Module Details |
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module. |
Title | An Introduction to Medicinal Chemistry | ||
Code | CHEM248 | ||
Coordinator |
Professor PM O'Neill Chemistry P.M.Oneill01@liverpool.ac.uk |
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Year | CATS Level | Semester | CATS Value |
Session 2024-25 | Level 5 FHEQ | Second Semester | 7.5 |
Pre-requisites before taking this module (or general academic requirements): |
Aims |
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The aim of this module is to introduce students to the fundamental principles that underpin modern medicinal chemistry, including an introduction to targets for drug action, methods of administration, qualitative and quantitative SAR, natural products medicinal chemistry, kinase drug discovery and solid phase chemistry /combinatorial chemistry. The course will also introduce approaches to the design of high quality hits using fragment based drug design introducing the concepts of Ligand Efficiency, and Lipophilic Ligand Efficiency. |
Learning Outcomes |
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(LO1) To evaluate the principle bonding interactions in drug receptor interactions. |
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(LO2) To explain the basic concepts of structure activity relationships (SAR) and quantitative structure activity relationships (QSAR) |
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(LO3) To outline structure activity relationships (SAR) as applied to Beta Blocker Drug Design |
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(LO4) To outline basic concepts of modulating drug metabolism by the use of fluorine substitution |
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(LO5) To understand and apply the basic concepts of Ligand Efficiency (LE) and Lipophilic Ligand Efficiency (LLE) and Fragment Based Drug Design. To be able to calculate LE and LLE parameters for named drug and fragment examples. |
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(LO6) To outline and plan Peptide synthesis, explain the role of protecting groups and combinatorial chemistry/ parallel synthesis approaches |
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(LO7) To analyze the properties of small molecule leads using Lipinski’s Rules and Pro-drug design |
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(LO8) To outline the importance of natural product drug discovery and understanding of kinase inhibitor mechanism |
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(S1) To be able to problem solve and the develop the ability to adapt and apply methodology to the solution of unfamiliar problems. |
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(S2) To develop communication skills through team working and online Teams Meetings / face to face tutorials |
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(S3) To develop organisational skills |
Teaching and Learning Strategies |
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Lectures. 14 x 1 hr. Selected lectures will have discussion points and questions which will be covered in following lectures. Coursework. Two assignments with marked work returned to students, supported by two feedback sessions on MS Teams (2 x 1 hr). Workshops. 2 x 2 hr in-person workshops to support the lectures *Lectures: 14 hr |
Syllabus |
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Lecture 1 Structures of Proteins: Bonds/ Energies Involved in Drug Receptor Interactions Introduction to Medicinal Chemistry: |
Recommended Texts |
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Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module. |
Teaching Schedule |
Lectures | Seminars | Tutorials | Lab Practicals | Fieldwork Placement | Other | TOTAL | |
Study Hours |
14 |
4 2 |
20 | ||||
Timetable (if known) | |||||||
Private Study | 55 | ||||||
TOTAL HOURS | 75 |
Assessment |
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EXAM | Duration | Timing (Semester) |
% of final mark |
Resit/resubmission opportunity |
Penalty for late submission |
Notes |
written exam Resit: A single resit including reassessment of the coursework. | 90 | 80 | ||||
CONTINUOUS | Duration | Timing (Semester) |
% of final mark |
Resit/resubmission opportunity |
Penalty for late submission |
Notes |
Two Assignments Exemptions: e-submission 3.2b Resit: No separate resit, reassessment is included in exam resit | 0 | 20 |