Module Details |
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module. |
Title | Foundations of Medicinal Chemistry | ||
Code | CHEM141 | ||
Coordinator |
Dr JW Gaynor Chemistry J.W.Gaynor@liverpool.ac.uk |
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Year | CATS Level | Semester | CATS Value |
Session 2016-17 | Level 4 FHEQ | First Semester | 15 |
Pre-requisites before taking this module (or general academic requirements): |
A level Chemistry or equivalent here |
Aims |
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The aim of this module is to provide students with and understanding of :
1. The key components of cells that act as the building blocks for the key macromolecular structures that are essential in medicinal chemistry.
2. How macromolecules interact with each other to allow for natural cellular processes (such as gene expression) that can be exploited by medicinal chemists
3. The key drug targets in medicinal chemistry
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Learning Outcomes |
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Upon successful completion of this module, a student will be able to demonstrate an understanding of the chemical components of cells. |
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Upon successful completion of this module, a student will be able to demonstrate an understanding of the structure, chemical bonding and interactions of a range of cellular macromolecules that allow natural cellular processes to occur |
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Upon successful completion of this module, a student will be able to demonstrate an understanding of the key drug targets in medicinal chemistry, including enzymes, receptors and nucleic acids |
Teaching and Learning Strategies |
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Lecture - The module consists of 28 lectures (45-50 minutes) which will be used to provide the background material necessary to succeed in this module. The learning approach will employ a mixture of traditional delivery alongside components with prior student engagement consisting of pre-recorded video captures to allow in class discussions of worked examples. The lecture component will be used as the main source of interaction with students. |
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Tutorial - In addition to the lecture series, there will be a series of tutorials to support the various pieces of coursework which will be evenly split between the cell biology and medicinal chemistry components of the course. Tutorials will give students the opportunity to raise specific or more general issues to cover areas of ambiguity. |
Syllabus |
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1 |
The course will have the following syllabus, but there is likely to be overlap in the delivery of the two sections.
FOUNDATIONS OF CELL BIOLOGY
Lectures 1-9 (Introduction to cell biology and chemical components of cells)
Lectures 10-12 (DNA, Ch
romosomes, Replication and Repair)
Lectures 13-15 (From DNA to protein: How cells read the genome)
WHAT ARE THE PRINCIPLE DRUG TARGETS IN MEDICINAL CHEMISTRY? ENZYMES, RECEPTORS & NUCLEIC ACIDS
Lectures 16-17 (Enzymes; Structure and function)
Lecture 18-20 (Enzymes as Drug Targets)
Lecture 21-23 (Receptors; Structure, function and signal transduction)
Lectures 24-25 (Receptors as Drug Targets; Agonists and Antagonists)
Lectures 26 (Nucleic Acids As Drug Targets 1)
REVISION LECTURES (Lectures 27-28) |
Recommended Texts |
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Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module. Explanation of Reading List: - Alberts'' Essential Cell Biology contains all the relevant cell biology material needed for the first half of the course and has an extensive online resource centre. - Patrick''s Medicinal Chemistry is the core medicinal chemistry textbook that students will use in future medicinal chemistry programmes (CHEM248/CHEM335, for example). There are also extensive online resources for instructors and students, including online MCQ tests that will be used as formative assessment. |
Teaching Schedule |
Lectures | Seminars | Tutorials | Lab Practicals | Fieldwork Placement | Other | TOTAL | |
Study Hours |
28 The module consists of 28 lectures (45-50 minutes) which will be used to provide the background material necessary to succeed in this module. The learning approach will employ a mixture of traditional delivery alongside components with prior student engagement consisting of pre-recorded video captures to allow in class discussions of worked examples. The lecture component will be used as the main source of interaction with students. |
6 In addition to the lecture series, there will be a series of tutorials to support the various pieces of coursework which will be evenly split between the cell biology and medicinal chemistry components of the course. Tutorials will give students the opportunity to raise specific or more general issues to cover areas of ambiguity. |
34 | ||||
Timetable (if known) | |||||||
Private Study | 116 | ||||||
TOTAL HOURS | 150 |
Assessment |
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EXAM | Duration | Timing (Semester) |
% of final mark |
Resit/resubmission opportunity |
Penalty for late submission |
Notes |
Unseen Written Exam | 120 | Semester 1 examination period | 80 | Yes | Standard UoL penalty applies | The final exam |
CONTINUOUS | Duration | Timing (Semester) |
% of final mark |
Resit/resubmission opportunity |
Penalty for late submission |
Notes |
Coursework | 6 hours of in class | Semester 1 | 20 | No reassessment opportunity | Standard UoL penalty applies | Tutorial submissions There is no reassessment opportunity, Work completed in tutorials is primarily formative in nature and hence learning outcomes are covered by the formal resit examination which would contribute 100% of the resit marks if a students failed this component. Notes (applying to all assessments) Each piece of tutorial work / coursework will be spread across the semester to allow for effective timing and will be completed by a variety of either electronic or paper submission. The material in the coursework component will be tailored to align with the the types of problems encountered in the final exam. The coursework will be assessed via a mixture of face-to-face and in class discussion, allowing for direct and immediate feedback, tutorial work submission with written feedback for later reflection and the use of online tests with immediate feedback. For these reasons, the tutorial work cannot be marked anonymously. |