Prof Michael Beresford MBChB MRCP(UK) MRCPCH PhD

Brough Chair, Professor of Child Health Women's and Children's Health

Research

Professor of Child Health

Professor Beresford is Brough Chair and Professor of Child Health in the Institute of Translational Medicine at University of Liverpool.

He is Lead of the National Institute of Health Research (NIHR) clinical Research Network (CRN) Specialty Cluster including the National Specialty Groups of Children and Musculoskeletal research, along with the emerging technology of Stratified/Personalized Medicine.

Experimental Arthritis Treatment Centre for Children

He is Director of the UK’s only Experimental Arthritis Treatment Centre for Children and Clinical Director of the NIHR Alder Hey Clinical Research Facility for Experimental Medicine.

He was Chair of the NIHR CRN: Children/Arthritis Research UK Paediatric Rheumatology Clinical Study Group, responsible for developing and overseeing a UK wide comprehensive portfolio of clinical trials and related studies covering the entire spectrum of diseases in paediatric rheumatology.

Juvenile-onset SLE


Professor Beresford Chairs the UK JSLE Study Group and has developed an internationally recognized Childhood Lupus translational research programme as part of the UK’s only Centre of Excellence for Childhood Lupus.

Research Grants

NIHR CRN Alliance funding for Liverpool CRN Theme office

DEPARTMENT OF HEALTH (UK) (NIHR)

April 2016 - March 2020

Clinical studies group in paediatric rheumatology.

ARTHRITIS RESEARCH UK

April 2016 - March 2020

A Randomised Controlled Trial of adalimumab versus pamidronate in Chronic Recurrent Multifocal Osteomyelitis (CRMO) using a Bayesian Design

ARTHRITIS RESEARCH UK

June 2016 - March 2021

Supporting translational research in Paediatric Rheumatology and Respiratory

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

March 2016 - November 2020

MAximizing Sle ThERapeutic PotentiaL by Application of Novel and Stratified approaches (MASTERPLANS)

MEDICAL RESEARCH COUNCIL (MRC)

June 2015 - December 2019

Steroid Induction Regimen for Juvenile Idiopathic Arthritis (SIRJIA)

DEPARTMENT OF HEALTH (UK) (NIHR)

January 2016 - March 2019

Lupus UK and British Paediatric Surveillance Unit study of the incidence and prevalence of Juvenile-onset Systemic Lupus Erythematosus in children and young people in the UK and Republic of Ireland

LUPUS UK (UK)

April 2016 - March 2021

CRN Children-Pharmacy & Formulations Work Stream

DEPARTMENT OF HEALTH (UK) (NIHR)

April 2015 - March 2016

A phase II trial of tocilizumab in anti-TNF refractory patients with JIA associated uvetis

ARTHRITIS RESEARCH UK

February 2015 - April 2019

Clinical Studies Group Chair in Paediatric Rheumatology.

ARTHRITIS RESEARCH UK

October 2014 - March 2016

Paediatric Clinical Research Facility

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2015 - March 2018

British Orthopaedic SCFE Surgery (BOSS) Study Investigating Slipped Capital Femoral Epiphysis (SCFE) as a childhood precursor to osteoarthritis

DEPARTMENT OF HEALTH (UK) (NIHR)

March 2015 - February 2020

The interactions of Type I & II Interferons with Neutrophils; contributions to autoimmune disease pathogenesis and potential therapeutic modifications

LUPUS UK (UK)

November 2013 - October 2014

Childhood Arthritis Response to Treatment consortium (CHART): partnership to define stratified medicine tools for childhood inflammatory arthritis

MEDICAL RESEARCH COUNCIL (MRC)

July 2014 - June 2018

NIHR Medicines for Children Research Network

ACTION MEDICAL RESEARCH (UK), BRITISH ASSOCIATION FOR PAEDIATRIC NEPHROLOGY (UK), DEPARTMENT OF HEALTH (UK) (NIHR), GAUCHERS ASSOCIATION (UK), KING'S COLLEGE LONDON (UK)

April 2010 - March 2017

Identifying and targeting immune pathways leading to the expression of renal biomarkers in juvenile lupus

ALDER HEY CHILDREN'S KIDNEY FUND (UK)

September 2013 - December 2019

Specialist Clinical Psychologist in Childhood Lupus

LUPUS UK (UK)

April 2014 - March 2018

Investigating immunopathogenesis of JSLE

DEPARTMENT OF HEALTH (UK) (NIHR)

April 2013 - May 2014

NIHR Alder Hey CRF: Experimental Medicine and Clinical Pharmacology

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

January 2013 - July 2013

Clinical Fellow in Paediatric and Neonatal Clinical Trials

DEPARTMENT OF HEALTH (UK) (NIHR)

February 2012 - July 2013

CRF Clinical Research Fellow

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

May 2015 - December 2018

Tracking cancer and mortality in UK Children and Young People with Lupus

LUPUS UK (UK)

September 2014 - August 2024

The role of the inflammatory cytokine interleukin 1 in Juvenile-onset Lupus Nephritis

ALDER HEY CHILDREN'S CHARITY (UK)

October 2013 - December 2016

MYPAN: Open label randomised controlled trial of mycophenolate mofetil versus cyclphoshamide for the induction of remission of childhood polyarteritis nodosa

ARTHRITIS RESEARCH UK

July 2013 - April 2020

2009 BSPAR annual scientific meeting

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

January 2010 - August 2014

Clinical Fellow in Paediatric and Neonatal Clinical Trials

THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)

April 2013 - December 2015

Setting up a European reference network for uniform treatment of rare paediatric Immune Mediated Inflammatory Diseases (IMID)

EUROPEAN COMMISSION

September 2012 - December 2015

Metfizz

EUROPEAN COMMISSION

October 2013 - March 2017

Validation of a composite disease activity score for juvenile idiopathic arthritis (JADAS) for use in a clinical setting and as a predictor of outcome

ARTHRITIS RESEARCH UK

August 2010 - December 2012

Administrative support for Professor Beresford

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2014 - March 2015

The role of Toll like receptors in Juvenile Systemic Lupus Erythematosus

ASSOCIATION OF PHYSICIANS OF GREAT BRITAIN AND IRELAND

September 2009 - August 2010

Flexibility and Sustainability Funding for Lucy Ballentine

DEPARTMENT OF HEALTH (UK) (NIHR)

January 2012 - December 2012

Investigating Biomarkers in Juvenile-onset Lupus Nephritis

ALDER HEY CHILDREN'S KIDNEY FUND (UK)

August 2009 - July 2013

Clinical Studies Group Chair in Paediatric Rheumatology.

ARTHRITIS RESEARCH CAMPAIGN, ARTHRITIS RESEARCH UK

October 2007 - September 2014

BPSU Behcet’s Study

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK), BEHCET'S SYNDROME SOCIETY (UK), THE UK VASCULITIS TRUST (UK)

December 2014 - December 2019

UK JSLE Conhort study & repository: Phase 2

LUPUS UK (UK)

November 2012 - December 2016

Use of dried blood spots to measure methotrexate polyglutamates as biomarkers of methotrexate use in paedriatric patients with juvenile Idiopathic Arthritis (JIA) and Juvenile Dermatomyostitis.

ARTHRITIS RESEARCH UK

June 2010 - July 2013

Investigating the serum effects on apoptosis in Juvenile Systemic Lupus Erythematosus (JSLE)

LUPUS UK (UK)

July 2010 - July 2013

Investigating neutrophil function in juvenile onset systemic lupus erythematosus.

ARTHRITIS RESEARCH CAMPAIGN

April 2007 - March 2008

Experimental Arthritis Treatment Centre (EATC) for Childhood Arthritis

ALDER HEY CHILDREN'S CHARITY (UK), ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK), ARTHRITIS RESEARCH UK

April 2014 - March 2022

TINN Trial EU FP7

EUROPEAN COMMISSION

November 2008 - October 2015

Lupus travel grant

ALDER HEY CHILDREN'S KIDNEY FUND (UK)

December 2014 - December 2019

A study of factors involved in phagocytosis in Juvenile Onset Systemic Lupus Erythematosus during periods of disease flare and quiescence

WELLCOME TRUST (UK)

July 2013 - September 2013

NIHR AlderHey CRF-­ Senior Lecturer in Clinical Pharmacology

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2013 - March 2019

Development of an Internationally agreed Minimal Dataset for Juvenile Dermatomyositis (JDM); a rare but severe, potentially life-threatening, childhood rheumatological condition

ARTHRITIS RESEARCH UK

January 2014 - June 2017

Feasibility study for an RCT to evaluate an intervention for parents early in the diagnosis of juvenile idiopathic arthritis.

DEPARTMENT OF HEALTH (UK) (NIHR)

January 2013 - September 2015

Research Collaborations

CAPS Steering Committee

External: ARC epidemiology Unit, Manchester University

Principal Investigator

Dr N Wilkinson

External: Nuffield Orthopaedic Centre, Oxford

UK JSLE Registry

Dr J Davidson

External: The University of Glasgow

UK JSLE registry

Professor S Edwards

Internal

Joint grant applications with a view to developing research program in juvenile onset SLE and paediatric rheumatology. This was successful with a £64K grant awarded to investigate neutrophil function in JSLE

Dr H Foster

External: The University of Newcastle-upon-Tyne

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Dr N McHugh

External: The University of Bath

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Dr H Venning

External: The University of Nottingham

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Dr C Pilkington

External: Institute of Child Health, London

JLSE Registry and Repository

Steering Committee

External: Institute of Child Health, London

Steering Committee member of UK JDM R&R

Professor D Isenberg

External: University College London

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Professor R Moots

Internal

Joint grant applications and close collaboration in developing strong links between the Department of Paediatric Rheumatology and the extensive program of clinical and basic science research. Application for grants were successful with an award of £64K for invesitgating neutrophil function in JSLE

Dr E Baildam

External: The University of Manchester

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Dr J McDonagh

External: The University of Birmingham

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE