Module Specification
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title MOLECULAR AND MEDICAL GENETICS
Code LIFE208
Coordinator Dr NJ Jones
Biochemistry
N.J.Jones@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2016-17 Level 5 FHEQ Second Semester 15

Pre-requisites before taking this module (other modules and/or general educational/academic requirements):
LIFE101; LIFE103 None 

Modules for which this module is a pre-requisite:
 

Co-requisite modules:
 

Linked Modules:
 

Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 30

         4

1

1

 36
Timetable (if known) This refers to timetabled lectures
  		        Review/assessment feedback
This refers to scheduled times for summative assessments
Formative essay writing assessment under examination conditions
  		 
Private Study 114
TOTAL HOURS 150

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Written Exam  2 hours  Semester 2  80  Yes  Standard UoL penalty applies  Assessment 1 
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Coursework  1 hour  Semester 2  10  No reassessment opportunity  Standard UoL penalty applies  Assessment 2 There is no reassessment opportunity,  
Coursework  1 hour (online)  Semester 2  10  No reassessment opportunity  Standard UoL penalty applies  Assessment 3 There is no reassessment opportunity, Notes (applying to all assessments) Assessment 208 includes short answer questions and an extended written piece. Assessment 208.1 includes short answer questions. Assessment 208.2 includes short answer questions (online). Full comensation applies to all assessment elements 

Aims

  • This module aims to:

     
    Introduce students with an interest in genetics and molecular biology to the range of biological mechanisms that control the structure and stability of the genetic material;

  • Describe how changes in the structure and stability of DNA can impact on health and disease;

  • Use examples from both prokaryotes and eukaryotes to develop principles that help explain problems associated with medical/clinical genetics;

     
  • Develop knowledge and understanding in genetics and molecular biology, and ability to apply, evaluate and interpret this knowledge to solve problems.

    		•

    Learning Outcomes

    On successful completion of this module, the students should be able to:

     
    Describe the principles of DNA replication, DNA damage and mutation, DNA repair, DNA recombination, genetic transfer systems and transposition, cell cycle control and cell division, genetic mapping and cytogenetics;

    Explain how these processes underpin an understanding of the genetic basis of human health and disease;

    Demonstrate that they can solve problems by applying the above knowledge to identify genes underlying disease and the likely causes of DNA mutations;

    Demonstrate knowledge and critical understanding of the principles of genetics and molecular biology, and how this knowledge has been applied to solve problems.

    Teaching and Learning Strategies

    Lecture -

    This refers to timetabled lectures

    Workshop -

    Review/assessment feedback

    Assessment -

    This refers to scheduled times for summative assessments

    Other -

    Formative essay writing assessment under examination conditions

    Syllabus
    1 
    Replication, repair, recombination and cell cycle control
    DNA Replication – chromosomes
    DNA Replication – Prokaryotes
    Plasmids – replication, conjugation and stability
    DNA Replication – Eukaryotes
    Cell cycle controls and checkpoints
    Introduction to oncogenes and tumour suppressor genes
    DNA damage, mutation and genome instability
    DNA repair mechanisms
    Genetic Recombination
    Transposons

     
    Human Genetics
    Chromosome mapping and karyotypes
    Human diseases and syndromes resulting from chromosomal abnormalities
    Mapping simple human traits
    Mapping quantitative traits to the human genome

    Recommended Texts
    Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
    Explanation of Reading List: