Module Specification |
| The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module. |
| Title | ANTIMICROBIAL CHEMOTHERAPY FOR CHEMISTS | ||
| Code | LIFE348 | ||
| Coordinator |
Dr SP Pushpakom Molecular and Clinical Pharmacology Sudeep.Pushpakom@liverpool.ac.uk |
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| Year | CATS Level | Semester | CATS Value |
| Session 2016-17 | Level 6 FHEQ | Second Semester | 15 |
Pre-requisites before taking this module (other modules and/or general educational/academic requirements): |
| PHAR295 PHAR295; PHARL280 |
Modules for which this module is a pre-requisite: |
Co-requisite modules: |
| PHAR453 |
Linked Modules: |
Teaching Schedule |
| Lectures | Seminars | Tutorials | Lab Practicals | Fieldwork Placement | Other | TOTAL | |
| Study Hours |
20 Lectures will introduce topics on HIV, hepatitis, malaria, TB and basic principles of chemotherapy with particular emphasis of drug action and toxicity. |
1 Revision tutorial |
21 | ||||
| Timetable (if known) | |||||||
| Private Study | 129 | ||||||
| TOTAL HOURS | 150 | ||||||
Assessment |
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| EXAM | Duration | Timing (Semester) |
% of final mark |
Resit/resubmission opportunity |
Penalty for late submission |
Notes |
| Unseen Written Exam | 120 | Semester 2 | 80 | Yes | Written exam Notes (applying to all assessments) Coursework assessment will focus on the topic of TB. It will consist of handwritten answers and hand-drawn chemical structures. This is NOT anonymous as it cannot be submitted electronically. Students are expected to handover the answer sheets to the TSO and need to provide at least student IDs on the assignment. Individual written feedback and provisional marks will be provided within 2 weeks of the hand-in date through the TSO. The written exam will comprise of essay questions. | |
| CONTINUOUS | Duration | Timing (Semester) |
% of final mark |
Resit/resubmission opportunity |
Penalty for late submission |
Notes |
| Coursework | Max 2 sides of A4 pa | Semester 2 | 20 | Yes | Standard UoL penalty applies | Written coursework |
Aims |
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1) To reinforce the relevance and importance of the principles of chemotherapy learned in year two (antibacterial chemotherapy). 2) To extend the application of chemotherapy principles to diseases caused by viruses (e.g. HIV/AIDS) and parasites (i.e. malaria) 3) To introduce novel concepts in drug design (Nanomedicine) and treatment strategy (Pharmacogenomics) in the context of chemotherapy. 4) To illustrate the importance of chemical structure and structure-based drug design in drug action. |
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Learning Outcomes |
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Critically evaluate how the principles of selective toxicity may be applied to the chemotherapy of infectious diseases |
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Discuss the clinical relevance of basic pharmacological principles of chemotherapy |
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Discuss the importance of drug resistance in the treatment and prevention of disease |
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Evaluate the importance of structure activity relationship (SAR) in modern drug design in the context of chemotherapy |
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Teaching and Learning Strategies |
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Lecture - Lectures will introduce topics on HIV, hepatitis, malaria, TB and basic principles of chemotherapy with particular emphasis of drug action and toxicity. |
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Tutorial - Revision tutorial |
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Syllabus |
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| 1 |
Antiviral therapy - Mechanisms of drug action and pharmacokinetics - Antiviral therapy for Hepatitis C infection - Antiviral therapy for Hepatitis C infection: New and emerging therapies - Pharmacogenetics of Antiviral therapy Basic principles of chemotherapy; selective toxicity Drug resistance - Evolution and Impact - Genetics and biochemical mechanisms Tuberculosis - Pharmacology, Medicinal Chemistry and Drug Discovery Nanomedicines and Chemotherapy 4-aminoquinolines - mechanism of Action/ SAR - Drug Metabolism/Drug Design Peroxide antimalarials: Mechanism of action/ SAR/Drug Metabolism The folate pathway in Plasmodium falciparum: A Target for Sulfur Based Drugs and DHFR Inhibitors |
Recommended Texts |
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Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module. Explanation of Reading List: |
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