The module aims to present a unified approach to the synthesis and characterisation of organic and inorganic compounds and will build on techniques introduced in the first year laboratory courses.

(LO1) Students will complete a number of different experiments and synthetic techniques across synthetic, organic and inorganic chemistry.

(LO2) Students will appreciate how spectroscopic techniques can be used in the characterisation of organic and inorganic compounds and will be able to use analytical and spectroscopic methods to characterise their synthesised compounds.

(LO3) Students will make use of scientific databases during some assignments and an electronic report.

(LO4) Students will assess the risks involved in chemical lab work and handle chemical materials in a safe manner.

(LO5) Students should be able to organise and plan their time effectively

(LO6) Students will experience working collaboratively with others in multiple learning environments

(S1) Organisational skills

(S2) Problem solving skills

(S3) Teamwork

Practical
Students will be expected to complete a series of synthetic experiments.
Each experiment will have a preliminary exercise (including safety issues) which must be completed to a satisfactory standard before the experiment is performed.
On completion of the experiment, students must produce a write-up describing what was done and submit their results.

Practical-related activities
3 x 1 hr lectures, introduction and safety.

Coursework
The laboratory sessions are complemented by workshops on spectroscopic techniques.
Students are expected to work through exercises with the support of teaching staff.
The knowledge gained in the workshops is tested in class and by means of online tests.

Coursework-related activities
6 x 1 hr lectures, spectroscopy and analytical characterisation
2 x 1 hr lectures, introduction to databases
4 x 2 hr workshops, spectroscopy and analytical characterisation
1 x 3 hr workshop, database, i n-person, computer-based
1 x 3 hr workshop, Topspin
1 x 2 hr workshop, problem-based group activity
1 x 1 hr tutorial, OpenChrom (online)

*Laboratory work: 72 hr
*Workshops: 16 hr
*Lectures: 11 hr
*tutorials: 1 hr

Practical
Students are expected to complete a variety of synthetic, organic and inorganic experiments which may include, but not limited to:
•A Hantzsch pyridine synthesis.
•Synthesis of dimedone by carbonyl condensations.
•A Grignard reaction using a protecting group.
•Separation of fluorene/fluorenone using column chromatography
•Preparation and analysis of iron(II) oxalate.
•Preparation and analysis of acetylacetonato-complexes of metals.
•Preparation of a cobaltammine and the determination of its molecular formula.
•Preparation of dichlorobis(ethylenediamine)cobalt(III) complex
•Preparation of a metal-organic framework based around magnesium formate (MOF)
•Comparing copper complexes of ‘soft’ PPh3 and ‘hard’ O=PPh3

Supporting exercises include a mixture of online and face-to-face strategies including lab book write ups, submis sion of results and calculations, pre- and post- lab assessments and engagement with safety and the course via checkpoints/assignments. The "MOF" experiment is completed in groups and students are assessed together initially, with group assessment subject to peer evaluation for to allow adjustments for individual grades. Other experiments may be completed in pairs but will be assessed individually.

Coursework
Workshops on spectroscopy and analytical methods: Revision and expansion of various spectroscopic techniques including mass spectrometry, infrared spectra, ultraviolet spectroscopy, elemental analyses and NMR (1H and 13C). Spin-spin coupling (J values) in 1H NMR and their use in the determination of stereochemistry and conformational analysis will be introduced. Interpretation of these spectroscopic methods will be required to determine the structures of organic and inorganic molecules.

Databases, TopSpin and electronic reports
This will include a re fresher of year 1 database/TopSpin material and the introduction of structure and text combination searches using databases such as Reaxys. The focus will be on small molecules, inorganic salts and simple organometallics and searching using chemical properties, reactions, stereochemistry, generic groups and reagents. This will culminate in how to combine all material learnt into an electronic report.

Safety
Annual safety lecture, NMR safety lecture and workshop on why risk assessments are needed (COSHH, carcinogens and general) and how they are generated via SDS and legislation.