Liver Fluke Publications

2017 Infection and Immunity

We have tracked immunity in dairy cattle infected naturally with Fasciola hepatica

Graham-Brown J, Hartley C, Clough H, Kadioglu A, Baylis M, Williams DJL. Dairy heifers naturally exposed to Fasciola hepatica develop a type-2 immune response and concomitant suppression of leukocyte proliferation. Infection and Immunity 2017 Oct 9. pii: IAI.00607-17

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2017 Transboundary and Emerging Diseases

We have identified research needs for liver fluke in Europe.

Beesley NJ, Caminade C, Charlier, J, Flynn RJ, Hodgkinson JE, Martinez-Morena A, Martinez-Valladares M, Perez J, Rinaldi L, Williams DJL. Fasciola and fasciolosis in ruminants in Europe: Identifying research needs. Transboundary and Emerging Diseases 2017 Oct

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2017 International Journal for Parasitology

We have carried out a population genetic study of liver fluke and link our findings with the impact this could have on the emergence and spread of drug resistance.

Beesley NJ, Williams DJ, Paterson S, Hodgkinson J. Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance.International Journal for Parasitology 2017 Jan; 47:11-20

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2016 Scientific Reports

We have used models to assess the potential effect a vaccine would have on controlling liver fluke.

Turner J, Howell A, McCann C, Caminade C, Bowers RG, Williams D, Baylis M. A model to assess the efficacy of vaccines for control of liver fluke infection. Scientific Reports 2016 Mar; 6: 23345

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2015 Preventive Veterinary Medicine

We assessed the epidemiology of Fasciola hepatica on high-yielding dairy herds and the impact infection had on production.

Howell A, Baylis M, Smith R, Pinchbeck G, Williams D. Epidemiology and impact of Fasciola hepatica exposure in high-yielding dairy herds. Preventive Veterinary Medicine 2015 Sep; 121: 41- 8

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2015 Parasitology

We determined that Fasciola hepatica from naturally infected sheep and cattle in Great Britain are diploid.

Beesley NJ, Cwiklinski K, Williams DJ, Hodgkinson J. Fasciola hepatica from naturally infected sheep and cattle in Great Britain are diploid. Parasitology 2015 Aug; 142: 1196 - 201

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2015 Genome Biology

Our work on the Fasciola hepatica genome has recently been published.

Cwiklinski K, Dalton JP, Dufresne PJ, La Course J, Williams DJ, Hodgkinson J, Paterson, S. The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution. Genome Biology 2015 April 3; 16: 71

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2015 Geospatial Health

We used models to assess the future climate suitablity for fasciolosis in Europe.

Camindae C, van Dijk J, Baylis M, Williams D. Modelling recent and future climatic suitability for fasciolosis in Europe. Geospatial Health 2015 Mar; 19: 301 - 8

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2014 Cattle Practice

Members of the liver fluke group have written an overview on liver fluke for veterinary practitioners which will be published in Cattle Practice later this year, as well as being available on the COWS website.

2014 Parasitology

Professor Diana Williams co-wrote a recent review for Parasitology advocating a change in how we use diagnostics to evaluate the impact of Fasciola hepatica infection on productivity of dairy and beef cattle.  The review also evaluates the likely effects of climate change on the epidemiology of fluke.  The paper highlights the need for research to develop non-chemotherapeutic management options, alongside more targeted use of anthelmintics, in the face of growing flukicide resistance and a changing pattern of disease.

Charlier J, Vercruysse J, Morgan E, van Dijk J, Williams DJ. Recent advances in the diagnosis, impact on production and prediction of Fasciola hepatica in cattle. Parasitology 2014 Mar; 141, 326 - 335

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2013 Parasitology

Dr Jane Hodgkinson was invited to write a review for a special edition of Parasitology to highlight her recent £700,000 BBSRC-funded project. The review summarizes the current understanding of drug resistance to the commonly used drug, triclabendazole, in Fasciola hepatica. The context for the project involves discussing the currently available genomic and genetic resources for F. hepatica. It then describes the generation of new genomic resources and subsequent non-biased approach to mapping the major genetic loci involved in conferring triclabendazole resistance in phenotyped F. hepatica populations.

Hodgkinson J, Cwiklinski K, Beesley NJ, Paterson S, Williams DJL. Identification of putative markers of triclabendazole resistance by a genome-wide analysis of genetically recombinant Fasciola hepatica. Parasitology 2013 Oct; 140, 1523 - 1533

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2012 Nature Communications

In 2012, research by the liver fluke group was published in Nature Communications. The study found that if cattle are infected with liver fluke we are not reliably able to diagnose infection with bovine tuberculosis (TB). Bovine TB has a major economic impact on milk and meat production and seriously impacts on the UK’s export market as well as being a zoonotic disease. This finding may compromise the government’s planned eradication programme for bovine TB in the UK, which is currently costing the tax payer about £100 million per year.

Claridge J, Diggle P, McCann CM, Mulcahy G, Flynn R, McNair J, et al. Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle. Nature Communications. 2012 May;3:853+.

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