Research outputs
2026
Current drug hypersensitivity challenges facing patients with cystic fibrosis.
Gardner, J., Clarke, E., Peckham, D., Whitaker, P., Roehmel, J. F., & Naisbitt, D. J. (2026). Current drug hypersensitivity challenges facing patients with cystic fibrosis.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, S1569-1993(26)00029-9. doi:10.1016/j.jcf.2026.01.010
2025
TSC22 domain family member 3 links natural killer cells to CD8+T cell-mediated drug hypersensitivity
Sun, L., Huai, P., Wang, Z., Zhao, Q., Lin, Y., Liu, T., . . . Zhang, F. (2025). TSC22 domain family member 3 links natural killer cells to CD8+T cell-mediated drug hypersensitivity. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 10(1). doi:10.1038/s41392-025-02300-0
Elucidating CD4+and CD8+T-cell involvement in patients with vancomycin-induced DRESS
Gardner, J., Martinez-Rivera, S., Line, J., Thomson, P., Clarke, E., Gibson, A., . . . Naisbitt, D. J. (2025). Elucidating CD4+and CD8+T-cell involvement in patients with vancomycin-induced DRESS. TOXICOLOGICAL SCIENCES, 206(2), 420-432. doi:10.1093/toxsci/kfaf074
Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy
Sun, L., Zhao, Q., Ao, S., Liu, T., Wang, Z., You, J., . . . Zhang, F. (2025). Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy. ALLERGY, 80(5), 1400-1416. doi:10.1111/all.16393
Immunogenic adverse events to CFTR modulators-An international survey
Urbantat, R. M., Behan, L., Wisniewski, S., Gardner, J., Stahl, M., Mall, M. A., . . . Roehmel, J. F. (2025). Immunogenic adverse events to CFTR modulators-An international survey. JOURNAL OF CYSTIC FIBROSIS, 24(3), 521-525. doi:10.1016/j.jcf.2025.03.003
Phenotypic and functional characterisation of liver-infiltrating T-cells in a case of CFTR modulator induced drug-induced liver injury.
Clarke, E., Gardner, J., Howsawi, A., Gillgrass, L., Roehmel, J. F., Whitaker, P., . . . Naisbitt, D. J. (2025). Phenotypic and functional characterisation of liver-infiltrating T-cells in a case of CFTR modulator induced drug-induced liver injury.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, S1569-1993(25)02506-8. doi:10.1016/j.jcf.2025.11.011
Understanding mechanisms of thrombosis and thrombocytopenia with adenoviral SARS-CoV-2 vaccines: a comprehensive synopsis
Nicolson, P. L. R., Abrams, S. T., Amirthalingam, G., Brown, K., Buka, R. J., Caulfield, M. J., . . . Pirmohamed, M. (2025). Understanding mechanisms of thrombosis and thrombocytopenia with adenoviral SARS-CoV-2 vaccines: a comprehensive synopsis.
2024
Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS.
Characterisation of liver-derived T-cells during and upon resolution of CFTR modulator induced liver injury
Clarke, E., Gardner, J., Gillgrass, L., Peckham, D., Meng, X., & Naisbitt, D. (2024). Characterisation of liver-derived T-cells during and upon resolution of CFTR modulator induced liver injury. TOXICOLOGY LETTERS, 399, S234. doi:10.1016/j.toxlet.2024.07.572
Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines.
Gardner, J., Abrams, S. T., Toh, C. -H., Parker, A. L., Lovatt, C., Nicolson, P. L. R., . . . Naisbitt, D. J. (2024). Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines.. NPJ vaccines, 9(1), 99. doi:10.1038/s41541-024-00895-z
Glycolysis: An early marker for vancomycin-specific T-cell activation
Gardner, J., Hammond, S., Jensen, R., Gibson, A., Krantz, M. S., Ardern-Jones, M., . . . Naisbitt, D. J. (2024). Glycolysis: An early marker for vancomycin-specific T-cell activation. CLINICAL AND EXPERIMENTAL ALLERGY, 54(1), 21-33. doi:10.1111/cea.14423
2023
A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment
Ogese, M. O., Lister, A., Farrell, L., Gardner, J., Kafu, L., Ali, S. -E., . . . Naisbitt, D. J. (2023). A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment. TOXICOLOGICAL SCIENCES. doi:10.1093/toxsci/kfad101
Activation of Human CD8+T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides
Almutairi, M., Lister, A., Zhao, Q., Line, J., Adair, K., Tailor, A., . . . Naisbitt, D. J. (2023). Activation of Human CD8+T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides. JOURNAL OF IMMUNOLOGY, 210(8), 1031-1042. doi:10.4049/jimmunol.2200531
Glycolytic switching: An early indicator for drug-specific T-cell activation
Gardner, J., Hammond, S., Betts, C., Chadwick, A., & Naisbitt, D. (2023). Glycolytic switching: An early indicator for drug-specific T-cell activation. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 180 (pp. 505). Retrieved from https://www.webofscience.com/
2022
DETERMINING THE IMMUNOGENICITY OF GLYCOPEPTIDE ANTIBIOTICS IMPLICATED IN DRUG HYPERSENSITIVITY REACTIONS
Gardner, J. (2022, September 8). DETERMINING THE IMMUNOGENICITY OF GLYCOPEPTIDE ANTIBIOTICS IMPLICATED IN DRUG HYPERSENSITIVITY REACTIONS.
Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity
Hammond, S., Olsson-Brown, A., Grice, S., Gibson, A., Gardner, J., Castrejon-Flores, J. L., . . . Naisbitt, D. J. (2022). Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity. TOXICOLOGICAL SCIENCES, 186(1), 58-69. doi:10.1093/toxsci/kfab144
Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.
Gardner, J., Ogese, M., Betts, C. J., Pirmohamed, M., & Naisbitt, D. J. (2022). Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.. Chemical research in toxicology, 35(2), 199-202. doi:10.1021/acs.chemrestox.1c00425
2021
Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK
Vaselli, N. M., Setiabudi, W., Subramaniam, K., Adams, E. R., Turtle, L., Iturriza-Gomara, M., . . . Hungerford, D. (2021). Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06443-7
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
Ogbe, A., Kronsteiner, B., Skelly, D. T., Pace, M., Brown, A., Adland, E., . . . Dunachie, S. (2021). T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21856-3
Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084
T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab
Hammond, S., Olsson-Brown, A., Gardner, J., Thomson, P., Ali, S. -E., Jolly, C., . . . Naisbitt, D. (2021). T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(5). doi:10.1136/jitc-2021-002521
Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol
Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317