The aim of this module is to ensure that students are aware of fundamental principles of organic chemistry, including nomenclature, structure and bonding, and the basic principles of static and dynamic stereochemistry. The major reactions associated with the common functional groups will be covered with emphasis on reaction mechanisms. In addition, this module will provide an introduction to the basic techniques associated with practical synthetic chemistry.

(LO1) By the end of this module students will be able to infer and draw the structures and shapes of major classes of organic compounds needed in organic chemical reactions

(LO2) By the end of this module students will be able to explain the principles of bonding in major classes of organic compounds

(LO3) By the end of this module students will be able to apply the basic principles of stereochemistry to an array of acyclic and cyclic structures

(LO4) By the end of this module students will be able to predict the outcomes of simple chemical transformations for a range of important functional groups

(LO5) By the end of this module students will be able to illustrate the major classes of reaction mechanisms through the use of curly arrows

(LO6) By the end of the lab component, students will complete the basic techniques of synthetic chemistry (isolation, purification, identification, and design and work-up of reactions) and characterisation using spectroscopic techniques and chemical methods.

(S1) Problem solving

(S2) Planning and time-management associated with practical work

(S3) Report Writing

Lectures. Includes core lectures (50 in-person / 4 asynchronous), 2 class-test feedback lectures, a lab induction and 3 revision lectures.

Practical. The lab component of the course will be delivered in the early part of semester 2 and allow students to have a lab induction and 6 full days (39 hours) in the practical labs to develop their synthetic lab skills. Students work within a group and work closely with a demonstrator. Additional independent study is required to help with laboratory preparation.

Workshops. Students will be supported through 12 active workshops throughout the year (12 x 2 hr sessions). The first session of each semester will be a PC session, introducing students to core tools they'll need throughout their organic chemistry curriculum (ChemDraw,ChemTube3D and analytical tools such as TopSpin and OpenChrom), with the remaining sessions taking place in smaller in-person workshops. All sessions are supported by demonstrators. Students will have ac cess to the workshop problem sheets in advance with the problems closely aligned to the lecture material delivered in the preceding weeks. The workshops will be formative, involving a mixture of in-class assessments, small group tasks and submissions after class.

*Lectures: 54 hr
*Practical: 39 hr
*Workshops: 24 hr

Organic structures
•Why we use these particular diagrams
•How organic chemists name molecules in writing and in speech
•What is the skeleton of an organic molecule
•What is a functional group
•Some abbreviations used by all organic chemists
•Drawing organic molecules realistically in an easily understood style
Structure of molecules ( to include simple sulfur and phosphorus compounds )
•How we know that electrons have different energies
•How electrons fit into atomic orbitals
•How atomic orbitals combine to make molecular orbitals
•Why organic molecules have linear, planar, or tetrahedral structures
•Connection between shape and electronic structure
•A true system of molecular orbital energies for simple molecules
•Why such rigour is not possible for typical organic molecule
•Predicting the locations of lone pair s and empty orbitals
•Interaction between theory and experiment

Organic reactions
•Why molecules generally don't react with each other!
•Why sometimes molecules do react with each other
•In chemical reactions electrons move from full to empty orbitals
•Molecular shape and structure determine reactivity
•Representing the movement of electrons in reactions by curly arrows

Nucleophilic addition to the carbonyl group
•How and why the C=O group reacts with nucleophiles
•Explaining the reactivity of the C=O group using molecular orbitals and curly arrows
•What sorts of molecules can be made by reactions of C=O groups
•How acid or base catalysts improve the reactivity of the C=O group

Declocalization and conjugation
•Interaction between orbitals over many bonds
•Stabilization by the sharing of electrons over molecules
22;Where colour comes from
•Molecular shape and structure determine reactivity
•Representing one aspect of structure by curly arrows
•Structure of aromatic compounds

Acidity, basicity, and pKa
•Why some molecules are acidic and others basic
•Why some acids are strong and others weak
•Why some bases are strong and others weak
•Estimating acidity and basicity using pH and pKa
•Structure and equilibria in proton transfer reactions
•Which protons in more complex molecules are more acidic
•Which lone pairs in more complex molecules are more basis

Using organometallic reagents to make C-C bonds
•Organometallics: nucleophilic and often strongly basic
•Making organometallics from halocompounds
•Making organometallics by deprotonating carbon atoms
•Using organometallics to make new C-C bonds from C=O groups

Nucl eophilic substitution at the carbonyl (C=O) group
•Nucleophilic attack followed by loss of leaving group
•What makes a good nucleophile
•What makes a good leaving group
•This is always a tetrahedral intermediate
•How to make acid derivatives
•Reactivity of acid derivatives
•How to make ketones from acids
•How to reduce acids to alcohols

Nucleophilic substitution at C=O with loss of carbonyl oxygen
•Replacement of carbonyl oxygen
•Acetal formation
•Imine formation
•Stable and unstable imines
•Reductive amination

Stereochemistry
•Three-dimensional shape of molecules
•Molecules with mirror images
•Molecules with symmetry
•How to separate mirror-image molecules
•Diastereoisomers
•Shape and biological activity
•How to draw stereochemistry

Elimination reactions
•Elimination reactions
•What factors favour elimination over substitution
•The two important mechanisms of elimination reactions
•The importance of conformation in elimination reactions
•How to use eliminations to make alkenes (and alkynes)

Electrophilic addition to alkenes
•Reactions of simple, unconjugated alkenes with electrophiles
•Converting C=C double bonds to other functional groups by electrophilic addition
•How to predict which end of an unsymmetrical alkene reacts with the electrophile
•Stereoselective and stereospecific reactions of alkenes
•How to make alkyl halides, epoxides, alc ohols, and ethers through electrophilic addition

Electrophilic aromatic substitution
•Phenols as aromatic enols
•Benzene and alkenes compared
•Activation and deactivation
•Position of substitution
•Competition and co-operation
•Problems with some reactions

Formation and reactions of enols and enolates
•How carbonyl compounds exist in equilibrium with isomers called enols
•How acid or base promotes the formation of enols and their conjugate bases, enolates
•How enols and enolates have inherent mucleophilic reactivity
•How this reactivity can be exploited to allow the introduction of functional groups next to carbonyl groups

The laboratory course will cover the basic techniques of preparative chemistry which potentially includes but is not limited to-
•Recrystallisation from single and mixed solvents, filtration
•Determ ination of m.p.,m.m.p. and use of I.R. for identification
•Separation of acid/base/neutral compounds using either extraction etc., use of rotary evaporator
•TLC and GC for measure of purity and for following a reaction
•Use of NMR
•Distillation at atmospheric pressure
•Chemoselective reductions of 3-nitroacetophenone
• A simple oxidation reaction analysed by GC