Photo of Professor Kevin Southern

Professor Kevin Southern MBChB, MRCP, FRCPCH, PhD

Professor of Child Health Women's & Children's Health

    Research

    Research Interest 1

    The focus of his research programme is to improve the lives of children with cystic fibrosis (CF). This work has evolved through, 1) his interest in evidence-based medicine (Editor of the CF and Genetics Disorders Cochrane Review Group (CRG) and author on numberous reviews), 2) his work on diagnostics, in particular newborn screening for CF (European Lead for CF Newborn Screening Working Group) and 3) his interst in clinical trials and pragmatic clinical outcome measure. KWS is well respect in the field as a clinical academic with a forward thinking approach to patient care and is regularly invited to speak at international meetins and contribute to guidelines on care, through both research activities and advocacy of CF screening. KWS runs the Liverpool Paediatric CF Research Programme, which has five active work packages.

    Research Grants

    A randomised registry-based open label study to assess change in respiratory function for people with cystic fibrosis (pwCF) with one or two Phe508del variants established on triple CFTR modulator combination therapy after rationalisation of muco-active aerosolised therapies (the CF STORM study)

    CYSTIC FIBROSIS TRUST (UK)

    October 2020 - February 2021

    A randomised open label trial to assess change in respiratory function for people with cystic fibrosis (pwCF) established on triple combination therapy (Kaftrio™) after rationalisation of nebulised mucoactive therapies (the CF STORM trial)

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    February 2021 - January 2024

    Rethinking Strategies for Positive Newborn Screening Result Delivery (ReSPoND)

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    October 2017 - March 2020

    Using the immune response to control Childhood Leukemia

    ALDER HEY CHILDREN'S CHARITY (UK)

    May 2014 - October 2017

    Discovery of Pseudomonas aeruginosa mutations associated with chronic lung infection in children with CF.

    ACTION MEDICAL RESEARCH (UK)

    August 2017 - September 2021

    Safe and appropriate use of blood components

    NHS BLOOD AND TRANSPLANT (NHSBT) (UK)

    July 2014 - December 2017

    The Cystic Fibrosis (CF) Anti-Staphylococcal Antibiotic Prophylaxis Trial (CF-START)

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    July 2016 - January 2027

    Safe and Appropriate Use of Blood Components

    NHS BLOOD AND TRANSPLANT (NHSBT) (UK)

    January 2015 - December 2017

    Delta Dose Study

    THE STUART GORDON FUND (UK)

    March 2016 - July 2017

    Development of Clinical Practice Guidelines on the Comprehensive Care Model for the Management of Hemophilia

    NATIONAL HEMOPHILIA FOUNDATION (USA)

    June 2015 - May 2016

    Cystic Fibrosis Research.

    ROYAL LIVERPOOL CHILDREN'S NHS TRUST (CHARITABLE) (UK)

    October 2004 - September 2005

    Characterisation of the nasal P D measurement in infants and children with cystic fibrosis.

    ROYAL LIVERPOOL CHILDRENS HOSP TRUST FUND

    June 2000 - May 2001

    MerseyBeat - Best Evidence, Application and Translation of research

    LIVERPOOL PRIMARY CARE TRUST (UK)

    March 2008 - September 2019

    Assessing the impact and safety of home intravenous antibiotic treatment (IVAT) for children with cystic fibrosis

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR), ROYAL LIVERPOOL CHILDREN'S NHS TRUST (CHARITABLE) (UK)

    June 2007 - June 2010

    Characterisation of the Nasal Potential Difference Measurement in Infants and Children with Cystic Fibrosis.

    CYSTIC FIBROSIS TRUST (UK)

    August 2000 - September 2001

    Clinical Exploitation of Data Produced by the Pseudomonas International Genomics Consortium.

    CYSTIC FIBROSIS TRUST (UK)

    October 2013 - September 2016

    Establishing robust and precise methodology for sweat testing infants at 5-6 weeks of age.

    ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

    March 2005 - October 2007

    Meningococcal Disease Research Fellow.

    JOHANNE HOLLY MENINGITIS FUND

    October 2003 - February 2004

    Airway epithelial ion transport studies in cystic fibrosis: establishing a safe method for the evaluation of new therapies in children with CF.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2001 - September 2004

    Core support for UK based Cochrane Collaborative Review Groups: Cystic Fibrosis and Genetic Disorders.

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    April 2004 - March 2023

    HIVAT study

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    February 2012 - January 2013

    Bridging funding.

    ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

    April 2004 - May 2004

    ECFS Neonatal Screening Working Group

    EUROPEAN CYSTIC FIBROSIS SOCIETY (DENMARK)

    September 2012 - June 2021

    The Development and Validation of a Burden of Care Index for Cystic Fibrosis.

    ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

    November 2005 - May 2007

    The register of paediatric inflammatory bowel disease.

    ROYAL LIVERPOOL CHILDREN'S NHS TRUST (CHARITABLE) (UK)

    April 2005 - June 2007

    Research Collaborations

    Claire Glasscoe

    Internal

    Sue Wray

    Internal

    Embryonic Lung development with Helen Wallace