Photo of Prof Dharani Hapangama

Prof Dharani Hapangama BSc(Hons) MBChB MD MRCOG DFFP

Professor of Gynaecology/Consultant Gynaecological Surgeon Women's and Children's Health

    Research

    Research Interest 1

    Endometrial stem cells, endometrial cell fate, telomeres, telomerase, endometriosis and endometrial cancer

    Research Grants

    Feasibility of utilising two novel approaches to characterise the human endometrial epithelial cell subtypes

    WELLBEING OF WOMEN (UK)

    May 2018 - July 2020

    Feasibility of employing Laser capture microdissection to conclusively isolate genes involved in the ectopic growth of endometrial epithelial / stromal cells in endometriotic lesions

    WELLBEING OF WOMEN (UK)

    January 2017 - August 2018

    PhD in Pathology

    THE HIGHER COMMITTEE FOR EDUCATION DEVELOPMENT IN IRAQ (HCED) (IRAQ)

    October 2015 - September 2020

    Ulipristal versus conventional management of heavy menstrual bleeding (HMB; including uterine fibroids): a randomised controlled trial and exploration of mechanism of action (UCON trial)

    DEPARTMENT OF HEALTH (UK) (NIHR)

    July 2015 - June 2019

    Analysis of human endometrial epithelial stem cells and their niche in health and disease by lineage labelling

    WELLBEING OF WOMEN (UK)

    August 2015 - July 2021

    Feasibility of employing two novel techniques to identify endometrial epithelial stem progenitor cells and their niche in the human endometrium

    WELLBEING OF WOMEN (UK)

    August 2012 - August 2016

    Endometriosis Millennium Fund 2004.

    ROYAL COLLEGE OF OBSTETRICIANS AND GYNAECOLOGISTS (UK)

    April 2004 - December 2011

    Endometrial Cancer Metastasis and Cancer Stem Cells Funder & Programme

    LIVERPOOL WOMEN'S NHS FOUNDATION TRUST (UK)

    October 2012 - September 2015

    Bench fees for Seham Alsaif

    UNIVERSITY OF DAMMAM (SAUDI ARABIA)

    June 2014 - May 2015

    The role of metastasis inducing proteins and telomerase in Endometrial cancer and in endometrial cancer stem cells; Implications for diagnosis, prognosis and treatment

    WELLBEING OF WOMEN (UK)

    January 2013 - January 2014

    To investigate the diagnostic and prognostic utility of MIPs in endometrial cancer

    THE HIGHER COMMITTEE FOR EDUCATION DEVELOPMENT IN IRAQ (HCED) (IRAQ)

    September 2012 - September 2016

    To investigate the role of the identified regulators of cell fate (RCF) and metastasis inducing proteins (MIP) in endometrial stem/progenitor cells (SPC) in establishing endometriosis.

    WELLBEING OF WOMEN

    October 2009 - July 2013

    Research Collaborations

    Professor Sue Wray

    Internal

    Dr Caroline Gargett

    External: Monash University

    Successful collaborative grant to study endometrial stem cells in endometriosis

    Professor PS Rudland

    Internal

    Collaborative studies, publications and successful external grant

    Dr Roger Barraclough

    Internal

    Successful collaborative grant, publications and studies

    Professor Asgi Fazleabas

    External: Michigan State University

    Collaborative studies & publications

    Dr Gabriele Saretzki

    External: University of Newcastle upon Tyne

    Collaborative studies, publications and successful grants

    Professor Hilary Critchley, Professor David Baird

    External: The University of Edinburgh

    I am in the process of receiving samples to carryout telomerase immuno-histochemistry for a study that I carried out in Edinburgh as a research fellow. I shall be the leading author of any resulting publications.

    Professor Thomas von Zglinicki

    External: The University of Newcastle-upon-Tyne

    Professor von Zglinicki is allowing me to use the his laboratory equipment to carryout Telomere length PCR measurements which has already been optimised in his lab.