The aim of this module is to further broaden and extend the knowledge of modern Organic Chemistry so that students will be able to enter directly into a PhD or embark on a career as a specialist chemist.

(LO1) By the end of the module students will have achieved a solid foundation in Organic Chemistry. In particular they will have a clear understanding of (a) stereocontrolled synthesis (b) main strategies in organic chemistryand be able to give examples of their use in modern synthetic methodology.

(S1) Students will develop their chemistry-related cognitive abilities and skills, ie abilities and skills relating to intellectual tasks, including problem-solving as required by the Chemistry subject benchmark statement. In particular, at master's level, they will gain the ability to adapt and apply methodology to the solution of unfamiliar problems.

Teaching Method 1 - Lecture
Description:
Attendance Recorded: No

Asymmetric Synthesis Cyclic control, reactions of endocyclic olefins Thermodynamic and kinetic control in the formation of spiroketals Acyclic control by 1,3-allylic strain Acyclic control in nucleophilic attack of aldehydes and ketones Zimmerman-Traxler transition state (aldol, pericyclic rearrangements, allylation reactions) Chiral auxiliaries in aldol and other reactions Main Group Organic Chemistry Definition of retrosynthesic analysis. Basic principlesof retrosynthesis Disconnections, synthons, synthetic equivalentsand reagents. The concept of umpolung. Revision of key reactions in synthesis. Methodsfor the synthesis of dicarbonyl compounds. Methods for the synthesis ofalkenes. Functional group interconversions. C-C bond disconnections. Aromatic and heterocyclic compounds. Sp 2 -Sp 2 coupling reactions. Key ring-forming reactions. Stereocontrol in synthesis.