Dr Dean Hammond PhD

Research Fellow Cellular and Molecular Physiology

    Publications

    2020

    Revealing mechanisms of mating plug function under sexual selection. (Journal article)

    Stockley, P., Franco, C., Claydon, A. J., Davidson, A., Hammond, D. E., Brownridge, P. J., . . . Beynon, R. J. (2020). Revealing mechanisms of mating plug function under sexual selection.. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1920526117

    DOI: 10.1073/pnas.1920526117

    The influence of hypoxia on the prostate cancer proteome (Journal article)

    Ross, J. A., Vissers, J. P. C., Nanda, J., Stewart, G. D., Husi, H., Habib, F. K., . . . Gethings, L. A. (2020). The influence of hypoxia on the prostate cancer proteome. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 58(6), 980-993. doi:10.1515/cclm-2019-0626

    DOI: 10.1515/cclm-2019-0626

    Rates of Synthesis of Individual Proteins in Muscles of Old Mice: A Heavy Water Approach (Conference Paper)

    Owen, E., Hammond, D., Staunton, C., Franco, C., Prescott, M., Brooks, S., . . . McArdle, A. (2020). Rates of Synthesis of Individual Proteins in Muscles of Old Mice: A Heavy Water Approach. In FASEB JOURNAL Vol. 34. doi:10.1096/fasebj.2020.34.s1.06592

    DOI: 10.1096/fasebj.2020.34.s1.06592

    2019

    The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis (Journal article)

    Tse, K., Hammond, D., Simpson, D., Beynon, R. J., Beamer, E., Tymianski, M., . . . Thippeswamy, T. (2019). The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis. JOURNAL OF NEUROSCIENCE RESEARCH, 97(11), 1378-1392. doi:10.1002/jnr.24441

    DOI: 10.1002/jnr.24441

    Integrin aVß6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion (Conference Paper)

    Thomas, J. R., Moore, K. M., Sproat, C., Mo, S., Wolanska, K. I., Maldonado, H., . . . Morgan, M. (2019). Integrin aVß6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A39). doi:10.1111/iep.12332

    DOI: 10.1111/iep.12332

    RAB8A and RAP1B cooperate to control integrin trafficking and function during angiogenic processes (Conference Paper)

    Wolanska, K. I., Maldonado, H., George, A. V., Rusilowicz, E. V., Newman, D., Hammond, D., & Morgan, M. R. (2019). RAB8A and RAP1B cooperate to control integrin trafficking and function during angiogenic processes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A42). Retrieved from http://gateway.webofknowledge.com/

    2018

    Specificity of the osmotic stress response in Candida albicans highlighted by quantitative proteomics (Journal article)

    Jacobsen, M. D., Beynon, R. J., Gethings, L. A., Claydon, A. J., Langridge, J. I., Vissers, J. P. C., . . . Hammond, D. E. (2018). Specificity of the osmotic stress response in Candida albicans highlighted by quantitative proteomics. Scientific Reports, 8. doi:10.1038/s41598-018-32792-6

    DOI: 10.1038/s41598-018-32792-6

    Integrin aVß6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion (Journal article)

    Thomas, J., Moore, K., Sproat, C., Maldonado-Lorca, H., Mo, S., Haider, S., . . . Morgan, M. (2018). Integrin aVß6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion. doi:10.1101/407908

    DOI: 10.1101/407908

    Integrin alpha V beta 6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion (Journal article)

    Thomas, J. R., Moore, K. M., Sproat, C., Mo, S., Wolanska, K. I., Maldonado, H., . . . Morgan, M. R. (2019). Integrin alpha V beta 6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 100(4), A39. Retrieved from http://gateway.webofknowledge.com/

    Stable Isotope Dynamic Labeling of Secretomes (SIDLS) Identifies Authentic Secretory Proteins Released by Cancer and Stromal Cells (Journal article)

    Hammond, D. E., Kumar, J. D., Raymond, L., Simpson, D. M., Beynon, R. J., Dockray, G. J., & Varro, A. (2018). Stable Isotope Dynamic Labeling of Secretomes (SIDLS) Identifies Authentic Secretory Proteins Released by Cancer and Stromal Cells. MOLECULAR & CELLULAR PROTEOMICS, 17(9), 1837-1849. doi:10.1074/mcp.TIR117.000516

    DOI: 10.1074/mcp.TIR117.000516

    Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer (Journal article)

    Ireland, L., Santos, A., Campbell, F., Figueiredo, C., Hammond, D., Ellies, L. G., . . . Mielgo Iza, A. (2018). Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. Oncogene, 37(15), 2022-2036. doi:10.1038/s41388-017-0115-x

    DOI: 10.1038/s41388-017-0115-x

    New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome (Journal article)

    Wilson, L. J., Linley, A., Hammond, D. E., Hood, F. E., Coulson, J. M., MacEwan, D. J., . . . Prior, I. A. (2018). New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome. CANCER RESEARCH, 78(1), 15-29. doi:10.1158/0008-5472.CAN-17-2291

    DOI: 10.1158/0008-5472.CAN-17-2291

    2016

    Protein turnover measurement using selected reaction monitoring-mass spectrometry (SRM-MS) (Journal article)

    Holman, S. W., Hammond, D. E., Simpson, D. M., Waters, J., Hurst, J. L., & Beynon, R. J. (2016). Protein turnover measurement using selected reaction monitoring-mass spectrometry (SRM-MS). Philosophical Transactions A: Mathematical, Physical and Engineering Sciences, 374(2079). doi:10.1098/rsta.2015.0362

    DOI: 10.1098/rsta.2015.0362

    In-depth proteomic profiling of the uveal melanoma secretome (Journal article)

    Angi, M., Kalirai, H., Prendergast, S., Simpson, D., Hammond, D. E., Madigan, M. C., . . . Coupland, S. E. (2016). In-depth proteomic profiling of the uveal melanoma secretome. Oncotarget, 7(31), 49623-49635. doi:10.18632/oncotarget.10418

    DOI: 10.18632/oncotarget.10418

    Proteome Dynamics: Tissue Variation in the Kinetics of Proteostasis in Intact Animals (Journal article)

    Hammond, D. E., Claydon, A. J., Simpson, D. M., Edward, D., Stockley, P., Hurst, J. L., & Beynon, R. J. (2016). Proteome Dynamics: Tissue Variation in the Kinetics of Proteostasis in Intact Animals. Molecular and Cellular Proteomics, 15(4), 1204-1219. doi:10.1074/mcp.M115.053488

    DOI: 10.1074/mcp.M115.053488

    Cross-species proteomics in analysis of mammalian sperm proteins (Journal article)

    Bayram, H., Claydon, A., Brownridge, P., Hurst, J., Mileham, A., Stockley, P., . . . Hammond, D. (2016). Cross-species proteomics in analysis of mammalian sperm proteins. Journal of Proteomics, 135, 38-50. doi:10.1016/j.jprot.2015.12.027

    DOI: 10.1016/j.jprot.2015.12.027

    Direct and Absolute Quantification of over 1800 Yeast Proteins via Selected Reaction Monitoring (Journal article)

    Lawless, C., Holman, S. W., Brownridge, P., Lanthaler, K., Harman, V. M., Watkins, R., . . . Hubbard, S. J. (2016). Direct and Absolute Quantification of over 1800 Yeast Proteins via Selected Reaction Monitoring. MOLECULAR & CELLULAR PROTEOMICS, 15(4), 1309-1322. doi:10.1074/mcp.M115.054288

    DOI: 10.1074/mcp.M115.054288

    2015

    Sperm competition risk drives plasticity in seminal fluid composition (Journal article)

    Ramm, S., Edward, D., Claydon, A., Hammond, D., Brownridge, P., Hurst, J., . . . Stockley, P. (2015). Sperm competition risk drives plasticity in seminal fluid composition. BMC Biology, 13. doi:10.1186/s12915-015-0197-2

    DOI: 10.1186/s12915-015-0197-2

    Differential Reprogramming of Isogenic Colorectal Cancer Cells by Distinct Activating KRAS Mutations (Journal article)

    Hammond, D., Mageean, C., Rusilowicz, E., Wickenden, J. A., Clague, M., & Prior, I. (2015). Differential Reprogramming of Isogenic Colorectal Cancer Cells by Distinct Activating KRAS Mutations. Journal of Proteome Research, 14(3), 1535-1546. doi:10.1021/pr501191a

    DOI: 10.1021/pr501191a

    2014

    Differential network reprogramming by distinct activating K-Ras mutations (Conference Paper)

    Hammond, D. E., Mageean, C. J., Rusilowicz, E. V., Clague, M. J., & Prior, I. A. (2014). Differential network reprogramming by distinct activating K-Ras mutations. In MOLECULAR CANCER RESEARCH Vol. 12. doi:10.1158/1557-3125.RASONC14-B30

    DOI: 10.1158/1557-3125.RASONC14-B30

    The role of proteomics in studies of protein moonlighting (Journal article)

    Beynon, R. J., Hammond, D., Harman, V., & Woolerton, Y. (2014). The role of proteomics in studies of protein moonlighting. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 1698-1703. doi:10.1042/BST20140277

    DOI: 10.1042/BST20140277

    PIM2 kinase is induced by cisplatin in ovarian cancer cells and limits drug efficacy (Journal article)

    Musiani, D., Hammond, D. E., Cirillo, L., Erriquez, J., Olivero, M., Clague, M. J., & Renzo, M. F. (2014). PIM2 kinase is induced by cisplatin in ovarian cancer cells and limits drug efficacy. Journal of Proteome Research, 13(11), 4970-4982. doi:10.1021/pr500651n

    DOI: 10.1021/pr500651n

    Experimental and Analytical Approaches to the Quantification of Protein Turnover on a Proteome-wide Scale (Chapter)

    Claydon, A. J., Hammond, D. E., & Beynon, R. J. (2014). Experimental and Analytical Approaches to the Quantification of Protein Turnover on a Proteome-wide Scale. In C. E. Eyers, & S. J. Gaskell (Eds.), New Developments in Mass Spectrometry: Quantitative Proteomics (pp. 257-276). Cambridge: The Royal Society of Chemistry.

    2013

    CoPY - Census of the Proteome of Yeast: Quantification of the S. cerevisiae proteome (Conference Paper)

    Lanthaler, K., Holman, S., Lawless, C., Watkins, R., Brownridge, P., Harman, V., . . . Beynon, R. (2013). CoPY - Census of the Proteome of Yeast: Quantification of the S. cerevisiae proteome. In YEAST Vol. 30 (pp. 188). Retrieved from http://gateway.webofknowledge.com/

    Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A (Journal article)

    Hammond, D., Zeng, K., Espert, A., Bastos, R. N., Baron, R. D., Gruneberg, U., & Barr, F. A. (2013). Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A. JOURNAL OF CELL SCIENCE, 126(15), 3429-3440. doi:10.1242/jcs.128397

    DOI: 10.1242/jcs.128397

    Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage due to dysregulated Aurora-A (Journal article)

    Hammond, D., Zeng, K., Espert, A., Bastos, R. N., Baron, R. D., Gruneberg, U., & Barr, F. A. (2013). Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage due to dysregulated Aurora-A. J Cell Sci, 31, 31.

    2012

    Global Snapshot of the Influence of Endocytosis upon EGF Receptor Signaling Output (Journal article)

    Omerovic, J., Hammond, D. E., Prior, I. A., & Clague, M. J. (2012). Global Snapshot of the Influence of Endocytosis upon EGF Receptor Signaling Output. Journal of Proteome Research, 11(11), 5157-5166. doi:10.1021/pr3007304

    DOI: 10.1021/pr3007304

    Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation (Journal article)

    Dunsch, A. K., Hammond, D., Lloyd, J., Schermelleh, L., Gruneberg, U., & Barr, F. A. (2012). Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation. JOURNAL OF CELL BIOLOGY, 198(6), 1039-1054. doi:10.1083/jcb.201202112

    DOI: 10.1083/jcb.201202112

    CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis (Journal article)

    Bastos, R. N., Penate, X., Bates, M., Hammond, D., & Barr, F. A. (2012). CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis. JOURNAL OF CELL BIOLOGY, 198(5), 865-880. doi:10.1083/jcb.201204107

    DOI: 10.1083/jcb.201204107

    2010

    Quantitative Analysis of HGF and EGF-Dependent Phosphotyrosine Signaling Networks (Journal article)

    Hammond, D. E., Hyde, R., Kratchmarova, I., Beynon, R. J., Blagoev, B., & Clague, M. J. (2010). Quantitative Analysis of HGF and EGF-Dependent Phosphotyrosine Signaling Networks. JOURNAL OF PROTEOME RESEARCH, 9(5), 2734-2742. doi:10.1021/pr100145w

    DOI: 10.1021/pr100145w

    2009

    Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells (Journal article)

    Buus, R., Faronato, M., Hammond, D. E., Urbe, S., & Clague, M. J. (2009). Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells. CURRENT BIOLOGY, 19(17), 1463-1466. doi:10.1016/j.cub.2009.07.040

    DOI: 10.1016/j.cub.2009.07.040

    Turnover of the Human Proteome: Determination of Protein Intracellular Stability by Dynamic SILAC (Journal article)

    Doherty, M. K., Hammond, D. E., Clagule, M. J., Gaskell, S. J., & Beynon, R. J. (2009). Turnover of the Human Proteome: Determination of Protein Intracellular Stability by Dynamic SILAC. JOURNAL OF PROTEOME RESEARCH, 8(1), 104-112. doi:10.1021/pr800641v

    DOI: 10.1021/pr800641v

    Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC (Journal article)

    Doherty, M. K., Hammond, D. E., Clague, M. J., Gaskell, S. J., & Beynon, R. J. (2009). Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC. J Proteome Res, 8(1), 104-112.

    2008

    Ras isoform abundance and signalling in human cancer cell lines (Journal article)

    Omerovic, J., Hammond, D. E., Clague, M. J., & Prior, I. A. (2008). Ras isoform abundance and signalling in human cancer cell lines. ONCOGENE, 27(19), 2754-2762. doi:10.1038/sj.onc.1210925

    DOI: 10.1038/sj.onc.1210925

    Ras isoform abundance and signalling in human cancer cell lines (Journal article)

    Omerovic, J., Hammond, D. E., Clague, M. J., & Prior, I. A. (2008). Ras isoform abundance and signalling in human cancer cell lines. Oncogene, 27(19), 2754-2762.

    2006

    Membrane traffic: Catching the lysosome express (Journal article)

    Clague, M. J., & Hammond, D. E. (2006). Membrane traffic: Catching the lysosome express. CURRENT BIOLOGY, 16(11), R416-R418. doi:10.1016/j.cub.2006.05.009

    DOI: 10.1016/j.cub.2006.05.009

    2004

    Met receptor dynamics and signalling (Journal article)

    Hammond, D. E., Carter, S., & Clague, M. J. (2004). Met receptor dynamics and signalling. SIGNALLING FROM INTERNALIZED GROWTH FACTOR RECEPTORS, 286, 21-+. Retrieved from http://gateway.webofknowledge.com/

    2003

    Endosomal dynamics of Met determine signaling output (Journal article)

    Hammond, D. E., Carter, S., McCullough, J., Urbe, S., Vande Woude, G., & Clague, M. J. (2003). Endosomal dynamics of Met determine signaling output. MOLECULAR BIOLOGY OF THE CELL, 14(4), 1346-1354. doi:10.1091/mbc.E02-09-0578

    DOI: 10.1091/mbc.E02-09-0578

    2001

    Down-regulation of MET, the receptor for hepatocyte growth factor (Journal article)

    Hammond, D. E., Urbe, S., Woude, G. F. V., & Clague, M. J. (2001). Down-regulation of MET, the receptor for hepatocyte growth factor. ONCOGENE, 20(22), 2761-2770. doi:10.1038/sj.onc.1204475

    DOI: 10.1038/sj.onc.1204475