Module Specification
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title ANTIMICROBIAL CHEMOTHERAPY FOR CHEMISTS
Code PHAR459
Coordinator Dr SP Pushpakom
Molecular and Clinical Pharmacology
Sudeep.Pushpakom@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2016-17 Level 6 FHEQ Second Semester 15

Pre-requisites before taking this module (other modules and/or general educational/academic requirements):
PHAR295 PHAR295; PHARL280 

Modules for which this module is a pre-requisite:
 

Co-requisite modules:
PHAR453 

Linked Modules:
 

Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 20

   2

       22
Timetable (if known)              
Private Study 128
TOTAL HOURS 150

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Written Exam  2.5 hours  Semester 2  90  next ordinary sitting    Assessment 2 Notes (applying to all assessments) In course assessment Written questions  
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Coursework    Semester 2  10  next ordinary sitting    Assessment 1 

Aims

The aim of this module, aimed specifically at F1B2 and F1BF students, is to reinforce the relevance and importance of the principles of chemotherapy learned in year two (antibacterial chemotherapy) and extend their application to diseases caused by viruses (e.g. HIV/AIDS) and parasites (i.e. malaria). It uses antimalarial chemotherapy to illustrate the importance of mechanism of action in drug design.


Learning Outcomes

Understand how theprinciples of selective toxicity may be applied to the chemotherapy ofinfectious and non-infectious disease.

Understand the clinical relevance of basic pharmacologicalprinciples of chemotherapy

Understand the importance of drug resistance in thetreatment and prevention of disease.

Be familiar with modern pharmacological approaches tochemotherapy


Teaching and Learning Strategies

Lecture -

Tutorial -


Syllabus
1  1

Basic principles of chemotherapy; selective toxicity
Dr Geoff Edwards
Definitions and concepts of antimicrobial chemotherapy. Basis for selective actions of antimicrobial drugs. Targets for chemotherapy.

2

Targets for antibacterial agents I: Nucleic acid synthesis and replication
Dr Geoff Edwards

3

Targets for antibacterial agents II: Protein synthesis and the cell wall
Dr Geoff Edwards

4

Drug resistance I: Evolution and impact
Dr Geoff Edwards

5

Drug resistance II: Genetics and biochemical mechanisms
Dr Geoff Edwards

6

Antiviral therapy: Introduction
Dr Sudeep Pushpakom

7

Antiviral therapy: Mechanisms of drug action and pharmacokinetics
Dr Sudeep Pushpakom

8

Antiviral therapy for Hepatitis C infection: Introduction
Dr Sudeep Pushpakom

9

Antiviral therapy for Hepatitis C infection: New and emerging therapies
Dr Sudeep Pushpakom

10

Pharmacogenetics of Antiviral therapy
Dr Sudeep Pushpakom

11

Tuberculosis I: Introduction
Dr I G Edwards

12

Tuberculosis II: Pharmacology, Medicinal Chemistry and Drug Discovery I
Dr G Nixon

13

Tuberculosis III: Tuberculosis: Pharmacology, Medicinal Chemistry and Drug Discovery II
Dr G Nixon

14

Tuberculosis IV: Tuberculosis: Pharmacology, Medicinal Chemistry and Drug Discovery III
Dr N Berry

15

Tuberculosis V: Tuberculosis: Pharmacology, Medicinal Chemistry and Drug Discovery IV
Dr N Berry

16

4-aminoquinolines I: mechanism of Action/ SAR
Prof Paul O''Neill

17

4-aminoquinolines II; Drug Metabolism/Drug Design
Prof Paul O''Neill

18

Peroxide antimalarials I: Mechanism of action/ SAR/Drug Metabolism
Prof Paul O''Neill

19

Peroxide antimalarialsII: Mechanism of action/SAR/Drug Metabolism
Dr Paul O''Neill

20

The folate pathway in Plasmodiu m falciparum: A Target for Sulfur Based Drugs and DHFR Inhibitors
Prof Paul O''Neill

21

Revision tutorial
Dr Geoff Edwards
Group based exercise to facilitate revision. Feedback from formative exercise

22

Revision tutorial
Prof Paul O''Neill


Recommended Texts
Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
Explanation of Reading List: