Module Specification
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title Principles of Pharmacology
Code LIFE207
Coordinator Prof CEP Goldring
Molecular and Clinical Pharmacology
C.E.P.Goldring@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2016-17 Level 5 FHEQ First Semester 15

Pre-requisites before taking this module (other modules and/or general educational/academic requirements):
LIFE106 None 

Modules for which this module is a pre-requisite:
 

Co-requisite modules:
 

Linked Modules:
 

Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 24

         3

 27
Timetable (if known) This refers to timetabled lectures
  		        This refers to scheduled times for summative assessments
  		 
Private Study 123
TOTAL HOURS 150

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Written Exam  2 hours  Semester 1  80  Yes  Non-standard penalty applies  Assessment 1 Non-standard penalty applies for late submission,  
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Coursework  1 hour  Semester 1  20  Yes    Assessment 2 Notes (applying to all assessments) Assessment 207 will objective assessments (e.g. multiple choice and extended matching questions) and extended written exercises Assessment 207.1 will be an extended written exercise on a topic revealed before the assessment and unseen objective assessments (e.g. multiple choice and extended matching questions), performed together under examination conditions.  

Aims
  • This module aims to:
     
    Develop an understanding of the quantitative aspects of drug action on cellular receptors;

  • Demonstrate the relationship between drug efficacy and chemical structure;

  • Introduce the basic principles of pharmacokinetics, outline the relationship between drug concentration and response, and include an introduction to the principles of toxicity of drugs and their metabolites;

  • Provide knowledge of the molecular biology of receptors;

  • Develop knowledge and understanding in pharmacology, and the ability to apply, evaluate and interpret this knowledge to solve pharmacological problems.

    		•

    Learning Outcomes
    On successful completion of this module, the students should be able to:
     
    Describe quantitative aspects of drug action;
    Define the relationship between drug efficacy and chemical structure;
    State key pharmacokinetic concepts such as clearance, volume of distribution, half life and steady state and to solve problems involving these parameters;
    Demonstrate the role of drug concentrations in determining response to treatment;
    Describe early biochemical events after drug administration that are of toxicological and biochemical significance;
    Describe the principles of selective toxicity and their application to both self and non-self targets;
    Demonstrate knowledge and critical understanding of the principles of pharmacology, and how this knowledge has been applied to solve problems.

    Teaching and Learning Strategies

    Lecture -

    This refers to timetabled lectures

    Assessment -

    This refers to scheduled times for summative assessments

    Syllabus
    1 
    Block 1
    Drugs and the peripheral nervous system
    Cholinergic; adrenergic; structure:activity relationships; SAR in the cholinergic system; SAR of anticholinesterases
     
     
    Block 2
    Receptor theory/pharmacodynamics
    Structure: activity relationships; agonist/receptor theories; competitive agonism; non-competitive antagonism; drug binding; drug targets
     
    Block 3.
    Pharmacokinetics
    Key pharmacokinetic parameters; oral absorption; hepatic clearance; renal clearance; pharmacokinetic variability; drug interactions.
     
    Block 4
    Drug disposition and metabolism
    Phase I oxidation; phase I reduction and hydrolysis; phase II glucuronide conjugation; phase Ii sulphate and mercapturic acid cnojugates
     
    Block 5
    Selective toxicity
    Antimicrobials; antifungals; antivirals; anticancer therapy; basic pharmacogenetics
     
    Revision session (Block 6)

    Recommended Texts
    Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
    Explanation of Reading List: