Photo of Prof Christian Hedrich

Prof Christian Hedrich MD, PhD

Professor of Child Health Women's and Children's Health

Publications

Selected Publications

  1. TCR+ CD3(+) CD4(-) CD8(-) effector T cells in psoriasis (Journal article - 2017)
  2. Altered expression of IL-10 family cytokines in CRMO result in enhanced inflammasome activation. (Journal article - 2015)
  3. cAMP Responsive Element Modulator (CREM) alpha Mediates Chromatin Remodeling of CD8 during the Generation of CD3(+)CD4(-)CD8(-) T Cells (Journal article - 2014)
  4. Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling (Journal article - 2014)
  5. cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus (Journal article - 2012)

2019

Innately adaptive or truly autoimmune. (Journal article)

Kessel, C., Hedrich, C. M., & Foell, D. (2019). Innately adaptive or truly autoimmune.. Arthritis & rheumatology (Hoboken, N.J.). doi:10.1002/art.41107

DOI: 10.1002/art.41107

SNPs talk to genes using landlines: long-range chromatin interactions link genetic risk with epigenetic patterns in Takayasu arteritis. (Journal article)

Hedrich, C. M., & Tsokos, G. (2019). SNPs talk to genes using landlines: long-range chromatin interactions link genetic risk with epigenetic patterns in Takayasu arteritis.. Annals of the rheumatic diseases, 78(10), 1293-1295. doi:10.1136/annrheumdis-2019-215957

DOI: 10.1136/annrheumdis-2019-215957

Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis. (Journal article)

Young, S., Sharma, N., Lee, J. H., Chitu, V., Neumeister, V., Sohr, E., . . . Craig, A. W. B. (2019). Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis.. Disease Models & Mechanisms, 12(8). doi:10.1242/dmm.040097

DOI: 10.1242/dmm.040097

The German National Registry of Primary Immunodeficiencies (2012-2017) (Journal article)

El-Helou, S. M., Biegner, A. -K., Bode, S., Ehl, S. R., Heeg, M., Maccari, M. E., . . . Grimbacher, B. (2019). The German National Registry of Primary Immunodeficiencies (2012-2017). FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.01272

DOI: 10.3389/fimmu.2019.01272

The Role of Epigenetics in Autoimmune/Inflammatory Disease (Journal article)

Surace, A. E. A., & Hedrich, C. M. (2019). The Role of Epigenetics in Autoimmune/Inflammatory Disease. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.01525

DOI: 10.3389/fimmu.2019.01525

CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability. (Journal article)

Kapplusch, F., Schulze, F., Rabe-Matschewsky, S., Russ, S., Herbig, M., Heymann, M. C., . . . Hofmann, S. R. (2019). CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability.. Clinical immunology (Orlando, Fla.), 208, 108232. doi:10.1016/j.clim.2019.06.008

DOI: 10.1016/j.clim.2019.06.008

CAMP RESPONSE ELEMENT MODULATOR (CREM) A INDUCES DUAL SPECIFICITY PROTEIN PHOSPHATASE (DUSP) 4 THROUGH EPIGENETIC REMODELING, PROMOTING IL-17A AND REDUCING IL-2 EXPRESSION IN T CELLS (Conference Paper)

Hofmann, S., Maebert, K., Kapplusch, F., Russ, S., & Hedrich, C. (2019). CAMP RESPONSE ELEMENT MODULATOR (CREM) A INDUCES DUAL SPECIFICITY PROTEIN PHOSPHATASE (DUSP) 4 THROUGH EPIGENETIC REMODELING, PROMOTING IL-17A AND REDUCING IL-2 EXPRESSION IN T CELLS. In ANNALS OF THE RHEUMATIC DISEASES Vol. 78 (pp. 172). doi:10.1136/annrheumdis-2019-eular.999

DOI: 10.1136/annrheumdis-2019-eular.999

CLINICAL RESPONSE TO HIGH-DOSE INTRAVENOUS METHYLPREDNISOLONE IN CHILDHOOD AUTOIMMUNE UVEITIS: A RETROSPECTIVE ANALYSIS (Conference Paper)

Schnabel, A., Unger, E., Bruck, N., Holl-Wieden, A., Morbach, H., Berner, R., . . . Hedrich, C. (2019). CLINICAL RESPONSE TO HIGH-DOSE INTRAVENOUS METHYLPREDNISOLONE IN CHILDHOOD AUTOIMMUNE UVEITIS: A RETROSPECTIVE ANALYSIS. In ANNALS OF THE RHEUMATIC DISEASES Vol. 78 (pp. 983). doi:10.1136/annrheumdis-2019-eular.2495

DOI: 10.1136/annrheumdis-2019-eular.2495

Defining consensus opinion to develop randomised controlled trials in rare diseases using Bayesian design: An example of a proposed trial of adalimumab versus pamidronate for children with CNO/CRMO (Journal article)

Ramanan, A. V., Hampson, L. V., Lythgoe, H., Jones, A. P., Hardwick, B., Hind, H., . . . Beresford, M. W. (2019). Defining consensus opinion to develop randomised controlled trials in rare diseases using Bayesian design: An example of a proposed trial of adalimumab versus pamidronate for children with CNO/CRMO. PLOS ONE, 14(6). doi:10.1371/journal.pone.0215739

DOI: 10.1371/journal.pone.0215739

PATHOPHYSIOLOGY AND THERAPEUTIC CONSEQUENCES AUTO-INFLAMMATORY BONE DISORDERS (Conference Paper)

Hedrich, C. (2019). PATHOPHYSIOLOGY AND THERAPEUTIC CONSEQUENCES AUTO-INFLAMMATORY BONE DISORDERS. In ANNALS OF THE RHEUMATIC DISEASES Vol. 78 (pp. 57-58). doi:10.1136/annrheumdis-2019-eular.8494

DOI: 10.1136/annrheumdis-2019-eular.8494

The role of epigenetics in paediatric rheumatic disease. (Journal article)

Charras, A., & Hedrich, C. M. (2019). The role of epigenetics in paediatric rheumatic disease.. Current opinion in rheumatology, 31(5), 450-463. doi:10.1097/bor.0000000000000627

DOI: 10.1097/bor.0000000000000627

Interference of canakinumab with commercial IL-1 beta ELISAs (Journal article)

Linge, M., Hedrich, C. M., Roesen-Wolff, A., & Winkler, S. (2019). Interference of canakinumab with commercial IL-1 beta ELISAs. CLINICAL IMMUNOLOGY, 205, 6-7. doi:10.1016/j.clim.2019.05.008

DOI: 10.1016/j.clim.2019.05.008

Vasculitis in juvenile-onset systemic lupus erythematosus (Journal article)

Smith, E. M., Lythgoe, H., & Hedrich, C. M. (2019). Vasculitis in juvenile-onset systemic lupus erythematosus. Frontiers in Pediatrics, 7(APR). doi:10.3389/fped.2019.00149

DOI: 10.3389/fped.2019.00149

THE MOLECULAR PATHOPHYSIOLOGY OF CNO AND CONSEQUENCES FOR PATIENT CARE (Conference Paper)

Hedrich, C. M. (2019). THE MOLECULAR PATHOPHYSIOLOGY OF CNO AND CONSEQUENCES FOR PATIENT CARE. In RHEUMATOLOGY Vol. 58. Retrieved from http://gateway.webofknowledge.com/

Outcomes following mycophenolate mofetil versus cyclophosphamide induction treatment for proliferative juvenile-onset lupus nephritis. (Journal article)

Smith, E., Al-Abadi, E., Armon, K., Bailey, K., Ciurtin, C., Davidson, J., . . . Hedrich, C. M. (2019). Outcomes following mycophenolate mofetil versus cyclophosphamide induction treatment for proliferative juvenile-onset lupus nephritis.. Lupus, 961203319836712. doi:10.1177/0961203319836712

DOI: 10.1177/0961203319836712

Conventional Treatment versus Stem Cell Transplantation Outcome in 105 Patients with Chronic Granulomatous Disease (Conference Paper)

Dedieu, C., Albert, M. H., Mahlaoui, N., Hauck, F., Hedrich, C., Baumann, U., . . . von Bernuth, H. (2019). Conventional Treatment versus Stem Cell Transplantation Outcome in 105 Patients with Chronic Granulomatous Disease. In JOURNAL OF CLINICAL IMMUNOLOGY Vol. 39 (pp. S136-S137). Retrieved from http://gateway.webofknowledge.com/

Childhood Vasculitis (Journal article)

Schnabel, A., & Hedrich, C. M. (2019). Childhood Vasculitis. FRONTIERS IN PEDIATRICS, 6. doi:10.3389/fped.2018.00421

DOI: 10.3389/fped.2018.00421

Primary CNS vasculitis in children (Journal article)

Hedrich, C. M., Hahn, G., & Smitka, M. (2019). Primary CNS vasculitis in children. AKTUELLE RHEUMATOLOGIE, 44(3), 205-211. doi:10.1055/a-0896-2526

DOI: 10.1055/a-0896-2526

2018

Truncating Mutations in SAMD9L Cause an Early-Onset Immune-Dysregulatory Syndrome of Neutrophilic Panniculitis, Interstitial Lung Disease and Cytopenias (Conference Paper)

de Jesus, A. A., Marrero, B., Sanchez, G. A. M., Burnham, J. S., Chan, A., Stepanovskiy, Y., . . . Goldbach-Mansky, R. (2018). Truncating Mutations in SAMD9L Cause an Early-Onset Immune-Dysregulatory Syndrome of Neutrophilic Panniculitis, Interstitial Lung Disease and Cytopenias. In ARTHRITIS & RHEUMATOLOGY Vol. 70. Retrieved from http://gateway.webofknowledge.com/

Kawasaki Disease (Journal article)

Hedrich, C. M., Schnabel, A., & Hospach, T. (2018). Kawasaki Disease. FRONTIERS IN PEDIATRICS, 6. doi:10.3389/fped.2018.00198

DOI: 10.3389/fped.2018.00198

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface (Journal article)

Moghaddas, F., Zeng, P., Zhang, Y., Schuetzle, H., Brenner, S., Hofmann, S. R., . . . Masters, S. L. (2018). Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 142(6), 1956-+. doi:10.1016/j.jaci.2018.04.033

DOI: 10.1016/j.jaci.2018.04.033

CD14(+) monocytes contribute to inflammation in chronic nonbacterial osteomyelitis (CNO) through increased NLRP3 inflammasome expression (Journal article)

Brandt, D., Sohr, E., Pablik, J., Schnabel, A., Kapplusch, F., Maebert, K., . . . Hedrich, C. M. (2018). CD14(+) monocytes contribute to inflammation in chronic nonbacterial osteomyelitis (CNO) through increased NLRP3 inflammasome expression. CLINICAL IMMUNOLOGY, 196, 77-84. doi:10.1016/j.clim.2018.04.011

DOI: 10.1016/j.clim.2018.04.011

Juvenile-onset systemic lupus erythematosus (jSLE) - Pathophysiological concepts and treatment options (Journal article)

Hedrich, C. M., Smith, E. M. D., & Beresford, M. W. (2018). Juvenile-onset systemic lupus erythematosus (jSLE) - Pathophysiological concepts and treatment options. Best Practice and Research: Clinical Rheumatology. doi:10.1016/j.berh.2018.02.001

DOI: 10.1016/j.berh.2018.02.001

IL10 promoter haplotypes may contribute to altered cytokine expression and systemic inflammation in celiac disease (Journal article)

Hofmann, S. R., Laass, M. W., Fehrs, A., Schuppan, D., Zevallos, V. F., Salminger, D., . . . Hedrich, C. M. (2018). IL10 promoter haplotypes may contribute to altered cytokine expression and systemic inflammation in celiac disease. CLINICAL IMMUNOLOGY, 190, 15-21. doi:10.1016/j.clim.2018.02.010

DOI: 10.1016/j.clim.2018.02.010

Mast Cells Enhance Sterile Inflammation in Chronic Nonbacterial Osteomyelitis (Journal article)

Young, S., Sharma, N., Lee, J. H. P., Chitu, V., Neumeister, V., Sohr, E., . . . Craig, A. W. B. (2018). Mast Cells Enhance Sterile Inflammation in Chronic Nonbacterial Osteomyelitis. doi:10.1101/259275

DOI: 10.1101/259275

Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages (Journal article)

Dabitao, D., Hedrich, C. M., Wang, F., Vacharathit, V., & Bream, J. H. (2018). Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages. JOURNAL OF IMMUNOLOGY, 200(6), 2154-2164. doi:10.4049/jimmunol.1701340

DOI: 10.4049/jimmunol.1701340

Mechanistic aspects of epigenetic dysregulation in SLE (Journal article)

Hedrich, C. M. (2018). Mechanistic aspects of epigenetic dysregulation in SLE. CLINICAL IMMUNOLOGY, 196, 3-11. doi:10.1016/j.clim.2018.02.002

DOI: 10.1016/j.clim.2018.02.002

Bacterial arthritis in children and adolescents, core theme diagnostics. Results of the Worlitz consensus meeting 2016, part 1 (Journal article)

Hospach, T., Hedrich, C., Fernandez, F., Girschick, H., Borte, M., Guenther, A., . . . Huppertz, H. -I. (2018). Bacterial arthritis in children and adolescents, core theme diagnostics. Results of the Worlitz consensus meeting 2016, part 1. MONATSSCHRIFT KINDERHEILKUNDE, 166(2), 141-147. doi:10.1007/s00112-017-0326-9

DOI: 10.1007/s00112-017-0326-9

Practice and consensus-based strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany (Journal article)

Hinze, C. H., Holzinger, D., Lainka, E., Haas, J. -P., Speth, F., Kallinich, T., . . . Project, P. R. O. -K. I. N. D. S. J. I. A. (2018). Practice and consensus-based strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany. PEDIATRIC RHEUMATOLOGY, 16. doi:10.1186/s12969-018-0224-2

DOI: 10.1186/s12969-018-0224-2

TCR alpha beta(+)CD3(+)CD4(-)CD8(-) (double negative) T cells in autoimmunity (Journal article)

Brandt, D., & Hedrich, C. M. (2018). TCR alpha beta(+)CD3(+)CD4(-)CD8(-) (double negative) T cells in autoimmunity. AUTOIMMUNITY REVIEWS, 17(4), 422-430. doi:10.1016/j.autrev.2018.02.001

DOI: 10.1016/j.autrev.2018.02.001

2017

Osteomyelitis bei Kindern und Jugendlichen (Journal article)

Schnabel, A., Peters, K., Hahn, G., & Hedrich, C. (2017). Osteomyelitis bei Kindern und Jugendlichen. Orthopädie & Rheuma, 20(6), 31-36. doi:10.1007/s15002-017-1016-7

DOI: 10.1007/s15002-017-1016-7

Serum Interleukin-6 and CCL11/Eotaxin May Be Suitable Biomarkers for the Diagnosis of Chronic Nonbacterial Osteomyelitis (Journal article)

Hofmann, S. R., Boettger, F., Range, U., Lueck, C., Morbach, H., Girschick, H. J., . . . Hedrich, C. M. (2017). Serum Interleukin-6 and CCL11/Eotaxin May Be Suitable Biomarkers for the Diagnosis of Chronic Nonbacterial Osteomyelitis. FRONTIERS IN PEDIATRICS, 5. doi:10.3389/fped.2017.00256

DOI: 10.3389/fped.2017.00256

The German PID-net registry (Conference Paper)

El-Helou, S. M., Biegner, A. K., Bode, S., Ehl, S., Heeg, M., Ritterbusch, H., . . . Grimbacher, B. (2017). The German PID-net registry. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 47 (pp. 174-175). Retrieved from http://gateway.webofknowledge.com/

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes (Journal article)

Grinstein, L., Endter, K., Hedrich, C. M., Reinke, S., Luksch, H., Schulze, F., . . . Winkler, S. (2018). An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes. CLINICAL IMMUNOLOGY, 191, 100-109. doi:10.1016/j.clim.2017.11.011

DOI: 10.1016/j.clim.2017.11.011

Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Anti-Inflammatory Drugs and/or with Active Spinal Lesions. (Journal article)

Zhao, Y., Wu, E. Y., Oliver, M. S., Cooper, A. M., Basiaga, M. L., Vora, S. S., . . . Rheumatolog, C. A. (2018). Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions. ARTHRITIS CARE & RESEARCH, 70(8), 1228-1237. doi:10.1002/acr.23462

DOI: 10.1002/acr.23462

Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment. (Journal article)

Hofmann, S. R., Kapplusch, F., Girschick, H. J., Morbach, H., Pablik, J., Ferguson, P. J., & Hedrich, C. M. (2017). Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment. CURRENT OSTEOPOROSIS REPORTS, 15(6), 542-554. doi:10.1007/s11914-017-0405-9

DOI: 10.1007/s11914-017-0405-9

Epigenetics in SLE (Journal article)

Hedrich, C. M. (2017). Epigenetics in SLE. CURRENT RHEUMATOLOGY REPORTS, 19(9). doi:10.1007/s11926-017-0685-1

DOI: 10.1007/s11926-017-0685-1

Neurotophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells (Journal article)

Bandola, J., Richter, C., Ryser, M., Jamal, A., Ashton, M. P., von Bonin, M., . . . Thieme, S. (2017). Neurotophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells. FRONTIERS IN IMMUNOLOGY, 8. doi:10.3389/fimmu.2017.00981

DOI: 10.3389/fimmu.2017.00981

Still's disease in children and adults (Journal article)

Hedrich, C. M., Guenther, C., & Aringer, M. (2017). Still's disease in children and adults. ZEITSCHRIFT FUR RHEUMATOLOGIE, 76(7), 595-607. doi:10.1007/s00393-017-0358-5

DOI: 10.1007/s00393-017-0358-5

Bacterial arthritis in children and adolescents, core theme treatment. Results of the Worlitz consensus meeting 2016, part 2 (Journal article)

Hospach, T., Hedrich, C., Fernandez, F., Girschick, H., Borte, M., Guenther, A., . . . Huppertz, H. -I. (2018). Bacterial arthritis in children and adolescents, core theme treatment. Results of the Worlitz consensus meeting 2016, part 2. MONATSSCHRIFT KINDERHEILKUNDE, 166(3), 239-248. doi:10.1007/s00112-017-0327-8

DOI: 10.1007/s00112-017-0327-8

The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review. (Journal article)

Hofmann, S. R., Kapplusch, F., Mäbert, K., & Hedrich, C. M. (2017). The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review.. Molecular and cellular pediatrics, 4(1), 7. doi:10.1186/s40348-017-0073-y

DOI: 10.1186/s40348-017-0073-y

TCR+ CD3(+) CD4(-) CD8(-) effector T cells in psoriasis (Journal article)

Brandt, D., Sergon, M., Abraham, S., Maebert, K., & Hedrich, C. M. (2017). TCR+ CD3(+) CD4(-) CD8(-) effector T cells in psoriasis. CLINICAL IMMUNOLOGY, 181, 51-59. doi:10.1016/j.clim.2017.06.002

DOI: 10.1016/j.clim.2017.06.002

Harmonisierung der Diagnostik und Therapie der systemischen juvenilen idiopathischen Arthritis in Deutschland (Journal article)

Hinze, C., Holzinger, D., Lainka, E., Haas, J. P., Speth, F., Kallinich, T., . . . Foell, D. (n.d.). Harmonisierung der Diagnostik und Therapie der systemischen juvenilen idiopathischen Arthritis in Deutschland. Arthritis und Rheuma.

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016. (Journal article)

van den Bruck, R., Weil, P. P., Ziegenhals, T., Schreiner, P., Juranek, S., Gödde, D., . . . Debatin, K. -M. (2017). Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.. Molecular and cellular pediatrics, 4(Suppl 1), 5. doi:10.1186/s40348-017-0071-0

DOI: 10.1186/s40348-017-0071-0

Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis (Journal article)

Schnabel, A., Range, U., Hahn, G., Berner, R., & Hedrich, C. M. (2017). Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis. JOURNAL OF RHEUMATOLOGY, 44(7), 1058-1065. doi:10.3899/jrheum.161255

DOI: 10.3899/jrheum.161255

Still's disease in children and adults (Journal article)

Hedrich, C. M., Guenther, C., & Aringer, M. (2017). Still's disease in children and adults. HAUTARZT, 68(6), 497-511. doi:10.1007/s00105-017-3983-7

DOI: 10.1007/s00105-017-3983-7

Childhood primary large vessel CNS vasculitis: single-centre experience and review of the literature (Journal article)

Walsh, S., Knöfler, R., Hahn, G., Lohse, J., Berner, R., Brenner, S., . . . Hedrich, C. M. (2017). Childhood primary large vessel CNS vasculitis: single-centre experience and review of the literature. Clinical and Experimental Rheumatology.

DNA methylation in systemic lupus erythematosus (Journal article)

Hedrich, C. M., Maebert, K., Rauen, T., & Tsokos, G. C. (2017). DNA methylation in systemic lupus erythematosus. EPIGENOMICS, 9(4), 505-525. doi:10.2217/epi-2016-0096

DOI: 10.2217/epi-2016-0096

Childhood primary large vessel CNS vasculitis: single-centre experience and review of the literature. (Journal article)

Walsh, S., Knöfler, R., Hahn, G., Lohse, J., Berner, R., Brenner, S., . . . Hedrich, C. M. (2017). Childhood primary large vessel CNS vasculitis: single-centre experience and review of the literature.. Clinical and experimental rheumatology, 35 Suppl 103(1), 213-220.

Childhood primary large-vessel CNS vasculitis: single-centre experience and review of the literature (Journal article)

Walsh, S., Knoefler, R., Hahn, G., Lohse, J., Berner, R., Brenner, S., . . . Hedrich, C. M. (2017). Childhood primary large-vessel CNS vasculitis: single-centre experience and review of the literature. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 35(1), S213-S220. Retrieved from http://gateway.webofknowledge.com/

SLE-Associated Defects Promote Altered T Cell Function (Journal article)

Crispin, J. C., Hedrich, C. M., Suarez-Fueyo, A., Comte, D., & Tsokos, G. C. (2017). SLE-Associated Defects Promote Altered T Cell Function. CRITICAL REVIEWS IN IMMUNOLOGY, 37(1), 39-58. doi:10.1615/CritRevImmunol.2018025213

DOI: 10.1615/CritRevImmunol.2018025213

2016

Unexpectedly high incidences of chronic non-bacterial as compared to bacterial osteomyelitis in children (Journal article)

Schnabel, A., Range, U., Hahn, G., Siepmann, T., Berner, R., & Hedrich, C. M. (2016). Unexpectedly high incidences of chronic non-bacterial as compared to bacterial osteomyelitis in children. RHEUMATOLOGY INTERNATIONAL, 36(12), 1737-1745. doi:10.1007/s00296-016-3572-6

DOI: 10.1007/s00296-016-3572-6

Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies (Journal article)

Hofmann, S. R., Schnabel, A., Roesen-Wolff, A., Morbach, H., Girschick, H. J., & Hedrich, C. M. (2016). Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies. JOURNAL OF RHEUMATOLOGY, 43(11), 1956-1964. doi:10.3899/jrheum.160256

DOI: 10.3899/jrheum.160256

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division (Journal article)

Stein, R., Kapplusch, F., Heymann, M. C., Russ, S., Staroske, W., Hedrich, C. M., . . . Hofmann, S. R. (2016). Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(35), 18419-18429. doi:10.1074/jbc.M116.718668

DOI: 10.1074/jbc.M116.718668

Inflammasome and Gout (Journal article)

Aringer, M., Hedrich, C., & Tausche, A. -K. (2016). Inflammasome and Gout. ZEITSCHRIFT FUR RHEUMATOLOGIE, 75(6), 537-541. doi:10.1007/s00393-016-0131-1

DOI: 10.1007/s00393-016-0131-1

Chronic nonbacterial and bacterial osteomyelitis. Differential diagnostics (Journal article)

Schnabel, A., Berner, R., & Hedrich, C. M. (2016). Chronic nonbacterial and bacterial osteomyelitis. Differential diagnostics. MONATSSCHRIFT KINDERHEILKUNDE, 164(6), 505-517. doi:10.1007/s00112-016-0094-y

DOI: 10.1007/s00112-016-0094-y

Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO) (Journal article)

Hofmann, S. R., Kubasch, A. S., Range, U., Laass, M. W., Morbach, H., Girschick, H. J., & Hedrich, C. M. (2016). Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO). RHEUMATOLOGY INTERNATIONAL, 36(6), 769-779. doi:10.1007/s00296-016-3466-7

DOI: 10.1007/s00296-016-3466-7

Caspase-1 regulates autoinflammation in rheumatic diseases (Journal article)

Winkler, S., Hedrich, C. M., & Roesen-Wolff, A. (2016). Caspase-1 regulates autoinflammation in rheumatic diseases. ZEITSCHRIFT FUR RHEUMATOLOGIE, 75(3), 265-+. doi:10.1007/s00393-016-0077-3

DOI: 10.1007/s00393-016-0077-3

Shaping the spectrum - From autoinflammation to autoimmunity (Journal article)

Hedrich, C. M. (2016). Shaping the spectrum - From autoinflammation to autoimmunity. CLINICAL IMMUNOLOGY, 165, 21-28. doi:10.1016/j.clim.2016.03.002

DOI: 10.1016/j.clim.2016.03.002

Acrodermatitis Chronica Atrophicans (Journal article)

Bruck, N., Fiebig, B., Schnabel, A., Lander, F., Berner, R., & Hedrich, C. M. (2016). Acrodermatitis Chronica Atrophicans. JOURNAL OF PEDIATRICS, 170, 335-+. doi:10.1016/j.jpeds.2015.11.011

DOI: 10.1016/j.jpeds.2015.11.011

Epigenetics (Chapter)

Hedrich, C. M. (2016). Epigenetics. In Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects (pp. 255-264). doi:10.1016/B978-0-12-801917-7.00030-9

DOI: 10.1016/B978-0-12-801917-7.00030-9

Pediatric stroke (Journal article)

Von Der Hagen, M., Bodechtel, U., Pütz, V., Hahn, G., Hedrich, C. M., Brenner, S., . . . Knöfler, R. (2016). Pediatric stroke. Padiatrische Praxis, 86(1), 55-68.

2015

Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1 beta expression and release (Journal article)

Hofmann, S. R., Kubasch, A. S., Ioannidis, C., Roesen-Wolff, A., Girschick, H. J., Morbach, H., & Hedrich, C. M. (2015). Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1 beta expression and release. CLINICAL IMMUNOLOGY, 161(2), 300-307. doi:10.1016/j.clim.2015.09.013

DOI: 10.1016/j.clim.2015.09.013

Altered Expression of IL-10 Family Cytokines in Chronic Recurrent Multifocal Osteomyelitis Result in Enhanced Inflammasome Activation (Conference Paper)

Hofmann, S., Roesen-Wolff, A., Girschick, H., Morbach, H., & Hedrich, C. (2015). Altered Expression of IL-10 Family Cytokines in Chronic Recurrent Multifocal Osteomyelitis Result in Enhanced Inflammasome Activation. In ARTHRITIS & RHEUMATOLOGY Vol. 67. Retrieved from http://gateway.webofknowledge.com/

Fluorescent tags influence the enzymatic activity and subcellular localization of procaspase-1 (Journal article)

Heymann, M. C., Rabe, S., Russ, S., Kapplusch, F., Schulze, F., Stein, R., . . . Hofmann, S. R. (2015). Fluorescent tags influence the enzymatic activity and subcellular localization of procaspase-1. CLINICAL IMMUNOLOGY, 160(2), 172-179. doi:10.1016/j.clim.2015.05.011

DOI: 10.1016/j.clim.2015.05.011

Altered expression of IL-10 family cytokines in CRMO result in enhanced inflammasome activation. (Journal article)

Hofmann, S., Kubasch, A., Rösen-Wolff, A., Girschick, H., Morbach, H., & Hedrich, C. (2015). Altered expression of IL-10 family cytokines in CRMO result in enhanced inflammasome activation.. Pediatric rheumatology online journal, 13(Suppl 1), O28. doi:10.1186/1546-0096-13-S1-O28

DOI: 10.1186/1546-0096-13-S1-O28

Choosing the right treatment for patients with a severe course of chronic non-bacterial osteomyelitis (CNO) - pamidronate or TNF-α blockade? (Journal article)

Morbach, H., Schnabel, A., Bruck, N., Holl-Wieden, A., Girschick, H., & Hedrich, C. (2015). Choosing the right treatment for patients with a severe course of chronic non-bacterial osteomyelitis (CNO) - pamidronate or TNF-α blockade?. Pediatric rheumatology online journal, 13(Suppl 1), P190. doi:10.1186/1546-0096-13-S1-P190

DOI: 10.1186/1546-0096-13-S1-P190

Serum biomarkers for the diagnosis of chronic recurrent multifocal osteomyelitis (CRMO). (Journal article)

Hofmann, S., Kubasch, A. -S., Range, U., Laass, M., Rösen-Wolff, A., Schwarz, T., . . . Hedrich, C. (2015). Serum biomarkers for the diagnosis of chronic recurrent multifocal osteomyelitis (CRMO).. Pediatric rheumatology online journal, 13(Suppl 1), O77. doi:10.1186/1546-0096-13-S1-O77

DOI: 10.1186/1546-0096-13-S1-O77

Current understanding of the pathophysiology of systemic juvenile idiopathic arthritis (sJIA) and target-directed therapeutic approaches (Journal article)

Bruck, N., Schnabel, A., & Hedrich, C. M. (2015). Current understanding of the pathophysiology of systemic juvenile idiopathic arthritis (sJIA) and target-directed therapeutic approaches. CLINICAL IMMUNOLOGY, 159(1), 72-83. doi:10.1016/j.clim.2015.04.018

DOI: 10.1016/j.clim.2015.04.018

Epigenetics and the Regulation of Inflammation (Chapter)

Hedrich, C. M. (2015). Epigenetics and the Regulation of Inflammation. In Epigenetics and Dermatology (pp. 85-111). doi:10.1016/B978-0-12-800957-4.00006-0

DOI: 10.1016/B978-0-12-800957-4.00006-0

2014

Scleroderma in childhood and adolescence-diagnosis and therapy. 1. Localized scleroderma (Journal article)

Girschick, H. J., Hedrich, C., Trcka, J., & Schäd-Trcka, S. (2014). Scleroderma in childhood and adolescence-diagnosis and therapy. 1. Localized scleroderma. Padiatrische Praxis, 83(1), 87-93.

Stat3 Promotes IL-10 Expression in SLE T Cells through Transactivation and Chromatin Remodeling (Conference Paper)

Hedrich, C., Rauen, T., Apostolidis, S., Grammatikos, A. P., Rodriguez, N. R., Ioannidis, C., . . . Tsokos, G. C. (2014). Stat3 Promotes IL-10 Expression in SLE T Cells through Transactivation and Chromatin Remodeling. In ARTHRITIS & RHEUMATOLOGY Vol. 66 (pp. S456-S457). Retrieved from http://gateway.webofknowledge.com/

Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling (Journal article)

Hedrich, C. M., Rauen, T., Apostolidis, S. A., Grammatikos, A. P., Rodriguez, N. R., Ioannidis, C., . . . Tsokos, G. C. (2014). Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(37), 13457-13462. doi:10.1073/pnas.1408023111

DOI: 10.1073/pnas.1408023111

Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells (Journal article)

Hedrich, C. M., Crispin, J. C., & Tsokos, G. C. (2014). Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells. AUTOIMMUNITY, 47(4), 234-241. doi:10.3109/08916934.2013.801462

DOI: 10.3109/08916934.2013.801462

CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance (Journal article)

Koga, T., Hedrich, C. M., Mizui, M., Yoshida, N., Otomo, K., Lieberman, L. A., . . . Tsokos, G. C. (2014). CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance. JOURNAL OF CLINICAL INVESTIGATION, 124(5), 2234-2245. doi:10.1172/JCI73411

DOI: 10.1172/JCI73411

cAMP Responsive Element Modulator (CREM) alpha Mediates Chromatin Remodeling of CD8 during the Generation of CD3(+)CD4(-)CD8(-) T Cells (Journal article)

Hedrich, C. M., Crispin, J. C., Rauen, T., Ioannidis, C., Koga, T., Rodriguez, N. R., . . . Tsokos, G. C. (2014). cAMP Responsive Element Modulator (CREM) alpha Mediates Chromatin Remodeling of CD8 during the Generation of CD3(+)CD4(-)CD8(-) T Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(4), 2361-2370. doi:10.1074/jbc.M113.523605

DOI: 10.1074/jbc.M113.523605

Scleroderma in childhood and adolescence - Diagnosis and therapy (Journal article)

Girschick, H. J., Hedrich, C., Trcka, J., & Schäd-Trcka, S. (2014). Scleroderma in childhood and adolescence - Diagnosis and therapy. Padiatrische Praxis, 83(2), 289-299.

2013

Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO) (Journal article)

Hedrich, C. M., Hofmann, S. R., Pablik, J., Morbach, H., & Girschick, H. J. (2013). Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). PEDIATRIC RHEUMATOLOGY, 11. doi:10.1186/1546-0096-11-47

DOI: 10.1186/1546-0096-11-47

cAMP-responsive Element Modulator alpha (CREM alpha) trans-Represses the Transmembrane Glycoprotein CD8 and Contributes to the Generation of CD3(+)CD4(-)CD8(-) T Cells in Health and Disease (Journal article)

Hedrich, C. M., Rauen, T., Crispin, J. C., Koga, T., Ioannidis, C., Zajdel, M., . . . Tsokos, G. C. (2013). cAMP-responsive Element Modulator alpha (CREM alpha) trans-Represses the Transmembrane Glycoprotein CD8 and Contributes to the Generation of CD3(+)CD4(-)CD8(-) T Cells in Health and Disease. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(44), 31880-31887. doi:10.1074/jbc.M113.508655

DOI: 10.1074/jbc.M113.508655

Inhibition of Calcium/Calmodulin-Dependent Protein Kinase 4 Ameliorates Th17 Related Autoimmune Disorder (Conference Paper)

Koga, T., Hedrich, C., Mizui, M., Yoshida, N., Lieberman, L., Crispin, J. C., & Tsokos, G. C. (2013). Inhibition of Calcium/Calmodulin-Dependent Protein Kinase 4 Ameliorates Th17 Related Autoimmune Disorder. In ARTHRITIS AND RHEUMATISM Vol. 65 (pp. S242). Retrieved from http://gateway.webofknowledge.com/

cAMP Responsive Element Modulator (CREM) alpha Governs CD8 Expression and Contributes to the Generation of CD3(+) CD4(-)CD8(-) T Cells in Lupus (Conference Paper)

Hedrich, C. M., Crispin, J. C., Rauen, T., Ioannidis, C., Koga, T., Rodriguez, N. R., . . . Tsokos, G. C. (2013). cAMP Responsive Element Modulator (CREM) alpha Governs CD8 Expression and Contributes to the Generation of CD3(+) CD4(-)CD8(-) T Cells in Lupus. In ARTHRITIS AND RHEUMATISM Vol. 65 (pp. S1163). Retrieved from http://gateway.webofknowledge.com/

Protein Phosphatase 2A Enables Expression of Interleukin 17 (IL-17) through Chromatin Remodeling (Journal article)

Apostolidis, S. A., Rauen, T., Hedrich, C. M., Tsokos, G. C., & Crispin, J. C. (2013). Protein Phosphatase 2A Enables Expression of Interleukin 17 (IL-17) through Chromatin Remodeling. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(37), 26775-26784. doi:10.1074/jbc.M113.483743

DOI: 10.1074/jbc.M113.483743

A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field (Journal article)

Hedrich, C. M., Hahn, G., Girschick, H. J., & Morbach, H. (2013). A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 9(9), 845-854. doi:10.1586/1744666X.2013.824670

DOI: 10.1586/1744666X.2013.824670

Pulmonary Hemosiderosis as possible Primary Manifestation of juvenile systemic Lupus erythematosus (Conference Paper)

Fiebig, B., Bruck, N., Schnabel, A., Hahn, G., Vogelberg, C., Berner, R., & Hedrich, C. (2013). Pulmonary Hemosiderosis as possible Primary Manifestation of juvenile systemic Lupus erythematosus. In ZEITSCHRIFT FUR RHEUMATOLOGIE Vol. 72 (pp. 70). Retrieved from http://gateway.webofknowledge.com/

Gene-function studies in systemic lupus erythematosus (Journal article)

Crispin, J. C., Hedrich, C. M., & Tsokos, G. C. (2013). Gene-function studies in systemic lupus erythematosus. NATURE REVIEWS RHEUMATOLOGY, 9(8), 476-484. doi:10.1038/nrrheum.2013.78

DOI: 10.1038/nrrheum.2013.78

The Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Promotes DNA Hypomethylation by Suppressing the Phosphorylated Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)/Phosphorylated ERK/DNMT1 Protein Pathway in T-cells from Controls and Systemic Lupus Erythematosus Patients (Journal article)

Sunahori, K., Nagpal, K., Hedrich, C. M., Mizui, M., Fitzgerald, L. M., & Tsokos, G. C. (2013). The Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Promotes DNA Hypomethylation by Suppressing the Phosphorylated Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)/Phosphorylated ERK/DNMT1 Protein Pathway in T-cells from Controls and Systemic Lupus Erythematosus Patients. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(30). doi:10.1074/jbc.M113.467266

DOI: 10.1074/jbc.M113.467266

Autoinflammatory bone disorders (Journal article)

Morbach, H., Hedrich, C. M., Beer, M., & Girschick, H. J. (2013). Autoinflammatory bone disorders. CLINICAL IMMUNOLOGY, 147(3), 185-196. doi:10.1016/j.clim.2012.12.012

DOI: 10.1016/j.clim.2012.12.012

Bridging the gap between autoinflammation and autoimmunity (Journal article)

Hedrich, C. M., & Tsokos, G. C. (2013). Bridging the gap between autoinflammation and autoimmunity. CLINICAL IMMUNOLOGY, 147(3), 151-154. doi:10.1016/j.clim.2013.03.006

DOI: 10.1016/j.clim.2013.03.006

cAMP responsive element modulator: a critical regulator of cytokine production (Journal article)

Rauen, T., Hedrich, C. M., Tenbrock, K., & Tsokos, G. C. (2013). cAMP responsive element modulator: a critical regulator of cytokine production. TRENDS IN MOLECULAR MEDICINE, 19(4), 262-269. doi:10.1016/j.molmed.2013.02.001

DOI: 10.1016/j.molmed.2013.02.001

Pathogenese des systemischen Lupus erythematodes (SLE) im Kindesalter (Journal article)

Hedrich, C. M., Sengler, C., & Girschick, H. J. (2013). Pathogenese des systemischen Lupus erythematodes (SLE) im Kindesalter. Arthritis und Rheuma.

2012

cAMP-responsive Element Modulator alpha (CREM alpha) Contributes to Decreased Notch-1 Expression in T Cells from Patients with Active Systemic Lupus Erythematosus (SLE) (Journal article)

Rauen, T., Grammatikos, A. P., Hedrich, C. M., Floege, J., Tenbrock, K., Ohl, K., . . . Tsokos, G. C. (2012). cAMP-responsive Element Modulator alpha (CREM alpha) Contributes to Decreased Notch-1 Expression in T Cells from Patients with Active Systemic Lupus Erythematosus (SLE). JOURNAL OF BIOLOGICAL CHEMISTRY, 287(51), 42525-42532. doi:10.1074/jbc.M112.425371

DOI: 10.1074/jbc.M112.425371

CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances ROR gamma t Recruitment to the IL17A Promoter in Human T Lymphocytes (Journal article)

Chatterjee, M., Hedrich, C. M., Rauen, T., Ioannidis, C., Terhorst, C., & Tsokos, G. C. (2012). CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances ROR gamma t Recruitment to the IL17A Promoter in Human T Lymphocytes. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(45). doi:10.1074/jbc.M112.415067

DOI: 10.1074/jbc.M112.415067

Anakinra: A safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA) (Journal article)

Hedrich, C. M., Bruck, N., Fiebig, B., & Gahr, M. (2012). Anakinra: A safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA). RHEUMATOLOGY INTERNATIONAL, 32(11), 3525-3530. doi:10.1007/s00296-011-2249-4

DOI: 10.1007/s00296-011-2249-4

cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus (Journal article)

Hedrich, C. M., Crispin, J. C., Rauen, T., Ioannidis, C., Apostolidis, S. A., Lo, M. S., . . . Tsokos, G. C. (2012). cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(41), 16606-16611. doi:10.1073/pnas.1210129109

DOI: 10.1073/pnas.1210129109

Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression (Journal article)

Hofmann, S. R., Morbach, H., Schwarz, T., Roesen-Wolff, A., Girschick, H. J., & Hedrich, C. M. (2012). Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression. CLINICAL IMMUNOLOGY, 145(1), 69-76. doi:10.1016/j.clim.2012.07.012

DOI: 10.1016/j.clim.2012.07.012

"Mutation negative" familial cold autoinflammatory syndrome (FCAS) in an 8-year-old boy: clinical course and functional studies (Journal article)

Hedrich, C. M., Bruck, N., Paul, D., Hahn, G., Gahr, M., & Roesen-Wolff, A. (2012). "Mutation negative" familial cold autoinflammatory syndrome (FCAS) in an 8-year-old boy: clinical course and functional studies. RHEUMATOLOGY INTERNATIONAL, 32(9), 2629-2636. doi:10.1007/s00296-011-2019-3

DOI: 10.1007/s00296-011-2019-3

A novel isoform of the orphan receptor ROR gamma t suppresses IL-17 production in human T cells (Journal article)

Rauen, T., Juang, Y. -T., Hedrich, C. M., Kis-Toth, K., & Tsokos, G. C. (2012). A novel isoform of the orphan receptor ROR gamma t suppresses IL-17 production in human T cells. GENES AND IMMUNITY, 13(4), 346-350. doi:10.1038/gene.2011.85

DOI: 10.1038/gene.2011.85

CAMP RESPONSIVE ELEMENT MODULATOR (CREM) ALPHA CONTRIBUTES TO DECREASED NOTCH-1 EXPRESSION IN T CELLS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) (Conference Paper)

Rauen, T., Grammatikos, A., Hedrich, C. M., Kyttaris, V. C., Tenbrock, K., Raffetseder, U., . . . Tsokos, G. C. (2013). CAMP RESPONSIVE ELEMENT MODULATOR (CREM) ALPHA CONTRIBUTES TO DECREASED NOTCH-1 EXPRESSION IN T CELLS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). In ANNALS OF THE RHEUMATIC DISEASES Vol. 71 (pp. 155). doi:10.1136/annrheumdis-2012-eular.1969

DOI: 10.1136/annrheumdis-2012-eular.1969

IMMUNOLOGICAL AND GENETIC BASIS OF CRMO (Conference Paper)

Hedrich, C. M. (2013). IMMUNOLOGICAL AND GENETIC BASIS OF CRMO. In ANNALS OF THE RHEUMATIC DISEASES Vol. 71 (pp. 10). doi:10.1136/annrheumdis-2012-eular.1514

DOI: 10.1136/annrheumdis-2012-eular.1514

Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury (Journal article)

Hofmann, S. R., Roesen-Wolff, A., Tsokos, G. C., & Hedrich, C. M. (2012). Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury. CLINICAL IMMUNOLOGY, 143(2), 116-127. doi:10.1016/j.clim.2012.02.005

DOI: 10.1016/j.clim.2012.02.005

cAMP responsive element modulator (CREM)alpha induces epigenetic remodeling of IL2 in T lymphocytes from SLE patients (Conference Paper)

Hedrich, C., Rauen, T., & Tsokos, G. (2012). cAMP responsive element modulator (CREM)alpha induces epigenetic remodeling of IL2 in T lymphocytes from SLE patients. In JOURNAL OF IMMUNOLOGY Vol. 188. Retrieved from http://gateway.webofknowledge.com/

Epigenetic patterns in systemic sclerosis and their contribution to attenuated CD70 signaling cascades (Journal article)

Hedrich, C. M., & Rauen, T. (2012). Epigenetic patterns in systemic sclerosis and their contribution to attenuated CD70 signaling cascades. CLINICAL IMMUNOLOGY, 143(1), 1-3. doi:10.1016/j.clim.2012.01.017

DOI: 10.1016/j.clim.2012.01.017

Dynamic CpG-DNA Methylation of Il10 and Il19 in CD4(+) T Lymphocytes and Macrophages: Effects on Tissue-Specific Gene Expression (Journal article)

Hofmann, S. R., Moeller, J., Rauen, T., Paul, D., Gahr, M., Roesen-Wolff, Z., . . . Hedrich, C. M. (2012). Dynamic CpG-DNA Methylation of Il10 and Il19 in CD4(+) T Lymphocytes and Macrophages: Effects on Tissue-Specific Gene Expression. KLINISCHE PADIATRIE, 224(2), 53-60. doi:10.1055/s-0031-1291359

DOI: 10.1055/s-0031-1291359

cAMP-responsive Element Modulator alpha (CREM alpha) Suppresses IL-17F Protein Expression in T Lymphocytes from Patients with Systemic Lupus Erythematosus (SLE) (Journal article)

Hedrich, C. M., Rauen, T., Kis-Toth, K., Kyttaris, V. C., & Tsokos, G. C. (2012). cAMP-responsive Element Modulator alpha (CREM alpha) Suppresses IL-17F Protein Expression in T Lymphocytes from Patients with Systemic Lupus Erythematosus (SLE). JOURNAL OF BIOLOGICAL CHEMISTRY, 287(7), 4715-4725. doi:10.1074/jbc.M111.323261

DOI: 10.1074/jbc.M111.323261

Increased Expression of SLAM Receptors SLAMF3 and SLAMF6 in Systemic Lupus Erythematosus T Lymphocytes Promotes Th17 Differentiation (Journal article)

Chatterjee, M., Rauen, T., Kis-Toth, K., Kyttaris, V. C., Hedrich, C. M., Terhorst, C., & Tsokos, G. C. (2012). Increased Expression of SLAM Receptors SLAMF3 and SLAMF6 in Systemic Lupus Erythematosus T Lymphocytes Promotes Th17 Differentiation. JOURNAL OF IMMUNOLOGY, 188(3), 1206-1212. doi:10.4049/jimmunol.1102773

DOI: 10.4049/jimmunol.1102773

Pilot study: possible association of IL10 promoter polymorphisms with CRMO (Journal article)

Hamel, J., Paul, D., Gahr, M., & Hedrich, C. M. (2012). Pilot study: possible association of IL10 promoter polymorphisms with CRMO. RHEUMATOLOGY INTERNATIONAL, 32(2), 555-556. doi:10.1007/s00296-010-1768-8

DOI: 10.1007/s00296-010-1768-8

Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3 '-Phosphatase in Maintenance of Mitochondrial Genome (Journal article)

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., . . . Hazra, T. K. (2012). Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3 '-Phosphatase in Maintenance of Mitochondrial Genome. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(4), 2819-2829. doi:10.1074/jbc.M111.272179

DOI: 10.1074/jbc.M111.272179

Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO). (Journal article)

Hofmann, S. R., Roesen-Wolff, A., Hahn, G., & Hedrich, C. M. (2012). Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO).. International journal of rheumatology, 2012, 310206. doi:10.1155/2012/310206

DOI: 10.1155/2012/310206

2011

cAMP-responsive Element Modulator (CREM)alpha Protein Induces Interleukin 17A Expression and Mediates Epigenetic Alterations at the Interleukin-17A Gene Locus in Patients with Systemic Lupus Erythematosus (Journal article)

Rauen, T., Hedrich, C. M., Juang, Y. -T., Tenbrock, K., & Tsokos, G. C. (2011). cAMP-responsive Element Modulator (CREM)alpha Protein Induces Interleukin 17A Expression and Mediates Epigenetic Alterations at the Interleukin-17A Gene Locus in Patients with Systemic Lupus Erythematosus. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(50), 43437-43446. doi:10.1074/jbc.M111.299313

DOI: 10.1074/jbc.M111.299313

cAMP-responsive Element Modulator (CREM)alpha Protein Signaling Mediates Epigenetic Remodeling of the Human Interleukin-2 Gene IMPLICATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS (Journal article)

Hedrich, C. M., Rauen, T., & Tsokos, G. C. (2011). cAMP-responsive Element Modulator (CREM)alpha Protein Signaling Mediates Epigenetic Remodeling of the Human Interleukin-2 Gene IMPLICATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(50), 43429-43436. doi:10.1074/jbc.M111.299339

DOI: 10.1074/jbc.M111.299339

Chronic non-bacterial osteomyelitis is associated with impaired Sp1 signaling, reduced IL10 promoter phosphorylation, and reduced myeloid IL-10 expression (Journal article)

Hofmann, S. R., Schwarz, T., Moeller, J. C., Morbach, H., Schnabel, A., Roesen-Wolff, A., . . . Hedrich, C. M. (2011). Chronic non-bacterial osteomyelitis is associated with impaired Sp1 signaling, reduced IL10 promoter phosphorylation, and reduced myeloid IL-10 expression. CLINICAL IMMUNOLOGY, 141(3), 317-327. doi:10.1016/j.clim.2011.08.012

DOI: 10.1016/j.clim.2011.08.012

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases (Journal article)

Hedrich, C. M., & Tsokos, G. C. (2011). Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. TRENDS IN MOLECULAR MEDICINE, 17(12), 714-724. doi:10.1016/j.molmed.2011.07.005

DOI: 10.1016/j.molmed.2011.07.005

Autologous stem cell transplantation in refractory paediatric Wegener's granulomatosis (Journal article)

Hedrich, C. M., Fiebig, B., Bruck, N., Hahn, G., Bornhaeuser, M., Gahr, M., & Suttorp, M. (2011). Autologous stem cell transplantation in refractory paediatric Wegener's granulomatosis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 29(5), 897-898. Retrieved from http://gateway.webofknowledge.com/

Mixed multilineage chimerism and course of globoid leukodystrophy after allogeneic transplantation of CD3/CD19 depleted hematopoietic cells (Conference Paper)

Link, C., Bornhaeuser, M., Thiede, C., Parmentier, S., Hedrich, C., Knoefler, R., . . . Suttorp, M. (2011). Mixed multilineage chimerism and course of globoid leukodystrophy after allogeneic transplantation of CD3/CD19 depleted hematopoietic cells. In ONKOLOGIE Vol. 34 (pp. 270). Retrieved from http://gateway.webofknowledge.com/

Presentations and Treatment of Childhood Scleroderma: Localized Scleroderma, Eosinophilic Fasciitis, Systemic Sclerosis, and Graft-Versus-Host Disease (Journal article)

Hedrich, C. M., Fiebig, B., Hahn, G., Suttorp, M., & Gahr, M. (2011). Presentations and Treatment of Childhood Scleroderma: Localized Scleroderma, Eosinophilic Fasciitis, Systemic Sclerosis, and Graft-Versus-Host Disease. CLINICAL PEDIATRICS, 50(7), 604-614. doi:10.1177/0009922810396546

DOI: 10.1177/0009922810396546

Mixed multilineage chimerism and course of globoid leukodystrophy after allogeneic transplantation of CD3/CD19 depleted haematopoietic cells (Conference Paper)

Link, C., Bornhaeuser, M., Thiede, C., Parmentier, S., Hedrich, C., Knoefler, R., . . . Suttorp, M. (2011). Mixed multilineage chimerism and course of globoid leukodystrophy after allogeneic transplantation of CD3/CD19 depleted haematopoietic cells. In BONE MARROW TRANSPLANTATION Vol. 46 (pp. S162). Retrieved from http://gateway.webofknowledge.com/

Chorioretinitis in a 7-Year-Old African Girl, Probably Related to JSSc Resolving to Methotrexate Therapy (Journal article)

Hedrich, C. M., Leszczynska, A., Hammermann, J., Bau, V., & Gahr, M. (2011). Chorioretinitis in a 7-Year-Old African Girl, Probably Related to JSSc Resolving to Methotrexate Therapy. KLINISCHE PADIATRIE, 223(2), 92-94. doi:10.1055/s-0030-1270438

DOI: 10.1055/s-0030-1270438

MENINGOENCEPHALITIS CAUSED BY VARICELLA-ZOSTER VIRUS REACTIVATION IN A CHILD WITH DOMINANT PARTIAL INTERFERON-GAMMA RECEPTOR-1 DEFICIENCY (Journal article)

Roesler, J., Hedrich, C., Laass, M. W., Heyne, K., & Roesen-Wolff, A. (2011). MENINGOENCEPHALITIS CAUSED BY VARICELLA-ZOSTER VIRUS REACTIVATION IN A CHILD WITH DOMINANT PARTIAL INTERFERON-GAMMA RECEPTOR-1 DEFICIENCY. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 30(3), 265-266. doi:10.1097/INF.0b013e3181f6f78a

DOI: 10.1097/INF.0b013e3181f6f78a

Early onset systemic lupus erythematosus: differential diagnoses, clinical presentation, and treatment options (Journal article)

Hedrich, C. M., Zappel, H., Straub, S., Laass, M. W., Wieczorek, K., Hahn, G., . . . Gahr, M. (2011). Early onset systemic lupus erythematosus: differential diagnoses, clinical presentation, and treatment options. CLINICAL RHEUMATOLOGY, 30(2), 275-283. doi:10.1007/s10067-010-1576-2

DOI: 10.1007/s10067-010-1576-2

2010

Dynamic DNA methylation patterns across the mouse and human IL10 genes during CD4(+) T cell activation, influence of IL-27 (Journal article)

Hedrich, C. M., Ramakrishnan, A., Dabitao, D., Wang, F., Ranatunga, D., & Bream, J. H. (2010). Dynamic DNA methylation patterns across the mouse and human IL10 genes during CD4(+) T cell activation, influence of IL-27. MOLECULAR IMMUNOLOGY, 48(1-3), 73-81. doi:10.1016/j.molimm.2010.09.009

DOI: 10.1016/j.molimm.2010.09.009

IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA) (Journal article)

Moeller, J. C., Paul, D., Ganser, G., Range, U., Gahr, M., Kelsch, R., . . . Hedrich, C. M. (2010). IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA). CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 28(6), 912-918. Retrieved from http://gateway.webofknowledge.com/

Cell type-specific regulation of IL-10 expression in inflammation and disease (Journal article)

Hedrich, C. M., & Bream, J. H. (2010). Cell type-specific regulation of IL-10 expression in inflammation and disease. IMMUNOLOGIC RESEARCH, 47(1-3), 185-206. doi:10.1007/s12026-009-8150-5

DOI: 10.1007/s12026-009-8150-5

Effects of cell-type specific hIL-10 expression on disease susceptibility (Conference Paper)

Ranatunga, D., Hedrich, C., Wang, F., McVicar, D., Norwak, N., Joshi, T., . . . Bream, J. (2010). Effects of cell-type specific hIL-10 expression on disease susceptibility. In JOURNAL OF IMMUNOLOGY Vol. 184. Retrieved from http://gateway.webofknowledge.com/

DNA methylation in T cell specific IL10 regulation (Conference Paper)

Hedrich, C. M., Ramakrishnan, A., Ranatunga, D., & Bream, J. H. (2010). DNA methylation in T cell specific IL10 regulation. In EUROPEAN JOURNAL OF PEDIATRICS Vol. 169 (pp. 383-384). Retrieved from http://gateway.webofknowledge.com/

2009

A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome (Journal article)

Ranatunga, D., Hedrich, C. M., Wang, F., McVicar, D. W., Nowak, N., Joshi, T., . . . Bream, J. H. (2009). A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(40), 17123-17128. doi:10.1073/pnas.0904955106

DOI: 10.1073/pnas.0904955106

A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression: implications on disease outcomes (Conference Paper)

Bream, J. H., Ranatunga, D., Hedrich, C. M., Wang, F., McVicar, D. W., Nowak, N., . . . Staeger, S. (2009). A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression: implications on disease outcomes. In CYTOKINE Vol. 48 (pp. 74-75). doi:10.1016/j.cyto.2009.07.250

DOI: 10.1016/j.cyto.2009.07.250

Autosomal Dominant Neurohypophyseal Diabetes Insipidus in Two Families (Journal article)

Hedrich, C. M., Zachurzok-Buczynska, A., Gawlik, A., Russ, S., Hahn, G., Koehler, K., . . . Huebner, A. (2009). Autosomal Dominant Neurohypophyseal Diabetes Insipidus in Two Families. HORMONE RESEARCH, 71(2), 111-119. doi:10.1159/000183900

DOI: 10.1159/000183900

2008

Chilblain lupus erythematosus-a review of literature. (Journal article)

Hedrich, C. M., Fiebig, B., Hauck, F. H., Sallmann, S., Hahn, G., Pfeiffer, C., . . . Gahr, M. (2008). Chilblain lupus erythematosus-a review of literature.. Clinical rheumatology, 27(10), 1341. doi:10.1007/s10067-008-0975-0

DOI: 10.1007/s10067-008-0975-0

Good response to IL-1 ss blockade by anakinra in a 23-year-old CINCA/NOMID patient without mutations in the CIAS1 gene. Cytokine profiles and functional studies (Journal article)

Hedrich, C. M., Fiebig, B., Sallmann, S., Bruck, N., Hahn, G., Roesler, J., . . . Gahr, M. (2008). Good response to IL-1 ss blockade by anakinra in a 23-year-old CINCA/NOMID patient without mutations in the CIAS1 gene. Cytokine profiles and functional studies. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 37(5), 385-389. doi:10.1080/03009740801978889

DOI: 10.1080/03009740801978889

Chilblain lupus erythematosus - a review of literature (Journal article)

Hedrich, C. M., Fiebig, B., Hauck, F. H., Sallmann, S., Hahn, G., Pfeiffer, C., . . . Gahr, M. (2008). Chilblain lupus erythematosus - a review of literature. CLINICAL RHEUMATOLOGY, 27(8), 949-954. doi:10.1007/s10067-008-0942-9

DOI: 10.1007/s10067-008-0942-9

Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells (Journal article)

Grant, L. R., Yao, Z. -J., Hedrich, C. M., Wang, F., Moorthy, A., Wilson, K., . . . Bream, J. H. (2008). Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells. GENES AND IMMUNITY, 9(4), 316-327. doi:10.1038/gene.2008.20

DOI: 10.1038/gene.2008.20

Osteoid osteomas of the fingers: an atypical localization? Two case reports and a review of the literature (Journal article)

Hedrich, C. M., Fiebig, B., Sallmann, S., Bruck, N., Thielemann, F., Hahn, G., . . . Gahr, M. (2008). Osteoid osteomas of the fingers: an atypical localization? Two case reports and a review of the literature. ZEITSCHRIFT FUR RHEUMATOLOGIE, 67(2), 145-+. doi:10.1007/s00393-008-0262-0

DOI: 10.1007/s00393-008-0262-0

Good response to IL-1 beta blockade by anakinra in a CINCA/NOMID patient without CIAS1 mutations (Conference Paper)

Hedrich, C., Fiebig, B., Bruck, N., Hahn, G., Roesler, J., Roesen-Wolff, A., . . . Gahr, M. (2008). Good response to IL-1 beta blockade by anakinra in a CINCA/NOMID patient without CIAS1 mutations. In CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Vol. 26 (pp. 203-204). Retrieved from http://gateway.webofknowledge.com/

2007

Chilblain Lupus erythematosus - Diagnosis and therapy with a 13-year old patients (Conference Paper)

Hedrich, C. M., Fiebig, B., Sallmann, S., Bruck, N., Hahn, G., Pfeiffer, C., . . . Gahr, M. (2007). Chilblain Lupus erythematosus - Diagnosis and therapy with a 13-year old patients. In ZEITSCHRIFT FUR RHEUMATOLOGIE Vol. 66 (pp. 633). Retrieved from http://gateway.webofknowledge.com/

Osteoid osteoma of finger - A atypical localisation? Conservative therapy approach! (Conference Paper)

Hedrich, C. M., Fiebig, B., Sallmann, S., Bruck, N., Thielemann, F., Hahn, G., . . . Gahr, M. (2007). Osteoid osteoma of finger - A atypical localisation? Conservative therapy approach!. In ZEITSCHRIFT FUR RHEUMATOLOGIE Vol. 66 (pp. 633). Retrieved from http://gateway.webofknowledge.com/

Sclerodermiform skin changes in infancy (Conference Paper)

Fiebig, B., Hedrich, C. M., Sallmann, S., Bruck, N., Pfeiffer, C., Hahn, G., . . . Gahr, M. (2007). Sclerodermiform skin changes in infancy. In ZEITSCHRIFT FUR RHEUMATOLOGIE Vol. 66 (pp. 629-630). Retrieved from http://gateway.webofknowledge.com/

Successful therapy with a 23 year old CINCA patient with anakinra: Course depending on cytokine profiles and functional analysis (Conference Paper)

Hedrich, C. M., Fiebig, B., Sallmann, S., Bruck, N., Hahn, G., Heubner, G., & Gahr, M. (2007). Successful therapy with a 23 year old CINCA patient with anakinra: Course depending on cytokine profiles and functional analysis. In ZEITSCHRIFT FUR RHEUMATOLOGIE Vol. 66 (pp. 632-633). Retrieved from http://gateway.webofknowledge.com/

Wegener's granulomatosis in pediatric patients (Journal article)

Fiebig, B., Hedrich, C. M., Heubner, G., & Gahr, M. (2007). Wegener's granulomatosis in pediatric patients. KLINISCHE PADIATRIE, 219(6), 348-354. doi:10.1055/s-2007-971047

DOI: 10.1055/s-2007-971047

Takayasu arteritis: Diagnosis, treatment and progression (Conference Paper)

Hedrich, C. M., Fiebig, B., Sallmann, S., Mayer, B., Hahn, G., & Gahr, M. (2007). Takayasu arteritis: Diagnosis, treatment and progression. In KLINISCHE PADIATRIE Vol. 219 (pp. 115). Retrieved from http://gateway.webofknowledge.com/

2006

Systemic lupus erythematosus in children and adolescents (Journal article)

Sallmann, S., Fiebig, B., Hedrich, C. M., Heubner, G., & Gahr, M. (2006). Systemic lupus erythematosus in children and adolescents. ZEITSCHRIFT FUR RHEUMATOLOGIE, 65(7), 576-+. doi:10.1007/s00393-006-0115-7

DOI: 10.1007/s00393-006-0115-7

2005

Diclofenac inhibits proliferation and matrix formation of osteoblast cells (Journal article)

Kaspar, D., Hedrich, C. M., Schmidt, C., Liedert, A., Claes, L. E., & Ignatius, A. A. (2005). Diclofenac inhibits proliferation and matrix formation of osteoblast cells. UNFALLCHIRURG, 108(1), 18-+. doi:10.1007/s00113-004-0858-z

DOI: 10.1007/s00113-004-0858-z