Photo of Dr Graeme Sills

Dr Graeme Sills BSc (Hons), PhD

Senior Lecturer Translational Medicine

Publications

2019

The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis (Journal article)

Tse, K., Hammond, D., Simpson, D., Beynon, R. J., Beamer, E., Tymianski, M., . . . Thippeswamy, T. (2019). The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis. JOURNAL OF NEUROSCIENCE RESEARCH, 97(11), 1378-1392. doi:10.1002/jnr.24441

DOI: 10.1002/jnr.24441

Sulthiame add-on therapy for epilepsy (Journal article)

Bresnahan, R., Martin-McGill, K. J., Milburn-McNulty, P., Powell, G., Sills, G. J., & Marson, A. G. (2019). Sulthiame add-on therapy for epilepsy. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (8). doi:10.1002/14651858.CD009472.pub4

DOI: 10.1002/14651858.CD009472.pub4

Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions. (Journal article)

Nicoletti, P., Barrett, S., McEvoy, L., Daly, A. K., Aithal, G., Lucena, M. I., . . . Pirmohamed, M. (2019). Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions.. Clinical pharmacology and therapeutics, 106(5), 1028-1036. doi:10.1002/cpt.1493

DOI: 10.1002/cpt.1493

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retraction of Vol 127, Pg 2118, 2017) (Journal article)

Walker, L. E., Frigerio, F., Ravizza, T., Ricci, E., Tse, K., Jenkins, R. E., . . . Pirmohamed, M. (2019). Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retraction of Vol 127, Pg 2118, 2017). JOURNAL OF CLINICAL INVESTIGATION, 129(5), 2166. doi:10.1172/JCI129285

DOI: 10.1172/JCI129285

A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine. (Journal article)

Berghuis, B., Stapleton, C., Sonsma, A. C. M., Hulst, J., de Haan, G. -J., Lindhout, D., . . . McCormack, M. (2019). A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.. Epilepsia Open, 4(1), 102-109. doi:10.1002/epi4.12297

DOI: 10.1002/epi4.12297

Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy. (Journal article)

Silvennoinen, K., de Lange, N., Zagaglia, S., Balestrini, S., Androsova, G., Wassenaar, M., . . . EpiPGX Consortium. (2019). Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy.. Epilepsia open, 4(3), 420-430. doi:10.1002/epi4.12349

DOI: 10.1002/epi4.12349

2018

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies (Journal article)

Abou-Khalil, B., Auce, P., Avbersek, A., Bahlo, M., Balding, D. J., Bast, T., . . . Conso, I. L. A. E. (2018). Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-07524-z

DOI: 10.1038/s41467-018-07524-z

Effects of Common Antiepileptic Drugs on Biomarkers of Oxidative Stress in a Human Neuroblastoma Cell Line (Conference Paper)

Al-Mosawi, R., Marson, A., Pirmohamed, M., & Sills, G. (2018). Effects of Common Antiepileptic Drugs on Biomarkers of Oxidative Stress in a Human Neuroblastoma Cell Line. In EPILEPSIA Vol. 59 (pp. S39). Retrieved from http://gateway.webofknowledge.com/

Retrospective Analysis Of Antiepileptic Drug Effectiveness And Tolerability In Juvenile Myoclonic Epilepsy (Conference Paper)

Silvennoinen, K., de Lange, N., Zagaglia, S., Balestrini, S., Androsova, G., Borghei, M., . . . Consortium, E. (2018). Retrospective Analysis Of Antiepileptic Drug Effectiveness And Tolerability In Juvenile Myoclonic Epilepsy. In EPILEPSIA Vol. 59 (pp. S219-S220). Retrieved from http://gateway.webofknowledge.com/

A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action (Journal article)

Wong, S. Q., Jones, A., Dodd, S., Grimes, D., Barclay, J. W., Marson, A. G., . . . Morgan, A. (2018). A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action. JOURNAL OF NEUROSCIENCE METHODS, 309, 132-142. doi:10.1016/j.jneumeth.2018.09.004

DOI: 10.1016/j.jneumeth.2018.09.004

Exploring oxidative stress pathways in epilepsy (Thesis / Dissertation)

Al-Mosawi, R. H. (2018, October 24). Exploring oxidative stress pathways in epilepsy.

2017

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients (Journal article)

McCormack, M., Gui, H., Ingason, A., Speed, D., Wright, G. E. B., Zhang, E. J., . . . Rau, S. (2017). Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients. Neurology, 90(4). doi:10.1212/WNL.0000000000004853

DOI: 10.1212/WNL.0000000000004853

A Genome-wide Analysis of Severe Cutaneous Adverse Drug Reactions to Anti-epileptic Drugs (Conference Paper)

Wright, G., McCormack, M., Amstutz, U., Shear, N., Gamberdella, A., Sills, G., . . . Cavalleri, G. (2017). A Genome-wide Analysis of Severe Cutaneous Adverse Drug Reactions to Anti-epileptic Drugs. In JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS Vol. 88 (pp. 178). doi:10.1016/j.vascn.2017.09.034

DOI: 10.1016/j.vascn.2017.09.034

Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (Journal article)

Androsova, G., Krause, R., Borghei, M., Wassenaar, M., Auce, P., Avbersek, A., . . . Consortium, E. (2017). Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. EPILEPSIA, 58(10), 1734-1741. doi:10.1111/epi.13871

DOI: 10.1111/epi.13871

Prospective clinical trials to investigate clinical and molecular biomarkers (Journal article)

Auvin, S., Walker, L. E., Gallentine, W., Jozwiak, S., Tombini, M., & Sills, G. J. (2017). Prospective clinical trials to investigate clinical and molecular biomarkers. EPILEPSIA, 58(S3), 20-26. doi:10.1111/epi.13782

DOI: 10.1111/epi.13782

Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy (Journal article)

Berghuis, B., van der Palen, J., de Haan, G. -J., Lindhout, D., Koeleman, B. P. C., Sander, J. W., & Consortium, E. (2017). Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy. EPILEPSIA, 58(7), 1227-1233. doi:10.1111/epi.13777

DOI: 10.1111/epi.13777

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Journal article)

Ricci, E. (2017). Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy. Journal of Clinical Investigation, 127(6), 2118-2132. doi:10.1172/JCI92001

DOI: 10.1172/JCI92001

Genetic regulation of gene expression in the epileptic human hippocampus (Journal article)

Mirza, N., Appleton, R., Burn, S., du Plessis, D., Duncan, R., Farah, J. O., . . . Pirmohamed, M. (2017). Genetic regulation of gene expression in the epileptic human hippocampus. HUMAN MOLECULAR GENETICS, 26(9), 1759-1769. doi:10.1093/hmg/ddx061

DOI: 10.1093/hmg/ddx061

Identifying new antiepileptic drugs through genomics-based drug repurposing (Journal article)

Mirza, N., Sills, G. J., Pirmohamed, M., & Marson, A. G. (2017). Identifying new antiepileptic drugs through genomics-based drug repurposing. HUMAN MOLECULAR GENETICS, 26(3), 527-537. doi:10.1093/hmg/ddw410

DOI: 10.1093/hmg/ddw410

Ultra-rare genetic variation in common epilepsies: a case-control sequencing study. (Journal article)

Epi4K consortium., & Epilepsy Phenome/Genome Project. (2017). Ultra-rare genetic variation in common epilepsies: a case-control sequencing study.. The Lancet. Neurology, 16(2), 135-143. doi:10.1016/s1474-4422(16)30359-3

DOI: 10.1016/s1474-4422(16)30359-3

2016

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease (Journal article)

Walker, L., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2016). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003

DOI: 10.1080/1354750X.2016.1265003

Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation (Journal article)

Wadsworth, I., Jaki, T., Sills, G. J., Appleton, R., Cross, J. H., Marson, A. G., . . . Hampson, L. V. (2016). Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation. CNS DRUGS, 30(11), 1011-1017. doi:10.1007/s40263-016-0383-y

DOI: 10.1007/s40263-016-0383-y

An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters (Journal article)

Mirza, N., Vasieva, O., Appleton, R., Burn, S., Carr, D., Crooks, D., . . . Pirmohamed, M. (2016). An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters. EPILEPSIA, 57(9), 1467-1474. doi:10.1111/epi.13473

DOI: 10.1111/epi.13473

NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly-diagnosed epilepsy (Journal article)

Warburton, A., Miyajima, F., Shazadi, K., Crossley, J., Johnson, M. R., Marson, T., . . . Sills, G. (2016). NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly-diagnosed epilepsy. Epilepsy and Behavior, 54, 117-127. doi:10.1016/j.yebeh.2015.11.013

DOI: 10.1016/j.yebeh.2015.11.013

Valproate (Chapter)

Marson, T., & Sills, G. (2016). Valproate. In The Treatment of Epilepsy (pp. 652-666). Chichester, UK: John Wiley & Sons Ltd.

2015

Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality (Journal article)

Mirza, N., Appleton, R., Burn, S., Carr, D. F., Crooks, D., du Plessis, D., . . . Pirmohamed, M. (2015). Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality. Human Molecular Genetics, 24(15), 4306-4316. doi:10.1093/hmg/ddv163

DOI: 10.1093/hmg/ddv163

Genome-Wide Two-Way Competing Risks Approach to Analyse Time to Antiepileptic Drug Withdrawal (Conference Paper)

Francis, B., Jorgensen, A., Morris, A., Ingason, A., Marson, A., Johnson, M., . . . Consortium, E. (2015). Genome-Wide Two-Way Competing Risks Approach to Analyse Time to Antiepileptic Drug Withdrawal. In HUMAN HEREDITY Vol. 80 (pp. 109-110). Retrieved from http://gateway.webofknowledge.com/

Two-Component Mixture Modelling Approach Integrating Genetic and Clinical Variables in Analysis of Time to First Seizure in Epilepsy (Conference Paper)

Francis, B., Jorgensen, A., Morris, A., Marson, A., Johnson, M., Sills, G., & Consortium, E. (2015). Two-Component Mixture Modelling Approach Integrating Genetic and Clinical Variables in Analysis of Time to First Seizure in Epilepsy. In HUMAN HEREDITY Vol. 79 (pp. 34). Retrieved from http://gateway.webofknowledge.com/

2014

WHICH GENETIC PATHWAYS UNDERLIE PHARMACORESISTANT EPILEPSY? (Conference Paper)

Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, T. (2014). WHICH GENETIC PATHWAYS UNDERLIE PHARMACORESISTANT EPILEPSY?. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 85. doi:10.1136/jnnp-2014-309236.6

DOI: 10.1136/jnnp-2014-309236.6

IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY (Conference Paper)

Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY. In EPILEPSIA Vol. 55 (pp. 10). Retrieved from http://gateway.webofknowledge.com/

Advantages of Repeated Low Dose against Single High Dose of Kainate in C57BL/6J Mouse Model of Status Epilepticus: Behavioral and Electroencephalographic Studies (Journal article)

Tse, K., Puttachary, S., Beamer, E., Sills, G. J., & Thippeswamy, T. (2014). Advantages of Repeated Low Dose against Single High Dose of Kainate in C57BL/6J Mouse Model of Status Epilepticus: Behavioral and Electroencephalographic Studies. PLOS ONE, 9(5). doi:10.1371/journal.pone.0096622

DOI: 10.1371/journal.pone.0096622

Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality (Conference Paper)

Mirza, N., Sills, G., Jorgensen, A., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality. In JOURNAL OF NEUROLOGY Vol. 261 (pp. S484-S485). Retrieved from http://gateway.webofknowledge.com/

Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality (Conference Paper)

Mirza, N., Sills, G., Jorgensen, A., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality. In EUROPEAN JOURNAL OF NEUROLOGY Vol. 21 (pp. 755). Retrieved from http://gateway.webofknowledge.com/

Sulthiame monotherapy for epilepsy (Journal article)

Milburn-McNulty, P., Powell, G., Sills, G. J., & Marson, A. G. (2014). Sulthiame monotherapy for epilepsy. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (3). doi:10.1002/14651858.CD010062.pub2

DOI: 10.1002/14651858.CD010062.pub2

High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures (Journal article)

Walker, L., Tse, K., Ricci, E., Thippeswamy, T., Sills, G. J., White, S. H., . . . Pirmohamed, M. (2014). High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures. LANCET, 383, 105. Retrieved from http://gateway.webofknowledge.com/

A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy (Journal article)

Thomas, R. H., Walsh, J., Church, C., Sills, G. J., Marson, A. G., Baker, G. A., & Rees, M. I. (2014). A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy. EPILEPSY & BEHAVIOR, 36, 124-129. doi:10.1016/j.yebeh.2014.04.027

DOI: 10.1016/j.yebeh.2014.04.027

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy (Journal article)

Speed, D., Hoggart, C., Petrovski, S., Tachmazidou, I., Coffey, A., Jorgensen, A., . . . Johnson, M. R. (2014). A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. Human Molecular Genetics, 23(1), 247-258. doi:10.1093/hmg/ddt403

DOI: 10.1093/hmg/ddt403

Epilepsy and the inflammasome: Targeting inflammation as a novel therapeutic strategy for seizure disorders (Journal article)

Edye, M. E., Walker, L. E., Sills, G., Allan, S. M., & Brough, D. (2014). Epilepsy and the inflammasome: Targeting inflammation as a novel therapeutic strategy for seizure disorders. Inflammasome, 1, 36-43.

Pharmacogenetics of antiepileptic drug-induced hypersensitivity (Journal article)

Bloch, K. M., Sills, G. J., Pirmohamed, M., & Alfirevic, A. (2014). Pharmacogenetics of antiepileptic drug-induced hypersensitivity. PHARMACOGENOMICS, 15(6), 857-868. doi:10.2217/PGS.14.65

DOI: 10.2217/PGS.14.65

Validation of a multigenic model to predict seizure control in newly treated epilepsy (Journal article)

Shazadi, K., Petrovski, P., Roten, A., Miller, H., Huggins, R. M., Brodie, M. J., . . . Sills, G. (2014). Validation of a multigenic model to predict seizure control in newly treated epilepsy. Epilepsy Research, 108(10), 1797-1805. doi:10.1016/j.eplepsyres.2014.08.022

DOI: 10.1016/j.eplepsyres.2014.08.022

What are the arguments for and against rational therapy for epilepsy? (Journal article)

Barker-Haliski, M., Sills, G. J., & White, H. S. (2014). What are the arguments for and against rational therapy for epilepsy?. Advances in experimental medicine and biology, 813, 295-308. doi:10.1007/978-94-017-8914-1_24

DOI: 10.1007/978-94-017-8914-1_24

2013

Issues related to development of new antiseizure treatments (Journal article)

Wilcox, K. S., Dixon-Salazar, T., Sills, G. J., Ben-Menachem, E., White, H. S., Porter, R. J., . . . Rogawski, M. A. (2013). Issues related to development of new antiseizure treatments. EPILEPSIA, 54, 24-34. doi:10.1111/epi.12296

DOI: 10.1111/epi.12296

Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy (Journal article)

Brenner, T., Sills, G. J., Hart, Y., Howell, S., Waters, P., Brodie, M. J., . . . Lang, B. (2013). Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy. EPILEPSIA, 54(6), 1028-1035. doi:10.1111/epi.12127

DOI: 10.1111/epi.12127

Sulthiame add-on therapy for epilepsy (Journal article)

Milburn-McNulty, P., Powell, G., Sills, G. J., & Marson, A. G. (2013). Sulthiame add-on therapy for epilepsy. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (3). doi:10.1002/14651858.CD009472.pub2

DOI: 10.1002/14651858.CD009472.pub2

Classical mechanisms of action of antiepileptic drugs (Chapter)

Sills, G. J. (2013). Classical mechanisms of action of antiepileptic drugs. In H. Potschka, & H. Lerche (Eds.), Therapeutic Targets and Perspectives in the Pharmacological Treatment of Epilepsy (pp. 62-65). Bremen: UNI-MED Verlag.

2012

N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses (Journal article)

Beamer, E., Otahal, J., Sills, G. J., & Thippeswamy, T. (2012). N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses. EUROPEAN JOURNAL OF NEUROSCIENCE, 36(9), 3194-3203. doi:10.1111/j.1460-9568.2012.08234.x

DOI: 10.1111/j.1460-9568.2012.08234.x

INVESTIGATION OF ANTIEPILEPTIC DRUG TRANSPORT BY SOLUTE CARRIERS OATP1A2 AND MCT1 (Conference Paper)

Jones, H. L., Dickens, D., Owen, A., Pirmohamed, M., & Sills, G. J. (2012). INVESTIGATION OF ANTIEPILEPTIC DRUG TRANSPORT BY SOLUTE CARRIERS OATP1A2 AND MCT1. In EPILEPSIA Vol. 53 (pp. 101). Retrieved from http://gateway.webofknowledge.com/

Antiepileptic drug trials and their methodology (Chapter)

Sills, G. J. (n.d.). Antiepileptic drug trials and their methodology. In Introduction to Epilepsy (pp. 367-373). Cambridge University Press. doi:10.1017/cbo9781139103992.070

DOI: 10.1017/cbo9781139103992.070

Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy? (Journal article)

Walker, L., & Sills, G. J. (2012). Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy?. EPILEPSY CURRENTS, 12(1), 8-12. doi:10.5698/1535-7511-12.1.8

DOI: 10.5698/1535-7511-12.1.8

2011

Antiepileptic drug therapy: Does mechanism of action matter? (Journal article)

Brodie, M. J., Covanis, A., Gil-Nagel, A., Lerche, H., Perucca, E., Sills, G. J., & White, H. S. (2011). Antiepileptic drug therapy: Does mechanism of action matter?. EPILEPSY & BEHAVIOR, 21(4), 331-341. doi:10.1016/j.yebeh.2011.05.025

DOI: 10.1016/j.yebeh.2011.05.025

Antiepileptic drug therapy: Does mechanism of action matter? (Journal article)

Brodie, M., Covanis, T., Gil-Nagel, A., Lerche, H., Perucca, E., Sills, G., & White, S. (2011). Antiepileptic drug therapy: Does mechanism of action matter?. EPILEPSY & BEHAVIOR, 21(4), 490. doi:10.1016/j.yebeh.2011.04.053

DOI: 10.1016/j.yebeh.2011.04.053

INFLUENCE OF A FUNCTIONAL SCN1A POLYMORPHISM ON MAXIMUM AND MAINTENANCE DOSES OF ANTIEPILEPTIC DRUGS IN NEWLY DIAGNOSED EPILEPSY (Conference Paper)

Shazadi, K., Sills, G. J., Pirmohamed, M., & Marson, A. G. (2011). INFLUENCE OF A FUNCTIONAL SCN1A POLYMORPHISM ON MAXIMUM AND MAINTENANCE DOSES OF ANTIEPILEPTIC DRUGS IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 52 (pp. 91-92). Retrieved from http://gateway.webofknowledge.com/

VALIDATION OF THE AUSTRALIAN FIVE-SNP GENETIC CLASSIFIER OF EARLY TREATMENT OUTCOMES IN NEWLY DIAGNOSED EPILEPSY (Conference Paper)

Sills, G., Shazadi, K., Petrovski, S., O'Brien, T., Pirmohamed, M., & Marson, A. (2011). VALIDATION OF THE AUSTRALIAN FIVE-SNP GENETIC CLASSIFIER OF EARLY TREATMENT OUTCOMES IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 52 (pp. 92). Retrieved from http://gateway.webofknowledge.com/

Combining antiepileptic drugs-Rational polytherapy? (Journal article)

Brodie, M. J., & Sills, G. J. (2011). Combining antiepileptic drugs-Rational polytherapy?. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 20(5), 369-375. doi:10.1016/j.seizure.2011.01.004

DOI: 10.1016/j.seizure.2011.01.004

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans (Journal article)

McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans. NEW ENGLAND JOURNAL OF MEDICINE, 364(12), 1134-1143. doi:10.1056/NEJMoa1013297

DOI: 10.1056/NEJMoa1013297

Interactions of antiepileptic drugs (Software / Code)

Sills, G. J. (2011). Interactions of antiepileptic drugs [Internet (free access)]. Joint Neurosciences Council. Retrieved from http://www.ebrainjnc.com/

Mechanisms of action of antiepileptic drugs (Chapter)

Sills, G. J. (2011). Mechanisms of action of antiepileptic drugs. In J. W. Sander, M. C. Walker, & J. E. Smalls (Eds.), Epilepsy 2011: From Science to Society. A Practical Guide to Epilepsy (pp. Chapter 25). London: ILAE (UK Chapter) and the National Society for Epilepsy, UK. Retrieved from http://www.epilepsysociety.org.uk/Forprofessionals/Articles

2010

GENETIC VARIABILITY IN DRUG METABOLISING ENZYMES AS DETERMINANT OF CARBAMAZEPINE DOSE REQUIREMENT IN NEWLY DIAGNOSED EPILEPSY (Conference Paper)

Shazadi, K., Sills, G. J., Alfirevic, A., Pirmohamed, M., & Marson, A. G. (2010). GENETIC VARIABILITY IN DRUG METABOLISING ENZYMES AS DETERMINANT OF CARBAMAZEPINE DOSE REQUIREMENT IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 51 (pp. 32). Retrieved from http://gateway.webofknowledge.com/

SV2A in Epilepsy: The Plot Thickens (Journal article)

Sills, G. J. (2010). SV2A in Epilepsy: The Plot Thickens. Epilepsy Currents, 10(2), 47-49. doi:10.1111/j.1535-7511.2009.01351.x

DOI: 10.1111/j.1535-7511.2009.01351.x

Response to drug treatment in newly diagnosed epilepsy: A pilot study of H-1 NMR- and MS-based metabonomic analysis (Journal article)

Al Zweiri, M., Sills, G. J., Leach, J. P., Brodie, M. J., Robertson, C., Watson, D. G., & Parkinson, J. A. (2010). Response to drug treatment in newly diagnosed epilepsy: A pilot study of H-1 NMR- and MS-based metabonomic analysis. EPILEPSY RESEARCH, 88(2-3), 189-195. doi:10.1016/j.eplepsyres.2009.11.005

DOI: 10.1016/j.eplepsyres.2009.11.005

2009

Binasal visual field defects are not specific to vigabatrin (Journal article)

Gonzalez, P., Sills, G. J., Parks, S., Kelly, K., Stephen, L. J., Keating, D., . . . Brodie, M. J. (2009). Binasal visual field defects are not specific to vigabatrin. EPILEPSY & BEHAVIOR, 16(3), 521-526. doi:10.1016/j.yebeh.2009.09.003

DOI: 10.1016/j.yebeh.2009.09.003

MODERN MONOTHERAPIES IN NEWLY DIAGNOSED EPILEPSY: COMPARATIVE RETENTION AND EFFICACY (Conference Paper)

Sills, G. J., Leach, J. P., Wilson, E. A., Parker, P., Kelly, K., Hamill, I., . . . Brodie, M. J. (2009). MODERN MONOTHERAPIES IN NEWLY DIAGNOSED EPILEPSY: COMPARATIVE RETENTION AND EFFICACY. In EPILEPSIA Vol. 50 (pp. 492-493). Retrieved from http://gateway.webofknowledge.com/

SERUM ANTIBODIES IN EPILEPSY (Conference Paper)

Brenner, T., Hart, Y., Howell, S. J., Palace, J., Sills, G. J., Brodie, M. J., . . . Lang, B. (2009). SERUM ANTIBODIES IN EPILEPSY. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 80. doi:10.1136/jnnp.2009.195198z

DOI: 10.1136/jnnp.2009.195198z

SERUM ANTIBODIES IN EPILEPSY (Conference Paper)

Brenner, T., Hart, Y., Howell, S. J., Palace, J., Sills, G. J., Brodie, M. J., . . . Lang, B. (2009). SERUM ANTIBODIES IN EPILEPSY. In EPILEPSIA Vol. 50 (pp. 484-485). Retrieved from http://gateway.webofknowledge.com/

RESPONSE TO DRUG TREATMENT IN NEWLY DIAGNOSED EPILEPSY: A PILOT STUDY OF 1H NMR- AND MS-BASED METABONOMIC ANALYSIS (Conference Paper)

Sills, G., Alzweiri, M., Leach, J., Brodie, M., Robertson, C., Watson, D., & Parkinson, J. (2009). RESPONSE TO DRUG TREATMENT IN NEWLY DIAGNOSED EPILEPSY: A PILOT STUDY OF 1H NMR- AND MS-BASED METABONOMIC ANALYSIS. In EPILEPSIA Vol. 50 (pp. 106). Retrieved from http://gateway.webofknowledge.com/

BREACHING THE BARRIER AND INFLAMING EPILEPSY RESEARCH (Journal article)

Sills, G. J., & Solomon, T. (2009). BREACHING THE BARRIER AND INFLAMING EPILEPSY RESEARCH. EPILEPSY CURRENTS, 9(5), 148-150. doi:10.1111/j.1535-7511.2009.01324.x

DOI: 10.1111/j.1535-7511.2009.01324.x

Breaching the Barrier and Inflaming Epilepsy Research (Journal article)

Sills, G. J., & Solomon, T. (2009). Breaching the Barrier and Inflaming Epilepsy Research. Epilepsy Currents, 9(5), 148-150. doi:10.1111/j.1535-7511.2009.01324.x

DOI: 10.1111/j.1535-7511.2009.01324.x

High resolution micro-SPECT scanning in rats using I-125 beta-CIT: Effects of chronic treatment with carbamazepine (Journal article)

Cain, S. M., Ruest, T., Pimlott, S., Patterson, J., Duncan, R., Dewar, D., & Sills, G. J. (2009). High resolution micro-SPECT scanning in rats using I-125 beta-CIT: Effects of chronic treatment with carbamazepine. EPILEPSIA, 50(8), 1962-1970. doi:10.1111/j.1528-1167.2009.02095.x

DOI: 10.1111/j.1528-1167.2009.02095.x

Genetic Variants in Microsomal Epoxide Hydrolase Influence Carbamazepine Dosing (Journal article)

Makmor-Bakry, M., Sills, G. J., Hitiris, N., Butler, E., Wilson, E. A., & Brodie, M. J. (2009). Genetic Variants in Microsomal Epoxide Hydrolase Influence Carbamazepine Dosing. CLINICAL NEUROPHARMACOLOGY, 32(4), 205-212. doi:10.1097/WNF.0b013e318187972a

DOI: 10.1097/WNF.0b013e318187972a

Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: Data from international pharmacogenetic cohorts (Journal article)

Szoeke, C., Sills, G. J., Kwan, P., Petrovski, S., Newton, M., Hitiris, N., . . . O'Brien, T. J. (2009). Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: Data from international pharmacogenetic cohorts. EPILEPSIA, 50(7), 1689-1696. doi:10.1111/j.1528-1167.2009.02059.x

DOI: 10.1111/j.1528-1167.2009.02059.x

A complete miniaturised genotyping system for the detection of single nucleotide polymorphisms in human DNA samples (Journal article)

Mohammed, M. -I., Sills, G. J., Brodie, M. J., Ellis, E. M., & Girkin, J. M. (2009). A complete miniaturised genotyping system for the detection of single nucleotide polymorphisms in human DNA samples. SENSORS AND ACTUATORS B-CHEMICAL, 139(1), 83-90. doi:10.1016/j.snb.2008.09.015

DOI: 10.1016/j.snb.2008.09.015

Clinical development of antiepileptic drugs (Chapter)

Sills, G. J., & Brodie, M. J. (2009). Clinical development of antiepileptic drugs. In P. A. Schwartzkroin (Ed.), Encyclopedia of Basic Epilepsy Research, Volume 3 (pp. 1477-1485). Oxford: Academic Press.

DO WE GET ANY HELP FROM ANIMAL MODELS? (Conference Paper)

Sills, G. (2009). DO WE GET ANY HELP FROM ANIMAL MODELS?. In EPILEPSIA Vol. 50 (pp. 27-28). Retrieved from http://gateway.webofknowledge.com/

Mechanisms of action of antiepileptic drugs (Chapter)

Sills, G. J. (2009). Mechanisms of action of antiepileptic drugs. In J. W. Sander, M. C. Walker, & J. E. Smalls (Eds.), Epilepsy 2009: From Benchside to Bedside. A Practical Guide to Epilepsy (pp. Chapter 25). London: ILAE (UK) and the National Society for Epilepsy. Retrieved from http://www.epilepsysociety.org.uk/Forprofessionals/Articles-1

Novel Therapeutic Strategies for Epilepsy—Releasing the Gene Genie (Journal article)

Sills, G. J. (2009). Novel Therapeutic Strategies for Epilepsy—Releasing the Gene Genie. Epilepsy Currents, 9(1), 26-27. doi:10.1111/j.1535-7511.2008.01280.x

DOI: 10.1111/j.1535-7511.2008.01280.x

Preclinical development of antiepileptic drugs (Chapter)

Sills, G. J., & Brodie, M. J. (2009). Preclinical development of antiepileptic drugs. In P. A. Schwartzkroin (Ed.), Encyclopedia of Basic Epilepsy Research, Volume 1 (pp. 97-103). Oxford: Academic Press.

TITRATION INFLUENCES INITIAL EFFICACY OF MONOTHERAPY IN NEWLY DIAGNOSED EPILEPSY (Conference Paper)

Sills, G., Leach, J., Wilson, E., Parker, P., Kelly, K., Hamill, I., . . . Brodie, M. (2009). TITRATION INFLUENCES INITIAL EFFICACY OF MONOTHERAPY IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 50 (pp. 70). Retrieved from http://gateway.webofknowledge.com/

2008

Comparison of different water-miscible solvents for the preparation of plasma and urine samples in metabolic profiling studies (Journal article)

Alzweiri, M., Watson, D. G., Robertson, C., Sills, G. J., & Parkinson, J. A. (2008). Comparison of different water-miscible solvents for the preparation of plasma and urine samples in metabolic profiling studies. TALANTA, 74(4), 1060-1065. doi:10.1016/j.talanta.2007.07.037

DOI: 10.1016/j.talanta.2007.07.037

Antiepileptic drug transport - of mice and men (Journal article)

Sills, G. J. (2008). Antiepileptic drug transport - of mice and men. Epilepsy Currents, 8, 48-50.

Molecular targets of antiepileptic drugs (Chapter)

Sills, G. J. (2008). Molecular targets of antiepileptic drugs. In P. Kahane, A. Berg, W. Loscher, D. Nordli, & E. Perucca (Eds.), Progress in Epileptic Disorders Volume 7: Drug-Resistant Epilepsies (pp. 85-107). Montrouge: John Libbey Eurotext.

2007

Drug resistance in epilepsy: Why is a simple explanation not enough ? (Journal article)

Loescher, W., & Sills, G. J. (2007). Drug resistance in epilepsy: Why is a simple explanation not enough ?. EPILEPSIA, 48(12), 2370-2372. Retrieved from http://gateway.webofknowledge.com/

Genetic predictors of lamotrigine maintenance dose; A role for ABCB1 P-glycoprotein? (Conference Paper)

Sills, G. J., Makmor-Bakry, M., Butler, E., Hitiris, N., & Brodie, M. J. (2007). Genetic predictors of lamotrigine maintenance dose; A role for ABCB1 P-glycoprotein?. In EPILEPSIA Vol. 48 (pp. 377). Retrieved from http://gateway.webofknowledge.com/

Predictors of pharmacoresistant epilepsy (Journal article)

Hitiris, N., Mohanraj, R., Norrie, J., Sills, G. J., & Brodie, M. J. (2007). Predictors of pharmacoresistant epilepsy. EPILEPSY RESEARCH, 75(2-3), 192-196. doi:10.1016/j.eplepsyres.2007.06.003

DOI: 10.1016/j.eplepsyres.2007.06.003

Sodium valproate versus tamotrigine: A randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy (Journal article)

Stephen, L. J., Sills, G. J., Leach, J. P., Butler, E., Parker, P., Hitiris, N., . . . Brodie, M. J. (2007). Sodium valproate versus tamotrigine: A randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. EPILEPSY RESEARCH, 75(2-3), 122-129. doi:10.1016/j.eplepsyres.2007.04.009

DOI: 10.1016/j.eplepsyres.2007.04.009

Discussion (Conference Paper)

Sills, G. (2007). Discussion. In Epileptic Disorders Vol. 9 (pp. 236).

Pharmacokinetics and drug interactions with zonisamide (Journal article)

Sills, G. J., & Brodie, M. J. (2007). Pharmacokinetics and drug interactions with zonisamide. EPILEPSIA, 48(3), 435-441. doi:10.1111/j.1528-1167.2007.00983.x

DOI: 10.1111/j.1528-1167.2007.00983.x

Sudden unexpected death in epilepsy: A search for risk factors (Journal article)

Hitiris, N., Suratman, S., Kelly, K., Stephen, L. J., Sills, G. J., & Brodie, M. J. (2007). Sudden unexpected death in epilepsy: A search for risk factors. EPILEPSY & BEHAVIOR, 10(1), 138-141. doi:10.1016/j.yebeh.2006.11.010

DOI: 10.1016/j.yebeh.2006.11.010

Means, motive and opportunity: establishing culpability in pharmacoresistant epilepsy (Journal article)

Sills, G. J. (2007). Means, motive and opportunity: establishing culpability in pharmacoresistant epilepsy. Epilepsy Currents, 7, 51-53.

Seizures beget seizures: a lack of experimental evidence and clinical relevance fails to dampen enthusiasm (Journal article)

Sills, G. J. (2007). Seizures beget seizures: a lack of experimental evidence and clinical relevance fails to dampen enthusiasm. Epilepsy Currents, 7, 103-104.

2006

Response: Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment (Journal article)

Sills, G. J., & Brodie, M. J. (2006). Response: Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. EPILEPSIA, 47(2), 450. doi:10.1111/j.1528-1167.2006.00444_2.x

DOI: 10.1111/j.1528-1167.2006.00444_2.x

The mechanisms of action of gabapentin and pregaballin (Journal article)

Sills, G. J. (2006). The mechanisms of action of gabapentin and pregaballin. CURRENT OPINION IN PHARMACOLOGY, 6(1), 108-113. doi:10.1016/j.coph.2005.11.003

DOI: 10.1016/j.coph.2005.11.003

Can the wide-field multifocal electroretinogram differentiate between vigabatrin-associated retinal toxicity and conventional visual field defects? (Conference Paper)

Gonzalez, P., McCall, A., McQuistan, A., Parks, S., Keating, D., Kelly, K., . . . Brodie, M. (2006). Can the wide-field multifocal electroretinogram differentiate between vigabatrin-associated retinal toxicity and conventional visual field defects?. In EPILEPSIA Vol. 47 (pp. 146-147). Retrieved from http://gateway.webofknowledge.com/

Excitable but lacking in energy: contradictions in the human epileptic hippocampus (Journal article)

Sills, G. J. (2006). Excitable but lacking in energy: contradictions in the human epileptic hippocampus. Epilepsy Currents, 6, 6-7.

Expanding mechanistic diversity of antiepileptic drugs (Conference Paper)

Sills, G. (2006). Expanding mechanistic diversity of antiepileptic drugs. In EPILEPSIA Vol. 47 (pp. 252). Retrieved from http://gateway.webofknowledge.com/

Genetic predictors of carbamazepine maintenance dose (Conference Paper)

Sills, G. J., Makmor-Bakry, M., Hitiris, N., Butler, E., & Brodie, M. J. (2006). Genetic predictors of carbamazepine maintenance dose. In EPILEPSIA Vol. 47 (pp. 371). Retrieved from http://gateway.webofknowledge.com/

Polymorphic variation in genes encoding metabolising enzymes for carbamazepine: Allele and genotype frequencies in a west of Scotland epilepsy population (Conference Paper)

Makmor-Bakry, M., Butler, E., Sills, G., & Brodie, M. (2006). Polymorphic variation in genes encoding metabolising enzymes for carbamazepine: Allele and genotype frequencies in a west of Scotland epilepsy population. In EPILEPSIA Vol. 47 (pp. 87). Retrieved from http://gateway.webofknowledge.com/

Randomised comparison of lamotrigine and valproate in newly diagnosed epilepsy - Efficacy, tolerability, and endocrine effects (Conference Paper)

Leach, J. P., Brodie, M. J., Sills, G., Stephens, L., & Butler, E. (2006). Randomised comparison of lamotrigine and valproate in newly diagnosed epilepsy - Efficacy, tolerability, and endocrine effects. In EPILEPSIA Vol. 47 (pp. 164). Retrieved from http://gateway.webofknowledge.com/

Sudden unexpected death in epilepsy: A search for risk factors (Conference Paper)

Kelly, K., Suratman, S., Stephen, L., Hitiris, N., Sills, G., & Brodie, M. (2006). Sudden unexpected death in epilepsy: A search for risk factors. In EPILEPSIA Vol. 47 (pp. 57). Retrieved from http://gateway.webofknowledge.com/

The multidrug transporter hypothesis of refractory epilepsy: corroboration and contradiction in equal measure (Journal article)

Sills, G. J. (2006). The multidrug transporter hypothesis of refractory epilepsy: corroboration and contradiction in equal measure. Epilepsy Currents, 6, 51-54.

Visual field assessment by static perimetry fails to reliably identify vigabatrin-related retinal dysfunction and by implication toxicity (Conference Paper)

Brodie, M. J., Gonzales, P., Sills, G. J., Parks, S., & Keating, D. (2006). Visual field assessment by static perimetry fails to reliably identify vigabatrin-related retinal dysfunction and by implication toxicity. In EPILEPSIA Vol. 47 (pp. 157). Retrieved from http://gateway.webofknowledge.com/

2005

Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment (Journal article)

Sills, G. J., Mohanraj, R., Butler, E., McCrindle, S., Collier, L., Wilson, E. A., & Brodie, M. J. (2005). Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. EPILEPSIA, 46(5), 643-647. doi:10.1111/j.1528-1167.2005.46304.x

DOI: 10.1111/j.1528-1167.2005.46304.x

Not another gabapentin mechanism! (Journal article)

Sills, G. J. (2005). Not another gabapentin mechanism!. Epilepsy Currents, 5, 75-77.

Pharmacogenetics of epilepsy: Multiple independent SNP studies may be of limited value in predicting response to drug treatment (Conference Paper)

Sills, G. J., Mohanraj, R., Butler, E., Wilson, E. A., Leach, J. P., & Brodie, M. J. (2005). Pharmacogenetics of epilepsy: Multiple independent SNP studies may be of limited value in predicting response to drug treatment. In EPILEPSIA Vol. 46 (pp. 371). Retrieved from http://gateway.webofknowledge.com/

Pharmacogenetics of epilepsy; one step forward (Journal article)

Sills, G. J. (2005). Pharmacogenetics of epilepsy; one step forward. Epilepsy Currents, 5, 236-238.

Pharmacogenomics of epilepsy: Multiple independent SNP studies may be of limited value in predicting response to drug treatment in small cohorts of epilepsy patients (Conference Paper)

Sills, G. J., Kelly, K., Mohanraj, R., Butler, E., McCrindle, S., Wilson, E. A., . . . Brodie, M. J. (2005). Pharmacogenomics of epilepsy: Multiple independent SNP studies may be of limited value in predicting response to drug treatment in small cohorts of epilepsy patients. In EPILEPSIA Vol. 46 (pp. 91). Retrieved from http://gateway.webofknowledge.com/

2004

Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models (Journal article)

Sills, G. J., Butler, E., Thompson, G. G., & Brodie, M. J. (2004). Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 13(5), 287-295. doi:10.1016/S1059-1311(03)00185-7

DOI: 10.1016/S1059-1311(03)00185-7

A single-nucleotide polymorphism in the SCN2A gene is associated with uncontrolled epilepsy (Conference Paper)

Sills, G. J., Mohanraj, R., Butler, E., Collier, L., McCrindle, S., Wilson, E. A., & Brodie, M. J. (2004). A single-nucleotide polymorphism in the SCN2A gene is associated with uncontrolled epilepsy. In EPILEPSIA Vol. 45 (pp. 226). Retrieved from http://gateway.webofknowledge.com/

Antiepileptic drugs as neuroprotective agents (Journal article)

Sills, G. J. (2004). Antiepileptic drugs as neuroprotective agents. International Journal of Neuroprotection and Neuroregeneration, 1, 13-20.

Changing channels: mechanisms and responsiveness to antiepileptic drugs in chronic epilepsy (Journal article)

Sills, G. J. (2004). Changing channels: mechanisms and responsiveness to antiepileptic drugs in chronic epilepsy. Epilepsy Currents, 4, 98-99.

Lack of association between the C3435t polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment (Conference Paper)

Sills, G. J., Mohanraj, R., Butler, E., McCrindle, S., Collier, L., Wilson, E. A., & Brodie, M. J. (2004). Lack of association between the C3435t polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. In EPILEPSIA Vol. 45 (pp. 68). Retrieved from http://gateway.webofknowledge.com/

Multi-drug resistance in epilepsy (Journal article)

Sills, G. J. (2004). Multi-drug resistance in epilepsy. MIMS Advances in Epilepsy, 10-12.

Multiple modes of action of antiepileptic drugs (Journal article)

Sills, G. J. (2004). Multiple modes of action of antiepileptic drugs. Primary Care in the NHS, 82-87.

Polymorphic variant of sodium channel gene SCN2A and response to antiepileptic drugs (Conference Paper)

Mohanaj, R., Sills, G. J., Butler, E., Collier, L. J., McCrindle, S. A., Wilson, E. A., & Brodie, M. J. (2004). Polymorphic variant of sodium channel gene SCN2A and response to antiepileptic drugs. In EPILEPSIA Vol. 45 (pp. 121). Retrieved from http://gateway.webofknowledge.com/

The same AED for all etiologies? (Conference Paper)

Sills, G. J. (2004). The same AED for all etiologies?. In EPILEPSIA Vol. 45 (pp. 30). Retrieved from http://gateway.webofknowledge.com/

2003

Peripheral retinal dysfunction in patients taking vigabatrin (Journal article)

McDonagh, J., Stephen, L. J., Dolan, F. M., Parks, S., Dutton, G. N., Kelly, K., . . . Brodie, M. J. (2003). Peripheral retinal dysfunction in patients taking vigabatrin. NEUROLOGY, 61(12), 1690-1694. doi:10.1212/01.WNL.0000098938.80082.25

DOI: 10.1212/01.WNL.0000098938.80082.25

Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina (Journal article)

Sills, G. J., Butler, E., Forrest, G., Ratnaraj, N., Patsalos, P. N., & Brodie, M. J. (2003). Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina. EPILEPSIA, 44(7), 886-892. doi:10.1046/j.1528-1157.2003.04203.x

DOI: 10.1046/j.1528-1157.2003.04203.x

Differential expression of multidrug resistance genes in naive rat brain (Journal article)

Kwan, P., Sills, G. J., Butler, E., Gant, T. W., & Brodie, M. J. (2003). Differential expression of multidrug resistance genes in naive rat brain. NEUROSCIENCE LETTERS, 339(1), 33-36. doi:10.1016/S0304-3940(02)01453-2

DOI: 10.1016/S0304-3940(02)01453-2

Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine (Journal article)

Sills, G. J. (2003). Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine. EPILEPTIC DISORDERS, 5(1), 51-56. Retrieved from http://gateway.webofknowledge.com/

Current limitations of antiepileptic drug therapy: a conference review (Journal article)

Deckers, C. L. P., Genton, P., Sills, G. J., & Schmidt, D. (2003). Current limitations of antiepileptic drug therapy: a conference review. EPILEPSY RESEARCH, 53(1-2), 1-17. doi:10.1016/S0920-1211(02)00257-7

DOI: 10.1016/S0920-1211(02)00257-7

Levetiracetam in patients with a learning disability and refractory epilepsy (Conference Paper)

Kelly, K., Stephen, L. J., Sills, G. J., & Brodie, M. J. (2003). Levetiracetam in patients with a learning disability and refractory epilepsy. In EPILEPSIA Vol. 44 (pp. 151). Retrieved from http://gateway.webofknowledge.com/

2002

Regional expression of multidrug resistance genes in genetically epilepsy-prone audiogenic rat brain after a single seizure (Journal article)

Kwan, P., Sills, G. J., Butler, E., Gant, T. W., Meldrum, B. S., & Brodie, M. J. (2002). Regional expression of multidrug resistance genes in genetically epilepsy-prone audiogenic rat brain after a single seizure. EPILEPSIA, 43(11), 1318-1323. doi:10.1046/j.1528-1157.2002.156702.x

DOI: 10.1046/j.1528-1157.2002.156702.x

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice. (Journal article)

Sills, G. J., Kwan, P., Butler, E., de Lange, E. C. M., van den Berg, D. J., & Brodie, M. J. (2002). P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice.. Epilepsy & behavior : E&B, 3(5), 427-432. doi:10.1016/s1525-5050(02)00511-5

DOI: 10.1016/s1525-5050(02)00511-5

Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride (Journal article)

Sills, G. J., Santangeli, S., Forrest, G., & Brodie, M. J. (2002). Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride. EPILEPSY RESEARCH, 49(3), 247-254. doi:10.1016/S0920-1211(02)00049-9

DOI: 10.1016/S0920-1211(02)00049-9

Topiramate in patients with learning disability and refractory epilepsy (Journal article)

Kelly, K., Stephen, L. J., Sills, G. J., & Brodie, M. J. (2002). Topiramate in patients with learning disability and refractory epilepsy. EPILEPSIA, 43(4), 399-402. doi:10.1046/j.1528-1157.2002.47401.x

DOI: 10.1046/j.1528-1157.2002.47401.x

Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice (Journal article)

Santangeli, S., Sills, G. J., Stone, T. W., & Brodie, M. J. (2002). Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice. NEUROSCIENCE LETTERS, 321(1-2), 33-36. doi:10.1016/S0304-3940(01)02511-3

DOI: 10.1016/S0304-3940(01)02511-3

Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes (Journal article)

Santangeli, S., Sills, G. J., Thompson, G. G., & Brodie, M. J. (2002). Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. EUROPEAN JOURNAL OF PHARMACOLOGY, 438(1-2), 63-68. doi:10.1016/S0014-2999(02)01297-9

DOI: 10.1016/S0014-2999(02)01297-9

2001

Update on the mechanisms of action of antiepileptic drugs (Journal article)

Sills, G. J., & Brodie, M. J. (2001). Update on the mechanisms of action of antiepileptic drugs. EPILEPTIC DISORDERS, 3(4), 165-172. Retrieved from http://gateway.webofknowledge.com/

Linkage and candidate gene analysis of idiopathic epilepsies. (Conference Paper)

Bailey, M. E. S., Carter, S. A., Tobias, E. S., Kwan, P., Sutton, R., Sills, G. J., . . . Johnson, K. J. (2001). Linkage and candidate gene analysis of idiopathic epilepsies.. In AMERICAN JOURNAL OF HUMAN GENETICS Vol. 69 (pp. 498). Retrieved from http://gateway.webofknowledge.com/

Visual field constriction - Accumulation of vigabatrin but not tiagabine in the retina (Journal article)

Sills, G. J., Patsalos, P. N., Butler, E., Forrest, G., Ratnaraj, N., & Brodie, M. J. (2001). Visual field constriction - Accumulation of vigabatrin but not tiagabine in the retina. NEUROLOGY, 57(2), 196-200. doi:10.1212/WNL.57.2.196

DOI: 10.1212/WNL.57.2.196

The mechanisms of action of commonly used antiepileptic drugs (Journal article)

Kwan, P., Sills, G. J., & Brodie, M. J. (2001). The mechanisms of action of commonly used antiepileptic drugs. PHARMACOLOGY & THERAPEUTICS, 90(1), 21-34. doi:10.1016/S0163-7258(01)00122-X

DOI: 10.1016/S0163-7258(01)00122-X

2000

A neurochemical study of the novel antiepileptic drug retigabine in mouse brain (Journal article)

Sills, G. J., Rundfeldt, C., Butler, E., Forrest, G., Thompson, G. G., & Brodie, M. J. (2000). A neurochemical study of the novel antiepileptic drug retigabine in mouse brain. PHARMACOLOGICAL RESEARCH, 42(6), 553-557. doi:10.1006/phrs.2000.0738

DOI: 10.1006/phrs.2000.0738

Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study (Journal article)

Kwan, P., Sills, G. J., Kelly, K., Butler, E., & Brodie, M. J. (2000). Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study. EPILEPSY RESEARCH, 42(2-3), 191-195. doi:10.1016/S0920-1211(00)00180-7

DOI: 10.1016/S0920-1211(00)00180-7

Simultaneous determination of remacemide hydrochloride and desglycinylremacemide (AR-R12495XX) in brain tissue by high-performance liquid chromatography (Journal article)

Santangeli, S., McNeill, C., Sills, G. J., & Brodie, M. J. (2000). Simultaneous determination of remacemide hydrochloride and desglycinylremacemide (AR-R12495XX) in brain tissue by high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY B, 746(2), 325-329. doi:10.1016/S0378-4347(00)00329-7

DOI: 10.1016/S0378-4347(00)00329-7

Topiramate in refractory epilepsy: A prospective observational study (Journal article)

Stephen, L. J., Sills, G. J., & Brodie, M. J. (2000). Topiramate in refractory epilepsy: A prospective observational study. EPILEPSIA, 41(8), 977-980. doi:10.1111/j.1528-1157.2000.tb00282.x

DOI: 10.1111/j.1528-1157.2000.tb00282.x

Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt (Journal article)

Sills, G. J., Leach, J. P., Kilpatrick, W. S., Fraser, C. M., Thompson, G. G., & Brodie, M. J. (2000). Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt. EPILEPSIA, 41, S30-S34. doi:10.1111/j.1528-1157.2000.tb06046.x

DOI: 10.1111/j.1528-1157.2000.tb06046.x

1999

Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study (Journal article)

Sills, G. J., Butler, E., Thompson, G. G., & Brodie, M. J. (1999). Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 8(7), 404-411. doi:10.1053/seiz.1999.0326

DOI: 10.1053/seiz.1999.0326

Bone density and antiepileptic drugs: a case-controlled study (Journal article)

Stephen, L. J., McLellan, A. R., Harrison, J. H., Shapiro, D., Dominiczak, M. H., Sills, G. J., & Brodie, M. J. (1999). Bone density and antiepileptic drugs: a case-controlled study. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 8(6), 339-342. doi:10.1053/seiz.1999.0301

DOI: 10.1053/seiz.1999.0301

Neurochemical studies with the anticonvulsant felbamate in mouse brain (Journal article)

Fraser, C. M., Sills, G. J., Forrest, G., Thompson, G. G., & Brodie, M. J. (1999). Neurochemical studies with the anticonvulsant felbamate in mouse brain. PHARMACOLOGICAL RESEARCH, 40(3), 257-261. doi:10.1006/phrs.1999.0511

DOI: 10.1006/phrs.1999.0511

Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain (Journal article)

Fraser, C. M., Sills, G. J., Forrest, G., Thompson, G. G., & Brodie, M. J. (1999). Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain. BRITISH JOURNAL OF PHARMACOLOGY, 126(7), 1634-1638. doi:10.1038/sj.bjp.0702472

DOI: 10.1038/sj.bjp.0702472

A neurochemical study of the novel antiepileptic drug retigabine in mouse brain. (Conference Paper)

Sills, G. J., Rundfeldt, C., Butler, E., Forrest, G., Thompson, G. G., & Brodie, M. J. (1999). A neurochemical study of the novel antiepileptic drug retigabine in mouse brain.. In EPILEPSIA Vol. 40 (pp. 128). Retrieved from http://gateway.webofknowledge.com/

A prospective observational study of topiramate in difficult-to-control epilepsy. (Conference Paper)

Brodie, M. J., Stephen, L. J., Dominiczak, M. H., & Sills, G. J. (1999). A prospective observational study of topiramate in difficult-to-control epilepsy.. In EPILEPSIA Vol. 40 (pp. 284). Retrieved from http://gateway.webofknowledge.com/

Bone density and antiepileptic drugs: A case-controlled study in older adults. (Conference Paper)

Stephen, L. J., McLellan, A., Harrison, J. H., Shapiro, D., Sills, G. J., & Brodie, M. J. (1999). Bone density and antiepileptic drugs: A case-controlled study in older adults.. In EPILEPSIA Vol. 40 (pp. 95). Retrieved from http://gateway.webofknowledge.com/

Combination studies with the novel anticonvulsant topiramate in the pentylenetetrazol seizure model. (Conference Paper)

Sills, G. J., Butler, E., Forrest, G., Thompson, G. G., & Brodie, M. J. (1999). Combination studies with the novel anticonvulsant topiramate in the pentylenetetrazol seizure model.. In EPILEPSIA Vol. 40 (pp. 128). Retrieved from http://gateway.webofknowledge.com/

Concentration-related pharmacodynamic studies with vigabatrin and tiagabine in rat brain and eye. (Conference Paper)

Sills, G. J., Patsalos, P. N., Butler, E., Forrest, G., Ratnaraj, N., & Brodie, M. J. (1999). Concentration-related pharmacodynamic studies with vigabatrin and tiagabine in rat brain and eye.. In EPILEPSIA Vol. 40 (pp. 132). Retrieved from http://gateway.webofknowledge.com/

Concentration-related pharmacodynamic study of vigabatrin and tiagabine in rat brain and eye. (Conference Paper)

Sills, G. J., Patsalos, P. N., Butler, E., Forrest, G., Ratnaraj, N., & Brodie, M. J. (1999). Concentration-related pharmacodynamic study of vigabatrin and tiagabine in rat brain and eye.. In EPILEPSIA Vol. 40 (pp. 244-245). Retrieved from http://gateway.webofknowledge.com/

Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue (Journal article)

Fraser, C. M., Sills, G. J., Butler, E., Thompson, G. G., Lindsay, K., Duncan, R., . . . Brodie, M. J. (1999). Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue. EPILEPTIC DISORDERS, 1(3), 153-157. Retrieved from http://gateway.webofknowledge.com/

Preliminary studies with human astrocyte cultures in antiepileptic drug research. (Conference Paper)

Sills, G. J., Fraser, C. M., Butler, E., Thompson, G. G., & Brodie, M. J. (1999). Preliminary studies with human astrocyte cultures in antiepileptic drug research.. In EPILEPSIA Vol. 40 (pp. 131-132). Retrieved from http://gateway.webofknowledge.com/

1998

Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study (Journal article)

Read, C. L., Stephen, L. J., Stolarek, I. H., Paul, A., Sills, G. J., & Brodie, M. J. (1998). Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 7(2), 159-162. doi:10.1016/S1059-1311(98)80058-7

DOI: 10.1016/S1059-1311(98)80058-7

Lamotrigine and topiramate may be a useful combination (Journal article)

Stephen, L. J., Sills, G. J., & Brodie, M. J. (1998). Lamotrigine and topiramate may be a useful combination. LANCET, 351(9107), 958-959. Retrieved from http://gateway.webofknowledge.com/

High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients (Journal article)

Wilson, E. A., Sills, G. J., Forrest, G., & Brodie, M. J. (1998). High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients. EPILEPSY RESEARCH, 29(2), 161-166. doi:10.1016/S0920-1211(97)00078-8

DOI: 10.1016/S0920-1211(97)00078-8

1997

Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain (Journal article)

Leach, J. P., Sills, G. J., Butler, E., Forrest, G., Thompson, G. G., & Brodie, M. J. (1997). Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain. BRITISH JOURNAL OF PHARMACOLOGY, 121(5), 923-926. Retrieved from http://gateway.webofknowledge.com/

Neurochemical actions of gabapentin in mouse brain (Journal article)

Leach, J. P., Sills, G. J., Butler, E., Forrest, G., Thompson, G. G., & Brodie, M. J. (1997). Neurochemical actions of gabapentin in mouse brain. EPILEPSY RESEARCH, 27(3), 175-180. doi:10.1016/S0920-1211(97)01034-6

DOI: 10.1016/S0920-1211(97)01034-6

Neurochemical actions of vigabatrin and tiagabine alone and in combination in mouse cortex (Journal article)

Leach, J. P., Sills, G. J., Butler, E., Forrest, G., Thompson, G. G., & Brodie, M. J. (1997). Neurochemical actions of vigabatrin and tiagabine alone and in combination in mouse cortex. GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 28(5), 715-719. doi:10.1016/S0306-3623(96)00357-6

DOI: 10.1016/S0306-3623(96)00357-6

Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain (Journal article)

Sills, G. J., Leach, J. P., Fraser, C. M., Forrest, G., Patsalos, P. N., & Brodie, M. J. (1997). Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. EUROPEAN JOURNAL OF PHARMACOLOGY, 325(1), 35-40. doi:10.1016/S0014-2999(97)00105-2

DOI: 10.1016/S0014-2999(97)00105-2

1996

Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes (Journal article)

Leach, J. P., Sills, G. J., Majid, A., Butler, E., Carswell, A., Thompson, G. G., & Brodie, M. J. (1996). Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 5(3), 229-234. doi:10.1016/S1059-1311(96)80041-0

DOI: 10.1016/S1059-1311(96)80041-0

Determination of gabapentin in plasma by high-performance liquid chromatography (Journal article)

Forrest, G., Sills, G. J., Leach, J. P., & Brodie, M. J. (1996). Determination of gabapentin in plasma by high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 681(2), 421-425. doi:10.1016/0378-4347(96)00074-6

DOI: 10.1016/0378-4347(96)00074-6

1995

CONCENTRATION RELATED EFFECTS OF VIGABATRIN ON GABA UPTAKE IN CULTURED RODENT ASTROCYTES (Conference Paper)

LEACH, J. P., SILLS, G., THOMPSON, G., FORREST, G., BULLER, E., & BRODIE, M. J. (1995). CONCENTRATION RELATED EFFECTS OF VIGABATRIN ON GABA UPTAKE IN CULTURED RODENT ASTROCYTES. In EPILEPSIA Vol. 36 (pp. D6). Retrieved from http://gateway.webofknowledge.com/

EFFECTS OF REPEATED TIAGABINE ADMINISTRATION ON EXPERIMENTALLY-INDUCED SEIZURES (Conference Paper)

SILLS, G. J., FORREST, G., LEACH, J. P., THOMPSON, G. G., & BRODIE, M. J. (1995). EFFECTS OF REPEATED TIAGABINE ADMINISTRATION ON EXPERIMENTALLY-INDUCED SEIZURES. In EPILEPSIA Vol. 36 (pp. S52). Retrieved from http://gateway.webofknowledge.com/

Established and new antiepileptic drugs: an overview (Chapter)

Hannah, J. A., Sills, G. J., & Brodie, M. J. (1995). Established and new antiepileptic drugs: an overview. In A. P. Aldenkamp, F. E. Dreifuss, W. O. Renier, & T. P. B. M. Suurmeijer (Eds.), Epilepsy in Children and Adolescents (pp. 101-129). New York: CRC Press.

VIGABATRIN AND TIAGABINE - EFFECTS ON WHOLE-BRAIN BIOCHEMISTRY ALONE AND IN COMBINATION (Conference Paper)

LEACH, J. P., THOMPSON, G., SILLS, G., FORREST, G., CARSWELL, A., & BRODIE, M. J. (1995). VIGABATRIN AND TIAGABINE - EFFECTS ON WHOLE-BRAIN BIOCHEMISTRY ALONE AND IN COMBINATION. In EPILEPSIA Vol. 36 (pp. S40-S41). Retrieved from http://gateway.webofknowledge.com/

1994

DOSE-RESPONSE RELATIONSHIPS WITH NIMODIPINE AGAINST ELECTROSHOCK SEIZURES IN MICE (Journal article)

SILLS, G. J., CARSWELL, A., & BRODIE, M. J. (1994). DOSE-RESPONSE RELATIONSHIPS WITH NIMODIPINE AGAINST ELECTROSHOCK SEIZURES IN MICE. EPILEPSIA, 35(2), 437-442. doi:10.1111/j.1528-1157.1994.tb02457.x

DOI: 10.1111/j.1528-1157.1994.tb02457.x

Experimental seizure models and new antiepileptic drugs (Thesis / Dissertation)

Sills, G. J. (1994). Experimental seizure models and new antiepileptic drugs. (PhD Thesis, University of Glasgow).

1993

INVESTIGATION OF THE ANTICONVULSANT EFFECTS AND MECHANISM OF ACTION OF VIGABATRIN IN EXPERIMENTAL SEIZURE MODELS (Conference Paper)

SILLS, G. J., KADIR, Z., WILKIE, S., THOMPSON, G. G., & BRODIE, M. J. (1993). INVESTIGATION OF THE ANTICONVULSANT EFFECTS AND MECHANISM OF ACTION OF VIGABATRIN IN EXPERIMENTAL SEIZURE MODELS. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 109 (pp. P28). Retrieved from http://gateway.webofknowledge.com/

POTASSIUM-STIMULATED CALCIUM INFLUX AND ITS INHIBITION BY NIMODIPINE IN CULTURED ASTROCYTES AND NEURONS (Conference Paper)

SILLS, G. J., BUTLER, E., CARSWELL, A., FORREST, G., THOMPSON, G. G., & BRODIE, M. J. (1993). POTASSIUM-STIMULATED CALCIUM INFLUX AND ITS INHIBITION BY NIMODIPINE IN CULTURED ASTROCYTES AND NEURONS. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 109 (pp. P78). Retrieved from http://gateway.webofknowledge.com/

THE EFFECTS OF DIHYDROPYRIDINES ON ELECTROSHOCK SEIZURES IN MICE (Conference Paper)

SILLS, G. J., CARSWELL, A., & BRODIE, M. J. (1993). THE EFFECTS OF DIHYDROPYRIDINES ON ELECTROSHOCK SEIZURES IN MICE. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 109 (pp. P27). Retrieved from http://gateway.webofknowledge.com/

1992

NICOTINYLALANINE INCREASES CEREBRAL KYNURENIC ACID CONTENT AND HAS ANTICONVULSANT ACTIVITY (Journal article)

CONNICK, J. H., HEYWOOD, G. C., SILLS, G. J., THOMPSON, G. G., BRODIE, M. J., & STONE, T. W. (1992). NICOTINYLALANINE INCREASES CEREBRAL KYNURENIC ACID CONTENT AND HAS ANTICONVULSANT ACTIVITY. GENERAL PHARMACOLOGY, 23(2), 235-239. doi:10.1016/0306-3623(92)90017-E

DOI: 10.1016/0306-3623(92)90017-E