Module Specification
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title Chemotherapy and Cellular Pharmacology
Code LIFE312
Coordinator Dr SP Pushpakom
Molecular and Clinical Pharmacology
Sudeep.Pushpakom@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2016-17 Level 6 FHEQ Second Semester 15

Pre-requisites before taking this module (other modules and/or general educational/academic requirements):
None 

Modules for which this module is a pre-requisite:
 

Co-requisite modules:
 

Linked Modules:
 

Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours     1
This refers to a timetabled tutorial
    21
This refers to timetabled lectures
22
Timetable (if known)              
Private Study 128
TOTAL HOURS 150

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Unseen Written Exam  120  Semester 2  80  Yes    Formal examination 
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Coursework  750 words plus diagr  Semester 2  20  Yes  Standard UoL penalty applies  Written coursework assignment Notes (applying to all assessments) Coursework is a written report that includes diagrams 

Aims

1. To develop the principles and concepts introduced in Level 5 modules on antibacterial chemotherapy and apply them to diseases caused by viruses (e.g. HIV/AIDS), bacteria (e.g. TB) and parasites (e.g. Malaria).

2.  To develop in students specialist knowledge and understanding in pharmacology.

3.  To develop in students the ability to apply, critically evaluate and interpret this knowledge to solve complex problems in pharmacology.

Learning Outcomes

To critically evaluate the principles of selective toxicity as applied to the chemotherapy of infectious disease.

To assess the clinical relevance of basic pharmacological principles of chemotherapy.

To evaluate the importance of drug resistance in the treatment and prevention of disease.

To evaluate modern pharmacological approaches to chemotherapy.

Teaching and Learning Strategies

Lectures - This refers to timetabled lectures

Tutorial - This refers to a timetabled tutorial

Syllabus
1 

Basic principles of chemotherapy; selective toxicity.

Antimicrobial drug resistance: Evolution and impact; genetics and biochemical mechanisms.

Nanomedicines: Formulation and pharmacology.

HIV and hepatitis C: Life cycles; chemotherapy; established and emerging antiretroviral and anti-hepatitis C drug targets; pharmacogenetics; drug-drug interactions.

Tuberculosis: Biology of Mycobacterium tuberculosis; anti-tuberculosis chemotherapy; mechanism of action; drug resistance; drug discovery; emerging targets.

Malaria: Biology of Plasmodium; 4-Aminoquinolines: Mechanism of Action/SAR; drug metabolism and drug design.  Peroxide Antimalarials: Mechanism of Action/SAR; drug metabolism novel targets.

Neglected tropical diseases: Biology; management; chemotherapy.


Recommended Texts
Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
Explanation of Reading List:

Additional reading from the scientific literature will be highlighted during lectures, with an indication of whether it is considered essential or recommended.

 

Rang H, Dale M, Ritter J, Flower R & Henderson G. (2012) Rang & Dale''s Pharmacology, 7th edition, Churchill Livingston, 2012.