Module Specification
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title MOLECULAR AND CHEMICAL PHARMACOLOGY
Code PHAR453
Coordinator Prof PM O'Neill
Chemistry
P.M.Oneill01@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2016-17 Level 6 FHEQ Second Semester 15

Pre-requisites before taking this module (other modules and/or general educational/academic requirements):
LIFE207; LIFE234 LIFE207; LIFE234; CHEM 248 An Introduction to Medicinal Chemistry  

Modules for which this module is a pre-requisite:
PHAR437; PHAR438; PHAR440; PHAR429; LIFE369 

Co-requisite modules:
LIFE312 

Linked Modules:
 

Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 19
Students will be delivered 18 lectures and 1 revision tutorial
    27
Students will complete a dry and wet component for 5 practicals
    46
Timetable (if known)              
Private Study 104
TOTAL HOURS 150

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Open Book Written Exam  2 hours  Semester 2  15  No reassessment opportunity  Non-standard penalty applies  Assessment 3 There is no reassessment opportunity, Non-standard penalty applies for late submission,  
Unseen Written Exam  2 hours  Semester 2  70  No reassessment opportunity  Non-standard penalty applies  Assessment 4 There is no reassessment opportunity, Non-standard penalty applies for late submission, Notes (applying to all assessments) Attendance at practicals and completion of questions Report on One Practical Assessment Session Written  
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Coursework  Attendance at practi  Semester 2  8  No reassessment opportunity  Non-standard penalty applies  Assessment 1 There is no reassessment opportunity, Non-standard penalty applies for late submission,  
Coursework  Submission of practi  Semester 2  7  No reassessment opportunity  Standard UoL penalty applies  Assessment 2 There is no reassessment opportunity,  

Aims

This module will also provide an understanding of the quantitative aspects of drug action. It will address in detail some further biochemical and pharmacological aspects of pharmacology, with a particular emphasis on the chemical modification of drug structure and its consequences for drug action and toxicity.


Learning Outcomes

At the end of this module students will develop and demonstrate knowledge and critical understanding, qualities, skills and other attributes in the following areas:

  • quantitative aspects of drug action
  • the actions of drugs on ion channels and in the treatment of inflammatory disorders
  • through named examples, the detailed relationship between drug efficacy and chemical structure
  • through named examples, how drug-metabolism can be used to chemically re-design existing drugs to improve their metabolic/toxicological, profiles

Teaching and Learning Strategies

Laboratory Work - Students will complete a dry and wet component for 5 practicals

Lecture - Students will be delivered 18 lectures and 1 revision tutorial

Syllabus
1  1

LECTURE COMPONENT

2

Signalling in the CNS (TPG)

3

Receptors in the CNS (TPG)

4

Anxiolytics (TPG)

5

Anti-psychotics (TPG)

6

Drugs to treat depression (TPG)

7

Recreational drugs and drug abuse (TPG)

8

Cardiac physiology (MJC)

9

Cardiac pharmacology (MJC)

10

Vascular pharmacology (MJC)

11

Atherosclerosis (MJC)

12

Drugs and the kidney (MJC)

13

Mediators of inflammation (DJN)

14

Mediators of cell-based immunity (DJN)

15

Auto-immune disease (DJN)

16

Anti-inflammatory drugs (DJN)

17

Immuno-suppressant drugs (DJN)

18

Peptide and protein-based signalling (DJN)

19

Revision tutorial

20

PRACTICAL COMPONENT

21

Competitive antagonism in the guinea pig ileum (SP)

22

Structure activity: vas deferens (NRK)

23

Drug metabolism - Phase I (DC)

24

Drug metabolism - Phase II (DA)

25

Molecular modelling (PON)


Recommended Texts
Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
Explanation of Reading List: