Prof Michael Beresford MBChB MRCP(UK) MRCPCH PhD

Brough Chair, Professor of Child Health Women's and Children's Health

Research

Professor of Child Health

Professor Beresford is Brough Chair and Professor of Child Health in the Institute of Translational Medicine at University of Liverpool.

He is Lead of the National Institute of Health Research (NIHR) clinical Research Network (CRN) Specialty Cluster including the National Specialty Groups of Children and Musculoskeletal research, along with the emerging technology of Stratified/Personalized Medicine.

Experimental Arthritis Treatment Centre for Children

He is Director of the UK’s only Experimental Arthritis Treatment Centre for Children and Clinical Director of the NIHR Alder Hey Clinical Research Facility for Experimental Medicine.

He was Chair of the NIHR CRN: Children/Arthritis Research UK Paediatric Rheumatology Clinical Study Group, responsible for developing and overseeing a UK wide comprehensive portfolio of clinical trials and related studies covering the entire spectrum of diseases in paediatric rheumatology.

Juvenile-onset SLE


Professor Beresford Chairs the UK JSLE Study Group and has developed an internationally recognized Childhood Lupus translational research programme as part of the UK’s only Centre of Excellence for Childhood Lupus.

Research Grants

  • NIHR CRN Alliance funding for Liverpool CRN Theme office
  • Clinical studies group in paediatric rheumatology.
  • A Randomised Controlled Trial of adalimumab versus pamidronate in Chronic Recurrent Multifocal Osteomyelitis (CRMO) using a Bayesian Design
  • Supporting translational research in Paediatric Rheumatology and Respiratory
  • MAximizing Sle ThERapeutic PotentiaL by Application of Novel and Stratified approaches (MASTERPLANS)
  • Steroid Induction Regimen for Juvenile Idiopathic Arthritis (JIA)
  • Lupus UK and British Paediatric Surveillance Unit study of the incidence and prevalence of Juvenile-onset Systemic Lupus Erythematosus in children and young people in the UK and Republic of Ireland
  • CRN Children-Pharmacy & Formulations Work Stream
  • A phase II trial of tocilizumab in anti-TNF refractory patients with JIA associated uvetis
  • Clinical Studies Group Chair in Paediatric Rheumatology.
  • Paediatric Clinical Research Facility
  • University of Liverpool Confidence in Concept Program – Enhancing Translation
  • British Orthopaedic SCFE Surgery (BOSS) Study Investigating Slipped Capital Femoral Epiphysis (SCFE) as a childhood precursor to osteoarthritis
  • The interactions of Type I & II Interferons with Neutrophils; contributions to autoimmune disease pathogenesis and potential therapeutic modifications
  • Childhood Arthritis Response to Treatment consortium (CHART): partnership to define stratified medicine tools for childhood inflammatory arthritis
  • NIHR Medicines for Children Research Network
  • Identifying and targeting immune pathways leading to the expression of renal biomarkers in juvenile lupus
  • Specialist Clinical Psychologist in Childhood Lupus
  • Investigating immunopathogenesis of JSLE
  • NIHR Alder Hey CRF: Experimental Medicine and Clinical Pharmacology
  • Clinical Fellow in Paediatric and Neonatal Clinical Trials
  • CRF Clinical Research Fellow
  • Tracking cancer and mortality in UK Children and Young People with Lupus
  • The role of the inflammatory cytokine interleukin 1 in Juvenile-onset Lupus Nephritis
  • MYPAN: Open label randomised controlled trial of mycophenolate mofetil versus cyclphoshamide for the induction of remission of childhood polyarteritis nodosa
  • 2009 BSPAR annual scientific meeting
  • Clinical Fellow in Paediatric and Neonatal Clinical Trials
  • Setting up a European reference network for uniform treatment of rare paediatric Immune Mediated Inflammatory Diseases (IMID)
  • Metfizz
  • Validation of a composite disease activity score for juvenile idiopathic arthritis (JADAS) for use in a clinical setting and as a predictor of outcome
  • Administrative support for Professor Beresford
  • The role of Toll like receptors in Juvenile Systemic Lupus Erythematosus
  • Flexibility and Sustainability Funding for Lucy Ballentine
  • Investigating Biomarkers in Juvenile-onset Lupus Nephritis
  • Clinical Studies Group Chair in Paediatric Rheumatology.
  • BPSU Behcet’s Study
  • UK JSLE Conhort study & repository: Phase 2
  • Use of dried blood spots to measure methotrexate polyglutamates as biomarkers of methotrexate use in paedriatric patients with juvenile Idiopathic Arthritis (JIA) and Juvenile Dermatomyostitis.
  • Investigating the serum effects on apoptosis in Juvenile Systemic Lupus Erythematosus (JSLE)
  • Investigating neutrophil function in juvenile onset systemic lupus erythematosus.
  • Experimental Arthritis Treatment Centre (EATC) for Childhood Arthritis
  • TINN Trial EU FP7
  • Lupus travel grant
  • A study of factors involved in phagocytosis in Juvenile Onset Systemic Lupus Erythematosus during periods of disease flare and quiescence
  • NIHR AlderHey CRF-­ Senior Lecturer in Clinical Pharmacology
  • Development of an Internationally agreed Minimal Dataset for Juvenile Dermatomyositis (JDM); a rare but severe, potentially life-threatening, childhood rheumatological condition
  • Feasibility study for an RCT to evaluate an intervention for parents early in the diagnosis of juvenile idiopathic arthritis.

Research Collaborations

CAPS Steering Committee

External: ARC epidemiology Unit, Manchester University

Principal Investigator

Dr N Wilkinson

External: Nuffield Orthopaedic Centre, Oxford

UK JSLE Registry

Dr J Davidson

External: The University of Glasgow

UK JSLE registry

Professor S Edwards

Internal

Joint grant applications with a view to developing research program in juvenile onset SLE and paediatric rheumatology. This was successful with a £64K grant awarded to investigate neutrophil function in JSLE

Dr H Foster

External: The University of Newcastle-upon-Tyne

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Dr N McHugh

External: The University of Bath

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Dr H Venning

External: The University of Nottingham

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Dr C Pilkington

External: Institute of Child Health, London

JLSE Registry and Repository

Steering Committee

External: Institute of Child Health, London

Steering Committee member of UK JDM R&R

Professor D Isenberg

External: University College London

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Professor R Moots

Internal

Joint grant applications and close collaboration in developing strong links between the Department of Paediatric Rheumatology and the extensive program of clinical and basic science research. Application for grants were successful with an award of £64K for invesitgating neutrophil function in JSLE

Dr E Baildam

External: The University of Manchester

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

Dr J McDonagh

External: The University of Birmingham

Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE