Publications
2025
Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levels.
Renaudineau, Y., Charras, A., Natoli, V., Congy-Jolivet, N., Haldenby, S., Liu, X., . . . UK jSLE Cohort Study Group. (2025). Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levels.. Journal of translational autoimmunity, 10, 100268. doi:10.1016/j.jtauto.2025.100268
Genetic and epigenetic factors shape phenotypes and outcomes in systemic lupus erythematosus - focus on juvenile-onset systemic lupus erythematosus.
Charras, A., Hiraki, L. T., Lewandowski, L., & Hedrich, C. M. (2025). Genetic and epigenetic factors shape phenotypes and outcomes in systemic lupus erythematosus - focus on juvenile-onset systemic lupus erythematosus.. Current opinion in rheumatology, 37(2), 149-163. doi:10.1097/bor.0000000000001072
Treatment options for preventing autoimmune-mediated congenital heart block: a systematic review.
Agarwal, A., Skoutelis, N., Zhou, Y., Kawanami, R., Charras, A., Occhigrossi, F., . . . Hawcutt, D. (2025). Treatment options for preventing autoimmune-mediated congenital heart block: a systematic review.. Archives of disease in childhood, archdischild-2024-327570. doi:10.1136/archdischild-2024-327570
2024
An improved understanding of paediatric chronic nonbacterial osteomyelitis (CNO) pathophysiology informs current and future treatment.
Roberts, E., Charras, A., Hahn, G., & Hedrich, C. M. (2024). An improved understanding of paediatric chronic nonbacterial osteomyelitis (CNO) pathophysiology informs current and future treatment. . Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, zjae141. doi:10.1093/jbmr/zjae141
AB1107 TYPE I INTERFERON ASSOCIATED GENE:GENE INTERRELATIONS MAY CONTRIBUTE TO EARLY DISEASE-ONSET AND HIGH DISEASE ACTIVITY IN JUVENILE-ONSET LUPUS
Charras, A., Renaudineau, Y., Natoli, V., Fusaro, M., MD Smith, E., Beresford, M. W., & Hedrich, C. (2024). AB1107 TYPE I INTERFERON ASSOCIATED GENE:GENE INTERRELATIONS MAY CONTRIBUTE TO EARLY DISEASE-ONSET AND HIGH DISEASE ACTIVITY IN JUVENILE-ONSET LUPUS. In Annals of the Rheumatic Diseases Vol. 83 (pp. 1883). Elsevier BV. doi:10.1136/annrheumdis-2024-eular.3812
POS0304 ALLELE COUNTS ASSOCIATE WITH EARLY DISEASE ONSET, ORGAN INVOLVEMENT AND DISEASE SEVERITY IN JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS
Natoli, V., Charras, A., Hasoon, M., Caamano Gutierrez, E., MD Smith, E., Beresford, M. W., & Hedrich, C. M. (2024). POS0304 ALLELE COUNTS ASSOCIATE WITH EARLY DISEASE ONSET, ORGAN INVOLVEMENT AND DISEASE SEVERITY IN JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS. In Annals of the Rheumatic Diseases Vol. 83 (pp. 261-262). Elsevier BV. doi:10.1136/annrheumdis-2024-eular.1103
Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus.
Renaudineau, Y., Charras, A., Natoli, V., Fusaro, M., Smith, E. M. D., Beresford, M. W., . . . UK jSLE Cohort Study. (2024). Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus.. Clinical immunology (Orlando, Fla.), 262, 110194. doi:10.1016/j.clim.2024.110194
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO).
Charras, A., Hofmann, S. R., Cox, A., Schulze, F., Russ, S., Northey, S., . . . Hedrich, C. M. (2024). P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO).. Journal of autoimmunity, 144, 103183. doi:10.1016/j.jaut.2024.103183
2023
Late Breaking Abstract - Age and vitamin D influence airway epithelial cells response to SARS-CoV-2 infection
Sposito, F., Pennington, S., David, C., Duggan, J., Northey, S., Biagini, G., . . . Hedrich, C. (2023). Late Breaking Abstract - Age and vitamin D influence airway epithelial cells response to SARS-CoV-2 infection. In Airway cell biology and immunopathology (pp. OA4962). European Respiratory Society. doi:10.1183/13993003.congress-2023.oa4962
Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome.
Sposito, F., Northey, S., Charras, A., McNamara, P. S., & Hedrich, C. M. (2023). Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome.. Genes and immunity. doi:10.1038/s41435-023-00218-7
Age differential CD13 and interferon expression in airway epithelia affect SARS-CoV-2 infection - effects of vitamin D.
Sposito, F., Pennington, S. H., A W David, C., Duggan, J., Northey, S., Biagini, G., . . . Hedrich, C. M. (2023). Age differential CD13 and interferon expression in airway epithelia affect SARS-CoV-2 infection - effects of vitamin D.. Mucosal immunology, S1933-0219(23)00064-8. doi:10.1016/j.mucimm.2023.08.002
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)
Natoli, V., Charras, A., Hahn, G., & Hedrich, C. M. (2023). Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE). MOLECULAR AND CELLULAR PEDIATRICS, 10(1). doi:10.1186/s40348-023-00161-7
Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome
OP0100 DNA METHYLATION PATTERNS IN CD4+ T CELLS DISCERN SKIN PSORIASIS FROM PSORIATIC ARTHRITIS
Natoli, V., Charras, A., Hofmann, S., Northey, S., Russ, S., Schulze, F., . . . Hedrich, C. (2023). OP0100 DNA METHYLATION PATTERNS IN CD4+ T CELLS DISCERN SKIN PSORIASIS FROM PSORIATIC ARTHRITIS. In Annals of the Rheumatic Diseases Vol. 82 (pp. 67-68). Elsevier BV. doi:10.1136/annrheumdis-2023-eular.4069
Altered DNA methylation and gene expression predict disease severity in patients with Aicardi-Goutieres syndrome
Garau, J., Charras, A., Varesio, C., Orcesi, S., Dragoni, F., Galli, J., . . . Hedrich, C. M. (2023). Altered DNA methylation and gene expression predict disease severity in patients with Aicardi-Goutieres syndrome. CLINICAL IMMUNOLOGY, 249. doi:10.1016/j.clim.2023.109299
Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE
Charras, A., Haldenby, S., Smith, E. M. D., Egbivwie, N., Olohan, L., Kenny, J. G., . . . Hedrich, C. M. (2023). Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE. RHEUMATOLOGY, 62(SI2), SI210-SI225. doi:10.1093/rheumatology/keac275
<i>P2RX7</i> Gene Variants Associate with Altered Inflammasome Assembly and Reduced Pyroptosis in Chronic Nonbacterial Osteomyelitis (CNO)
DNA methylation patterns in CD4+ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis
Natoli, V., Charras, A., Hofmann, S. R., Northey, S., Russ, S., Schulze, F., . . . Hedrich, C. M. (2023). DNA methylation patterns in CD4+ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis. Frontiers in Immunology, 14. doi:10.3389/fimmu.2023.1245876
2022
Assessing the robustness of clinical trials by estimating Jadad's score using artificial intelligence approaches.
Casy, T., Grasseau, A., Charras, A., Rouvière, B., Pers, J. -O., Foulquier, N., & Saraux, A. (2022). Assessing the robustness of clinical trials by estimating Jadad's score using artificial intelligence approaches.. Computers in biology and medicine, 148, 105851. doi:10.1016/j.compbiomed.2022.105851
678 Damaging variants in P2X7R associate with Chronic Nonbacterial Osteomyelitis (CNO)
Charras, A., Hofmann, S. R., Cox, A., Schulze, F., Russ, S., Hartmann, H., . . . Hedrich, C. M. (2022). 678 Damaging variants in P2X7R associate with Chronic Nonbacterial Osteomyelitis (CNO). In British Society for Rheumatology (pp. A260). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2022-rcpch.421
883 Altered DNA methylation patterns in monocytes from Chronic Nonbacterial Osteomyelitis (CNO) patients remain after induction of remission
Carlsson, E., Charras, A., Duffy, G., Beresford, M., Girschick, H., Morbach, H., & Hedrich, C. (2022). 883 Altered DNA methylation patterns in monocytes from Chronic Nonbacterial Osteomyelitis (CNO) patients remain after induction of remission. In British Society for Rheumatology (pp. A261.2-A262). BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2022-rcpch.423
2021
DNA Methylation Patterns in CD8<SUP>+</SUP> T Cells Discern Psoriasis From Psoriatic Arthritis and Correlate With Cutaneous Disease Activity
Charras, A., Garau, J., Hofmann, S. R., Carlsson, E., Cereda, C., Russ, S., . . . Hedrich, C. M. (2021). DNA Methylation Patterns in CD8<SUP>+</SUP> T Cells Discern Psoriasis From Psoriatic Arthritis and Correlate With Cutaneous Disease Activity. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9. doi:10.3389/fcell.2021.746145
Systemic Lupus Erythematosus in Children and Young People
Charras, A., Smith, E., & Hedrich, C. M. (2021). Systemic Lupus Erythematosus in Children and Young People. CURRENT RHEUMATOLOGY REPORTS, 23(3). doi:10.1007/s11926-021-00985-0
TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.
Montibus, B., Cercy, J., Bouschet, T., Charras, A., Maupetit-Méhouas, S., Nury, D., . . . Arnaud, P. (2021). TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.. Cellular and molecular life sciences : CMLS, 78(2), 757-768. doi:10.1007/s00018-020-03541-8
2020
JAK Inhibitors Suppress Innate Epigenetic Reprogramming: a Promise for Patients with Sjögren's Syndrome.
Charras, A., Arvaniti, P., Le Dantec, C., Arleevskaya, M. I., Zachou, K., Dalekos, G. N., . . . Renaudineau, Y. (2020). JAK Inhibitors Suppress Innate Epigenetic Reprogramming: a Promise for Patients with Sjögren's Syndrome.. Clinical reviews in allergy & immunology, 58(2), 182-193. doi:10.1007/s12016-019-08743-y
Linking genetic variation with epigenetic profiles in Sjogren's syndrome
Arvaniti, P., Le Dantec, C., Charras, A., Arleevskaya, M. A., Hedrich, C. M., Zachou, K., . . . Renaudineau, Y. (2020). Linking genetic variation with epigenetic profiles in Sjogren's syndrome. CLINICAL IMMUNOLOGY, 210. doi:10.1016/j.clim.2019.108314
2019
JAK Inhibitors and Oxidative Stress Control.
Charras, A., Arvaniti, P., Le Dantec, C., Dalekos, G. N., Zachou, K., Bordron, A., & Renaudineau, Y. (2019). JAK Inhibitors and Oxidative Stress Control.. Frontiers in immunology, 10, 2814. doi:10.3389/fimmu.2019.02814
The role of epigenetics in paediatric rheumatic disease
Charras, A., & Hedrich, C. M. (2019). The role of epigenetics in paediatric rheumatic disease. CURRENT OPINION IN RHEUMATOLOGY, 31(5), 450-463. doi:10.1097/BOR.0000000000000627
Sjögren’s Syndrome
Le Pottier, L., Amrouche, K., Charras, A., Bordron, A., & Pers, J. -O. (2019). Sjögren’s Syndrome. In Rare Diseases of the Immune System (pp. 53-94). Springer International Publishing. doi:10.1007/978-3-030-03934-9_4
2018
[Influence of epigenetic in Sjögren's syndrome].
Bordron, A., Charras, A., Le Dantec, C., & Renaudineau, Y. (2018). [Influence of epigenetic in Sjögren's syndrome].. La Revue de medecine interne, 39(5), 346-351. doi:10.1016/j.revmed.2017.09.003
Chapter 11 Primary Sjögren’s Syndrome and Epigenetics
Charras, A., Le Dantec, C., Konsta, O. D., Brooks, W. H., Bordron, A., & Renaudineau, Y. (2018). Chapter 11 Primary Sjögren’s Syndrome and Epigenetics. In The Epigenetics of Autoimmunity (pp. 221-239). Elsevier. doi:10.1016/b978-0-12-809912-4.00011-8
Primary Sjögren’s Syndrome and Epigenetics
Charras, A., Le Dantec, C., Konsta, O. D., Brooks, W. H., Bordron, A., & Renaudineau, Y. (2018). Primary Sjögren’s Syndrome and Epigenetics. In The Epigenetics of Autoimmunity (pp. 221-239). Elsevier. doi:10.1016/b978-0-12-809912-4.00011-8
2017
Signature et conséquences des anomalies de méthylation de l’ADN au cours du syndrome sec de Gougerot–Sjögren
Charras, A., Le Dantec, C., Konsta, O. D., Bagacean, C., Pers, J. O., Kapsogeorgou, E. K., . . . Renaudineau, Y. (2017). Signature et conséquences des anomalies de méthylation de l’ADN au cours du syndrome sec de Gougerot–Sjögren. La Revue de Médecine Interne, 38, A71. doi:10.1016/j.revmed.2017.03.055
Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjögren's syndrome.
Charras, A., Konsta, O. D., Le Dantec, C., Bagacean, C., Kapsogeorgou, E. K., Tzioufas, A. G., . . . Renaudineau, Y. (2017). Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjögren's syndrome.. Annals of the rheumatic diseases, 76(3), 625-628. doi:10.1136/annrheumdis-2016-210167
2016
Epigenetic Mechanisms in Sjögren’s Syndrome
Le Dantec, C., Charras, A., Bordron, A., Brooks, W., & Renaudineau, Y. (2016). Epigenetic Mechanisms in Sjögren’s Syndrome. European Medical Journal, 21-28. doi:10.33590/emj/10311584
Epigenetic modifications in salivary glands from patients with Sjögren's syndrome affect cytokeratin 19 expression.
Konsta, O. D., Charras, A., Le Dantec, C., Kapsogeorgeou, E., Bordron, A., Brooks, W. H., . . . Renaudineau, Y. (2016). Epigenetic modifications in salivary glands from patients with Sjögren's syndrome affect cytokeratin 19 expression.. Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie, 53(1), e01.
Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration.
Konsta, O. D., Le Dantec, C., Charras, A., Cornec, D., Kapsogeorgou, E. K., Tzioufas, A. G., . . . Renaudineau, Y. (2016). Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration.. Journal of autoimmunity, 68, 30-38. doi:10.1016/j.jaut.2015.12.002
Similarities and Differences of Epigenetic Mechanisms in Lupus and Sjogren's Syndrome
C, L. D., A, C., H Brooks, W., & Renaudineau, Y. (2016). Similarities and Differences of Epigenetic Mechanisms in Lupus and Sjogren's Syndrome. Lupus: Open Access, 01(01). doi:10.35248/2684-1630.16.1.e101
2015
An in silico Approach Reveals Associations between Genetic and Epigenetic Factors within Regulatory Elements in B Cells from Primary Sjögren's Syndrome Patients.
Konsta, O. D., Le Dantec, C., Charras, A., Brooks, W. H., Arleevskaya, M. I., Bordron, A., & Renaudineau, Y. (2015). An in silico Approach Reveals Associations between Genetic and Epigenetic Factors within Regulatory Elements in B Cells from Primary Sjögren's Syndrome Patients.. Frontiers in immunology, 6, 437. doi:10.3389/fimmu.2015.00437