Photo of Prof Mark Caddick

Prof Mark Caddick BSc. PhD.

Professor Functional and Comparative Genomics

    Biography

    Personal Statement

    Our current work is focused on the mechanisms of regulated transcript degradation and the link between translation and the modification of RNA, which involves the addition of a short pyrimidine tags to the transcripts. This tag marks transcripts for silencing, triggering a shift in their subcellular localisation and promoting rapid degradation. Additional interest include: whole transcriptome sequencing to define the functional genome; nitrogen metabolism and its regulation; the application of comparative genomics to decipher the regulatory code.

    Personal Distinctions

    • mRNA Tagging, Degradation and Translation: How, When and Why? (Invitation to Speak, Orgnaising committee 2014)
    • The Transcriptome and How To Turn It Off: RNA Degradation and Translational Repression (Invitation to Speak, Organising committee 2012)
    • mRNA 3’ tagging is induced by nonsense mediated decay and promotes translational repression (Invitation to Speak, Organising Committee 2011)
    • The co-ordinated regulation of transcript stability and translation (Invitation to Speak, Meeting organising committee 2011)
    • The role of mRNA 3' tagging in RNA degradation and the cesation of translation.
    • Invited Lecture: mRNA degradation in A. nidulans: CUCU spells the end. (Invitation to Speak, IMC9 organising committee. 2010)
    • High-throughput sequencing of the A. nidulans transcriptome (Invitation to Speak, EUROFUNG Committee 2010)
    • Invited Lecture: High-throughput sequencing of the A. nidulans transcriptome (Invitation to Speak, Aspergilus gemone committee 2010)
    • EUROFUNG executive committee member (EUROFUNGBASE consortium 2010)
    • Looking downstream from the promoter:Multiple regulatory mechanisms in fungi (Invitation to Speak, Eurofung 2008)
    • RNA stability, a fundamental aspect of gene regulation (Invitation to Speak, Slovinian Microbilogy Society 2008)
    • Lecture; Regulated transcript stability in Aspergillus nidulans (Invitation to Speak, The Genetics Society of Ammerica 2007)
    • Plenary lecture - The role of RNA degradation in regulating nitrogen metabolism (Invitation to Speak, Alicia Gonzalez - University of Mexico 2006)
    • Plenary lecture- Gene Regulation (Invitation to Speak, AAA organisers 2006)
    • Comparative genomic analysis of Aspergillus regulatory elements (Invitation to Speak, EUROFUNG organisers 2005)
    • “Nitrogen regulation of transcript stability in A. nidulans (Invitation to Speak, Aspergillus Genomes Research Policy Committee 2005)
    • Member of Aspergillus genomic tools working group (Aspergillus Genomes Research Policy Committee 2005)
    • Member of Aspegillus niger annotation team - heading transcription factor analysis (DSM 2005)
    • Member of Aspergillus Genome Annotation - to head signalling and transcription (Genome consortimu including TIGR & Sanger center/ 2003)
    • Plenary lecture: Nitrogen metabolite signalling in Aspergillus nidulans (Invitation to Speak, Conference organisers 2002)
    • Plenery Lecture: The regulatoin of nitrogen metabolism in Aspergillus nidulans (Invitation to Speak, Mycological Society 2002)
    • Plenary lecture ; Nitrogen metabolite signalling in Aspergillus nidulans (Invitation to Speak, Conference organisers 2001)

    Administrative Roles

    • Head of The Department of Functional and Comparative Genomics.
    • Course Leader: “Advanced Genetic Techniques” BIOL276.

    Untitled Document