Photo of Dr Jason Parsons

Dr Jason Parsons BSc, PhD

Senior Lecturer and Research Group Leader Molecular & Clinical Cancer Medicine

    Publications

    2020

    Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer (Journal article)

    Clifford, R. E., Govindarajah, N., Bowden, D., Sutton, P., Glenn, M., Darvish-Damavandi, M., . . . Vimalachandran, D. (2020). Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer. CELLS, 9(12). doi:10.3390/cells9122693

    DOI: 10.3390/cells9122693

    Base excision repair and its implications to cancer therapy (Journal article)

    Grundy, G. J., & Parsons, J. L. (2020). Base excision repair and its implications to cancer therapy.. Essays in biochemistry, 64(5), 831-843. doi:10.1042/ebc20200013

    DOI: 10.1042/ebc20200013

    microRNA-184 is induced by store-operated calcium entry and regulates early keratinocyte differentiation (Journal article)

    Richardson, A., Powell, A. K., Sexton, D. W., Parsons, J. L., Reynolds, N. J., & Ross, K. (2020). microRNA-184 is induced by store-operated calcium entry and regulates early keratinocyte differentiation. JOURNAL OF CELLULAR PHYSIOLOGY, 235(10), 6854-6861. doi:10.1002/jcp.29579

    DOI: 10.1002/jcp.29579

    LhARA: The Laser-hybrid Accelerator for Radiobiological Applications (Journal article)

    Aymar, G., Becker, T., Boogert, S., Borghesi, M., Bingham, R., Brenner, C., . . . Xiao, R. (2020). LhARA: The Laser-hybrid Accelerator for Radiobiological Applications. FRONTIERS IN PHYSICS, 8. doi:10.3389/fphy.2020.567738

    DOI: 10.3389/fphy.2020.567738

    Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment (Journal article)

    Fabbrizi, M. R., & Parsons, J. L. (n.d.). Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment. Cancer Drug Resistance. doi:10.20517/cdr.2020.49

    DOI: 10.20517/cdr.2020.49

    FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy (Journal article)

    Hughes, J. R., & Parsons, J. L. (n.d.). FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy. International Journal of Molecular Sciences, 21(18). doi:10.3390/ijms21186492

    DOI: 10.3390/ijms21186492

    The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma (Journal article)

    Zhou, C., & Parsons, J. L. (2020). The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma. Expert Reviews in Molecular Medicine, 22. doi:10.1017/erm.2020.4

    DOI: 10.1017/erm.2020.4

    Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons (Journal article)

    Vitti, E. T., Kacperek, A., & Parsons, J. L. (2020). Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons. CANCERS, 12(6). doi:10.3390/cancers12061490

    DOI: 10.3390/cancers12061490

    The Laser-hybrid Accelerator for Radiobiological Applications (Journal article)

    Aymar, G., Becker, T., Boogert, S., Borghesi, M., Bingham, R., Brenner, C., . . . Xiao, R. (n.d.). The Laser-hybrid Accelerator for Radiobiological Applications. Retrieved from http://arxiv.org/abs/2006.00493v1

    Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons (Journal article)

    Hussain, R. N., Coupland, S. E., Khzouz, J., Kalirai, H., & Parsons, J. L. (n.d.). Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons. Cancers, 12(6), 1388. doi:10.3390/cancers12061388

    DOI: 10.3390/cancers12061388

    Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling. (Journal article)

    Madders, E. C. E. T., & Parsons, J. L. (2020). Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling.. Advances in experimental medicine and biology, 1241, 59-75. doi:10.1007/978-3-030-41283-8_5

    DOI: 10.1007/978-3-030-41283-8_5

    HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling (Journal article)

    Bennett, L., Madders, E. C. E. T., & Parsons, J. L. (2020). HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling. Nucleic Acids Research, 48(03), 1301-1313. doi:10.1093/nar/gkz1129

    DOI: 10.1093/nar/gkz1129

    2019

    The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8. (Journal article)

    Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., . . . Ramadan, K. (2019). The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.. The EMBO journal, 38(21). doi:10.15252/embj.2019102361

    DOI: 10.15252/embj.2019102361

    The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair (Journal article)

    Vitti, E. T., & Parsons, J. L. (2019). The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair. Cancers, 11(7). doi:10.3390/cancers11070946

    DOI: 10.3390/cancers11070946

    Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage (Journal article)

    Carter, R. J., Nickson, C. M., Thompson, J. M., Kacperek, A., Hill, M. A., & Parsons, J. L. (2019). Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage. International Journal of Radiation: Oncology - Biology - Physics, 104(3), 656-665. doi:10.1016/j.ijrobp.2019.02.053

    DOI: 10.1016/j.ijrobp.2019.02.053

    Sphingolipids and acid ceramidase as therapeutic targets in cancer therapy (Journal article)

    Govindarajah, N., Clifford, R., Bowden, D., Sutton, P. A., Parsons, J. L., & Vimalachandran, D. (2019). Sphingolipids and acid ceramidase as therapeutic targets in cancer therapy. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 138, 104-111. doi:10.1016/j.critrevonc.2019.03.018

    DOI: 10.1016/j.critrevonc.2019.03.018

    The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks (Journal article)

    Albelazi, M. S., Martin, P. R., Mohammed, S., Mutti, L., Parsons, J. L., & Elder, R. H. (2019). The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks. GENES, 10(4). doi:10.3390/genes10040315

    DOI: 10.3390/genes10040315

    2018

    Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer (Journal article)

    Clifford, R., Govindarajah, N., Parsons, J. L., Gollins, S., West, N. P., & Vimalachandran, D. (2018). Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer. British Journal of Surgery, 105(12), 1553-1572. doi:10.1002/bjs.10993

    DOI: 10.1002/bjs.10993

    NTH1 is a new target for ubiquitylation-dependent regulation by TRIM26 required for the cellular response to oxidative stress (Journal article)

    Williams, S. C., & Parsons, J. L. (2018). NTH1 is a new target for ubiquitylation-dependent regulation by TRIM26 required for the cellular response to oxidative stress. Molecular and cellular biology, 38(12), 15 pages. doi:10.1128/mcb.00616-17

    DOI: 10.1128/mcb.00616-17

    Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response (Journal article)

    Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., . . . Vimalachandran, D. (2018). Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. JOURNAL OF PROTEOMICS, 179, 53-60. doi:10.1016/j.jprot.2018.02.030

    DOI: 10.1016/j.jprot.2018.02.030

    PARP-1 FRAGMENTS AND ACID CERAMIDASE (AC) EXPRESSION: A POTENTIAL MECHANISM OF RADIORESISTANCE IN COLORECTAL CANCER? (Conference Paper)

    Govindarajah, N., Sutton, P., Bowden, D., Parsons, J. L., & Vimalachandran, D. (2018). PARP-1 FRAGMENTS AND ACID CERAMIDASE (AC) EXPRESSION: A POTENTIAL MECHANISM OF RADIORESISTANCE IN COLORECTAL CANCER?. In DISEASES OF THE COLON & RECTUM Vol. 61 (pp. E68). Retrieved from http://gateway.webofknowledge.com/

    Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response (Journal article)

    Carter, R. J., Nickson, C. M., Thompson, J. M., Kacperek, A., Hill, M. A., & Parsons, J. L. (2018). Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response. International Journal of Radiation: Oncology - Biology - Physics, 100(3), 776-784. doi:10.1016/j.ijrobp.2017.11.012

    DOI: 10.1016/j.ijrobp.2017.11.012

    INVESTIGATING THE ROLE OF ACID CERAMIDASE IN THE RADIOTHERAPY RESPONSE OF AN IN VITRO MODEL OF COLORECTAL CANCER (Conference Paper)

    Govindarajah, N., Sutton, P., Bowden, D., Parsons, J. L., & Vimalachandran, D. (2018). INVESTIGATING THE ROLE OF ACID CERAMIDASE IN THE RADIOTHERAPY RESPONSE OF AN IN VITRO MODEL OF COLORECTAL CANCER. In BRITISH JOURNAL OF SURGERY Vol. 105 (pp. 16). Retrieved from http://gateway.webofknowledge.com/

    2017

    The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure (Journal article)

    Martin, P. R., Couve, S., Zutterling, C., Albelazi, M. S., Groisman, R., Matkarimov, B. T., . . . Saparbaev, M. K. (2017). The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-17693-4

    DOI: 10.1038/s41598-017-17693-4

    Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity (Journal article)

    Nickson, C. M., Moori, P., Carter, R. J., Rubbi, C. P., & Parsons, J. L. (2017). Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity. Oncotarget, 8, 29963-29975. doi:10.18632/oncotarget.16265

    DOI: 10.18632/oncotarget.16265

    Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response (Journal article)

    Edmonds, M. J., Carter, R. J., Nickson, C. M., Williams, S. C., & Parsons, J. L. (2017). Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response. Nucleic Acids Research, 45(2), 726-738. doi:10.1093/nar/gkw959

    DOI: 10.1093/nar/gkw959

    2016

    Base Excision Repair, a Pathway Regulated by Posttranslational Modifications (Journal article)

    Carter, R. J., & Parsons, J. L. (2016). Base Excision Repair, a Pathway Regulated by Posttranslational Modifications. Molecular and Cellular Biology, 36(10), 1426-1437. doi:10.1128/MCB.00030-16

    DOI: 10.1128/MCB.00030-16

    The Base Excision Repair Pathway (Chapter)

    Parsons, J. L., & Edmonds, M. J. (2016). The Base Excision Repair Pathway. In Encyclopedia of Cell Biology (pp. 442-450). Elsevier. doi:10.1016/b978-0-12-394447-4.10046-x

    DOI: 10.1016/b978-0-12-394447-4.10046-x

    2014

    Regulation of base excision repair proteins by ubiquitylation (Journal article)

    Edmonds, M. J., & Parsons, J. L. (2014). Regulation of base excision repair proteins by ubiquitylation. EXPERIMENTAL CELL RESEARCH, 329(1), 132-138. doi:10.1016/j.yexcr.2014.07.031

    DOI: 10.1016/j.yexcr.2014.07.031

    Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay (Journal article)

    Nickson, C. M., & Parsons, J. L. (2014). Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay. FRONTIERS IN GENETICS, 5. doi:10.3389/fgene.2014.00232

    DOI: 10.3389/fgene.2014.00232

    ARF induction in response to DNA strand breaks is regulated by PARP1 (Journal article)

    Orlando, G., Khoronenkova, S. V., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2014). ARF induction in response to DNA strand breaks is regulated by PARP1. Nucleic Acids Research, 42(4), 2320-2329. doi:10.1093/nar/gkt1185

    DOI: 10.1093/nar/gkt1185

    2013

    Co-ordination of base excision repair and genome stability (Journal article)

    Parsons, J. L., & Dianov, G. L. (2013). Co-ordination of base excision repair and genome stability. DNA REPAIR, 12(5), 326-333. doi:10.1016/j.dnarep.2013.02.001

    DOI: 10.1016/j.dnarep.2013.02.001

    Biological and Therapeutic Relevance of Nonreplicative DNA Polymerases to Cancer (Journal article)

    Parsons, J. L., Nicolay, N. H., & Sharma, R. A. (2013). Biological and Therapeutic Relevance of Nonreplicative DNA Polymerases to Cancer. ANTIOXIDANTS & REDOX SIGNALING, 18(8), 851-873. doi:10.1089/ars.2011.4203

    DOI: 10.1089/ars.2011.4203

    2012

    Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress (Journal article)

    Parsons, J. L., Khoronenkova, S. V., Dianova, I. I., Ternette, N., Kessler, B. M., Datta, P. K., & Dianov, G. L. (2012). Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress. NUCLEIC ACIDS RESEARCH, 40(22), 11404-11415. doi:10.1093/nar/gks909

    DOI: 10.1093/nar/gks909

    ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage (Journal article)

    Khoronenkova, S. V., Dianova, I. I., Ternette, N., Kessler, B. M., Parsons, J. L., & Dianov, G. L. (2012). ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage. MOLECULAR CELL, 45(6), 801-813. doi:10.1016/j.molcel.2012.01.021

    DOI: 10.1016/j.molcel.2012.01.021

    Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of phosphorylation and ubiquitination (Journal article)

    Markkanen, E., van Loon, B., Ferrari, E., Parsons, J. L., Dianov, G. L., & Huebscher, U. (2012). Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of phosphorylation and ubiquitination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(2), 437-442. doi:10.1073/pnas.1110449109

    DOI: 10.1073/pnas.1110449109

    In vitro base excision repair using mammalian cell extracts. (Journal article)

    Parsons, J. L., & Dianov, G. L. (2012). In vitro base excision repair using mammalian cell extracts.. Methods in molecular biology (Clifton, N.J.), 920, 245-262. doi:10.1007/978-1-61779-998-3_17

    DOI: 10.1007/978-1-61779-998-3_17

    Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability (Journal article)

    Meisenberg, C., Tait, P. S., Dianova, I. I., Wright, K., Edelmann, M. J., Ternette, N., . . . Dianov, G. L. (2012). Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. NUCLEIC ACIDS RESEARCH, 40(2), 701-711. doi:10.1093/nar/gkr744

    DOI: 10.1093/nar/gkr744

    2011

    Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes (Journal article)

    Altun, M., Kramer, H. B., Willems, L. I., McDermott, J. L., Leach, C. A., Goldenberg, S. J., . . . Kessler, B. M. (2011). Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes. CHEMISTRY & BIOLOGY, 18(11), 1401-1412. doi:10.1016/j.chembiol.2011.08.018

    DOI: 10.1016/j.chembiol.2011.08.018

    CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair (Journal article)

    Strom, C. E., Mortusewicz, O., Finch, D., Parsons, J. L., Lagerqvist, A., Johansson, F., . . . Helleday, T. (2011). CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair. DNA REPAIR, 10(9), 961-969. doi:10.1016/j.dnarep.2011.07.004

    DOI: 10.1016/j.dnarep.2011.07.004

    USP7/HAUSP stimulates repair of oxidative DNA lesions (Journal article)

    Khoronenkova, S. V., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2011). USP7/HAUSP stimulates repair of oxidative DNA lesions. NUCLEIC ACIDS RESEARCH, 39(7), 2604-2609. doi:10.1093/nar/gkq1210

    DOI: 10.1093/nar/gkq1210

    USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase beta (Journal article)

    Parsons, J. L., Dianova, I. I., Khoronenkova, S. V., Edelmann, M. J., Kessler, B. M., & Dianov, G. L. (2011). USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase beta. MOLECULAR CELL, 41(5), 609-615. doi:10.1016/j.molcel.2011.02.016

    DOI: 10.1016/j.molcel.2011.02.016

    Regulation of DNA repair by ubiquitylation (Journal article)

    Dianov, G. L., Meisenberg, C., & Parsons, J. L. (2011). Regulation of DNA repair by ubiquitylation. BIOCHEMISTRY-MOSCOW, 76(1), 69-79. doi:10.1134/S0006297911010093

    DOI: 10.1134/S0006297911010093

    2010

    XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair (Journal article)

    Parsons, J. L., Dianova, I. I., Finch, D., Tait, P. S., Strom, C. E., Helleday, T., & Dianov, G. L. (2010). XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair. DNA REPAIR, 9(7), 835-841. doi:10.1016/j.dnarep.2010.04.008

    DOI: 10.1016/j.dnarep.2010.04.008

    Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy (Journal article)

    Yang, J., Parsons, J., Nicolay, N. H., Caporali, S., Harrington, C. F., Singh, R., . . . Sharma, R. A. (2010). Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy. ONCOGENE, 29(3), 463-468. doi:10.1038/onc.2009.327

    DOI: 10.1038/onc.2009.327

    2009

    Ubiquitin ligase ARF-BP1/Mule modulates base excision repair (Journal article)

    Parsons, J. L., Tait, P. S., Finch, D., Dianova, I. I., Edelmann, M. J., Khoronenkova, S. V., . . . Dianov, G. L. (2009). Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. EMBO JOURNAL, 28(20), 3207-3215. doi:10.1038/emboj.2009.243

    DOI: 10.1038/emboj.2009.243

    2008

    Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks (Journal article)

    Woodhouse, B. C., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2008). Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks. DNA REPAIR, 7(6), 932-940. doi:10.1016/j.dnarep.2008.03.017

    DOI: 10.1016/j.dnarep.2008.03.017

    CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins (Journal article)

    Parsons, J. L., Tait, P. S., Finch, D., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2008). CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins. MOLECULAR CELL, 29(4), 477-487. doi:10.1016/j.molcel.2007.12.027

    DOI: 10.1016/j.molcel.2007.12.027

    2007

    NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break (Journal article)

    Parsons, J. L., Kavli, B., Slupphaug, G., & Dianov, G. L. (2007). NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break. BIOCHEMISTRY, 46(13), 4158-4163. doi:10.1021/bi0622569

    DOI: 10.1021/bi0622569

    Co-ordination of DNA single strand break repair (Journal article)

    Dianou, G. L., & Parsons, J. L. (2007). Co-ordination of DNA single strand break repair. DNA REPAIR, 6(4), 454-460. doi:10.1016/j.dnarep.2006.10.009

    DOI: 10.1016/j.dnarep.2006.10.009

    Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity (Journal article)

    Schwerdtle, T., Hamann, I., Jahnke, G., Walter, I., Richter, C., Parsons, J. L., . . . Hartwig, A. (2007). Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity. MOLECULAR NUTRITION & FOOD RESEARCH, 51(2), 201-210. doi:10.1002/mnfr.200600107

    DOI: 10.1002/mnfr.200600107

    DNA polymerase delta-dependent repair of DNA single strand breaks containing 3 '-end proximal lesions (Journal article)

    Parsons, J. L., Preston, B. D., O'Connor, T. R., & Dianov, G. L. (2007). DNA polymerase delta-dependent repair of DNA single strand breaks containing 3 '-end proximal lesions. NUCLEIC ACIDS RESEARCH, 35(4), 1054-1063. doi:10.1093/nar/gkl1115

    DOI: 10.1093/nar/gkl1115

    Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells (Journal article)

    Walter, I., Schwerdtle, T., Thuy, C., Parsons, J. L., Dianov, G. L., & Hartwig, A. (2007). Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells. DNA REPAIR, 6(1), 61-70. doi:10.1016/j.dnarep.2006.08.008

    DOI: 10.1016/j.dnarep.2006.08.008

    2006

    The multiple influences of glutathione on bromate genotoxicity: Implications for the dose-response relationship (Journal article)

    Chipman, J. K., Parsons, J. L., & Beddowes, E. J. (2006). The multiple influences of glutathione on bromate genotoxicity: Implications for the dose-response relationship. TOXICOLOGY, 221(2-3), 187-189. doi:10.1016/j.tox.2005.12.006

    DOI: 10.1016/j.tox.2005.12.006

    2005

    End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair (Journal article)

    Parsons, J. L., Dianova, I. I., Boswell, E., Weinfeld, M., & Dianov, G. L. (2005). End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair. FEBS JOURNAL, 272(22), 5753-5763. doi:10.1111/j.1742-4658.2005.04962.x

    DOI: 10.1111/j.1742-4658.2005.04962.x

    NEIL1 excises 3 ' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1 (Journal article)

    Parsons, J. L., Zharkov, D. O., & Dianov, G. L. (2005). NEIL1 excises 3 ' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. NUCLEIC ACIDS RESEARCH, 33(15), 4849-4856. doi:10.1093/nar/gki816

    DOI: 10.1093/nar/gki816

    Isolation of a small molecule inhibitor of DNA base excision repair (Journal article)

    Madhusudan, S., Smart, F., Shrimpton, P., Parsons, J. L., Gardiner, L., Houlbrook, S., . . . Hickson, I. D. (2005). Isolation of a small molecule inhibitor of DNA base excision repair. NUCLEIC ACIDS RESEARCH, 33(15), 4711-4724. doi:10.1093/nar/gki781

    DOI: 10.1093/nar/gki781

    DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair (Journal article)

    Parsons, J. L., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2005). DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair. BIOCHEMISTRY, 44(31), 10613-10619. doi:10.1021/bi050085m

    DOI: 10.1021/bi050085m

    APE1-dependent repair of DNA single-strand breaks containing 3 '-end 8-oxoguanine (Journal article)

    Parsons, J. L., Dianova, I. I., & Dianov, G. L. (2005). APE1-dependent repair of DNA single-strand breaks containing 3 '-end 8-oxoguanine. NUCLEIC ACIDS RESEARCH, 33(7), 2204-2209. doi:10.1093/nar/gki518

    DOI: 10.1093/nar/gki518

    Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts (Journal article)

    Parsons, J. L., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2005). Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts. FEBS JOURNAL, 272(8), 2012-2021. doi:10.1111/j.1742-4658.2005.04628.x

    DOI: 10.1111/j.1742-4658.2005.04628.x

    2004

    Monitoring base excision repair proteins on damaged DNA using human cell extracts (Journal article)

    Parsons, J. L., & Dianov, G. L. (2004). Monitoring base excision repair proteins on damaged DNA using human cell extracts. BIOCHEMICAL SOCIETY TRANSACTIONS, 32, 962-963. doi:10.1042/BST0320962

    DOI: 10.1042/BST0320962

    APE1 is the major 3 '-phosphoglycolate activity in human cell extracts (Journal article)

    Parsons, J. L., Dianova, I. I., & Dianov, G. L. (2004). APE1 is the major 3 '-phosphoglycolate activity in human cell extracts. NUCLEIC ACIDS RESEARCH, 32(12), 3531-3536. doi:10.1093/nar/gkh676

    DOI: 10.1093/nar/gkh676

    XRCC1-DNA polymerase beta interaction is required for efficient base excision repair (Journal article)

    Dianova, I. I., Sleeth, K. M., Allinson, S. L., Parsons, J. L., Breslin, C., Caldecott, K. W., & Dianov, G. L. (2004). XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. NUCLEIC ACIDS RESEARCH, 32(8), 2550-2555. doi:10.1093/nar/gkh567

    DOI: 10.1093/nar/gkh567

    2003

    DNA N-glycosylase deficient mice: a tale of redundancy (Journal article)

    Parsons, J. L., & Elder, R. H. (2003). DNA N-glycosylase deficient mice: a tale of redundancy. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 531(1-2), 165-175. doi:10.1016/j.mrfmmm.2003.05.001

    DOI: 10.1016/j.mrfmmm.2003.05.001

    Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases (Journal article)

    Karahalil, B., de Souza-Pinto, N. C., Parsons, J. L., Elder, R. H., & Bohr, V. A. (2003). Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(36), 33701-33707. doi:10.1074/jbc.M301617200

    DOI: 10.1074/jbc.M301617200

    2000

    The role of glutathione in DNA damage by potassium bromate in vitro (Journal article)

    Parsons, J. L., & Chipman, J. K. (2000). The role of glutathione in DNA damage by potassium bromate in vitro. MUTAGENESIS, 15(4), 311-316. doi:10.1093/mutage/15.4.311

    DOI: 10.1093/mutage/15.4.311

    1998

    DNA oxidation by potassium bromate; a direct mechanism or linked to lipid peroxidation? (Journal article)

    Chipman, J. K., Davies, J. E., Parsons, J. L., Nair, J., O'Neill, G., & Fawell, J. K. (1998). DNA oxidation by potassium bromate; a direct mechanism or linked to lipid peroxidation?. TOXICOLOGY, 126(2), 93-102. doi:10.1016/S0300-483X(97)00174-1

    DOI: 10.1016/S0300-483X(97)00174-1