
Dr Jason Parsons BSc, PhD
Senior Lecturer and Research Group Leader Molecular & Clinical Cancer Medicine
- +44 (0)151 794 8848
- Work email J.Parsons@liverpool.ac.uk
- About
- Research
- Publications
- Teaching
- Professional Activities
Publications
Selected Publications
- Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons (Journal article - 2020)
- Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons (Journal article - 2020)
- HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling (Journal article - 2020)
- Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage (Journal article - 2019)
- The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair (Journal article - 2019)
- Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response (Journal article - 2018)
- Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity (Journal article - 2017)
2020
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer (Journal article)
Clifford, R. E., Govindarajah, N., Bowden, D., Sutton, P., Glenn, M., Darvish-Damavandi, M., . . . Vimalachandran, D. (2020). Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer. CELLS, 9(12). doi:10.3390/cells9122693
Base excision repair and its implications to cancer therapy (Journal article)
Grundy, G. J., & Parsons, J. L. (2020). Base excision repair and its implications to cancer therapy.. Essays in biochemistry, 64(5), 831-843. doi:10.1042/ebc20200013
microRNA-184 is induced by store-operated calcium entry and regulates early keratinocyte differentiation (Journal article)
Richardson, A., Powell, A. K., Sexton, D. W., Parsons, J. L., Reynolds, N. J., & Ross, K. (2020). microRNA-184 is induced by store-operated calcium entry and regulates early keratinocyte differentiation. JOURNAL OF CELLULAR PHYSIOLOGY, 235(10), 6854-6861. doi:10.1002/jcp.29579
LhARA: The Laser-hybrid Accelerator for Radiobiological Applications (Journal article)
Aymar, G., Becker, T., Boogert, S., Borghesi, M., Bingham, R., Brenner, C., . . . Xiao, R. (2020). LhARA: The Laser-hybrid Accelerator for Radiobiological Applications. FRONTIERS IN PHYSICS, 8. doi:10.3389/fphy.2020.567738
Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment (Journal article)
Fabbrizi, M. R., & Parsons, J. L. (n.d.). Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment. Cancer Drug Resistance. doi:10.20517/cdr.2020.49
FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy (Journal article)
Hughes, J. R., & Parsons, J. L. (n.d.). FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy. International Journal of Molecular Sciences, 21(18). doi:10.3390/ijms21186492
The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma (Journal article)
Zhou, C., & Parsons, J. L. (2020). The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma. Expert Reviews in Molecular Medicine, 22. doi:10.1017/erm.2020.4
Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons (Journal article)
Vitti, E. T., Kacperek, A., & Parsons, J. L. (2020). Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons. CANCERS, 12(6). doi:10.3390/cancers12061490
The Laser-hybrid Accelerator for Radiobiological Applications (Journal article)
Aymar, G., Becker, T., Boogert, S., Borghesi, M., Bingham, R., Brenner, C., . . . Xiao, R. (n.d.). The Laser-hybrid Accelerator for Radiobiological Applications. Retrieved from http://arxiv.org/abs/2006.00493v1
Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons (Journal article)
Hussain, R. N., Coupland, S. E., Khzouz, J., Kalirai, H., & Parsons, J. L. (n.d.). Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons. Cancers, 12(6), 1388. doi:10.3390/cancers12061388
Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling. (Journal article)
Madders, E. C. E. T., & Parsons, J. L. (2020). Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling.. Advances in experimental medicine and biology, 1241, 59-75. doi:10.1007/978-3-030-41283-8_5
HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling (Journal article)
Bennett, L., Madders, E. C. E. T., & Parsons, J. L. (2020). HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling. Nucleic Acids Research, 48(03), 1301-1313. doi:10.1093/nar/gkz1129
2019
The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8. (Journal article)
Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., . . . Ramadan, K. (2019). The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.. The EMBO journal, 38(21). doi:10.15252/embj.2019102361
The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair (Journal article)
Vitti, E. T., & Parsons, J. L. (2019). The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair. Cancers, 11(7). doi:10.3390/cancers11070946
Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage (Journal article)
Carter, R. J., Nickson, C. M., Thompson, J. M., Kacperek, A., Hill, M. A., & Parsons, J. L. (2019). Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage. International Journal of Radiation: Oncology - Biology - Physics, 104(3), 656-665. doi:10.1016/j.ijrobp.2019.02.053
Sphingolipids and acid ceramidase as therapeutic targets in cancer therapy (Journal article)
Govindarajah, N., Clifford, R., Bowden, D., Sutton, P. A., Parsons, J. L., & Vimalachandran, D. (2019). Sphingolipids and acid ceramidase as therapeutic targets in cancer therapy. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 138, 104-111. doi:10.1016/j.critrevonc.2019.03.018
The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks (Journal article)
Albelazi, M. S., Martin, P. R., Mohammed, S., Mutti, L., Parsons, J. L., & Elder, R. H. (2019). The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks. GENES, 10(4). doi:10.3390/genes10040315
2018
Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer (Journal article)
Clifford, R., Govindarajah, N., Parsons, J. L., Gollins, S., West, N. P., & Vimalachandran, D. (2018). Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer. British Journal of Surgery, 105(12), 1553-1572. doi:10.1002/bjs.10993
NTH1 is a new target for ubiquitylation-dependent regulation by TRIM26 required for the cellular response to oxidative stress (Journal article)
Williams, S. C., & Parsons, J. L. (2018). NTH1 is a new target for ubiquitylation-dependent regulation by TRIM26 required for the cellular response to oxidative stress. Molecular and cellular biology, 38(12), 15 pages. doi:10.1128/mcb.00616-17
Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response (Journal article)
Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., . . . Vimalachandran, D. (2018). Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. JOURNAL OF PROTEOMICS, 179, 53-60. doi:10.1016/j.jprot.2018.02.030
PARP-1 FRAGMENTS AND ACID CERAMIDASE (AC) EXPRESSION: A POTENTIAL MECHANISM OF RADIORESISTANCE IN COLORECTAL CANCER? (Conference Paper)
Govindarajah, N., Sutton, P., Bowden, D., Parsons, J. L., & Vimalachandran, D. (2018). PARP-1 FRAGMENTS AND ACID CERAMIDASE (AC) EXPRESSION: A POTENTIAL MECHANISM OF RADIORESISTANCE IN COLORECTAL CANCER?. In DISEASES OF THE COLON & RECTUM Vol. 61 (pp. E68). Retrieved from http://gateway.webofknowledge.com/
Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response (Journal article)
Carter, R. J., Nickson, C. M., Thompson, J. M., Kacperek, A., Hill, M. A., & Parsons, J. L. (2018). Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response. International Journal of Radiation: Oncology - Biology - Physics, 100(3), 776-784. doi:10.1016/j.ijrobp.2017.11.012
INVESTIGATING THE ROLE OF ACID CERAMIDASE IN THE RADIOTHERAPY RESPONSE OF AN IN VITRO MODEL OF COLORECTAL CANCER (Conference Paper)
Govindarajah, N., Sutton, P., Bowden, D., Parsons, J. L., & Vimalachandran, D. (2018). INVESTIGATING THE ROLE OF ACID CERAMIDASE IN THE RADIOTHERAPY RESPONSE OF AN IN VITRO MODEL OF COLORECTAL CANCER. In BRITISH JOURNAL OF SURGERY Vol. 105 (pp. 16). Retrieved from http://gateway.webofknowledge.com/
2017
The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure (Journal article)
Martin, P. R., Couve, S., Zutterling, C., Albelazi, M. S., Groisman, R., Matkarimov, B. T., . . . Saparbaev, M. K. (2017). The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-17693-4
Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity (Journal article)
Nickson, C. M., Moori, P., Carter, R. J., Rubbi, C. P., & Parsons, J. L. (2017). Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity. Oncotarget, 8, 29963-29975. doi:10.18632/oncotarget.16265
Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response (Journal article)
Edmonds, M. J., Carter, R. J., Nickson, C. M., Williams, S. C., & Parsons, J. L. (2017). Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response. Nucleic Acids Research, 45(2), 726-738. doi:10.1093/nar/gkw959
2016
Base Excision Repair, a Pathway Regulated by Posttranslational Modifications (Journal article)
Carter, R. J., & Parsons, J. L. (2016). Base Excision Repair, a Pathway Regulated by Posttranslational Modifications. Molecular and Cellular Biology, 36(10), 1426-1437. doi:10.1128/MCB.00030-16
The Base Excision Repair Pathway (Chapter)
Parsons, J. L., & Edmonds, M. J. (2016). The Base Excision Repair Pathway. In Encyclopedia of Cell Biology (pp. 442-450). Elsevier. doi:10.1016/b978-0-12-394447-4.10046-x
2014
Regulation of base excision repair proteins by ubiquitylation (Journal article)
Edmonds, M. J., & Parsons, J. L. (2014). Regulation of base excision repair proteins by ubiquitylation. EXPERIMENTAL CELL RESEARCH, 329(1), 132-138. doi:10.1016/j.yexcr.2014.07.031
Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay (Journal article)
Nickson, C. M., & Parsons, J. L. (2014). Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay. FRONTIERS IN GENETICS, 5. doi:10.3389/fgene.2014.00232
ARF induction in response to DNA strand breaks is regulated by PARP1 (Journal article)
Orlando, G., Khoronenkova, S. V., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2014). ARF induction in response to DNA strand breaks is regulated by PARP1. Nucleic Acids Research, 42(4), 2320-2329. doi:10.1093/nar/gkt1185
2013
Co-ordination of base excision repair and genome stability (Journal article)
Parsons, J. L., & Dianov, G. L. (2013). Co-ordination of base excision repair and genome stability. DNA REPAIR, 12(5), 326-333. doi:10.1016/j.dnarep.2013.02.001
Biological and Therapeutic Relevance of Nonreplicative DNA Polymerases to Cancer (Journal article)
Parsons, J. L., Nicolay, N. H., & Sharma, R. A. (2013). Biological and Therapeutic Relevance of Nonreplicative DNA Polymerases to Cancer. ANTIOXIDANTS & REDOX SIGNALING, 18(8), 851-873. doi:10.1089/ars.2011.4203
2012
Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress (Journal article)
Parsons, J. L., Khoronenkova, S. V., Dianova, I. I., Ternette, N., Kessler, B. M., Datta, P. K., & Dianov, G. L. (2012). Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress. NUCLEIC ACIDS RESEARCH, 40(22), 11404-11415. doi:10.1093/nar/gks909
ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage (Journal article)
Khoronenkova, S. V., Dianova, I. I., Ternette, N., Kessler, B. M., Parsons, J. L., & Dianov, G. L. (2012). ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage. MOLECULAR CELL, 45(6), 801-813. doi:10.1016/j.molcel.2012.01.021
Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of phosphorylation and ubiquitination (Journal article)
Markkanen, E., van Loon, B., Ferrari, E., Parsons, J. L., Dianov, G. L., & Huebscher, U. (2012). Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of phosphorylation and ubiquitination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(2), 437-442. doi:10.1073/pnas.1110449109
In vitro base excision repair using mammalian cell extracts. (Journal article)
Parsons, J. L., & Dianov, G. L. (2012). In vitro base excision repair using mammalian cell extracts.. Methods in molecular biology (Clifton, N.J.), 920, 245-262. doi:10.1007/978-1-61779-998-3_17
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability (Journal article)
Meisenberg, C., Tait, P. S., Dianova, I. I., Wright, K., Edelmann, M. J., Ternette, N., . . . Dianov, G. L. (2012). Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. NUCLEIC ACIDS RESEARCH, 40(2), 701-711. doi:10.1093/nar/gkr744
2011
Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes (Journal article)
Altun, M., Kramer, H. B., Willems, L. I., McDermott, J. L., Leach, C. A., Goldenberg, S. J., . . . Kessler, B. M. (2011). Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes. CHEMISTRY & BIOLOGY, 18(11), 1401-1412. doi:10.1016/j.chembiol.2011.08.018
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair (Journal article)
Strom, C. E., Mortusewicz, O., Finch, D., Parsons, J. L., Lagerqvist, A., Johansson, F., . . . Helleday, T. (2011). CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair. DNA REPAIR, 10(9), 961-969. doi:10.1016/j.dnarep.2011.07.004
USP7/HAUSP stimulates repair of oxidative DNA lesions (Journal article)
Khoronenkova, S. V., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2011). USP7/HAUSP stimulates repair of oxidative DNA lesions. NUCLEIC ACIDS RESEARCH, 39(7), 2604-2609. doi:10.1093/nar/gkq1210
USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase beta (Journal article)
Parsons, J. L., Dianova, I. I., Khoronenkova, S. V., Edelmann, M. J., Kessler, B. M., & Dianov, G. L. (2011). USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase beta. MOLECULAR CELL, 41(5), 609-615. doi:10.1016/j.molcel.2011.02.016
Regulation of DNA repair by ubiquitylation (Journal article)
Dianov, G. L., Meisenberg, C., & Parsons, J. L. (2011). Regulation of DNA repair by ubiquitylation. BIOCHEMISTRY-MOSCOW, 76(1), 69-79. doi:10.1134/S0006297911010093
2010
XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair (Journal article)
Parsons, J. L., Dianova, I. I., Finch, D., Tait, P. S., Strom, C. E., Helleday, T., & Dianov, G. L. (2010). XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair. DNA REPAIR, 9(7), 835-841. doi:10.1016/j.dnarep.2010.04.008
Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy (Journal article)
Yang, J., Parsons, J., Nicolay, N. H., Caporali, S., Harrington, C. F., Singh, R., . . . Sharma, R. A. (2010). Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy. ONCOGENE, 29(3), 463-468. doi:10.1038/onc.2009.327
2009
Ubiquitin ligase ARF-BP1/Mule modulates base excision repair (Journal article)
Parsons, J. L., Tait, P. S., Finch, D., Dianova, I. I., Edelmann, M. J., Khoronenkova, S. V., . . . Dianov, G. L. (2009). Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. EMBO JOURNAL, 28(20), 3207-3215. doi:10.1038/emboj.2009.243
2008
Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks (Journal article)
Woodhouse, B. C., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2008). Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks. DNA REPAIR, 7(6), 932-940. doi:10.1016/j.dnarep.2008.03.017
CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins (Journal article)
Parsons, J. L., Tait, P. S., Finch, D., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2008). CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins. MOLECULAR CELL, 29(4), 477-487. doi:10.1016/j.molcel.2007.12.027
2007
NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break (Journal article)
Parsons, J. L., Kavli, B., Slupphaug, G., & Dianov, G. L. (2007). NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break. BIOCHEMISTRY, 46(13), 4158-4163. doi:10.1021/bi0622569
Co-ordination of DNA single strand break repair (Journal article)
Dianou, G. L., & Parsons, J. L. (2007). Co-ordination of DNA single strand break repair. DNA REPAIR, 6(4), 454-460. doi:10.1016/j.dnarep.2006.10.009
Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity (Journal article)
Schwerdtle, T., Hamann, I., Jahnke, G., Walter, I., Richter, C., Parsons, J. L., . . . Hartwig, A. (2007). Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity. MOLECULAR NUTRITION & FOOD RESEARCH, 51(2), 201-210. doi:10.1002/mnfr.200600107
DNA polymerase delta-dependent repair of DNA single strand breaks containing 3 '-end proximal lesions (Journal article)
Parsons, J. L., Preston, B. D., O'Connor, T. R., & Dianov, G. L. (2007). DNA polymerase delta-dependent repair of DNA single strand breaks containing 3 '-end proximal lesions. NUCLEIC ACIDS RESEARCH, 35(4), 1054-1063. doi:10.1093/nar/gkl1115
Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells (Journal article)
Walter, I., Schwerdtle, T., Thuy, C., Parsons, J. L., Dianov, G. L., & Hartwig, A. (2007). Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells. DNA REPAIR, 6(1), 61-70. doi:10.1016/j.dnarep.2006.08.008
2006
The multiple influences of glutathione on bromate genotoxicity: Implications for the dose-response relationship (Journal article)
Chipman, J. K., Parsons, J. L., & Beddowes, E. J. (2006). The multiple influences of glutathione on bromate genotoxicity: Implications for the dose-response relationship. TOXICOLOGY, 221(2-3), 187-189. doi:10.1016/j.tox.2005.12.006
2005
End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair (Journal article)
Parsons, J. L., Dianova, I. I., Boswell, E., Weinfeld, M., & Dianov, G. L. (2005). End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair. FEBS JOURNAL, 272(22), 5753-5763. doi:10.1111/j.1742-4658.2005.04962.x
NEIL1 excises 3 ' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1 (Journal article)
Parsons, J. L., Zharkov, D. O., & Dianov, G. L. (2005). NEIL1 excises 3 ' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. NUCLEIC ACIDS RESEARCH, 33(15), 4849-4856. doi:10.1093/nar/gki816
Isolation of a small molecule inhibitor of DNA base excision repair (Journal article)
Madhusudan, S., Smart, F., Shrimpton, P., Parsons, J. L., Gardiner, L., Houlbrook, S., . . . Hickson, I. D. (2005). Isolation of a small molecule inhibitor of DNA base excision repair. NUCLEIC ACIDS RESEARCH, 33(15), 4711-4724. doi:10.1093/nar/gki781
DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair (Journal article)
Parsons, J. L., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2005). DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair. BIOCHEMISTRY, 44(31), 10613-10619. doi:10.1021/bi050085m
APE1-dependent repair of DNA single-strand breaks containing 3 '-end 8-oxoguanine (Journal article)
Parsons, J. L., Dianova, I. I., & Dianov, G. L. (2005). APE1-dependent repair of DNA single-strand breaks containing 3 '-end 8-oxoguanine. NUCLEIC ACIDS RESEARCH, 33(7), 2204-2209. doi:10.1093/nar/gki518
Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts (Journal article)
Parsons, J. L., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2005). Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts. FEBS JOURNAL, 272(8), 2012-2021. doi:10.1111/j.1742-4658.2005.04628.x
2004
Monitoring base excision repair proteins on damaged DNA using human cell extracts (Journal article)
Parsons, J. L., & Dianov, G. L. (2004). Monitoring base excision repair proteins on damaged DNA using human cell extracts. BIOCHEMICAL SOCIETY TRANSACTIONS, 32, 962-963. doi:10.1042/BST0320962
APE1 is the major 3 '-phosphoglycolate activity in human cell extracts (Journal article)
Parsons, J. L., Dianova, I. I., & Dianov, G. L. (2004). APE1 is the major 3 '-phosphoglycolate activity in human cell extracts. NUCLEIC ACIDS RESEARCH, 32(12), 3531-3536. doi:10.1093/nar/gkh676
XRCC1-DNA polymerase beta interaction is required for efficient base excision repair (Journal article)
Dianova, I. I., Sleeth, K. M., Allinson, S. L., Parsons, J. L., Breslin, C., Caldecott, K. W., & Dianov, G. L. (2004). XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. NUCLEIC ACIDS RESEARCH, 32(8), 2550-2555. doi:10.1093/nar/gkh567
2003
DNA N-glycosylase deficient mice: a tale of redundancy (Journal article)
Parsons, J. L., & Elder, R. H. (2003). DNA N-glycosylase deficient mice: a tale of redundancy. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 531(1-2), 165-175. doi:10.1016/j.mrfmmm.2003.05.001
Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases (Journal article)
Karahalil, B., de Souza-Pinto, N. C., Parsons, J. L., Elder, R. H., & Bohr, V. A. (2003). Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(36), 33701-33707. doi:10.1074/jbc.M301617200
2000
The role of glutathione in DNA damage by potassium bromate in vitro (Journal article)
Parsons, J. L., & Chipman, J. K. (2000). The role of glutathione in DNA damage by potassium bromate in vitro. MUTAGENESIS, 15(4), 311-316. doi:10.1093/mutage/15.4.311
1998
DNA oxidation by potassium bromate; a direct mechanism or linked to lipid peroxidation? (Journal article)
Chipman, J. K., Davies, J. E., Parsons, J. L., Nair, J., O'Neill, G., & Fawell, J. K. (1998). DNA oxidation by potassium bromate; a direct mechanism or linked to lipid peroxidation?. TOXICOLOGY, 126(2), 93-102. doi:10.1016/S0300-483X(97)00174-1
- About
- Research
- Publications
- Teaching
- Professional Activities