cystic Fibrosis, 19, S114-S115. doi:10.1016/s1569-1993(20)30540-3
Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions
Naisbitt, D. J., Olsson-Brown, A., Gibson, A., Meng, X., Ogese, M. O., Tailor, A., & Thomson, P. (2020). Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions. ALLERGY, 75(4), 781-797. doi:10.1111/all.14127
T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity
Hammond, S., Thomson, P. J., Ogese, M. O., & Naisbitt, D. J. (2020). T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 33(1), 77-94. doi:10.1021/acs.chemrestox.9b00327
2019
Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.
Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology, 70(5), 1732-1749. doi:10.1002/hep.30701
Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01
Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01. Allergy, 74(8), 1533-1548. doi:10.1111/all.13769
Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions
Ariza, A., Isabel Montanez, M., Ogese, M. O., Tailor, A., Fernandez, T. D., Torres, M. J., & Naisbitt, D. J. (2019). Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 143 (pp. AB184). doi:10.1016/j.jaci.2018.12.563
2018
Genetic and nongenetic factors that may predispose individuals to allergic drug reactions
Gibson, A., Ogese, M., & Pirmohamed, M. (2018). Genetic and nongenetic factors that may predispose individuals to allergic drug reactions. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 18(4), 325-332. doi:10.1097/ACI.0000000000000459
The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017)
Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019
2017
Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors
Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors
Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2017). The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors. JOURNAL OF IMMUNOLOGY, 199(4), 1223-1237. doi:10.4049/jimmunol.1602029
Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells
Ogese, M. O., Faulkner, L., Jenkins, R. E., French, N. S., Copple, I. M., Antoine, D. J., . . . Naisbitt, D. J. (2017). Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. TOXICOLOGICAL SCIENCES, 158(1), 76-89. doi:10.1093/toxsci/kfx069
Test systems in Drug Discovery for hazard identification and risk assessment of human Drug-Induced Liver Injury.
Weaver, R. J., Betts, C., Blomme, E. A. G., Gerets, H. H. J., Gjervig Jensen, K., Hewitt, P. G., . . . Park, B. K. (2017). Test systems in Drug Discovery for hazard identification and risk assessment of human Drug-Induced Liver Injury.. Expert opinion on drug metabolism & toxicology. doi:10.1080/17425255.2017.1341489
Trimethoprim-induced aseptic meningism
Lochlainn, M. N., Gooi, H. C., Ogese, M. O., Naisbitt, D. J., & Jafar-Mohammadi, B. (2017). Trimethoprim-induced aseptic meningism. BRITISH JOURNAL OF HOSPITAL MEDICINE, 78(2), 108-109. doi:10.12968/hmed.2017.78.2.108
New Approaches to Investigate Drug-Induced Hypersensitivity
Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333
2016
Reactive Metabolites: Current and Emerging Risk and Hazard Assessments
Thompson, R. A., Isin, E. M., Ogese, M. O., Mettetal, J. T., & Williams, D. P. (2016). Reactive Metabolites: Current and Emerging Risk and Hazard Assessments. CHEMICAL RESEARCH IN TOXICOLOGY, 29(4), 505-533. doi:10.1021/acs.chemrestox.5b00410
7th Drug hypersensitivity meeting: part two
Elera, J. D., Boteanu, C., Blanco, M. A. J., Gonzalez-Mendiola, R., García, I. C., Alvarez, A., . . . Santiago, T. L. (2016). 7th Drug hypersensitivity meeting: part two. Clinical and translational allergy, 6(Suppl 3).
2015
Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury
Kim, S. -H., Saide, K., Farrell, J., Faulkner, L., Tailor, A., Ogese, M., . . . Naisbitt, D. J. (2015). Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury. Hepatology, 62(3), 887-899. doi:10.1002/hep.27912
HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis
Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546
Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function
Gibson, A., Ogese, M., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. J. (2015). Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function. Journal of Immunology, 192(06), 2611-2621. doi:10.4049/jimmunol.1302720
Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase
Ogese, M. O., Jenkins,, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase. Chemical Research in Toxicology, 28(1), 144-154. doi:10.1021/tx500458k
2014
Abs No: HLA-A*31:01 positive hypersensitive patient
Lichtenfels, M., Farrell, J., Ogese, M., Bell, C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). Abs No: HLA-A*31:01 positive hypersensitive patient. Clinical and translational allergy, 4(Suppl 3), P117. doi:10.1186/2045-7022-4-s3-p117
HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes
Ogese, M., Saide, K., Whitaker, P., Peckham, D., Faulkner, L., Alfirevic, A., . . . Naisbitt, D. (2014). HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes. Clinical and translational allergy, 4(Suppl 3), P110. doi:10.1186/2045-7022-4-s3-p110
Negative regulation by Programmed Death Ligand‐1 during drug‐specific priming of T‐cells and the influence of Programmed Death‐1 on effector T‐cell function
Gibson, A., Ogese, M., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. J. (2014). Negative regulation by Programmed Death Ligand‐1 during drug‐specific priming of T‐cells and the influence of Programmed Death‐1 on effector T‐cell function. Clinical and Translational Allergy, 4(S3). doi:10.1186/2045-7022-4-s3-o2
HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient
Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient. Chemical Research in Toxicology, 27(02), 175-177. doi:10.1021/tx400460w
In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs
Naisbitt, D. J., Nattrass, R. G., & Ogese, M. O. (2014). In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 34(3), 691-+. doi:10.1016/j.iac.2014.04.009
2012
IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers
Kiorpelidou, E., Foster, B., Farrell, J., Ogese, M. O., Faulkner, L., Goldring, C. E., . . . Naisbitt, D. J. (2012). IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers. CHEMICAL RESEARCH IN TOXICOLOGY, 25(10), 2054-2056. doi:10.1021/tx300350s
Undated
Definition of antigenic determinants in drug hypersensitive patients: an integrated clinical, chemical and cellular approach to quantify and characterize the drug signals presented to T-Lymphocytes
Ogese, M. (n.d.). Definition of antigenic determinants in drug hypersensitive patients: an integrated clinical, chemical and cellular approach to quantify and characterize the drug signals presented to T-Lymphocytes. (PhD Thesis, University of Liverpool).