Jay Hinton joined the Institute of Integrative Biology, University of Liverpool, in 2012. Jay’s interest in the way that bacterial pathogens cause disease in humans led him to begin working on Salmonella in 1990. He discovered that the H-NS protein is responsible for silencing gene expression in bacteria in 2006, and pioneered an approach that revealed a "snapshot" of bacterial gene expression during the process of infection of mammalian cells in 2003. Recently, Jay has focused on the role played by small RNA molecules in the regulation of infection of mammalian cells by Salmonella, and the mechanisms that bacterial pathogens use to cause disease in humans.
Jay is now using RNA-seq-based transcriptomics to understand the virulence of new variants of Salmonella in the current epidemic of invasive disease in sub-Saharan Africa, and to investigate the infection biology of these dangerous bacteria. The underlying theme of current research is to understand the intricate interplay of gene expression that leads to bacterial disease, to pave the way for new antibiotics and vaccines.