Professor Ruwanthi Kolamunnage-Dona BSc (Hons), MSc, PhD
Professor of Medical Statistics Health Data Science
Research
Research Interests:
Joint Modelling of Longitudinal & Time-to-Event Data
Longitudinal Data Analysis
Survival Analysis
Competing Risks Data Analysis
Statistical Analysis with Missing Data
Time-dependent ROC Curves
Statistical Shape Analysis
Biomarker-Guided Clinical Trials: Design, Analysis & Interpretation
JoineR Collaboration:
https://www.liverpool.ac.uk/translational-medicine/departmentsandgroups/joine-r/
Biomarker-guided trial designs (BiGTeD):
www.BiGTeD.org
Centre of Excellence in Infectious Diseases Research (CEIDR)
Research Group Membership
- Medical Statistics
- Joint Modelling Group
Research Grants
Data Accelerator Project (System P & AMR-X)
NHS CHESHIRE AND MERSEYSIDE ICB (UK)
December 2023 - January 2027
Mental Health Research for Innovation Centre (M-RIC)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2023 - December 2027
Serial measurement of the subclinical leukaemic burden as an early biomarker for overt relapse in chronic lymphocytic leukaemia
CANCER RESEARCH UK (UK)
March 2014 - March 2021
Online tool to guide biomarker-guided randomised controlled trials
MEDICAL RESEARCH COUNCIL
March 2016 - August 2017
R19 Evidence synthesis for biomarker validity to inform biomarker-stratified trials
MEDICAL RESEARCH COUNCIL
September 2017 - June 2021
Joint modelling of multivariate longitudinal and event time outcomes in clinical research (JoineR-M)
MEDICAL RESEARCH COUNCIL
August 2015 - December 2018
Improving the efficiency of biomarker-driven designs by using continuous biomarker information
MEDICAL RESEARCH COUNCIL
January 2018 - November 2019
Development of New Mathematical Sciences Capabilities for Healthcare Technologies
ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL
December 2015 - April 2021
TAILoR (TelmisArtan and InsuLin Resistance in HIV): A dose-ranging Phase II randomised open trial of telmistartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on Combination Antiretroviral Therapy (CART)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2012 - February 2020
A Randomised Control Trial of Extended Brief Interventions for alcohol-dependent patients in an acute care setting.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
November 2009 - October 2012
DISTINCTIVE - Diagnostic comparison of procalcitonin and the aPTT biphasic waveform in children with bacterial sepsis on the intensive care unit
ALDER HEY IMAGINE APPEAL (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2010 - August 2014
Developing a rapid, robust and comprehensive assay for histones and chromatin breakdown products via xMAP technology
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
March 2011 - September 2012
Development of a rapid salivary test to detect serious bacterial infection in children presenting to the accident and emergency department. SPICED.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2010 - May 2012
The Prospective Investigation into urinary NGAL Utility in Paediatric Oncology Patients (PINGU Project) : A pilot study
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
January 2012 - December 2014
Phase IIa, randomised, open label, controlled trial of rostuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (PROteKT)
THE MOULTON CHARITABLE FOUNDATION (UK)
June 2014 - January 2018
Research Collaborations
Dr John H. Rex
Project: New Opportunities for Treatment of Multi-Drug Resistant Fungal Disease
External: Infection, Global Medicines Development, AstraZeneca Pharmaceuticals & F2G, Ltd.
Pharmacodynamics of the Orotomides Against Aspergillus fumigatus.
Dr Laura Kovanda
Project: Pharmacodynamics of Isavuconazole for Invasive Mould Disease
External: Astellas Pharma Global Development, Inc., Northbrook, IL, USA
Role of Galactomannan for Real-Time Monitoring of Therapeutic Response
Professor Robin Henderson
Project: JoineR
External: The University of Newcastle-upon-Tyne
Joint modelling of longitudinal and event time outcomes in clinical research
Professor Barry Pizer
Project: Paediatric Oncology
External: Alder Hey Hospital
Diagnosis and management of paediatric oncology patients with central venous catheter-associated infections.
Dr Pete Philipson
Project: Joint modelling of multivariate longitudinal and event time outcomes in clinical research (JoineR-M)
External: The University of Northumbria at Newcastle
Development of a novel but sufficiently flexible joint modelling approach for multiple longitudinal biomarkers and correlated event time outcomes. MEDICAL RESEARCH COUNCIL Methodology Research Panel grant.
Professor Peter Diggle
Project: JoineR
External: The University of Lancaster
Joint modelling of longitudinal and event time outcomes in clinical research
Professor William Hope
Project: Antimicrobial Pharmacodynamics
Internal
Antimicrobial drug development and individualisation of antimicrobial therapy
Professor Philip Johnson
Project: Hepatobiliary cancer and biomarkers
Internal
Pre-radiographic detection of Hepatocellular Carcinoma: Implications for Surveillance and Resection
Professor Enitan D Carrol
Project: SPICED and DISTINCIVE
Internal
SPICED study: Development of a rapid salivary test to detect serious bacterial infection (SBI) in children presenting to the accident and emergency department.
DISTINCIVE study: Diagnostic comparison of procalcitonin and the aPTT biphasic waveform in children with bacterial sepsis on the intensive care unit.
Professor Mari Lloyd-Williams
Project: Academic Palliative and Supportive Care Studies Group (APSCSG)
Internal
A prospective longitudinal study to determine the prevalence, aetiology and natural history of depression and demoralisation in patients with advanced metastatic cancer
Professor Cheng-Hock Toh
Project: Haemostasis & Thrombosis
Internal
Biomarkers (aPTT Waveform, Lipoprotein-Complexed C Reactive Protein Assays, etc) in the Early Diagnosis and Prognosis of Sepsis