Module Specification
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title DRUG METABOLISM AND RESPONSE
Code LIFE403
Coordinator Dr D Antoine
Molecular and Clinical Pharmacology
D.Antoine@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2016-17 Level 7 FHEQ First Semester 7.5

Pre-requisites before taking this module (other modules and/or general educational/academic requirements):
None 

Modules for which this module is a pre-requisite:
 

Co-requisite modules:
 

Linked Modules:
 

Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 15
Lectures to introduce key concepts
  1
Revision tutorial
    1
workshop around the application of using PKPD calculations for problem solving
17
Timetable (if known)     This refers to a timetabled revision tutorial
  		       
Private Study 58
TOTAL HOURS 75

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Unseen Written Exam  120  Semester 1  80  Yes    Exam 
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Coursework  2 page document up t  Semester 1  20  Yes  Standard UoL penalty applies  Summative assessment Notes (applying to all assessments) - none 

Aims

  1. To demonstrate the relevance and importance of the principles of drug metabolism and pharmacokinetics

  2. To explain the importance of the relationship between drug disposition and drug response

  3. To develop in students the ability to apply, critically evaluate and interpret this knowledge and understanding, to solve complex problems in pharmacology

Learning Outcomes

To appraise the principles of drug disposition and drug response, particularly in relation to why subjects differ in their response to drugs

To critically discuss the relevance of basic pharmacokinetic principles to achieving a good response to therapy

To critically analyse pharmacokinetic data

To evaluate  the dispositional basis of adverse drug reactions

Teaching and Learning Strategies

Lecture - Lectures to introduce key concepts

Tutorial - Revision tutorial

This refers to a timetabled revision tutorial

Workshop - workshop around the application of using PKPD calculations for problem solving

Syllabus
1 

Topic 1 – Importance of drug metabolism to drug response

Overview of the Cytochrome P450 superfamily and their function, phase 1 and 2 metabolism, molecular mechanisms of induction and inhibition of metabolism, the impact of genetic variation on the relationship between drug metabolism and drug toxicity, clinical consequences of metabolism mediated drug related hepatotoxicity


Topic 2 – Pharmacokinetic principles

Overview of basic concepts/definitions, principles of bioavailability and clearance (impact of hepatic and renal clearance ), factors affecting pharmacokinetic variability (drug-drug interactions)


Topic 3 – Importance of drug metabolism to drug development

Summary and introduction to concepts in drug discovery and drug development, Understanding the relationship between structure, concentration and biolo gical effect , Metabolite issues in drug discovery and development (focus on safety assessment and reactive metabolite theory)

Recommended Texts
Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
Explanation of Reading List: