Prof Martin Leuwer Dr. med. (MD), Dr. med. habil. (PhD)

Professor (Clin,Hcc) Molecular and Clinical Pharmacology

    Publications

    2014

    Circulating anti-inflammatory adipokines High Molecular Weight Adiponectin and Zinc-alpha 2-glycoprotein (ZAG) are inhibited in early sepsis, but increase with clinical recovery: a pilot study (Journal article)

    Welters, I. D., Bing, C., Ding, C., Leuwer, M., & Hall, A. M. (2014). Circulating anti-inflammatory adipokines High Molecular Weight Adiponectin and Zinc-alpha 2-glycoprotein (ZAG) are inhibited in early sepsis, but increase with clinical recovery: a pilot study. BMC Anesthesiology, 14. doi:10.1186/1471-2253-14-124

    DOI: 10.1186/1471-2253-14-124

    2013

    Propofol Derivatives (Patent)

    Leuwer, M. (2013). Propofol Derivatives.

    2012

    Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. (Journal article)

    Devereaux, P. J., Chan, M. T., Alonso-Coello, P., Walsh, M., Berwanger, O., Villar, J. C., . . . Yusuf, S. (2012). Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery.. JAMA, 307, 2295-2304. doi:10.1097/01.sa.0000426599.08366.af

    DOI: 10.1097/01.sa.0000426599.08366.af

    2011

    Acute sore throat revisited: clinical and experimental evidence for the efficacy of over-the-counter AMC/DCBA throat lozenges. (Journal article)

    Oxford, J. S., & Leuwer, M. (2011). Acute sore throat revisited: clinical and experimental evidence for the efficacy of over-the-counter AMC/DCBA throat lozenges.. Int J Clin Pract. 2011 May;65(5):524-30., 65(5), 524-530.

    Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells. (Journal article)

    Ahrens, J., Foadi, N., Eberhardt, A., Haeseler, G., Dengler, R., Leffler, A., . . . Leuwer, M. (2011). Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells.. Pharmacology. 2011;87(5-6):311-7., 87(5-6), 311-317.

    Paracetamol fails to positively modulate and directly activate chloride currents in human a1-glycine receptors. (Journal article)

    de la Roche, J., Buchholz, V., Dengler, R., Haeseler, G., Leuwer, M., & Ahrens, J. (2011). Paracetamol fails to positively modulate and directly activate chloride currents in human a1-glycine receptors.. Pharmacology. 2011;87(1-2):115-20, 87(1-2), 115-120.

    Plasma endotoxin in horses presented to an equine referral hospital: correlation to selected clinical parameters and outcomes. (Journal article)

    Senior, J. M., Proudman, C. J., Leuwer, M., & Carter, S. D. (2011). Plasma endotoxin in horses presented to an equine referral hospital: correlation to selected clinical parameters and outcomes.. Equine Vet J. 2011 Sep;43(5):585-91, 43(5), 585-591.

    2010

    Interdisziplinaere Intensivmedizin (Book)

    Leuwer, M., Marx, G., Trappe, H. J., & Zuzan, O. (Eds.) (2010). Interdisziplinaere Intensivmedizin. Stuttgart-New York: Thieme.

    2009

    Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice (Journal article)

    Leuwer, M., Welters, I., Marx, G., Rushton, A., Bao, H., Hunter, L., & Trayhurn, P. (2009). Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice. Pflügers Archiv - European Journal of Physiology, 457(4), 731-741. doi:10.1007/s00424-008-0564-8

    DOI: 10.1007/s00424-008-0564-8

    Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice. (Journal article)

    Leuwer, M., Welters, I., Marx, G., Rushton, A., Bao, H., Hunter, L., & Trayhurn, P. (2009). Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice.. Pflugers Archiv : European journal of physiology, 457(4), 731-741. doi:10.1007/s00424-008-0564-8

    DOI: 10.1007/s00424-008-0564-8

    2008

    High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues (Journal article)

    Haeseler, G., Karst, M., Foadi, N., Gudehus, S., Roeder, A., Hecker, H., . . . Leuwer, M. (2008). High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues. British Journal of Pharmacology, 155(2), 265-275. doi:10.1038/bjp.2008.255

    DOI: 10.1038/bjp.2008.255

    Endotoxin reduces availability of voltage-gated human skeletal muscle sodium channels at depolarized membrane potentials* (Journal article)

    Haeseler, G., Foadi, N., Wiegand, E., Ahrens, J., Krampfl, K., Dengler, R., & Leuwer, M. (2008). Endotoxin reduces availability of voltage-gated human skeletal muscle sodium channels at depolarized membrane potentials*. Critical Care Medicine, 36(4), 1239-1247. doi:10.1097/ccm.0b013e31816a02cf

    DOI: 10.1097/ccm.0b013e31816a02cf

    A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine a1 and a1ß receptor (Journal article)

    Ahrens, J., Leuwer, M., Stachura, S., Krampfl, K., Belelli, D., Lambert, J. J., & Haeseler, G. (2008). A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine a1 and a1ß receptor. Anaesthesia and Analgesia (acceped for publication).

    2007

    Analgesia (Patent)

    Leuwer, M. (2007). Analgesia.

    Glycine Agonists (Patent)

    Leuwer, M. (2007). Glycine Agonists.

    2006

    Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock (Journal article)

    Marx, G., Pedder, S., Smith, L., Swaraj, S., Grime, S., Stockdale, H., & Leuwer, M. (2006). Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock. Critical Care Medicine, 34(12), 3005-3010. doi:10.1097/01.ccm.0000242755.74063.ed

    DOI: 10.1097/01.ccm.0000242755.74063.ed

    Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels (Journal article)

    Haeseler, G., Foadi, N., Ahrens, J., Dengler, R., Hecker, H., & Leuwer, M. (2006). Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels. Pain, 126(1), 234-244. doi:10.1016/j.pain.2006.07.003

    DOI: 10.1016/j.pain.2006.07.003

    Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model (Journal article)

    Marx, G., Schuerholz, T., Pedder, S., Simon, T., Grime, S., Sümpelmann, R., & Leuwer, M. (2006). Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model. Critical Care Medicine, 34(5), 1483-1488. doi:10.1097/01.ccm.0000216706.29242.83

    DOI: 10.1097/01.ccm.0000216706.29242.83

    High-affinity blockade of voltage-operated skeletal muscle sodium channels by 2,6-dimethyl-4-chlorophenol (Journal article)

    Haeseler, G., Gudehus, S., Bufler, J., Dengler, R., & Leuwer, M. (2006). High-affinity blockade of voltage-operated skeletal muscle sodium channels by 2,6-dimethyl-4-chlorophenol. European Journal of Anaesthesiology, 23(3), 190-196. doi:10.1017/s0265021505002176

    DOI: 10.1017/s0265021505002176

    Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock. (Journal article)

    Marx, G., Pedder, S., Smith, L., Swaraj, S., Grime, S., Stockdale, H., & Leuwer, M. (2006). Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock.. Crit. Care Med. 2006; 34: 3005-10, 34, 3005-3010.

    Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model. (Journal article)

    Marx, G., Schuerholz, T., Pedder, S., Simon, T., Grime, S., Sümpelmann, R., & Leuwer, M. (2006). Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model.. Crit. Care. Med. 2006; 34: 1483-8, 34, 1483-1488.

    Pre-operative and anaesthesia-related risk factors for mortality in equine colic cases (Journal article)

    Proudman, C. J., Dugdale, A. H. A., Senior, J. M., Edwards, G. B., Smith, J. E., Leuwer, M. L., & French, N. P. (2006). Pre-operative and anaesthesia-related risk factors for mortality in equine colic cases. VETERINARY JOURNAL, 171(1), 89-97. doi:10.1016/j.tvjl.2004.09.005

    DOI: 10.1016/j.tvjl.2004.09.005

    Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels. (Journal article)

    Haeseler, G., Foadi, N., Ahrens, J., Dengler, R., Hecker, H., & Leuwer, M. (2006). Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels.. Pain 2006; 126: 234-44, 126, 234-244.

    2005

    Structural features of phenol derivatives determining potency for activation of chloride currents via a 1 homomeric and a 1 ß heteromeric glycine receptors (Journal article)

    Haeseler, G., Ahrens, J., Krampfl, K., Bufler, J., Dengler, R., Hecker, H., . . . Leuwer, M. (2005). Structural features of phenol derivatives determining potency for activation of chloride currents via a 1 homomeric and a 1 ß heteromeric glycine receptors. British Journal of Pharmacology, 145(7), 916-925. doi:10.1038/sj.bjp.0706254

    DOI: 10.1038/sj.bjp.0706254

    Comparison of cardiac output measurements by arterial trans-cardiopulmonary and pulmonary arterial thermodilution with direct Fick in septic shock (Journal article)

    Marx, G., Schuerholz, T., Sümpelmann, R., Simon, T., & Leuwer, M. (2005). Comparison of cardiac output measurements by arterial trans-cardiopulmonary and pulmonary arterial thermodilution with direct Fick in septic shock. European Journal of Anaesthesiology, 22(2), 129-134. doi:10.1017/s0265021505000244

    DOI: 10.1017/s0265021505000244

    Neuromuscular blocking agents and skeletal muscle relaxants (Chapter)

    Zuzan, O., & Leuwer, M. (2005). Neuromuscular blocking agents and skeletal muscle relaxants. In J. K. Aronson (Ed.), Meyler¿s Side Effects of Drugs, Annual 28 (pp. 155-159). Amsterdam: Elsevier Science.

    Terminal complement complex in septic shock with capillary leakage: marker of complement activation? (Journal article)

    Terminal complement complex in septic shock with capillary leakage: marker of complement activation? (2005). European Journal of Anaesthesia, 22(7), 541-547.

    2004

    2,6 Di-tert-butylphenol, a Nonanesthetic Propofol Analog, Modulates a1ß Glycine Receptor Function in a Manner Distinct from Propofol (Journal article)

    Ahrens, J., Haeseler, G., Leuwer, M., Mohammadi, B., Krampfl, K., Dengler, R., & Bufler, J. (2004). 2,6 Di-tert-butylphenol, a Nonanesthetic Propofol Analog, Modulates a1ß Glycine Receptor Function in a Manner Distinct from Propofol. Anesthesia & Analgesia, 99(1), 91-96. doi:10.1213/01.ane.0000120083.10269.54

    DOI: 10.1213/01.ane.0000120083.10269.54

    Ringer's solution but not hydroxyethyl starch or modified fluid gelatin enhances platelet microvesicle formation in a porcine model of septic shock † (Journal article)

    Schuerholz, T., Sümpelmann, R., Piepenbrock, S., Leuwer, M., & Marx, G. (2004). Ringer's solution but not hydroxyethyl starch or modified fluid gelatin enhances platelet microvesicle formation in a porcine model of septic shock †. British Journal of Anaesthesia, 92(5), 716-721. doi:10.1093/bja/aeh127

    DOI: 10.1093/bja/aeh127

    RESUSCITATION FROM SEPTIC SHOCK WITH CAPILLARY LEAKAGE: HYDROXYETHYL STARCH (130 KD), BUT NOT RINGER’S SOLUTION MAINTAINS PLASMA VOLUME AND SYSTEMIC OXYGENATION (Journal article)

    Marx, G., Pedder, S., Smith, L., Swaraj, S., Grime, S., Stockdale, H., & Leuwer, M. (2004). RESUSCITATION FROM SEPTIC SHOCK WITH CAPILLARY LEAKAGE: HYDROXYETHYL STARCH (130 KD), BUT NOT RINGER’S SOLUTION MAINTAINS PLASMA VOLUME AND SYSTEMIC OXYGENATION. Shock, 21(4), 336-341. doi:10.1097/00024382-200404000-00008

    DOI: 10.1097/00024382-200404000-00008

    Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis (Journal article)

    Marx, G., Cope, T., McCrossan, L., Swaraj, S., Cowan, C., Mostafa, S. M., . . . Leuwer, M. (2004). Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis. European Journal of Anaesthesiology, 21(2), 132-138. doi:10.1097/00003643-200402000-00009

    DOI: 10.1097/00003643-200402000-00009

    An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity (Journal article)

    Leuwer, M., Haeseler, G., Hecker, H., Bufler, J., Dengler, R., & Aronson, J. K. (2004). An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity. British Journal of Pharmacology, 141(1), 47-54. doi:10.1038/sj.bjp.0705594

    DOI: 10.1038/sj.bjp.0705594

    2003

    Blockade of Voltage-Operated Neuronal and Skeletal Muscle Sodium Channels by S(+)- and R(???)-Ketamine (Journal article)

    Haeseler, G., Tetzlaff, D., Bufler, J., Dengler, R., M??nte, S., Hecker, H., & Leuwer, M. (2003). Blockade of Voltage-Operated Neuronal and Skeletal Muscle Sodium Channels by S(+)- and R(???)-Ketamine. Anesthesia & Analgesia, 1019-1026. doi:10.1213/01.ane.0000052513.91900.d5

    DOI: 10.1213/01.ane.0000052513.91900.d5

    High-affinity block of voltage-operated rat IIA neuronal sodium channels by 2,6 di-tert-butylphenol, a propofol analogue (Journal article)

    High-affinity block of voltage-operated rat IIA neuronal sodium channels by 2,6 di-tert-butylphenol, a propofol analogue (2003). European Journal of Anaesthesia, 20(3), 220-224.

    (Journal article)

    Marx, G., Pedder, S., Swaraj, S., Pfeiffer, U., & Leuwer, M. (2003). Unknown Title. Critical Care, 7(Suppl 2), P188. doi:10.1186/cc2077

    DOI: 10.1186/cc2077

    2002

    Block of voltage-operated sodium channels by 2,6-dimethylphenol, a structural analogue of lidocaine's aromatic tail (Journal article)

    Haeseler, G., Bufler, J., Merken, S., Dengler, R., Aronson, J., & Leuwer, M. (2002). Block of voltage-operated sodium channels by 2,6-dimethylphenol, a structural analogue of lidocaine's aromatic tail. British Journal of Pharmacology, 137(2), 285-293. doi:10.1038/sj.bjp.0704854

    DOI: 10.1038/sj.bjp.0704854

    Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol (Journal article)

    Haeseler, G., Maue, D., Grosskreutz, J., Bufler, J., Nentwig, B., Piepenbrock, S., . . . Leuwer, M. (2002). Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol. European Journal of Anaesthesiology, 19(8), 571-579. doi:10.1097/00003643-200208000-00005

    DOI: 10.1097/00003643-200208000-00005

    Hydroxyethyl starch and modified fluid gelatin maintain plasma volume in a porcine model of septic shock with capillary leakage (Journal article)

    Marx, G., Cobas Meyer, M., Schuerholz, T., Vangerow, B., Gratz, K., Hecker, H., . . . Leuwer, M. (2002). Hydroxyethyl starch and modified fluid gelatin maintain plasma volume in a porcine model of septic shock with capillary leakage. Intensive Care Medicine, 28(5), 629-635. doi:10.1007/s00134-002-1260-3

    DOI: 10.1007/s00134-002-1260-3

    Intranasale Midazolamapplikation zur Anxiolyse bei der Magnetresonanztomographie (Journal article)

    Muente, S., Hollenhorst, J., Friedrich, L., Heine, J., Leuwer, M., Piepenbrock, S., & Becker, H. (2002). Intranasale Midazolamapplikation zur Anxiolyse bei der Magnetresonanztomographie. Klinische Neuroradiologie, 12, 82-87.

    2001

    Effects of C1 inhibitor and r-SP-C surfactant on oxygenation and histology in rats with lavage-induced acute lung injury (Journal article)

    Vangerow, B., Häfner, D., Rueckoldt, H., Marx, G., Ott, N., Leuwer, M., . . . Germann, P. G. (2001). Effects of C1 inhibitor and r-SP-C surfactant on oxygenation and histology in rats with lavage-induced acute lung injury. Intensive Care Medicine, 27(9), 1526-1531. doi:10.1007/s001340101036

    DOI: 10.1007/s001340101036

    Structural requirements of phenol derivatives for direct activation of chloride currents via GABAA receptors (Journal article)

    Mohammadi, B., Haeseler, G., Leuwer, M., Dengler, R., Krampfl, K., & Bufler, J. (2001). Structural requirements of phenol derivatives for direct activation of chloride currents via GABAA receptors. European Journal of Pharmacology, 421(2), 85-91. doi:10.1016/s0014-2999(01)01033-0

    DOI: 10.1016/s0014-2999(01)01033-0

    General anesthesia for interventional neuroradiology: propofol versus isoflurane (Journal article)

    Münte, S., Münte, T. F., Kuche, H. -C., Osthaus, A., Herzog, T., Heine, J., . . . Piepenbrock, S. (2001). General anesthesia for interventional neuroradiology: propofol versus isoflurane. Journal of Clinical Anesthesia, 13(3), 186-192. doi:10.1016/s0952-8180(01)00256-2

    DOI: 10.1016/s0952-8180(01)00256-2

    Propofol Blocks Human Skeletal Muscle Sodium Channels in a Voltage-Dependent Manner (Journal article)

    Haeseler, G., Störmer, M., Bufler, J., Dengler, R., Hecker, H., Piepenbrock, S., & Leuwer, M. (2001). Propofol Blocks Human Skeletal Muscle Sodium Channels in a Voltage-Dependent Manner. Anesthesia & Analgesia, 92(5), 1192-1198. doi:10.1097/00000539-200105000-00021

    DOI: 10.1097/00000539-200105000-00021

    Structural requirements for voltage-dependent block of muscle sodium channels by phenol derivatives (Journal article)

    Haeseler, G., Piepenbrink, A., Bufler, J., Dengler, R., Aronson, J. K., Piepenbrock, S., & Leuwer, M. (2001). Structural requirements for voltage-dependent block of muscle sodium channels by phenol derivatives. British Journal of Pharmacology, 132(8), 1916-1924. doi:10.1038/sj.bjp.0704024

    DOI: 10.1038/sj.bjp.0704024

    Application of a new verification technique allowing craniospinal irradiation in supine position (Journal article)

    Rades, D., Baumann, R., Bremer, M., Leuwer, M., & Karstens, J. H. (2001). Application of a new verification technique allowing craniospinal irradiation in supine position. Radiotherapy and Oncology, 58(2), 215-217. doi:10.1016/s0167-8140(00)00261-9

    DOI: 10.1016/s0167-8140(00)00261-9

    Phenol derivatives accelerate inactivation kinetics in one inactivation-deficient mutant human skeletal muscle Na+ channel (Journal article)

    Haeseler, G., Piepenbrink, A., Bufler, J., Dengler, R., Hecker, H., Aronson, J., . . . Leuwer, M. (2001). Phenol derivatives accelerate inactivation kinetics in one inactivation-deficient mutant human skeletal muscle Na+ channel. European Journal of Pharmacology, 416, 11-18.

    The anesthetic propofol modulates gating in paramyotonia congenita mutant muscle sodium channels (Journal article)

    The anesthetic propofol modulates gating in paramyotonia congenita mutant muscle sodium channels (2001). Muscle Nerve, 24(6), 736-743.

    Using intranasal midazolam spray to prevent claustrophobia induced by MR imaging (Journal article)

    Using intranasal midazolam spray to prevent claustrophobia induced by MR imaging (2001). American Journal of Roentgenology, 176(4), 865-868.

    2000

    Anaesthesia with midazolam and S-(+)-ketamine in spontaneously breathing paediatric patients during magnetic resonance imaging (Journal article)

    Haeseler, G., Zuzan, O., Köhn, G., Piepenbrock, S., & Leuwer, M. (2000). Anaesthesia with midazolam and S-(+)-ketamine in spontaneously breathing paediatric patients during magnetic resonance imaging. Pediatric Anesthesia, 10(5), 513-519. doi:10.1046/j.1460-9592.2000.00569.x

    DOI: 10.1046/j.1460-9592.2000.00569.x

    Anaesthesia with propofol decreases FMLP-induced neutrophil respiratory burst but not phagocytosis compared with isoflurane (Journal article)

    Heine, J., Jaeger, K., Osthaus, A., Weingaertner, N., Münte, S., Piepenbrock, S., & Leuwer, M. (2000). Anaesthesia with propofol decreases FMLP-induced neutrophil respiratory burst but not phagocytosis compared with isoflurane. British Journal of Anaesthesia, 85(3), 424-430. doi:10.1093/bja/85.3.424

    DOI: 10.1093/bja/85.3.424

    Voltage-dependent blockade of normal and mutant muscle sodium channels by benzylalcohol (Journal article)

    Haeseler, G., Mamarvar, M., Bufler, J., Dengler, R., Hecker, H., Aronson, J. K., . . . Leuwer, M. (2000). Voltage-dependent blockade of normal and mutant muscle sodium channels by benzylalcohol. British Journal of Pharmacology, 130(6), 1321-1330. doi:10.1038/sj.bjp.0703447

    DOI: 10.1038/sj.bjp.0703447

    Succinylcholine Metabolite Succinic Acid Alters Steady State Activation in Muscle Sodium Channels (Journal article)

    Haeseler, G., Petzold, J., Hecker, H., Würz, A., Dengler, R., Piepenbrock, S., . . . Leuwer, M. (2000). Succinylcholine Metabolite Succinic Acid Alters Steady State Activation in Muscle Sodium Channels. Anesthesiology, 92(5), 1385-1391. doi:10.1097/00000542-200005000-00029

    DOI: 10.1097/00000542-200005000-00029

    Endoluminal grafting of abdominal aortic aneurysms: experience with the Talent endoluminal stent graft (Journal article)

    Chavan, A., Cohnert, T. U., Heine, J., Leuwer, M., J?rgensen, M., Haverich, A., . . . Harringer, W. (2000). Endoluminal grafting of abdominal aortic aneurysms: experience with the Talent endoluminal stent graft. European Radiology, 10(4), 636-641. doi:10.1007/s003300050976

    DOI: 10.1007/s003300050976

    No Implicit Memory for Stories Played during Isoflurane/Alfentanil/Nitrous Oxide Anesthesia: A Reading Speed Measurement (Journal article)

    Münte, S., Lüllwitz, E., Leuwer, M., Mitzlaff, B., Münte, T. F., Hussein, S., & Piepenbrock, S. A. (2000). No Implicit Memory for Stories Played during Isoflurane/Alfentanil/Nitrous Oxide Anesthesia: A Reading Speed Measurement. Anesthesia & Analgesia, 90(3), 733-738. doi:10.1097/00000539-200003000-00041

    DOI: 10.1097/00000539-200003000-00041

    Absorption and hemodynamic effects of airway administration of adrenaline in patients with severe cardiac disease (Journal article)

    Absorption and hemodynamic effects of airway administration of adrenaline in patients with severe cardiac disease (2000). Annals of Internal Medicine, 132(10), 800-803.

    Acute vascular rejection is associated with systemic complement activation in a pig-to-primate kidney xenograft model (Journal article)

    Acute vascular rejection is associated with systemic complement activation in a pig-to-primate kidney xenograft model (2000). Xenotransplantation, 7(3), 186-196.

    Effects of C1 inhibitor and r-SP-C surfactant on oxygenation and histology in rats with lavage-inducedacute lung injury (Journal article)

    Vangerow, B., Haefner, D., Rueckoldt, H., Marx, G., Ott, N., Leuwer, M., . . . Germann, P. G. (2000). Effects of C1 inhibitor and r-SP-C surfactant on oxygenation and histology in rats with lavage-inducedacute lung injury. Intensive Care Medicine, 27, 1526-1531.

    Postoperative reading speed does not indicate implicit memory in elderly cardiac patients after propofol and remifentanyl anaesthesia (Journal article)

    Münte, S., Münte, T. F., Mitzlaff, B., Walz, R., Leuwer, M., & Piepenbrock, S. (2000). Postoperative reading speed does not indicate implicit memory in elderly cardiac patients after propofol and remifentanyl anaesthesia. Acta Anaesthesiologica Scandinavica, 45, 750-755.

    1999

    Xenon inhalation increases airway pressure in ventilated patients (Journal article)

    Rueckoldt, H., Vangerow, B., Marx, G., Haubitz, B., Cobas Meyer, M., Piepenbrock, S., & Leuwer, M. (1999). Xenon inhalation increases airway pressure in ventilated patients. Acta Anaesthesiologica Scandinavica, 43(10), 1060-1064. doi:10.1034/j.1399-6576.1999.431016.x

    DOI: 10.1034/j.1399-6576.1999.431016.x

    Septic shock after liver transplantation for Caroli's disease: clinical improvement after treatment with C1-esterase inhibitor (Journal article)

    Marx, G., Nashan, B., Cobas Meyer, M., Vangerow, B., Schlitt, H. J., Ziesing, S., . . . Rueckoldt, H. (1999). Septic shock after liver transplantation for Caroli's disease: clinical improvement after treatment with C1-esterase inhibitor. Intensive Care Medicine, 25(9), 1017-1020. doi:10.1007/s001340051000

    DOI: 10.1007/s001340051000

    GM-CSF increases in vitro the respiratory burst of human neutrophils after liver transplantation (Journal article)

    Jaeger, K., Scheinichen, D., Heine, J., Ruschulte, H., Kuse, E., Winkler, M., & Leuwer, M. (1999). GM-CSF increases in vitro the respiratory burst of human neutrophils after liver transplantation. Intensive Care Medicine, 25(6), 612-615. doi:10.1007/s001340050911

    DOI: 10.1007/s001340050911

    Effect of magnetic resonance imaging on human respiratory burst of neutrophils (Journal article)

    Heine, J., Scheinichen, D., Jaeger, K., Herzog, T., Sümpelmann, R., & Leuwer, M. (1999). Effect of magnetic resonance imaging on human respiratory burst of neutrophils. FEBS Letters, 446(1), 15-17. doi:10.1016/s0014-5793(99)00183-0

    DOI: 10.1016/s0014-5793(99)00183-0

    Increased Reading Speed for Stories Presented during General Anesthesia  (Journal article)

    Munte, S., Kobbe, I., Demertzis, A., Lullwitz, E., Munte, T. F., Piepenbrock, S., & Leuwer, M. (1999). Increased Reading Speed for Stories Presented during General Anesthesia . Anesthesiology, 90(3), 662-669. doi:10.1097/00000542-199903000-00006

    DOI: 10.1097/00000542-199903000-00006

    Compositional, structural and functional alterations in pulmonary surfactant in surgical patients after the early onset of SIRS or sepsis (Journal article)

    Compositional, structural and functional alterations in pulmonary surfactant in surgical patients after the early onset of SIRS or sepsis (1999). Critical Care Medicine, 27(1), 82-89.

    Craniospinal Axis Irradiation in Children. Treatment in supine position including field verification as a prerequisite for anesthesia without intubation (Journal article)

    Craniospinal Axis Irradiation in Children. Treatment in supine position including field verification as a prerequisite for anesthesia without intubation (1999). Strahlentherapie und Onkologie, 175(8), 409-412.

    Der innerklinische Transport von Patienten mit erhöhtem intrakraniellen Druck (Journal article)

    Der innerklinische Transport von Patienten mit erhöhtem intrakraniellen Druck (1999). Anaesthesiologie Intensivmedizin Notfallmedizin Schmerztherapie, 34, S58-S61.

    Die Pharmakokinetik von Azlocillin bei anurischen. Patienten während der kontinuierlichen arteriovenösen hämofiltration (Journal article)

    Krupp, A., Leuwer, M., Schmidt, H., & Eberhardt, B. (1999). Die Pharmakokinetik von Azlocillin bei anurischen. Patienten während der kontinuierlichen arteriovenösen hämofiltration. Strahlentherapie und Onkologie, 175, 409-412.

    Die intravenöse Anästhesie mit Propofol hemmt den Respiratory Burst jedoch nicht die Phagozytoseleistung neutrophiler Granulozyten (Journal article)

    Heine, J., Jaeger, K., Weingärtner, N., Piepenbrock, S., & Leuwer, M. (1999). Die intravenöse Anästhesie mit Propofol hemmt den Respiratory Burst jedoch nicht die Phagozytoseleistung neutrophiler Granulozyten. Anaesthesiologie & Intensivmedizin, 40, 865-866.

    Different effects of dopamine and dopexamine hydrochloride on the isolated perfused rat kidney (Journal article)

    Different effects of dopamine and dopexamine hydrochloride on the isolated perfused rat kidney (1999). British Journal of Anaesthesia, 83(6), 898-902.

    Gelenkblockierungen im Bereich der Halswirbelsäule bei neuromuskulärer Blockade. Der Einfluß von Intubation und Lagerung (Journal article)

    Goldmann, R., Kriebel-Goldmann, C., Leuwer, M., & Piepenbrock, S. (1999). Gelenkblockierungen im Bereich der Halswirbelsäule bei neuromuskulärer Blockade. Der Einfluß von Intubation und Lagerung. Manuelle Medizin, 37, 137-142.

    Iatrogene Trachealverletzung als Folge mehrfacher Intubationsversuche (Fallbericht) (Journal article)

    Jaeger, K., Andre, M., Ruschulte, H., Osthaus, A., Debertin, A. S., Heine, J., & Leuwer, M. (1999). Iatrogene Trachealverletzung als Folge mehrfacher Intubationsversuche (Fallbericht). Notfall & Rettungsmedizin, 2, 500-503.

    In vitro influence of parenteral lipid emulsions on the respiratory burst of neutrophils (Journal article)

    In vitro influence of parenteral lipid emulsions on the respiratory burst of neutrophils (1999). Nutrition, 15(7-8), 540-645.

    Kein implizites Gedächtnis für während Isofluran/Alfentanil/N2O-Anästhesie vorgespielte Geschichten (Journal article)

    Münte, S., Lüllwitz, E., Mitzlaff, B., Münte, T. F., Piepenbrock, S., & Leuwer, M. (1999). Kein implizites Gedächtnis für während Isofluran/Alfentanil/N2O-Anästhesie vorgespielte Geschichten. Anaesthesiologie & Intensivmedizin, 40, 850-851.

    Low-dose dopexamine in patients undergoing hemihepatectomy: an evaluation of effects on reduction of hepatic dysfunction and ischaemic liver injury (Journal article)

    Marx, G., Leuwer, M., Höltje, M., Bornscheuer, A., Hermann, H., Mahr, K. H., . . . Rückoldt, H. (1999). Low-dose dopexamine in patients undergoing hemihepatectomy: an evaluation of effects on reduction of hepatic dysfunction and ischaemic liver injury. Acta Anaesthesiologica Scandinavica, 44, 410-416.

    Neutrophil respiratory burst following liver transplantation: In vitro effects of granulocyte colony-stimulating factor (Journal article)

    Jaeger, K., Ruschulte, H., Heine, J., Scheinichen, D., Leuwer, M., Winkler, M., & Kuse, E. R. (1999). Neutrophil respiratory burst following liver transplantation: In vitro effects of granulocyte colony-stimulating factor. Transplant Infectious Disease, 1, 153-156.

    Stellenwert der Larynxmaske im Rettungsdienst - eine Umfrage unter norddeutschen Notärzten (Journal article)

    Jaeger, K., Osthaus, A., Andre, M., Ruschulte, H., Heine, J., Scheinichen, D., & Leuwer, M. (1999). Stellenwert der Larynxmaske im Rettungsdienst - eine Umfrage unter norddeutschen Notärzten. Anaesthesiol. Reanimat., 24, 79-81.

    Voltage-dependent inhibition of normal, Paramyotonia Congenita and Hyperkalemic Periodic Paralysis mutant muscle sodium channels by 4-Chloro-m-Cresol (Journal article)

    Voltage-dependent inhibition of normal, Paramyotonia Congenita and Hyperkalemic Periodic Paralysis mutant muscle sodium channels by 4-Chloro-m-Cresol (1999). British Journal of Pharmacology, 128(6), 1259-1267.

    1998

    Remifentanil, fentanyl, and alfentanil have no influence on the respiratory burst of human neutrophilsin vitro (Journal article)

    Jaeger, K., Scheinichen, D., Heine, J., André, M., Bund, M., Piepenbrock, S., & Leuwer, M. (1998). Remifentanil, fentanyl, and alfentanil have no influence on the respiratory burst of human neutrophilsin vitro. Acta Anaesthesiologica Scandinavica, 42(9), 1110-1113. doi:10.1111/j.1399-6576.1998.tb05386.x

    DOI: 10.1111/j.1399-6576.1998.tb05386.x

    Evaluation of noninvasive determinants for capillary leakage syndrome in septic shock patients (Journal article)

    Marx, G., Vangerow, B., Burczyk, C., Gratz, K. F., Maassen, N., Cobas Meyer, M., & Leuwer, M. (1998). Evaluation of noninvasive determinants for capillary leakage syndrome in septic shock patients. Intensive Care Medicine, 26, 1252-1258.

    Predictors for deterioration of respiratory function after transfer of critically ill patients (Journal article)

    Predictors for deterioration of respiratory function after transfer of critically ill patients (1998). Intensive Care Medicine, 24(11), 1157-1162.

    Pulsoxymetrie und Kapnometrie bei Intensivtransporten. Kombinierter Einsatz verringert das Transportrisiko (Journal article)

    Rückoldt, H., Marx, G., Leuwer, M., Panning, B., & Piepenbrock, S. (1998). Pulsoxymetrie und Kapnometrie bei Intensivtransporten. Kombinierter Einsatz verringert das Transportrisiko. Anaesthesiologie Intensivmedizin Notfallmedizin Schmerztherapie, 32, 31-32.

    1997

    Alterations in pulmonary surfactant during the course of sepsis-induced ARDS predisposition (Journal article)

    Stamme, C., Leuwer, M., Lührs, J., Ensink, M., Tschorn, H., Vangerow, B., . . . Piepenbrock, S. (1997). Alterations in pulmonary surfactant during the course of sepsis-induced ARDS predisposition. Applied Cardiopulmonary Pathophysiology, 6, 223-232.

    Das Verhalten von Gelenkfunktionsstörungen im Bereich der Lenden- und Brustwirbelsäule unter Muskelrelaxierung (Journal article)

    Goldmann, R., Kriebel-Goldmann, C., Leuwer, M., & Piepenbrock, S. (1997). Das Verhalten von Gelenkfunktionsstörungen im Bereich der Lenden- und Brustwirbelsäule unter Muskelrelaxierung. Manuelle Medizin, 35, 304-312.

    Einfluß von Remifentanil auf den Respiratory Burst humaner neutrophiler Granulozyten (Journal article)

    Jaeger, K., Andre, M., Scheinichen, D., Heine, J., Kleine, H. D., Leuwer, M., & Piepenbrock, S. (1997). Einfluß von Remifentanil auf den Respiratory Burst humaner neutrophiler Granulozyten. Anaesthesiol. Reanimat., 22, 121-124.

    Inhibition of neutrophil respiratory burst and chemotaxis in vivo by thiopentone but not by methohexitone (Journal article)

    Heine, J., Andre, M., Scheinichen, D., Jaeger, K., Emmendörffer, A., & Leuwer, M. (1997). Inhibition of neutrophil respiratory burst and chemotaxis in vivo by thiopentone but not by methohexitone. Neurosurgical Focus, 2, 1-3.

    Intubationsbedingungen und Verlauf der neuromuskulären Blockade nach Rocuronium bei endoskopischen Eingriffen in der HNO-Heilkunde (Journal article)

    Lüllwitz, E., Zuzan, O., Florey Schultze, T., Leuwer, M., & Piepenbrock, S. (1997). Intubationsbedingungen und Verlauf der neuromuskulären Blockade nach Rocuronium bei endoskopischen Eingriffen in der HNO-Heilkunde. Anaesthesist, 46, 14-20.

    1996

    Flow cytometry evaluation of the in vitro influence of four i.v. anaesthetics on respiratory burst of neutrophils (Journal article)

    Heine, J., Leuwer, M., Scheinichen, D., Arseniev, L., Jaeger, K., & Piepenbrock, S. (1996). Flow cytometry evaluation of the in vitro influence of four i.v. anaesthetics on respiratory burst of neutrophils. British Journal of Anaesthesia, 77(3), 387-392. doi:10.1093/bja/77.3.387

    DOI: 10.1093/bja/77.3.387

    Are thiopentone, methohexitone, and propofol inhibitors of neutrophil respiratory burst and chemotaxis? (Journal article)

    Leuwer, M., Heine, J., Scheinichen, D., Jaeger, K., Emmendörffer, A., & Piepenbrock, S. (1996). Are thiopentone, methohexitone, and propofol inhibitors of neutrophil respiratory burst and chemotaxis?. Anaesthesiologie Intensivmedizin Notfallmedizin Schmerztherapie, 31, 448-449.

    Effect of halothane, enflurane and isoflurane on the pharmacodynamics of mivacurium in children (Journal article)

    Neidhart, G., Pabelick, C., Kuhn, I., Leuwer, M., & Vettermann, J. (1996). Effect of halothane, enflurane and isoflurane on the pharmacodynamics of mivacurium in children. Anaesthesiologie Intensivmedizin Notfallmedizin Schmerztherapie, 31, 293-297.

    1995

    Dose response, time course of action and recovery of rocuronium bromide in children during halothane anaesthesia (Journal article)

    Dose response, time course of action and recovery of rocuronium bromide in children during halothane anaesthesia (1995). European Journal of Anaesthesia, 12, 73-78.

    1994

    Are thiopentone, methohexitone, and propofol inhibitors of neutrophil respiratory burst and chemotaxis? (Journal article)

    Motsch, J., Leuwer, M., Pfau, J., & Martin, E. (1994). Are thiopentone, methohexitone, and propofol inhibitors of neutrophil respiratory burst and chemotaxis?. European Journal of Anaesthesia, 11, 75-77.

    1990

    Der Einfluß der kontinuierlichen arteriovenösen Hämofiltration auf die Pharmakokinitik von Azlocillin bei anurischen Patienten (Journal article)

    Krupp, A., Leuwer, M., Schmidt, H., & Eberhardt, B. (1990). Der Einfluß der kontinuierlichen arteriovenösen Hämofiltration auf die Pharmakokinitik von Azlocillin bei anurischen Patienten. Anaesthesist, 39, 275-278.

    Fentanylgabe zur Narkoseeinleitung bei Sectio caesarea. Pharmakokinetik und Pharmakodynamik bei Mutter und Kind (Journal article)

    Meyer-Breiting, P., & Leuwer, M. (1990). Fentanylgabe zur Narkoseeinleitung bei Sectio caesarea. Pharmakokinetik und Pharmakodynamik bei Mutter und Kind. Anaesthesist, 39, 144-150.

    1988

    Das Mutterschutz-Gesetz und seine Auswirkungen in der Anästhesiologie aus der Sicht der Betroffenen (Journal article)

    Meyer-Breiting, P., Dudziak, R., & Leuwer, M. (1988). Das Mutterschutz-Gesetz und seine Auswirkungen in der Anästhesiologie aus der Sicht der Betroffenen. Anasthesiologie & Intensivmedizin, 29, 179-183.

    Standard calculation of ethanol elimination rate is not sufficient to provide ethanol substitution therapy in the postoperative course of alcohol-dependent patients (Journal article)

    Wilkens, L., Ruschulte, H., Rückoldt, H., Hecker, H., Schröder, D., Piepenbrock, S., & Leuwer, M. (1988). Standard calculation of ethanol elimination rate is not sufficient to provide ethanol substitution therapy in the postoperative course of alcohol-dependent patients. Intensive Care Medicine, 24, 459-463.

    Wiederholte Injektion von Atracurium zur Muskelrelaxation bei abdominalchirurgischen Eingriffen (Journal article)

    Leuwer, M., & Klein, G. (1988). Wiederholte Injektion von Atracurium zur Muskelrelaxation bei abdominalchirurgischen Eingriffen. Anasthesiologie Intensivemedizin Notfallmedizin Schmerztherapie, 23, 291-296.

    1987

    Nichtinvasive, kontinuierliche Messung des Herzzeitvolumens mit Ultraschall ("ACCUCOM") (Journal article)

    Klein, G., & Leuwer, M. (1987). Nichtinvasive, kontinuierliche Messung des Herzzeitvolumens mit Ultraschall ("ACCUCOM"). Anaesthesiologie & Intensivmedizin, 28, 189-193.

    1981

    Spinalänaesthesie mit Bupivacain 0.5% isobar und Mepivacain 4% hyperbar in einer 1:1 Mischung (Journal article)

    Leuwer, M., & Salomon, F. (1981). Spinalänaesthesie mit Bupivacain 0.5% isobar und Mepivacain 4% hyperbar in einer 1:1 Mischung. Wehrmed. Mschr., 10, 396-400.

    1980

    Die Befindlichkeitsskala nach D.v.Zerssen. Ein Meßinstrument für die emotionale Wirkung von Musik bei psychisch Gesunden und psychotisch Kranken (Journal article)

    Leuwer, M. (1980). Die Befindlichkeitsskala nach D.v.Zerssen. Ein Meßinstrument für die emotionale Wirkung von Musik bei psychisch Gesunden und psychotisch Kranken. Musikther. Umsch., 1, 265-275.