Module Details

The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title Supramolecular Chemistry
Code CHEM446
Coordinator Dr AG Slater
Chemistry
Anna.Slater@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2021-22 Level 7 FHEQ First Semester 7.5

Pre-requisites before taking this module (or general academic requirements):

 

Aims

Supramolecular chemistry deals with the interactions between molecules and has become one of the fundamental areas of chemical research. The aims of the module are to introduce and develop the students’ knowledge of the chemistry of molecular assemblies and intermolecular bonds, or "chemistry beyond the molecule". The module will introduce the concepts of non-covalent chemistry, host-guest chemistry, molecular recognition, self-assembly and self-organisation. The module also aims to develop the students' knowledge of how to characterise supramolecular complexes.


Learning Outcomes

(LO1) By the end of this module the students will be knowledgeable of non-covalent bonding such as hydrogen-bonding, ion-ion interactions, ion-dipole interactions, van der Waals forces, pi-pi stacking interactions, solvatophobic forces etc. with respect to  supramolecular chemistry. able to describe, understand and rationalise a range of supramolecular assemblies

(LO2) Students will be able to show understanding of the underlying principles of complementarity, preorganisation, and cooperative interactions with respect to supramolecular chemistry, and be able to rationalise the characteristics of binding in a given supramolecular complex with respect to these three key concepts.

(LO3) Students will be able to describe, show understanding of and rationalise a range of supramolecular assemblies, including their formation, their behaviour, and their applications in the context of supramolecular chemistry.

(LO4) Students will be able to explain the principles of solvent effects on supramolecular complexes, why and how solvents affect the strength of supramolecular interactions, and design potential supramolecular hosts taking these principles into account.

(LO5) Students will be able to evaluate which characterisation method is suitable for a given supramolecular complex (including NMR, ITC, MS, UV/Vis titration), and explain what the data show for each method.

(LO6) Students will be able to comment critically on and synthesise a summary of the key messages from a recent research paper describing applications for supramolecular complexes.


Teaching and Learning Strategies

In 2020/21, this module will be delivered online via approx. 30 asynchronous short videos (10-20 minutes, 3 per week), 2 workshop sessions (synchronous, face to face if this is possible, timetabled in weeks 3 and 7), and a series of supplementary materials (1 item per week – examples are profiles of supramolecular chemists, a dive into a research paper, or a description of an application of supramolecular chemistry).
Each video will have an associated quiz for students to test their knowledge. Each week a drop-in office hour session will be timetabled so students can join for questions and discussion, alongside a module discussion board. In weeks 11 and 12 there will be revision material recorded including worked examples from past exam papers.


Syllabus

 

Supramolecular chemistry covers a wide range of systems including host-guest sytems, clathrates, cavitands, supramolecular polymers and gels. In this module, the students will be introduced to concepts such as self-assembling compounds, dynamic covalent chemistry, molecular self-assembly, host-guest complexes and biological mimics. The syllabus will include:
Introduction to supramolecular chemistry – nature of supramolecular interactions, solvation effects, cooperativity, host-guest interactions, chelation, macrocyclic effect, characterisation of supramolecular systems.
Cation-binding  – Why bind cations?, Synthesis of macrocycles,  crown ethers, cryptands, spherands, proton binding, calixarenes, Siderophores.
Anion binding – Why bind anions, Properties of anions, recognition using electrostatic Hydrogen bonds and Lewis acidic hosts.
Simultaneous cation and anion binding – Cascade approach, Separate binding sites,
Neutral gue st binding – Hydrogen bonds, Hydrophobic effect.
Solid state Host-Guest systems – clathrates, calixarenes, molecular crystals.
Self Assembly – pi-electron donor-acceptor systems, transition metal directed assemblies, hydrogen bond assemblies, anion directed assemblies.
Characterising supramolecular systems
Biological Mimics and Supramolecular Catalysis – enzyme mimics, ion-channel mimics.
Supramolecular Chemistry of Life – porphyrins, plant photosynthesis, enzymes.
Interfaces and Liquid Assemblies – non-covalent networks, supramolecular Polymers.
Present and future applications – Phase transfer reagents, separation of mixtures, Sensors, Switches and Molecular Machinery,


Recommended Texts

Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.

Teaching Schedule

  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours     12

    10

2

24
Timetable (if known)              
Private Study 51
TOTAL HOURS 75

Assessment

EXAM Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes
online time-controlled written exam Written Examination comprising a mix of problem based and descriptive questions designed to test the students' knowledge and understanding of, and ability to app  2 hours + 1hour for     80       
CONTINUOUS Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes
The coursework is a set of 3 questions which is set before the Easter vacation. The questions will be designed to allow students to apply the principles of supramolecular chemistry to model systems th  15 hours    20