Module Specification
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title Drug Metabolism and Drug Response
Code LIFE315
Coordinator Dr D Antoine
Molecular and Clinical Pharmacology
D.Antoine@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2016-17 Level 6 FHEQ First Semester 15

Pre-requisites before taking this module (other modules and/or general educational/academic requirements):
LIFE207 None 

Modules for which this module is a pre-requisite:
 

Co-requisite modules:
 

Linked Modules:
 

Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 21

   1

     2

 24
Timetable (if known) This refers to approximately 2 timetabled lectures per week
  		  This refers to a timetabled revision tutorial
  		    This refers to two one hour workshops
  		 
Private Study 126
TOTAL HOURS 150

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Unseen Written Exam  2 hours  1  80  Yes  Standard UoL penalty applies  Assessment 1 
Unseen Written Exam  1 hour  1  20  Yes  Standard UoL penalty applies  Assessment 2 Notes (applying to all assessments) Assessment 1 will be a written examination. Assessment 2 will be a written examination. 
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
             

Aims

  1. To demonstrate the relevance and importance of the principles of drug metabolism and pharmacokinetics

  2. To explain the importance of the relationship between drug disposition and drug response

  3. To develop in students the ability to apply, critically evaluate and interpret this knowledge and understanding, to solve complex problems in pharmacology

Learning Outcomes

To appraise the principles of drug disposition and drug response, particularly in relation to why subjects differ in their response to drugs

To critically discuss the relevance of basic pharmacokinetic principles to achieving a good response to therapy

To critically analyse pharmacokinetic data
To evaluate the dispositional basis of adverse drug reactions

Teaching and Learning Strategies

Lecture -

This refers to approximately 2 timetabled lectures per week

Tutorial -

This refers to a timetabled revision tutorial

Workshop -

This refers to two one hour workshops

Syllabus
1 

Topic 1 – Importance of drug metabolism to drug response

Overview of the Cytochrome P450 superfamily and their function, phase 1 and 2 metabolism, molecular mechanisms of induction and inhibition of metabolism, the impact of genetic variation on the relationship between drug metabolism and drug toxicity, clinical consequences of metabolism mediated drug related hepatotoxicity


Topic 2 – Pharmacokinetic principles

Overview of basic concepts/definitions, principles of bioavailability and clearance (impact of hepatic and renal clearance), factors affecting pharmacokinetic variability (drug-drug interactions, genetics)


Topic 3 – Importance of drug metabolism to drug development

Summary and introduction to concepts in drug discovery and drug development, Understanding the relationship between structure, concentration and biological effect, Metabolite issues in drug discovery and development (focus on s afety assessment and reactive metabolite theory)

Topic 4 – PBPK modelling for the understanding of variation in drug response

General principles in drug transport biology (Renal and Hepatic), Pharmacogenomics of transporters and the impact on drug response, Physiologically based pharmacokinetic modelling (PBPK)

 

Recommended Texts
Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
Explanation of Reading List: