Photo of Prof Paul McNamara

Prof Paul McNamara MBBS MRCPCH PhD

Professor in Child Health, Honorary Consultant in Paediatric Respiratory Medicine Women's and Children's Health

Research

Research Interest 1

Bronchiolitis
Cystic Fibrosis
Aspiration lung disease in children
Paediatric Infectious Disease
Asthma

Research Group Membership
Research Grants

Supporting translational research in Paediatric Rheumatology and Respiratory

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

March 2016 - November 2020

The Cystic Fibrosis (CF) Anti-Staphylococcal Antibiotic Prophylaxis Trial (CF-START)

DEPARTMENT OF HEALTH (UK) (NIHR)

July 2016 - August 2025

Clinical fellows post in paediatric endocrinology

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

September 2015 - August 2017

MICA: Towards using historical data for research prioritisation in children

MEDICAL RESEARCH COUNCIL (MRC)

March 2015 - February 2018

Investigating the potential of Nrf2 induction in airway epithelial cells as a treatment for RSV bronchiolitis

BRITISH SOCIETY FOR ANTIMICROBIAL CHEMOTHERAPY (UK)

August 2013 - December 2014

The role of mucus production in paediatric respiratory disease.

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

October 2010 - September 2011

A novel vaccine candidate against pneumococcal infection in children

ACTION MEDICAL RESEARCH (UK)

November 2010 - November 2012

Investigating the role of BAFF in paediatric respiratory disease

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

July 2013 - June 2015

The role of Interleukin-9-mediated mucin production in the pathogenesis of viral and bacterial respiratory disease in children.

WELLCOME TRUST (UK)

August 2005 - March 2010

The effect of pepsin and bile acids on the respiratory epithelium

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

October 2012 - September 2015

Investigation of the pro and anti-inflammatory effects of neutrophils in RSV bronchiolitis

WELLCOME TRUST (UK)

April 2013 - March 2015

Application of nanomedicine to childhood diseases.

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

October 2013 - September 2016

UK Influenza Rapid Response Influenza Clinical Network (UK-Flu Response)

WELLCOME TRUST (UK)

November 2009 - July 2011

Pepsin as a marker of aspiration in children with cerebral palsy

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

March 2011 - August 2012

The optimisation of a technique for accurately measuring pepsin and bile acids in respiratory secretions

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

December 2012 - August 2013

A pilot study to assess whethr humidified oxygen is more effective than standard oxygen therapy in treating children with acute severe asthma

DEPARTMENT OF HEALTH (UK) (NIHR)

November 2013 - October 2016

Research Collaborations

Prof Chris Sanderson

Internal

Investigating the role of NRF2 induction in RSV disease.

Prof Rob Beynon

Internal

Development of assay to measure pepsin and bile acids in respiratory secretions as a marker of reflux aspiration. Also using proteomic methods to understand which proteins in airway epithelium are ubiquitinylated in response to RSV infection.

Dr Ray Pickles

External: University of North Carolina at Chapel Hill

Development of joint application to NIH on pathogenesis of RSV disease.

Ass. Prof Nikki Johnson

External: University of Wisconsin

Development of Pepsin ELISA

Prof Richard Hegele

External: University of Toronto, Canada

Sharing samples

Dr Craig Winstanley

Internal

Collaboration on inflammatory responses to WT and LES PsAs in airway epithelial cells

Prof Bernie Carter

External: University of Central Lancashire

Development of bronchiolitis scoring instrument

Dr Qibo Zhang

Internal

Ongoing collaboration on immunological responses to normal bacterial flora in the oropharynx

Prof Jeff Pearson & Dr Chris Ward

External: University of Newcastle upon Tyne

Co-applicants on grant to Sparks

Prof David Thornton

External: The University of Manchester

Pulmonary Mucin production

Assoc. Prof Steve Stick

External: Princess Margaret Hospital, Perth, Australia

Collaboration investigating the mechanisms underlying the development of asthma in children

Dr Kevin Southern

Internal

Investigation into the importance of IL-9 production in Cystic Fibrosis

Dr Brian Flanagan

Internal

Investigation into the immunopathogenesis of RSV disease