Photo of Dr Steve Mcwilliam

Dr Steve Mcwilliam BA MBBS PhD MRCPCH

NIHR Academic Clinical Lecturer in Paediatric Clinical Pharmacology Women's and Children's Health

About

Personal Statement

I am an NIHR Academic Clinical Lecturer in Paediatric Clinical Pharmacology. I studied medicine at Oxford University and at King’s College London, and moved to Liverpool in 2008 to take up an NIHR Academic Clinical Fellowship in Paediatric Pharmacology. During the three years of this fellowship I completed a clinical study measuring urinary biomarkers of kidney injury in preterm infants, particularly in relation to treatment with gentamicin, an aminoglycoside antibiotic. This provided the preliminary data which supported my successful application for a North West England MRC Fellowship in Clinical Pharmacology and Therapeutics.

My PhD, entitled ‘Novel approaches to aminoglycoside-induced nephrotoxicity in children’ focused on developing urinary biomarkers for the identification of aminoglycoside-induced kidney toxicity, and demonstrating the potential of statins to prevent this toxicity. My PhD research has led to a national, multicentre phase IIa clinical trial, investigating the potential of rosuvastatin to prevent aminoglycoside-induced kidney toxicity in children with cystic fibrosis (the PROteKT study). This is important as around one third of adults with cystic fibrosis may develop kidney impairment as a result of exposure to aminoglycosides.

This clinical trial provides the main focus of my work as an NIHR Academic Clinical Lecturer, and it is hoped that this may lead on to a larger phase III clinical trial. In addition to this I am pursuing my interest in drug-induced kidney injury in children in collaboration with other researchers at the University of Liverpool, and internationally. I am also completing my training as a Paediatric Clinical Pharmacologist.