Photo of Dr Ruwanthi Kolamunnage-Dona

Dr Ruwanthi Kolamunnage-Dona Ph.D

Reader in Medical Statistics Health Data Science

Research

Research Interests:

Longitudinal Data Analysis
Survival Analysis
Competing Risks Data Analysis
Joint Modelling of Longitudinal & Time-to-Event Data
Statistical Analysis with Missing Data
Time-dependent ROC Curves
Statistical Shape Analysis
Biomarker-Guided Clinical Trials: Design, Analysis & Interpretation

JoineR Collaboration:
https://www.liverpool.ac.uk/translational-medicine/departmentsandgroups/joine-r/
Biomarker-guided trial designs (BiGTeD):
www.BiGTeD.org
Centre of Excellence in Infectious Diseases Research:
https://www.liverpool.ac.uk/centre-of-excellence-infectious-diseases-research/about/team/

Research Group Membership

Research Grants

Serial measurement of the subclinical leukaemic burden as an early biomarker for overt relapse in chronic lymphocytic leukaemia

CANCER RESEARCH UK (CRUK) (UK)

March 2014 - March 2021

Online tool to guide biomarker-guided randomised controlled trials

MEDICAL RESEARCH COUNCIL (MRC)

March 2016 - August 2017

R19 Evidence synthesis for biomarker validity to inform biomarker-stratified trials

MEDICAL RESEARCH COUNCIL (MRC)

September 2017 - June 2021

Joint modelling of multivariate longitudinal and event time outcomes in clinical research (JoineR-M)

MEDICAL RESEARCH COUNCIL (MRC)

August 2015 - December 2018

Improving the efficiency of biomarker-driven designs by using continuous biomarker information

MEDICAL RESEARCH COUNCIL (MRC)

January 2018 - November 2019

Development of New Mathematical Sciences Capabilities for Healthcare Technologies

ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

December 2015 - April 2021

TAILoR (TelmisArtan and InsuLin Resistance in HIV): A dose-ranging Phase II randomised open trial of telmistartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on Combination Antiretroviral Therapy (CART)

DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

January 2012 - February 2020

A Randomised Control Trial of Extended Brief Interventions for alcohol-dependent patients in an acute care setting.

DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

November 2009 - October 2012

DISTINCTIVE - Diagnostic comparison of procalcitonin and the aPTT biphasic waveform in children with bacterial sepsis on the intensive care unit

ALDER HEY IMAGINE APPEAL (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

September 2010 - August 2014

Developing a rapid, robust and comprehensive assay for histones and chromatin breakdown products via xMAP technology

DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

March 2011 - September 2012

Development of a rapid salivary test to detect serious bacterial infection in children presenting to the accident and emergency department. SPICED.

DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

September 2010 - May 2012

The Prospective Investigation into urinary NGAL Utility in Paediatric Oncology Patients (PINGU Project) : A pilot study

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

January 2012 - December 2014

Phase IIa, randomised, open label, controlled trial of rostuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (PROteKT)

THE MOULTON CHARITABLE FOUNDATION (UK)

June 2014 - January 2018

Research Collaborations

Dr John H. Rex

Project: New Opportunities for Treatment of Multi-Drug Resistant Fungal Disease
External: Infection, Global Medicines Development, AstraZeneca Pharmaceuticals & F2G, Ltd.

Pharmacodynamics of the Orotomides Against Aspergillus fumigatus.

Dr Laura Kovanda

Project: Pharmacodynamics of Isavuconazole for Invasive Mould Disease
External: Astellas Pharma Global Development, Inc., Northbrook, IL, USA

Role of Galactomannan for Real-Time Monitoring of Therapeutic Response

Professor Barry Pizer

Project: Paediatric Oncology
External: Alder Hey Hospital

Diagnosis and management of paediatric oncology patients with central venous catheter-associated infections.

Dr Pete Philipson

Project: Joint modelling of multivariate longitudinal and event time outcomes in clinical research (JoineR-M)
External: The University of Northumbria at Newcastle

Development of a novel but sufficiently flexible joint modelling approach for multiple longitudinal biomarkers and correlated event time outcomes. MEDICAL RESEARCH COUNCIL Methodology Research Panel grant.

Professor Peter Diggle

Project: JoineR
External: The University of Lancaster

Joint modelling of longitudinal and event time outcomes in clinical research

Professor Robin Henderson

Project: JoineR
External: The University of Newcastle-upon-Tyne

Joint modelling of longitudinal and event time outcomes in clinical research

Professor Enitan D Carrol

Project: SPICED and DISTINCIVE
Internal

SPICED study: Development of a rapid salivary test to detect serious bacterial infection (SBI) in children presenting to the accident and emergency department.

DISTINCIVE study: Diagnostic comparison of procalcitonin and the aPTT biphasic waveform in children with bacterial sepsis on the intensive care unit.

Professor Mari Lloyd-Williams

Project: Academic Palliative and Supportive Care Studies Group (APSCSG)
Internal

A prospective longitudinal study to determine the prevalence, aetiology and natural history of depression and demoralisation in patients with advanced metastatic cancer

Professor Cheng-Hock Toh

Project: Haemostasis & Thrombosis
Internal

Biomarkers (aPTT Waveform, Lipoprotein-Complexed C Reactive Protein Assays, etc) in the Early Diagnosis and Prognosis of Sepsis

Professor Philip Johnson

Project: Hepatobiliary cancer and biomarkers
Internal

Pre-radiographic detection of Hepatocellular Carcinoma: Implications for Surveillance and Resection

Professor William Hope

Project: Antimicrobial Pharmacodynamics
Internal

Antimicrobial drug development and individualisation of antimicrobial therapy