Professor Carrol Gamble BSc PhD

Professor of Medical Statistics Health Data Science

+44 (0)151 794 9759
Work email C.Gamble@liverpool.ac.uk

Publications

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2024

The overlap between randomised evaluations of recruitment and retention interventions: An updated review of recruitment (Online Resource for Recruitment in Clinical triAls) and retention (Online Resource for Retention in Clinical triAls) literature. (Journal article)

Kearney, A., Butlin, L., Coffey, T., Conway, T., Cotterill, S., Evans, A., . . . Gamble, C. (2024). The overlap between randomised evaluations of recruitment and retention interventions: An updated review of recruitment (Online Resource for Recruitment in Clinical triAls) and retention (Online Resource for Retention in Clinical triAls) literature.. Clinical trials (London, England), 17407745241238444. doi:10.1177/17407745241238444

DOI: 10.1177/17407745241238444

Good Statistical Practice-development of tailored Good Clinical Practice training for statisticians. (Journal article)

Stocken, D. D., Mossop, H., Armstrong, E., Lewis, S., Dutton, S. J., Peckitt, C., . . . Brown, J. (2024). Good Statistical Practice-development of tailored Good Clinical Practice training for statisticians.. Trials, 25(1), 113. doi:10.1186/s13063-024-07940-1

DOI: 10.1186/s13063-024-07940-1

Questioning approaches to consent in time critical obstetric trials: findings from a mixed-methods study. (Presentation material)

Deja, E., Weeks, A., Van Netten, C., Gamble, C., Meher, S., Gyte, G., . . . Woolfall, K. (2024). Questioning approaches to consent in time critical obstetric trials: findings from a mixed-methods study.. doi:10.1136/bmjopen-2023-081874

DOI: 10.1136/bmjopen-2023-081874

Determining a risk-proportionate approach to the validation of statistical programming for clinical trials. (Journal article)

Gamble, C., Lewis, S., Stocken, D., Juszczak, E., Bradburn, M., Doré, C., & Kean, S. (2024). Determining a risk-proportionate approach to the validation of statistical programming for clinical trials.. Clinical trials (London, England), 21(1), 85-94. doi:10.1177/17407745231204036

DOI: 10.1177/17407745231204036

Guidance to inform research recruitment processes for studies involving critically ill patients (Journal article)

Woolfall, K., Paddock, K., Watkins, M., Kearney, A., Neville, K., Frith, L., . . . Young, B. (2023). Guidance to inform research recruitment processes for studies involving critically ill patients. JOURNAL OF THE INTENSIVE CARE SOCIETY. doi:10.1177/17511437231197293

DOI: 10.1177/17511437231197293

The use of healthcare systems data for RCTs (Journal article)

Toader, A. -M., Gamble, C. L., Dodd, S., & Williamson, P. R. (n.d.). The use of healthcare systems data for RCTs. Trials, 25(1). doi:10.1186/s13063-023-07846-4

DOI: 10.1186/s13063-023-07846-4

Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage. (Journal article)

Toader, A. -M., Campbell, M. K., Quint, J. K., Robling, M., Sydes, M. R., Thorn, J., . . . Williamson, P. (2024). Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.. Trials, 25(1), 94. doi:10.1186/s13063-024-07926-z

DOI: 10.1186/s13063-024-07926-z

2023

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. (Journal article)

Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4

DOI: 10.1038/s41467-023-42320-4

Involving patients and the public In sTatistIcal Analysis pLans (INITIAL): A delphi survey. (Journal article)

Goulão, B., Morris, T. P., Blazeby, J., Gamble, C., Gillies, K., Laidlaw, L., . . . Totton, N. (2023). Involving patients and the public In sTatistIcal Analysis pLans (INITIAL): A delphi survey.. PloS one, 18(12), e0292257. doi:10.1371/journal.pone.0292257

DOI: 10.1371/journal.pone.0292257

Timing of Primary Surgery for Cleft Palate. Reply. (Journal article)

Gamble, C., & Munro, K. (2023). Timing of Primary Surgery for Cleft Palate. Reply.. The New England journal of medicine, 389(23), 2209. doi:10.1056/nejmc2311517

DOI: 10.1056/nejmc2311517

Correction: Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing. (Journal article)

Law, M., Couturier, D. -L., Choodari-Oskooei, B., Crout, P., Gamble, C., Jacko, P., . . . Jaki, T. (2023). Correction: Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing.. Trials, 24(1), 744. doi:10.1186/s13063-023-07763-6

DOI: 10.1186/s13063-023-07763-6

The development and acceptability of an educational and training intervention for recruiters to neonatal trials: the TRAIN project. (Journal article)

Smith, V., Delaney, H., Hunter, A., Torgerson, D., Treweek, S., Gamble, C., . . . Devane, D. (2023). The development and acceptability of an educational and training intervention for recruiters to neonatal trials: the TRAIN project.. BMC medical research methodology, 23(1), 265. doi:10.1186/s12874-023-02086-1

DOI: 10.1186/s12874-023-02086-1

A multi-country analysis of COVID-19 hospitalizations by vaccination status. (Journal article)

Gonçalves, B. P., Jassat, W., Baruch, J., Hashmi, M., Rojek, A., Dasgupta, A., . . . ISARIC Clinical Characterisation Group. (2023). A multi-country analysis of COVID-19 hospitalizations by vaccination status.. Med (New York, N.Y.), 4(11), 797-812.e2. doi:10.1016/j.medj.2023.08.005

DOI: 10.1016/j.medj.2023.08.005

The use of healthcare systems data for RCTs (Preprint)

DOI: 10.21203/rs.3.rs-3373403/v1

Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing. (Journal article)

Law, M., Couturier, D. -L., Choodari-Oskooei, B., Crout, P., Gamble, C., Jacko, P., . . . Jaki, T. (2023). Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing.. Trials, 24(1), 640. doi:10.1186/s13063-023-07576-7

DOI: 10.1186/s13063-023-07576-7

Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera. (Journal article)

Roper, K. J., Thomas, J., Albalawi, W., Maddocks, E., Dobson, S., Alshehri, A., . . . Pollakis, G. (2023). Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.. Scientific reports, 13(1), 15014. doi:10.1038/s41598-023-41928-2

DOI: 10.1038/s41598-023-41928-2

A second update on mapping the human genetic architecture of COVID-19. (Journal article)

COVID-19 Host Genetics Initiative. (2023). A second update on mapping the human genetic architecture of COVID-19.. Nature, 621(7977), E7-E26. doi:10.1038/s41586-023-06355-3

DOI: 10.1038/s41586-023-06355-3

Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort. (Journal article)

Shah, N., Xue, B., Xu, Z., Yang, H., Marwali, E., Dalton, H., . . . ISARIC Clinical Characterisation Group. (2023). Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort.. Artificial organs, 47(9), 1490-1502. doi:10.1111/aor.14542

DOI: 10.1111/aor.14542

Timing of Primary Surgery for Cleft Palate. (Journal article)

Gamble, C., Persson, C., Willadsen, E., Albery, L., Soegaard Andersen, H., Zattoni Antoneli, M., . . . TOPS Study Group. (2023). Timing of Primary Surgery for Cleft Palate.. The New England journal of medicine, 389(9), 795-807. doi:10.1056/nejmoa2215162

DOI: 10.1056/nejmoa2215162

Providing multimedia information to children and young people increases recruitment to trials: pre-planned meta-analysis of SWATs (Journal article)

Knapp, P., Moe-Byrne, T., Martin-Kerry, J., Sheridan, R., Roche, J., Coleman, E., . . . Ainsworth, J. (2023). Providing multimedia information to children and young people increases recruitment to trials: pre-planned meta-analysis of SWATs. BMC MEDICINE, 21(1). doi:10.1186/s12916-023-02936-1

DOI: 10.1186/s12916-023-02936-1

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (Journal article)

Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. NATURE, 617(7962), 764-+. doi:10.1038/s41586-023-06034-3

DOI: 10.1038/s41586-023-06034-3

The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection. (Journal article)

Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5

DOI: 10.1186/s13059-023-02881-5

Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19. (Journal article)

Kartsonaki, C., Baillie, J. K., Barrio, N. G., Baruch, J., Beane, A., Blumberg, L., . . . ISARIC Clinical Characterisation Group. (2023). Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.. International journal of epidemiology, dyad012. doi:10.1093/ije/dyad012

DOI: 10.1093/ije/dyad012

Factors affecting ventriculoperitoneal shunt revision: a post hoc analysis of the British Antibiotic and Silver Impregnated Catheter Shunt multicenter randomized controlled trial (Journal article)

Sunderland, G. J., Conroy, E. J., Nelson, A., Gamble, C., Jenkinson, M. D., Griffiths, M. J., & Mallucci, C. L. (2023). Factors affecting ventriculoperitoneal shunt revision: a post hoc analysis of the British Antibiotic and Silver Impregnated Catheter Shunt multicenter randomized controlled trial. JOURNAL OF NEUROSURGERY, 138(2), 483-493. doi:10.3171/2022.4.JNS22572

DOI: 10.3171/2022.4.JNS22572

Developing guidance for a risk-proportionate approach to blinding statisticians within clinical trials: a mixed methods study (Journal article)

Iflaifel, M., Sprange, K., Bell, J., Cook, A., Gamble, C., Julious, S. A., . . . Partlett, C. (2023). Developing guidance for a risk-proportionate approach to blinding statisticians within clinical trials: a mixed methods study. TRIALS, 24(1). doi:10.1186/s13063-022-06992-5

DOI: 10.1186/s13063-022-06992-5

Inter-rater reliability in classification of canonical babbling status based on canonical babbling ratio in infants with isolated cleft palate randomised to Timing of Primary Surgery for Cleft Palate (TOPS) (Journal article)

Willadsen, E., Cooper, R., Conroy, E., Gamble, C., Albery, L., Andersen, H., . . . Persson, C. (n.d.). Inter-rater reliability in classification of canonical babbling status based on canonical babbling ratio in infants with isolated cleft palate randomised to Timing of Primary Surgery for Cleft Palate (TOPS). Clinical Linguistics & Phonetics, 1-22. doi:10.1080/02699206.2021.2012259

DOI: 10.1080/02699206.2021.2012259

Qualitative data sharing practices in clinical trials in the UK and Ireland: towards the production of good practice guidance. (Journal article)

McCarthy, M., Gillies, K., Rousseau, N., Wade, J., Gamble, C., Toomey, E., . . . Houghton, C. (2023). Qualitative data sharing practices in clinical trials in the UK and Ireland: towards the production of good practice guidance.. HRB open research, 6, 10. doi:10.12688/hrbopenres.13667.1

DOI: 10.12688/hrbopenres.13667.1

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (Journal article)

Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402

DOI: 10.1016/j.ebiom.2022.104402

The effectiveness and acceptability of multimedia information when recruiting children and young people to trials: the TRECA meta-analysis of SWATs. (Journal article)

Knapp, P., Martin-Kerry, J., Moe-Byrne, T., Sheridan, R., Coleman, E., Roche, J., . . . Stones, C. (2023). The effectiveness and acceptability of multimedia information when recruiting children and young people to trials: the TRECA meta-analysis of SWATs.. Health and social care delivery research, 11(24), 1-112. doi:10.3310/htpm3841

DOI: 10.3310/htpm3841

2022

Apixaban following discharge in hospitalised adults with COVID-19: Preliminary results from a multicentre, open-label, randomised controlled platform clinical trial (Preprint)

DOI: 10.1101/2022.12.07.22283175

Query Resolution of Literature Knowledge Graphs using Hybrid Document Embeddings. (Conference Paper)

Coenen, F., Muhammad, I., Gamble, C., Kearney, A., & Williams, P. (2022). Query Resolution of Literature Knowledge Graphs using Hybrid Document Embeddings..

Response to Medicines and Healthcare products Regulatory Agency’s “Consultation on proposals for legislative changes for clinical trials” (Preprint)

DOI: 10.21203/rs.3.rs-2210654/v1

Learning from stakeholders to inform good practice guidance on consent to research in intensive care units: a mixed-methods study. (Journal article)

Paddock, K., Woolfall, K., Kearney, A., Pattison, N., Frith, L., Gamble, C., . . . Young, B. (2022). Learning from stakeholders to inform good practice guidance on consent to research in intensive care units: a mixed-methods study.. BMJ open, 12(11), e066149. doi:10.1136/bmjopen-2022-066149

DOI: 10.1136/bmjopen-2022-066149

Managing clustering effects and learning effects in the design and analysis of randomised surgical trials: a review of existing guidance (Journal article)

Conroy, E. J., Blazeby, J. M., Burnside, G., Cook, J. A., & Gamble, C. (2022). Managing clustering effects and learning effects in the design and analysis of randomised surgical trials: a review of existing guidance. TRIALS, 23(1). doi:10.1186/s13063-022-06743-6

DOI: 10.1186/s13063-022-06743-6

Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study (Journal article)

Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531

DOI: 10.1093/ofid/ofac531

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19. (Journal article)

Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585

DOI: 10.1111/imm.13585

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study (Journal article)

Reyes, L. F., Murthy, S., Garcia-Gallo, E., Merson, L., Ibanez-Prada, E. D., Rello, J., . . . Olliaro, P. L. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. CRITICAL CARE, 26(1). doi:10.1186/s13054-022-04155-1

DOI: 10.1186/s13054-022-04155-1

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19 (Journal article)

Garcia-Gallo, E., Merson, L., Kennon, K., Kelly, S., Citarella, B. W., Fryer, D. V., . . . Reyes, L. F. (2022). ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. SCIENTIFIC DATA, 9(1). doi:10.1038/s41597-022-01534-9

DOI: 10.1038/s41597-022-01534-9

Opportunities and challenges for the development of "core outcome sets" in neuro-oncology (Journal article)

Millward, C. P., Armstrong, T. S., Barrington, H., Brodbelt, A. R., Bulbeck, H., Byrne, A., . . . Jenkinson, M. D. (2022). Opportunities and challenges for the development of "core outcome sets" in neuro-oncology. NEURO-ONCOLOGY, 24(7), 1048-1055. doi:10.1093/neuonc/noac062

DOI: 10.1093/neuonc/noac062

Blinding of study statisticians in clinical trials: a qualitative study in UK clinical trials units (Journal article)

Iflaifel, M., Partlett, C., Bell, J., Cook, A., Gamble, C., Julious, S., . . . Sprange, K. (2022). Blinding of study statisticians in clinical trials: a qualitative study in UK clinical trials units. TRIALS, 23(1). doi:10.1186/s13063-022-06481-9

DOI: 10.1186/s13063-022-06481-9

SURG-13. The COMBAT Project - Core post operative morbidity set for paediatric brain tumours (Journal article)

Trichinopoly Krishna, S., Millward, C., Mallucci, C., Gamble, C., Jenkinson, M., & Pizer, B. (2022). SURG-13. The COMBAT Project - Core post operative morbidity set for paediatric brain tumours. Neuro-Oncology, 24(Supplement_1), i144-i145. doi:10.1093/neuonc/noac079.531

DOI: 10.1093/neuonc/noac079.531

Increased transparency was required when reporting imputation of primary outcome data in clinical trials (Journal article)

Kearney, A., Rosala-Hallas, A., Rainford, N., Blazeby, J. M., Clarke, M., Lane, A. J., & Gamble, C. (2022). Increased transparency was required when reporting imputation of primary outcome data in clinical trials. JOURNAL OF CLINICAL EPIDEMIOLOGY, 146, 60-67. doi:10.1016/j.jclinepi.2022.02.008

DOI: 10.1016/j.jclinepi.2022.02.008

Visualising harms in publications of randomised controlled trials: consensus and recommendations. (Journal article)

Phillips, R., Cro, S., Wheeler, G., Bond, S., Morris, T. P., Creanor, S., . . . Cornelius, V. (2022). Visualising harms in publications of randomised controlled trials: consensus and recommendations.. BMJ (Clinical research ed.), 377, e068983. doi:10.1136/bmj-2021-068983

DOI: 10.1136/bmj-2021-068983

Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (Journal article)

Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/

Early phase clinical trials extension to guidelines for the content of statistical analysis plans (Journal article)

Homer, V., Yap, C., Bond, S., Holmes, J., Stocken, D., Walker, K., . . . Gaunt, P. (2022). Early phase clinical trials extension to guidelines for the content of statistical analysis plans. BMJ-BRITISH MEDICAL JOURNAL, 376. doi:10.1136/bmj-2021-068177

DOI: 10.1136/bmj-2021-068177

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. (Journal article)

Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046

DOI: 10.1016/j.cell.2021.12.046

Developing an online, searchable database to systematically map and organise current literature on retention research (ORRCA2) (Journal article)

Kearney, A., Ashford, P. -A., Butlin, L., Conway, T., Cragg, W. J., Devane, D., . . . Gamble, C. (2022). Developing an online, searchable database to systematically map and organise current literature on retention research (ORRCA2). CLINICAL TRIALS, 19(1), 71-80. doi:10.1177/17407745211053803

DOI: 10.1177/17407745211053803

A Concept Analysis of 'trial recruitment' using a modified Hybrid Model (Conference Paper)

Delaney, H., Devane, D., Hunter, A., Treweek, S., Gamble, C., Mills, N., & Smith, V. (2019). A Concept Analysis of 'trial recruitment' using a modified Hybrid Model. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (Journal article)

Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629

DOI: 10.1136/thoraxjnl-2021-217629

THE COMBAT PROJECT - CORE POST OPERATIVE MORBIDITY SET FOR PAEDIATRIC BRAIN TUMOURS (Conference Paper)

Krishna, S. T., Millward, C., Mallucci, C., Gamble, C., Jenkinson, M., & Pizer, B. (2022). THE COMBAT PROJECT - CORE POST OPERATIVE MORBIDITY SET FOR PAEDIATRIC BRAIN TUMOURS. In NEURO-ONCOLOGY Vol. 24 (pp. 144-145). Retrieved from https://www.webofscience.com/

2021

Mapping the human genetic architecture of COVID-19 (Journal article)

Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-x

DOI: 10.1038/s41586-021-03767-x

The value of open-source clinical science in pandemic response: lessons from ISARIC (Journal article)

The value of open-source clinical science in pandemic response: lessons from ISARIC (2021). LANCET INFECTIOUS DISEASES, 21(12), 1623-1624. doi:10.1016/S1473-3099(21)00565-X

DOI: 10.1016/S1473-3099(21)00565-X

A risk-adjusted and anatomically stratified cohort comparison study of open surgery, endovascular techniques and medical management for juxtarenal aortic aneurysms-the UK COMPlex AneurySm Study (UK-COMPASS): a study protocol. (Journal article)

Patel, S. R., Ormesher, D. C., Smith, S. R., Wong, K. H. F., Bevis, P., Bicknell, C. D., . . . Vallabhaneni, S. R. (2021). A risk-adjusted and anatomically stratified cohort comparison study of open surgery, endovascular techniques and medical management for juxtarenal aortic aneurysms-the UK COMPlex AneurySm Study (UK-COMPASS): a study protocol.. BMJ open, 11(11), e054493. doi:10.1136/bmjopen-2021-054493

DOI: 10.1136/bmjopen-2021-054493

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells (Journal article)

de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353

DOI: 10.1016/j.isci.2021.103353

Reducing bias in trials due to reactions to measurement: experts produced recommendations informed by evidence. (Journal article)

French, D. P., Miles, L. M., Elbourne, D., Farmer, A., Gulliford, M., Locock, L., . . . MERIT Collaborative Group. (2021). Reducing bias in trials due to reactions to measurement: experts produced recommendations informed by evidence.. Journal of clinical epidemiology, 139, 130-139. doi:10.1016/j.jclinepi.2021.06.028

DOI: 10.1016/j.jclinepi.2021.06.028

A prenylated dsRNA sensor protects against severe COVID-19 (Journal article)

Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624

DOI: 10.1126/science.abj3624

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study (Journal article)

Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Zucman, D. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION, 49(5), 889-905. doi:10.1007/s15010-021-01599-5

DOI: 10.1007/s15010-021-01599-5

Strategies to enhance recruitment and consent to intensive care studies: a qualitative study with researchers and patient-public involvement contributors (Journal article)

Paddock, K., Woolfall, K., Frith, L., Watkins, M., Gamble, C., Welters, I., & Young, B. (2021). Strategies to enhance recruitment and consent to intensive care studies: a qualitative study with researchers and patient-public involvement contributors. BMJ OPEN, 11(9). doi:10.1136/bmjopen-2020-048193

DOI: 10.1136/bmjopen-2020-048193

Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK (Journal article)

Vaselli, N. M., Setiabudi, W., Subramaniam, K., Adams, E. R., Turtle, L., Iturriza-Gomara, M., . . . Hungerford, D. (2021). Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06443-7

DOI: 10.1186/s12879-021-06443-7

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study (Journal article)

Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2

DOI: 10.1016/S2666-5247(21)00090-2

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study (Journal article)

Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK (Journal article)

Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2

DOI: 10.1016/S2213-2600(21)00175-2

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study. (Journal article)

Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1

DOI: 10.1016/s2665-9913(21)00104-1

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort (Journal article)

Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178

DOI: 10.1002/oby.23178

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK (Journal article)

Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8

DOI: 10.1016/S2213-2600(21)00013-8

Evaluation of the effectiveness of remdesivir in severe COVID-19 using observational data from a prospective national cohort study (Preprint)

DOI: 10.1101/2021.06.18.21259072

Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England (Journal article)

Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-x

DOI: 10.1186/s12913-021-06509-x

Neurosurgical CSF Diversion in Idiopathic Intracranial Hypertension: A Narrative Review (Journal article)

Sunderland, G. J., Jenkinson, M. D., Conroy, E. J., Gamble, C., & Mallucci, C. L. (2021). Neurosurgical CSF Diversion in Idiopathic Intracranial Hypertension: A Narrative Review. LIFE-BASEL, 11(5). doi:10.3390/life11050393

DOI: 10.3390/life11050393

Genetic mechanisms of critical illness in COVID-19 (Journal article)

Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-y

DOI: 10.1038/s41586-020-03065-y

Planning for success: overcoming challenges to recruitment and conduct of an open-label emergency department–led paediatric trial (Journal article)

Roper, L., Lyttle, M. D., Gamble, C., Humphreys, A., Messahel, S., Lee, E. D., . . . Woolfall, K. (n.d.). Planning for success: overcoming challenges to recruitment and conduct of an open-label emergency department–led paediatric trial. Emergency Medicine Journal. doi:10.1136/emermed-2020-209487

DOI: 10.1136/emermed-2020-209487

Seven-step framework to enhance practitioner explanations and parental understandings of research without prior consent in paediatric emergency and critical care trials (Journal article)

Roper, L., Lyttle, M. D., Gamble, C., Humphreys, A., Messahel, S., Lee, E. D., . . . Woolfall, K. (2021). Seven-step framework to enhance practitioner explanations and parental understandings of research without prior consent in paediatric emergency and critical care trials. EMERGENCY MEDICINE JOURNAL, 38(3), 198-204. doi:10.1136/emermed-2020-209488

DOI: 10.1136/emermed-2020-209488

Adding a fourth rater to three had little impact in pre-linguistic outcome classification (Journal article)

Persson, C., Conroy, E. J., Gamble, C., Rosala-Hallas, A., Shaw, W., & Willadsen, E. (2021). Adding a fourth rater to three had little impact in pre-linguistic outcome classification. CLINICAL LINGUISTICS & PHONETICS, 35(2), 138-153. doi:10.1080/02699206.2020.1758793

DOI: 10.1080/02699206.2020.1758793

A randomised controlled trial comparing palate surgery at 6 months versus 12 months of age (the TOPS trial): a statistical analysis plan (Journal article)

Conroy, E. J., Cooper, R., Shaw, W., Persson, C., Willadsen, E., Munro, K. J., . . . Gamble, C. (2021). A randomised controlled trial comparing palate surgery at 6 months versus 12 months of age (the TOPS trial): a statistical analysis plan. TRIALS, 22(1). doi:10.1186/s13063-020-04886-y

DOI: 10.1186/s13063-020-04886-y

A study protocol of qualitative data sharing practices in clinical trials in the UK and Ireland: towards the production of good practice guidance. (Journal article)

Houghton, C., McCarthy, M., Gillies, K., Rousseau, N., Wade, J., Gamble, C., . . . Biesty, L. (2021). A study protocol of qualitative data sharing practices in clinical trials in the UK and Ireland: towards the production of good practice guidance.. HRB open research, 4, 47. doi:10.12688/hrbopenres.13269.2

DOI: 10.12688/hrbopenres.13269.2

Document Ranking for Curated Document Databases Using BERT and Knowledge Graph Embeddings: Introducing GRAB-Rank (Conference Paper)

Muhammad, I., Bollegala, D., Coenen, F., Gamble, C., Kearney, A., & Williamson, P. (2021). Document Ranking for Curated Document Databases Using BERT and Knowledge Graph Embeddings: Introducing GRAB-Rank. In BIG DATA ANALYTICS AND KNOWLEDGE DISCOVERY (DAWAK 2021) Vol. 12925 (pp. 116-127). doi:10.1007/978-3-030-86534-4_10

DOI: 10.1007/978-3-030-86534-4_10

2020

A concept analysis of ‘trial recruitment’ using the hybrid model – Phase 1 findings (Journal article)

Delaney, H., Devane, D., Hunter, A., Treweek, S., Mills, N., Gamble, C., & Smith, V. (n.d.). A concept analysis of ‘trial recruitment’ using the hybrid model – Phase 1 findings. HRB Open Research, 3, 92. doi:10.12688/hrbopenres.13173.1

DOI: 10.12688/hrbopenres.13173.1

RTID-10. SURGEONS TRIAL OF PROPHYLAXIS FOR EPILEPSY IN SEIZURE NAÏVE PATIENTS WITH MENINGIOMA: A RANDOMIZED CONTROLLED TRIAL (STOP ‘EM) (Journal article)

Jenkinson, M., Helmy, A., Huckey, H., Mills, S., Grant, R., Hughes, D., . . . Gamble, C. (2020). RTID-10. SURGEONS TRIAL OF PROPHYLAXIS FOR EPILEPSY IN SEIZURE NAÏVE PATIENTS WITH MENINGIOMA: A RANDOMIZED CONTROLLED TRIAL (STOP ‘EM). Neuro-Oncology, 22(Supplement_2), ii195. doi:10.1093/neuonc/noaa215.815

DOI: 10.1093/neuonc/noaa215.815

Antimicrobial-impregnated central venous catheters for preventing neonatal bloodstream infection: the PREVAIL RCT (Journal article)

Gilbert, R., Brown, M., Faria, R., Fraser, C., Donohue, C., Rainford, N., . . . Oddie, S. J. (n.d.). Antimicrobial-impregnated central venous catheters for preventing neonatal bloodstream infection: the PREVAIL RCT. Health Technology Assessment, 24(57), 1-190. doi:10.3310/hta24570

DOI: 10.3310/hta24570

Antimicrobial-impregnated central venous catheters for preventing neonatal bloodstream infection: the PREVAIL RCT. (Journal article)

Gilbert, R., Brown, M., Faria, R., Fraser, C., Donohue, C., Rainford, N., . . . Oddie, S. J. (2020). Antimicrobial-impregnated central venous catheters for preventing neonatal bloodstream infection: the PREVAIL RCT.. Health technology assessment (Winchester, England), 24(57), 1-190. doi:10.1093/ije/dyw098

DOI: 10.1093/ije/dyw098

Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis (Journal article)

Gross--Hodge, E., Carroll, W. D., Rainford, N., Gamble, C., & Gilchrist, F. J. (2020). Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis. ARCHIVES OF DISEASE IN CHILDHOOD, 105(11), 1111-1113. doi:10.1136/archdischild-2019-317917

DOI: 10.1136/archdischild-2019-317917

Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT. (Journal article)

Appleton, R. E., Rainford, N. E., Gamble, C., Messahel, S., Humphreys, A., Hickey, H., . . . Lyttle, M. D. (2020). Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT.. Health technology assessment (Winchester, England), 24(58), 1-96. doi:10.3310/hta24580

DOI: 10.3310/hta24580

Prospective reporting of statistical analysis plans for randomised controlled trials (Journal article)

Hemming, K., Kearney, A., Gamble, C., Li, T., Juni, P., Chan, A. -W., & Sydes, M. R. (2020). Prospective reporting of statistical analysis plans for randomised controlled trials. TRIALS, 21(1). doi:10.1186/s13063-020-04828-8

DOI: 10.1186/s13063-020-04828-8

Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020 (Journal article)

Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685

DOI: 10.2807/1560-7917.ES.2020.25.42.2000685

Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19 (Journal article)

Gupta, R., Harrison, E., Ho, A., Docherty, A., Knight, S., van Smeden, M., . . . Noursadeghi, M. (2020). Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19. doi:10.1101/2020.10.09.20209957

DOI: 10.1101/2020.10.09.20209957

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. (Journal article)

Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339

DOI: 10.1136/bmj.m3339

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score (Journal article)

Knight, S., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T., . . . Harrison, E. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. doi:10.1101/2020.07.30.20165464

DOI: 10.1101/2020.07.30.20165464

Statistical models to predict recruitment in clinical trials were rarely used by statisticians in UK and European networks (Journal article)

Gkioni, E., Dodd, S., Rius, R., & Gamble, C. (2020). Statistical models to predict recruitment in clinical trials were rarely used by statisticians in UK and European networks. JOURNAL OF CLINICAL EPIDEMIOLOGY, 124, 58-68. doi:10.1016/j.jclinepi.2020.03.012

DOI: 10.1016/j.jclinepi.2020.03.012

Understanding and optimising patient and public involvement in trial oversight: an ethnographic study of eight clinical trials (Journal article)

Coulman, K. D., Nicholson, A., Shaw, A., Daykin, A., Selman, L. E., Macefield, R., . . . Lane, J. A. (2020). Understanding and optimising patient and public involvement in trial oversight: an ethnographic study of eight clinical trials. TRIALS, 21(1). doi:10.1186/s13063-020-04495-9

DOI: 10.1186/s13063-020-04495-9

Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients (Journal article)

Harrison, E., Docherty, A., Barr, B., Buchan, I., Carson, G., Drake, T., . . . Investigators, I. (2020). Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients. doi:10.2139/ssrn.3618215

DOI: 10.2139/ssrn.3618215

P154: "Do the best you can until you know better": Why, how and when Pilot and Feasibility Studies (PFS) should be utilised to optimise surgical trials (Journal article)

Fairhurst, K., Potter, S., Blazeby, J., Gamble, C., & Avery, K. (2020). P154: "Do the best you can until you know better": Why, how and when Pilot and Feasibility Studies (PFS) should be utilised to optimise surgical trials. European Journal of Surgical Oncology, 46(6), e51. doi:10.1016/j.ejso.2020.03.193

DOI: 10.1016/j.ejso.2020.03.193

Use of routinely collected data in a UK cohort of publicly funded randomised clinical trials [version 2] (Journal article)

McKay, A., Jones, A., Gamble, C., Farmer, A., & Williamson, P. (2020). Use of routinely collected data in a UK cohort of publicly funded randomised clinical trials [version 2]. F1000Research. doi:10.12688/f1000research.23316.2

DOI: 10.12688/f1000research.23316.2

Managing clustering effects and learning effects in the design and analysis of multicentre randomised trials: a survey to establish current practice. (Journal article)

Conroy, E. J., Blazeby, J. M., Burnside, G., Cook, J. A., & Gamble, C. (2020). Managing clustering effects and learning effects in the design and analysis of multicentre randomised trials: a survey to establish current practice.. Trials, 21. doi:10.1186/s13063-020-04318-x

DOI: 10.1186/s13063-020-04318-x

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. (Journal article)

Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H. E., Pius, R., Norman, L., . . . ISARIC4C investigators. (2020). Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.. BMJ (Clinical research ed.), 369. doi:10.1136/bmj.m1985

DOI: 10.1136/bmj.m1985

Use of routinely collected data in a UK cohort of publicly funded randomised clinical trials [version 1] (Journal article)

McKay, A. J., Jones, A. P., Gamble, C. L., Farmer, A. J., & Williamson, P. R. (2020). Use of routinely collected data in a UK cohort of publicly funded randomised clinical trials [version 1]. F1000Research, 9. doi:10.12688/f1000research.23316.1

DOI: 10.12688/f1000research.23316.1

Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (Journal article)

Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H., Pius, R., Norman, L., . . . ISARIC4C Investigators. (2020). Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. doi:10.1101/2020.04.23.20076042

DOI: 10.1101/2020.04.23.20076042

Challenges Conveying Clinical Equipoise and Exploring Patient Treatment Preferences in an Oncology Trial Comparing Active Monitoring with Radiotherapy (ROAM/EORTC 1308) (Journal article)

Sherratt, F. C., Brown, S. L., Haylock, B. J., Francis, P., Hickey, H., Gamble, C., . . . Young, B. (2020). Challenges Conveying Clinical Equipoise and Exploring Patient Treatment Preferences in an Oncology Trial Comparing Active Monitoring with Radiotherapy (ROAM/EORTC 1308). ONCOLOGIST, 25(4), E691-E700. doi:10.1634/theoncologist.2019-0571

DOI: 10.1634/theoncologist.2019-0571

A third trial oversight committee: Functions, benefits and issues (Journal article)

Lane, J. A., Gamble, C., Cragg, W. J., Tembo, D., & Sydes, M. R. (2020). A third trial oversight committee: Functions, benefits and issues. CLINICAL TRIALS, 17(1), 106-112. doi:10.1177/1740774519881619

DOI: 10.1177/1740774519881619

Maintaining Curated Document Databases Using a Learning to Rank Model: The ORRCA Experience (Conference Paper)

Muhammad, I., Bollegala, D., Coenen, F., Gamble, C., Kearney, A., & Williamson, P. (2020). Maintaining Curated Document Databases Using a Learning to Rank Model: The ORRCA Experience. In Unknown Conference (pp. 345-357). Springer International Publishing. doi:10.1007/978-3-030-63799-6_26

DOI: 10.1007/978-3-030-63799-6_26

Open Information Extraction for Knowledge Graph Construction (Conference Paper)

Muhammad, I., Kearney, A., Gamble, C., Coenen, F., & Williamson, P. (2020). Open Information Extraction for Knowledge Graph Construction. In Unknown Conference (pp. 103-113). Springer International Publishing. doi:10.1007/978-3-030-59028-4_10

DOI: 10.1007/978-3-030-59028-4_10

SURGEONS TRIAL OF PROPHYLAXIS FOR EPILEPSY IN SEIZURE NAIVE PATIENTS WITH MENINGIOMA: A RANDOMIZED CONTROLLED TRIAL (STOP 'EM) (Conference Paper)

Jenkinson, M., Helmy, A., Huckey, H., Mills, S., Grant, R., Hughes, D., . . . Gamble, C. (2020). SURGEONS TRIAL OF PROPHYLAXIS FOR EPILEPSY IN SEIZURE NAIVE PATIENTS WITH MENINGIOMA: A RANDOMIZED CONTROLLED TRIAL (STOP 'EM). In NEURO-ONCOLOGY Vol. 22 (pp. 195). Retrieved from https://www.webofscience.com/

Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT (Journal article)

Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Moitt, T., . . . Gamble, C. (2020). Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT. HEALTH TECHNOLOGY ASSESSMENT, 24(17), 1-+. doi:10.3310/hta24170

DOI: 10.3310/hta24170

2019

A systematic review describes models for recruitment prediction at the design stage of a clinical trial (Journal article)

Gkioni, E., Rius, R., Dodd, S., & Gamble, C. (2019). A systematic review describes models for recruitment prediction at the design stage of a clinical trial. Journal of Clinical Epidemiology, 115, 141-149. doi:10.1016/j.jclinepi.2019.07.002

DOI: 10.1016/j.jclinepi.2019.07.002

What are the most important unanswered research questions in trial retention? A James Lind Alliance Priority Setting Partnership: the PRioRiTy II (Prioritising Retention in Randomised Trials) study (Journal article)

Brunsdon, D., Biesty, L., Brocklehurst, P., Brueton, V., Devane, D., Elliott, J., . . . Gillies, K. (2019). What are the most important unanswered research questions in trial retention? A James Lind Alliance Priority Setting Partnership: the PRioRiTy II (Prioritising Retention in Randomised Trials) study. Trials, 20. doi:10.1186/s13063-019-3687-7

DOI: 10.1186/s13063-019-3687-7

Allowance for learning and clustering effects in the design and analysis of multicentre randomised trials: current practice and experiences (Conference Paper)

Conroy, E. J., Blazeby, J. M., Burnside, G., Cook, J. A., & Gamble, C. (2019). Allowance for learning and clustering effects in the design and analysis of multicentre randomised trials: current practice and experiences. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Managing learning and clustering effects at the design stage in randomised surgical trials: a retrospective cohort of trial funding applications (Conference Paper)

Conroy, E., Rosala-Hallas, A., Blazeby, J. M., Burnside, G., Cook, J. A., & Gamble, C. (2019). Managing learning and clustering effects at the design stage in randomised surgical trials: a retrospective cohort of trial funding applications. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Measuring speech development in infants: methodological considerations based on experiences within the TOPS trial (Conference Paper)

Cooper, R., Conroy, E. J., Gamble, C., Willadsen, E., Persson, C., & Shaw, W. (2019). Measuring speech development in infants: methodological considerations based on experiences within the TOPS trial. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Exploring patient treatment preferences enhances trial recruitment, so why do trial recruiters often avoid doing it? (Conference Paper)

Sherratt, F. C., Beasant, L., Crawley, E., Hall, N. J., Francis, P., Hickey, H., . . . Young, B. (2019). Exploring patient treatment preferences enhances trial recruitment, so why do trial recruiters often avoid doing it?. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

ORRCA and ORRCA2: A large-scale, international, collaboration to map recruitment and retention literature (Conference Paper)

Kearney, A., Rosala-Hallas, A., Cragg, W. J., Devane, D., Gillies, K., Harman, N. L., . . . Gamble, C. (2019). ORRCA and ORRCA2: A large-scale, international, collaboration to map recruitment and retention literature. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis (Conference Paper)

Grose-Hodge, E., Carroll, W., Rainford, N., Gamble, C., & Gilchrist, F. (2019). Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis. In EUROPEAN RESPIRATORY JOURNAL Vol. 54. doi:10.1183/13993003.congress-2019.PA5002

DOI: 10.1183/13993003.congress-2019.PA5002

A review of current practice in the design and assessment of internal pilots in UK NIHR clinical trials (Journal article)

Rosala-Hallas, A., Gamble, C., Blazeby, J., & Williamson, P. R. (2019). A review of current practice in the design and assessment of internal pilots in UK NIHR clinical trials. TRIALS, 20(1). doi:10.1186/s13063-019-3669-9

DOI: 10.1186/s13063-019-3669-9

Managing clustering effects and learning effects in the design and analysis of multicentre randomised trials: A survey to establish current practice (Journal article)

Conroy, E., Blazeby, J., Burnside, G., Cook, J., & Gamble, C. (2019). Managing clustering effects and learning effects in the design and analysis of multicentre randomised trials: A survey to establish current practice. doi:10.21203/rs.2.14122/v1

DOI: 10.21203/rs.2.14122/v1

Funders improved the management of learning and clustering effects through design and analysis of randomized trials involving surgery (Journal article)

Conroy, E. J., Rosala-Hallas, A., Blazeby, J. M., Burnside, G., Cook, J. A., & Gamble, C. (2019). Funders improved the management of learning and clustering effects through design and analysis of randomized trials involving surgery. JOURNAL OF CLINICAL EPIDEMIOLOGY, 113, 28-35. doi:10.1016/j.jclinepi.2019.05.007

DOI: 10.1016/j.jclinepi.2019.05.007

Clinical trial data sharing: here's the challenge. (Journal article)

Kochhar, S., Knoppers, B., Gamble, C., Chant, A., Koplan, J., & Humphreys, G. S. (2019). Clinical trial data sharing: here's the challenge.. BMJ open, 9(8), e032334. doi:10.1136/bmjopen-2019-032334

DOI: 10.1136/bmjopen-2019-032334

Timing Of Primary Surgery for cleft palate (TOPS): protocol for a randomised trial of palate surgery at 6 months versus 12 months of age (Journal article)

Shaw, W., Semb, G., Lohmander, A., Persson, C., Willadsen, E., Clayton-Smith, J., . . . Williamson, P. (2019). Timing Of Primary Surgery for cleft palate (TOPS): protocol for a randomised trial of palate surgery at 6 months versus 12 months of age. BMJ OPEN, 9(7). doi:10.1136/bmjopen-2019-029780

DOI: 10.1136/bmjopen-2019-029780

Value of surgical pilot and feasibility study protocols (Journal article)

Fairhurst, K., Blazeby, J. M., Potter, S., Gamble, C., Rowlands, C., & Avery, K. N. L. (2019). Value of surgical pilot and feasibility study protocols. British Journal of Surgery, 106(8), 968-978. doi:10.1002/bjs.11167

DOI: 10.1002/bjs.11167

DIABRISK-SL trial: further consideration of age and impact of imputations (Journal article)

Gkioni, E., Glonti, K., Dodd, S., & Gamble, C. (2019). DIABRISK-SL trial: further consideration of age and impact of imputations. BMC MEDICINE, 17. doi:10.1186/s12916-019-1361-2

DOI: 10.1186/s12916-019-1361-2

A descriptive study of syllable inventory in 12 month old infants with isolated cleft palate: results from 485 infants (Conference Paper)

Persson, C., Cooper, R., Conroy, E. J., Gamble, C., & Willadsen, E. (2019, June 12). A descriptive study of syllable inventory in 12 month old infants with isolated cleft palate: results from 485 infants. In European Cleft Palate Craniofacial Association. Utrecht, the Netherlands.

Assessment of canonical babbling status in infants with cleft palate: agreement between parents and speech therapists: results of 485 infants in a randomised controlled trial (Conference Paper)

Willadsen, E., Cooper, R., Conroy, E. J., Persson, C., & Gamble, C. (2019, June 12). Assessment of canonical babbling status in infants with cleft palate: agreement between parents and speech therapists: results of 485 infants in a randomised controlled trial. In European Cleft Palate Craniofacial Associate Congress. Utrecht, The Netherlands.

Antimicrobial-impregnated central venous catheters for prevention of neonatal bloodstream infection (PREVAIL): an open-label, parallel-group, pragmatic, randomised controlled trial (Journal article)

Gilbert, R., Brown, M., Rainford, N., Donohue, C., Fraser, C., Sinha, A., . . . Team, P. R. E. V. A. I. L. T. (2019). Antimicrobial-impregnated central venous catheters for prevention of neonatal bloodstream infection (PREVAIL): an open-label, parallel-group, pragmatic, randomised controlled trial. Lancet Child and Adolescent Health, 3(6), 381-390. doi:10.1016/S2352-4642(19)30114-2

DOI: 10.1016/S2352-4642(19)30114-2

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial (Journal article)

Lyttle, M., Rainford, N., Gamble, C., Messahel, S., Humphreys, A., Hickey, H., . . . Appleton, R. (2019). Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. The Lancet, 393(10186), 2125-2134. doi:10.1016/S0140-6736(19)30724-X

DOI: 10.1016/S0140-6736(19)30724-X

G320(P) Successful conduct of a UK multi-centre emergency department led paediatric clinical trial: lessons from the eclipse trial (Conference Paper)

Woolfall, K., Roper, L., Lyttle, M. D., Gamble, C., Humphreys, A., Messahel, S., . . . Appleton, R. (2019). G320(P) Successful conduct of a UK multi-centre emergency department led paediatric clinical trial: lessons from the eclipse trial. In ASSOCIATION OF PAEDIATRIC EMERGENCY MEDICINE. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2019-rcpch.311

DOI: 10.1136/archdischild-2019-rcpch.311

P6 The emergency treatment with levetiracetam or phenytoin in status epilepticus in children: a pragmatic, randomised controlled trial (the ‘eclipse’ trial) (Conference Paper)

Appleton, R. E., Lyttle, M. D., Gamble, C., Bacon, N., Woolfall, K., Messahel, S., & Lee, E. (2019). P6 The emergency treatment with levetiracetam or phenytoin in status epilepticus in children: a pragmatic, randomised controlled trial (the ‘eclipse’ trial). In PLENARY. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2019-rcpch.6

DOI: 10.1136/archdischild-2019-rcpch.6

Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation (Journal article)

Blair, J. C., Mckay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . Investigators, S. C. I. P. I. (2019). Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation. BMJ: British Medical Journal, 365. doi:10.1136/bmj.l1226

DOI: 10.1136/bmj.l1226

Enhancing practitioners' confidence in recruitment and consent in the EcLiPSE trial: a mixed-method evaluation of site training - a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study (Journal article)

Woolfall, K., Roper, L., Humphreys, A., Lyttle, M. D., Messahel, S., Lee, E., . . . Appleton, R. (2019). Enhancing practitioners' confidence in recruitment and consent in the EcLiPSE trial: a mixed-method evaluation of site training - a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study. TRIALS, 20. doi:10.1186/s13063-019-3273-z

DOI: 10.1186/s13063-019-3273-z

What are the most important unanswered research questions in trial retention? A James Lind Alliance Priority Setting Partnership – The PRioRiTy II (Prioritising Retention in Randomised Trials) Study (Journal article)

Brunsdon, D., Biesty, L., Brocklehurst, P., Brueton, V., Devane, D., Elliott, J., . . . Gillies, K. (2019). What are the most important unanswered research questions in trial retention? A James Lind Alliance Priority Setting Partnership – The PRioRiTy II (Prioritising Retention in Randomised Trials) Study. doi:10.21203/rs.2.439/v1

DOI: 10.21203/rs.2.439/v1

Randomized trials involving surgery did not routinely report considerations of learning and clustering effects (Journal article)

Conroy, E. J., Rosala-Hallas, A., Blazeby, J. M., Burnside, G., Cook, J. A., & Gamble, C. (2019). Randomized trials involving surgery did not routinely report considerations of learning and clustering effects. Journal of Clinical Epidemiology, 107, 27-35. doi:10.1016/j.jclinepi.2018.11.004

DOI: 10.1016/j.jclinepi.2018.11.004

Assessing attrition in Randomised Control Trials, the identification of attrition risk factors and the challenges of poor reporting: A comparison of reports from 2013 and 2018 (Conference Paper)

Kearney, A., Rosala-Hallas, A., Rainford, N., Blazeby, J. M., Clarke, M., Lane, A. J., . . . Gamble, C. (2019). Assessing attrition in Randomised Control Trials, the identification of attrition risk factors and the challenges of poor reporting: A comparison of reports from 2013 and 2018. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Enhancing practitioner explanations and parental understandings of recruitment and consent- an adapted model for paediatric emergency medicine trials (Conference Paper)

Roper, L., Woolfall, K., Lyttle, M. D., Gamble, C., Humphreys, A., Hickey, H., . . . Appleton, R. E. (2019). Enhancing practitioner explanations and parental understandings of recruitment and consent- an adapted model for paediatric emergency medicine trials. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Good Statistical Practice: GCP for Statisticians (Conference Paper)

Mossop, H., Armstrong, E., Lewis, S., Dutton, S., Peckitt, C., McParland, L., . . . Stocken, D. (2019). Good Statistical Practice: GCP for Statisticians. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Identifying trial retention uncertainties using a James Lind Alliance Priority Setting Partnership - The PRioRiTy II (Prioritising Retention in Randomised Trials) Study (Conference Paper)

Gillies, K., Brunsdon, D., Biesty, L., Brocklehurst, P., Brueton, V., Devane, D., . . . Wren, S. (2019). Identifying trial retention uncertainties using a James Lind Alliance Priority Setting Partnership - The PRioRiTy II (Prioritising Retention in Randomised Trials) Study. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Internal pilots in clinical trials: Current practice in design and assessment (Conference Paper)

Rosala-Hallas, A., Gamble, C., Blazeby, J., & Williamson, P. R. (2019). Internal pilots in clinical trials: Current practice in design and assessment. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Making a challenging trial possible: Lessons from the Emergency Department led EcLiPSE trial (Conference Paper)

Woolfall, K., Roper, L., Lyttle, M. D., Gamble, C., Humphreys, A., Messahel, S., . . . Appleton, R. (2019). Making a challenging trial possible: Lessons from the Emergency Department led EcLiPSE trial. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Patient and public involvement (PPI) in trial oversight: an ethnographic study of eight clinical trials (Conference Paper)

Coulman, K., Nicholson, A., Shaw, A., Daykin, A., Cramer, H., Gamble, C., . . . Lane, J. A. (2019). Patient and public involvement (PPI) in trial oversight: an ethnographic study of eight clinical trials. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Prediction and monitoring of patient recruitment in clinical trials: gaps between current practice and available methodology (Conference Paper)

Gkioni, E., Dodd, S., Rius, R., & Gamble, C. (2019). Prediction and monitoring of patient recruitment in clinical trials: gaps between current practice and available methodology. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

The MRC HTMR recruitment working group: Driving recruitment research through collaboration (Conference Paper)

Harman, N. L., Elliott, D., Gamble, C., Gillies, K., McAneney, H., Realpe, A., . . . Shorter, G. W. (2019). The MRC HTMR recruitment working group: Driving recruitment research through collaboration. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Unique challenges and proposed solutions for designing and conducting pilot and feasibility work to optimise surgical trials (Conference Paper)

Fairhurst, K., Potter, S., Blazeby, J., Gamble, C., & Avery, K. (2019). Unique challenges and proposed solutions for designing and conducting pilot and feasibility work to optimise surgical trials. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

Use of routinely collected data from electronic health records for outcomes in NIHR HTA trials (Conference Paper)

Mckay, A. J., Farmer, A. J., Gamble, C., Jones, A. P., & Williamson, P. R. (2019). Use of routinely collected data from electronic health records for outcomes in NIHR HTA trials. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

When is enough enough? Patient, relative, and health care professionals experiences of research information provision in the intensive care unit (Conference Paper)

Paddock, K., Frith, L., Gamble, C., Welters, I., Woolfall, K., & Young, B. (2019). When is enough enough? Patient, relative, and health care professionals experiences of research information provision in the intensive care unit. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/

2018

Development of an online resource for recruitment research in clinical trials to organise and map current literature (Journal article)

Kearney, A., Harman, N. L., Rosala-Hallas, A., Beecher, C., Blazeby, J. M., Bower, P., . . . Gamble, C. (2018). Development of an online resource for recruitment research in clinical trials to organise and map current literature. CLINICAL TRIALS, 15(6), 533-542. doi:10.1177/1740774518796156

DOI: 10.1177/1740774518796156

Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma (Journal article)

Jenkinson, M. D., Weber, D. C., Haylock, B. J., Sherratt, F. C., Young, B., Weller, M., . . . Gamble, C. (2018). Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma. JOURNAL OF NEUROSURGERY, 129(4), 1104-1105. doi:10.3171/2018.6.JNS181418

DOI: 10.3171/2018.6.JNS181418

Reducing attrition within clinical trials: The communication of retention and withdrawal within patient information leaflets (Journal article)

Kearney, A., Rosala-Hallas, A., Bacon, N., Daykin, A., Shaw, A. R. G., Lane, A. J., . . . Gamble, C. (2018). Reducing attrition within clinical trials: The communication of retention and withdrawal within patient information leaflets. PLOS ONE, 13(10). doi:10.1371/journal.pone.0204886

DOI: 10.1371/journal.pone.0204886

Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews (Journal article)

Kirkham, J. J., Altman, D., Chan, A. -W., Gamble, C. L., Dwan, K. M., & Williamson, P. (2018). Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews. BMJ: British Medical Journal, 2018(362). doi:10.1136/bmj.k3802

DOI: 10.1136/bmj.k3802

Children’s views on research without prior consent in emergency situations: a UK qualitative study (Journal article)

Roper, L., Sherratt, F., Young, B., Mcnamara, P., Dawson, A., Appleton, R., . . . Woolfall, K. (2018). Children’s views on research without prior consent in emergency situations: aUK qualitative study. BMJ Open, 8(6). doi:10.1136/bmjopen-2018-022894

DOI: 10.1136/bmjopen-2018-022894

Statistical Analysis Plans for Clinical Trials Reply (Journal article)

Gamble, C., Lewis, S., & Senn, S. (2018). Statistical Analysis Plans for Clinical Trials Reply. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 319(18), 1938-1939. doi:10.1001/jama.2018.2585

DOI: 10.1001/jama.2018.2585

Identifying trial recruitment uncertainties using a James Lind Alliance Priority Setting Partnership - the PRioRiTy (Prioritising Recruitment in Randomised Trials) study (Journal article)

Healy, P., Galvin, S., Williamson, P. R., Treweek, S., Whiting, C., Maeso, B., . . . Devane, D. (2018). Identifying trial recruitment uncertainties using a James Lind Alliance Priority Setting Partnership - the PRioRiTy (Prioritising Recruitment in Randomised Trials) study. Trials, 19. doi:10.1186/s13063-018-2544-4

DOI: 10.1186/s13063-018-2544-4

Training health professionals to recruit into challenging randomized controlled trials improved confidence: the development of the QuinteT randomized controlled trial recruitment training intervention (Journal article)

Mills, N., Gaunt, D., Blazeby, J. M., Elliott, D., Husbands, S., Holding, P., . . . Donovan, J. L. (2018). Training health professionals to recruit into challenging randomized controlled trials improved confidence: the development of the QuinteT randomized controlled trial recruitment training intervention. JOURNAL OF CLINICAL EPIDEMIOLOGY, 95, 34-44. doi:10.1016/j.jclinepi.2017.11.015

DOI: 10.1016/j.jclinepi.2017.11.015

Detailed systematic analysis of recruitment strategies in randomised controlled trials in patients with an unscheduled admission to hospital (Journal article)

Rowlands, C., Rooshenas, L., Fairhurst, K., Rees, J., Gamble, C., & Blazeby, J. M. (2018). Detailed systematic analysis of recruitment strategies in randomised controlled trials in patients with an unscheduled admission to hospital. BMJ OPEN, 8(2). doi:10.1136/bmjopen-2017-018581

DOI: 10.1136/bmjopen-2017-018581

'Recruitment, recruitment, recruitment' - the need for more focus on retention: a qualitative study of five trials (Journal article)

Daykin, A., Clement, C., Gamble, C., Kearney, A., Blazeby, J., Clarke, M., . . . Shaw, A. (2018). 'Recruitment, recruitment, recruitment' - the need for more focus on retention: a qualitative study of five trials. TRIALS, 19. doi:10.1186/s13063-018-2467-0

DOI: 10.1186/s13063-018-2467-0

2017

'We all want to succeed, but we've also got to be realistic about what is happening': an ethnographic study of relationships in trial oversight and their impact (Journal article)

Daykin, A., Selman, L. E., Cramer, H., McCann, S., Shorter, G. W., Sydes, M. R., . . . Shaw, A. (2017). 'We all want to succeed, but we've also got to be realistic about what is happening': an ethnographic study of relationships in trial oversight and their impact. TRIALS, 18. doi:10.1186/s13063-017-2305-9

DOI: 10.1186/s13063-017-2305-9

Guidelines for the content of statistical analysis plans in clinical trials (Journal article)

Gamble, C. L., Krishan, A., Stocken, D., Lewis, S., Juszczak, E., Dore, C., . . . Loder, E. (2017). Guidelines for the content of statistical analysis plans in clinical trials. JAMA: Journal of the American Medical Association, 318(23), 2337-2343. doi:10.1001/jama.2017.18556

DOI: 10.1001/jama.2017.18556

A cohort examination to establish reporting of the remit and function of Trial Steering Committees in randomised controlled trials (Journal article)

Conroy, E. J., Arch, B., Harman, N. L., Lane, J. A., Lewis, S. C., Norrie, J., . . . Gamble, C. (2017). A cohort examination to establish reporting of the remit and function of Trial Steering Committees in randomised controlled trials. TRIALS, 18. doi:10.1186/s13063-017-2300-1

DOI: 10.1186/s13063-017-2300-1

Priorities for methodological research on patient and public involvement in clinical trials: A modified Delphi process (Journal article)

Kearney, A., Williamson, P., Young, B., Gamble, C., Bagley, H., Denegri, S., . . . woolfall, K. (2017). Priorities for methodological research on patient and public involvement in clinical trials: A modified Delphi process. Health Expectations, 20(6), 1401-1410. doi:10.1111/hex.12583

DOI: 10.1111/hex.12583

Cost-Effectiveness of Pediatric Central Venous Catheters in the UK: A Secondary Publication from the CATCH Clinical Trial (Journal article)

Ridyard, C. H., Plumpton, C. O., Gilbert, R. E., & Hughes, D. A. (2017). Cost-Effectiveness of Pediatric Central Venous Catheters in the UK: A Secondary Publication from the CATCH Clinical Trial. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00644

DOI: 10.3389/fphar.2017.00644

Identifying research priorities for effective retention strategies in clinical trials (Journal article)

Kearney, A., Daykin, A., Shaw, A. R. G., Lane, A. J., Blazeby, J. M., Clarke, M., . . . Gamble, C. (2017). Identifying research priorities for effective retention strategies in clinical trials. Trials, 18. doi:10.1186/s13063-017-2132-z

DOI: 10.1186/s13063-017-2132-z

Emergency treatment with levetiracetam or phenytoin in status epilepticus in children-the EcLiPSE study: study protocol for a randomised controlled trial (Journal article)

Lyttle, M. D., Gamble, C., Messahel, S., Hickey, H., Iyer, A., Woolfall, K., . . . Appleton, R. E. (2017). Emergency treatment with levetiracetam or phenytoin in status epilepticus in children-the EcLiPSE study: study protocol for a randomised controlled trial. TRIALS, 18. doi:10.1186/s13063-017-2010-8

DOI: 10.1186/s13063-017-2010-8

Developing and evaluating multimedia information resources to improve engagement of children, adolescents, and their parents with trials (TRECA study): Study protocol for a series of linked randomised controlled trials (Journal article)

Martin-Kerry, J., Bower, P., Young, B., Graffy, J., Sheridan, R., Watt, I., . . . Knapp, P. (2017). Developing and evaluating multimedia information resources to improve engagement of children, adolescents, and their parents with trials (TRECA study): Study protocol for a series of linked randomised controlled trials. TRIALS, 18. doi:10.1186/s13063-017-1962-z

DOI: 10.1186/s13063-017-1962-z

Response to letter to editor: 'Comment on Arch et al., Trials. 2016;17:517' (Journal article)

Arch, B. N., Blair, J., Mckay, A., Gregory, J. W., Newland, P., & Gamble, C. (2017). Response to letter to editor: 'Comment on Arch et al., Trials. 2016;17:517'. TRIALS, 18. doi:10.1186/s13063-017-1981-9

DOI: 10.1186/s13063-017-1981-9

"To have and to hold, from this day forward": understanding current practice regarding retention of trial participants (Conference Paper)

Clement, C., Daykin, A., Gamble, C., Kearney, A., Blazeby, J., Clarke, M., . . . Heawood, A. (2017). "To have and to hold, from this day forward": understanding current practice regarding retention of trial participants. In TRIALS Vol. 18. Retrieved from http://gateway.webofknowledge.com/

Design and analysis of the learning curve and clustering effects in randomised surgical trials - A review of current practice (Conference Paper)

Conroy., Blazeby, J., Burnside, G., Cook, J., & Gamble, C. (2017). Design and analysis of the learning curve and clustering effects in randomised surgical trials - A review of current practice. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Site training to improve healthcare practitioners? Confidence in recruiting to a challenging critical care trial (Conference Paper)

Woolfall, K., Roper, L., Humphreys, A., Lyttle, M. D., Messahel, S., Lee, E., . . . Hickey, H. (2017). Site training to improve healthcare practitioners? Confidence in recruiting to a challenging critical care trial. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

G275 Children and Young People’s Views on Research Without Prior Consent in Life Threatening Situations: A Qualitative Study (Conference Paper)

Roper, L., Sherratt, F., Young, B., McNamara, P., Appleton, R., Crawley, E., . . . Woolfall, K. (2017). G275 Children and Young People’s Views on Research Without Prior Consent in Life Threatening Situations: A Qualitative Study. In Association of Paediatric Emergency Medicine. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2017-313087.269

DOI: 10.1136/archdischild-2017-313087.269

P12.10 The ROAM / EORTC 1308 trial: Radiation versus observation following surgical resection of atypical meningioma - study update (Journal article)

Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Bulbeck, H., Farrell, M., . . . Weber, D. (2017). P12.10 The ROAM / EORTC 1308 trial: Radiation versus observation following surgical resection of atypical meningioma - study update. Neuro-oncology, 19(Suppl 3), iii97.

THE ROAM / EORTC 1308 TRIAL: RADIATION VERSUS OBSERVATION FOLLOWING SURGICAL RESECTION OF ATYPICAL MENINGIOMA - STUDY UPDATE (Conference Paper)

Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Bulbeck, H., Farrell, M., . . . Weber, D. (2017). THE ROAM / EORTC 1308 TRIAL: RADIATION VERSUS OBSERVATION FOLLOWING SURGICAL RESECTION OF ATYPICAL MENINGIOMA - STUDY UPDATE. In NEURO-ONCOLOGY Vol. 19 (pp. 97). Retrieved from https://www.webofscience.com/

Measurement of HbA1c in multicentre diabetes trials - should blood samples be tested locally or sent to a central laboratory: an agreement analysis (vol 17, pg 517, 2016) (Journal article)

Arch, B. N., Blair, J., Mckay, A., Gregory, J. W., Newland, P., & Gamble, C. (2017). Measurement of HbA1c in multicentre diabetes trials - should blood samples be tested locally or sent to a central laboratory: an agreement analysis (vol 17, pg 517, 2016). TRIALS, 18. doi:10.1186/s13063-017-1914-7

DOI: 10.1186/s13063-017-1914-7

Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies (Journal article)

Avery, K. N. L., Williamson, P. R., Gamble, C., Francischetto, E. O., Metcalfe, C., Davidson, P., . . . Blazeby, J. M. (2017). Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies. BMJ OPEN, 7(2). doi:10.1136/bmjopen-2016-013537

DOI: 10.1136/bmjopen-2016-013537

An evaluation of the impact of quintet RCT recruitment training on the self-confidence and self-assessed recruitment practice of recruiters to surgical trials (Conference Paper)

Mills, N., Blazeby, J. M., Gaunt, D., Elliott, D., Husbands, S., Holding, P., . . . Donovan, J. L. (2017). An evaluation of the impact of quintet RCT recruitment training on the self-confidence and self-assessed recruitment practice of recruiters to surgical trials. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Changing roles and relationships within trial oversight: an ethnographic study of eight clinical trials facing challenges (Conference Paper)

Daykin, A., Selman, L. E., Cramer, H., McCann, S., Shorter, G. W., Sydes, M. R., . . . Lane, J. A. (2017). Changing roles and relationships within trial oversight: an ethnographic study of eight clinical trials facing challenges. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study (Journal article)

de Graaf, H., Sukhtankar, P., Arch, B., Ahmad, N., Lees, A., Bennett, A., . . . Faust, S. N. (2017). Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study. HEALTH TECHNOLOGY ASSESSMENT, 21(48), 1-+. Retrieved from https://www.webofscience.com/

Identifying effective retention strategies: a research agenda (Conference Paper)

Kearney, A., Daykin, A., Heawood, A. J., Lane, A., Blazeby, J., Clarke, M., . . . Gamble, C. (2017). Identifying effective retention strategies: a research agenda. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Improving the planning and monitoring of recruitment to clinical trials (Conference Paper)

Gkioni, E., Rius, R., & Gamble, C. (2017). Improving the planning and monitoring of recruitment to clinical trials. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Key design features of pilot and feasibility studies to inform successful surgical trials: a systematic analysis of funded studies (Conference Paper)

Fairhurst, K., Blazeby, J., Potter, S., Blatch-Jones, A., Rowlands, C., Gamble, C., & Avery, K. (2017). Key design features of pilot and feasibility studies to inform successful surgical trials: a systematic analysis of funded studies. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

More than the emperor's new clothes: enhancing meaningful patient and public involvement in trial oversight committees through qualitative research with eight clinical trials facing challenges (Conference Paper)

Nicolson, A., Daykin, A., Coulman, K., Clement, C., Cramer, H., Gamble, C., . . . Sydes, M. R. (2017). More than the emperor's new clothes: enhancing meaningful patient and public involvement in trial oversight committees through qualitative research with eight clinical trials facing challenges. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Online resource for recruitment research in clinical trials research (ORRCA) (Conference Paper)

Kearney, A., Harman, N. L., Bacon, N., Daykin, A., Heawood, A. J., Lane, A., . . . Bower, P. (2017). Online resource for recruitment research in clinical trials research (ORRCA). In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Outcome selection in clinical trials - Looking back at the problems and moving forward with solutions (Conference Paper)

Williamson, P., Kirkham, J. K., Gamble, C., & Dwan, K. (2017). Outcome selection in clinical trials - Looking back at the problems and moving forward with solutions. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Recruitment to randomised controlled trials in patients receiving unplanned hospital care: a systematic review and in-depth analysis using the ORRCA database (Conference Paper)

Rowlands, C., Rooshenhas, L., Rees, J., Fairhurst, K., Gamble, C., & Blazeby, J. M. (2017). Recruitment to randomised controlled trials in patients receiving unplanned hospital care: a systematic review and in-depth analysis using the ORRCA database. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Reducing attrition: the communication of retention and withdrawal within patient information sheets (Conference Paper)

Kearney, A., Rosala-Hallas, A., Bacon, N., Daykin, A., Heawood, A. J., Lane, A., . . . Gamble, C. (2017). Reducing attrition: the communication of retention and withdrawal within patient information sheets. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

Reported reasons for missing data (Conference Paper)

Kearney, A., Rosala-Hallas, A., Bacon, N., Daykin, A., Heawood, A. J., Lane, A., . . . Gamble, C. (2017). Reported reasons for missing data. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/

2016

CHILDREN AND YOUNG PEOPLE SUPPORT RESEARCH WITHOUT PRIOR CONSENT IN LIFE THREATENING SITUATIONS: A QUALITATIVE STUDY (Conference Paper)

Woolfall, K., Roper, L., Sherratt, F., McNamara, P., Appleton, R., Crawley, E., . . . Young, B. (2016). CHILDREN AND YOUNG PEOPLE SUPPORT RESEARCH WITHOUT PRIOR CONSENT IN LIFE THREATENING SITUATIONS: A QUALITATIVE STUDY. In EUROPEAN JOURNAL OF PEDIATRICS Vol. 175 (pp. 1525-1526). Retrieved from https://www.webofscience.com/

Measurement of HbA1c in multicentre diabetes trials – should blood samples be tested locally or sent to a central laboratory: an agreement analysis (Journal article)

Arch, B., Blair, J., McKay, A., Gregory, J. W., Newland, P., & Gamble, C. L. (2016). Measurement of HbA1c in multicentre diabetes trials – should blood samples be tested locally or sent to a central laboratory: an agreement analysis. Trials, 17. doi:10.1186/s13063-016-1640-6

DOI: 10.1186/s13063-016-1640-6

What are the roles and valued attributes of a Trial Steering Committee? Ethnographic study of eight clinical trials facing challenges (Journal article)

Daykin, A., Selman, L. E., Cramer, H., McCann, S., Shorter, G. W., Sydes, M. R., . . . Shaw, A. (2016). What are the roles and valued attributes of a Trial Steering Committee? Ethnographic study of eight clinical trials facing challenges. TRIALS, 17. doi:10.1186/s13063-016-1425-y

DOI: 10.1186/s13063-016-1425-y

A patient and public involvement (PPI) toolkit for meaningful and flexible involvement in clinical trials - a work in progress. (Journal article)

Bagley, H. J., Short, H., Harman, N. L., Hickey, H. R., Gamble, C. L., Woolfall, K., . . . Williamson, P. R. (2016). A patient and public involvement (PPI) toolkit for meaningful and flexible involvement in clinical trials - a work in progress.. Research involvement and engagement, 2, 15. doi:10.1186/s40900-016-0029-8

DOI: 10.1186/s40900-016-0029-8

Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial (Journal article)

Gilbert, R. E., Mok, Q., Dwan, K., Harron, K., Moitt, T., Millar, M., . . . Investigators, C. A. T. C. H. T. (2016). Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial. The Lancet, 387(10029), 1732-1742. doi:10.1016/S0140-6736(16)00340-8

DOI: 10.1016/S0140-6736(16)00340-8

Feasibility study to examine discrepancy rates in prespecified and reported outcomes in articles submitted to The BMJ (Journal article)

Weston, J., Dwan, K., Altman, D., Clarke, M., Gamble, C., Schroter, S., . . . Kirkham, J. J. (2016). Feasibility study to examine discrepancy rates in prespecified and reported outcomes in articles submitted to The BMJ. BMJ Open, 6(4). doi:10.1136/bmjopen-2015-010075

DOI: 10.1136/bmjopen-2015-010075

Reporting of harms outcomes: a comparison of journal publications with unpublished clinical study reports of orlistat trials (Journal article)

Hodkinson, A., Gamble, C., & Smith, C. T. (2016). Reporting of harms outcomes: a comparison of journal publications with unpublished clinical study reports of orlistat trials. TRIALS, 17. doi:10.1186/s13063-016-1327-z

DOI: 10.1186/s13063-016-1327-z

CATheter Infections in CHildren (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children (Journal article)

Harron, K., Mok, Q., Dwan, K., Ridyard, C. H., Moitt, T., Millar, M., . . . Gilbert, R. E. (2016). CATheter Infections in CHildren (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children. HEALTH TECHNOLOGY ASSESSMENT, 20(18), 1-+. doi:10.3310/hta20180

DOI: 10.3310/hta20180

Fifteen-minute consultation: an evidence-based approach to research without prior consent (deferred consent) in neonatal and paediatric critical care trials (Journal article)

Woolfall, K., Frith, L., Dawson, A., Gamble, C., & Lyttle, M. D. (2016). Fifteen-minute consultation: an evidence-based approach to research without prior consent (deferred consent) in neonatal and paediatric critical care trials. ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION, 101(1), 49-53. doi:10.1136/archdischild-2015-309245

DOI: 10.1136/archdischild-2015-309245

Limits of Agreement between HbA1c Levels Measured in Different Laboratories Following the Introduction of the International Federation of Clinical Chemistry and Laboratory Medicine Standardised Values (Conference Paper)

Arch, B., McKay, A., Newland, P., Blair, J., Gregory, J., Peak, M., . . . Gamble, C. (2016). Limits of Agreement between HbA1c Levels Measured in Different Laboratories Following the Introduction of the International Federation of Clinical Chemistry and Laboratory Medicine Standardised Values. In HORMONE RESEARCH IN PAEDIATRICS Vol. 86 (pp. 83). Retrieved from https://www.webofscience.com/

2015

Exploring the role and function of trial steering committees: results of an expert panel meeting (Journal article)

Harman, N. L., Conroy, E. J., Lewis, S. C., Murray, G., Norrie, J., Sydes, M. R., . . . Gamble, C. (2015). Exploring the role and function of trial steering committees: results of an expert panel meeting. Trials, 16. doi:10.1186/s13063-015-1125-z

DOI: 10.1186/s13063-015-1125-z

"To have, to hold, from this day forward": understanding current practice regarding the retention of trial participants (Conference Paper)

Daykin, A., Lane, A., Gamble, C., Kearney, A., Blazeby, J., Clarke, M., . . . Heawood, A. (2015). "To have, to hold, from this day forward": understanding current practice regarding the retention of trial participants. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-P104

DOI: 10.1186/1745-6215-16-S2-P104

A review of the description of patient withdrawal in trial protocols and patient information sheets (PIS) (Conference Paper)

Kearney, A., Daykin, A., Heawood, A., Lane, A., Blazeby, J., Clarke, M., . . . Gamble, C. (2015). A review of the description of patient withdrawal in trial protocols and patient information sheets (PIS). In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-P46

DOI: 10.1186/1745-6215-16-S2-P46

Development of an online resource for recruitment research in clinical trials (ORRCA) (Journal article)

Harman, N., Treweek, S., Clarke, M., Williamson, P., Bower, P., & Gamble, C. (2015). Development of an online resource for recruitment research in clinical trials (ORRCA). TRIALS, 16. doi:10.1186/1745-6215-16-S2-P98

DOI: 10.1186/1745-6215-16-S2-P98

Development of guidance for statistical analysis plans (SAPs) for clinical trials (Journal article)

Krishan, A., Stocken, D., Lewis, S., Juszczak, E., Dore, C., Williamson, P., . . . Gamble, C. (2015). Development of guidance for statistical analysis plans (SAPs) for clinical trials. TRIALS, 16. doi:10.1186/1745-6215-16-S2-O41

DOI: 10.1186/1745-6215-16-S2-O41

Enhancing public involvement in trial oversight committees through qualitative research with eight trials facing challenges (Conference Paper)

Nicholson, A., Daykin, A., Macefield, R., McCann, S., Shorter, G., Sydes, M., . . . Lane, J. A. (2015). Enhancing public involvement in trial oversight committees through qualitative research with eight trials facing challenges. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-P78

DOI: 10.1186/1745-6215-16-S2-P78

Exploring the role and functionality of trial steering committees (Conference Paper)

Harman, N., Conroy, E., Lewis, S., Murray, G., Norrie, J., Sydes, M., . . . Gamble, C. (2015). Exploring the role and functionality of trial steering committees. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-P189

DOI: 10.1186/1745-6215-16-S2-P189

Optimising the design of internal pilot work to inform efficient randomised controlled trials: issues to consider when developing progression criteria (Conference Paper)

Avery, K., Williamson, P., Gamble, C., Francischetto, E. O., Metcalfe, C., Davidson, P., & Blazeby, J. (2015). Optimising the design of internal pilot work to inform efficient randomised controlled trials: issues to consider when developing progression criteria. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-P10

DOI: 10.1186/1745-6215-16-S2-P10

Pragmatic approaches to mitigating missing data and research priorities to assess the effectiveness of interventions (Conference Paper)

Kearney, A., Daykin, A., Heawood, A., Lane, A., Blazeby, J., Clarke, M., . . . Gamble, C. (2015). Pragmatic approaches to mitigating missing data and research priorities to assess the effectiveness of interventions. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-P238

DOI: 10.1186/1745-6215-16-S2-P238

Realising the potential of patient and public involvement to make a difference: what can trial teams do? (Conference Paper)

Young, B., Dudley, L., Williamson, P., & Gamble, C. (2015). Realising the potential of patient and public involvement to make a difference: what can trial teams do?. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-O93

DOI: 10.1186/1745-6215-16-S2-O93

Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature (Conference Paper)

Conroy, E. J., Arch, B., Lewis, S., Lane, A., Sydes, M. R., Norrie, J., . . . Gamble, C. (2015). Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature. In Trials Vol. 16. Springer Science and Business Media LLC. doi:10.1186/1745-6215-16-s2-p177

DOI: 10.1186/1745-6215-16-s2-p177

Selective reporting in clinical trials - an examination of discrepancy rates in pre-specified and reported outcomes in articles submitted to the BMJ (Conference Paper)

Weston, J., Dwan, K., Altman, D., Clarke, M., Gamble, C., Groves, T., . . . Kirkham, J. (2015). Selective reporting in clinical trials - an examination of discrepancy rates in pre-specified and reported outcomes in articles submitted to the BMJ. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-O72

DOI: 10.1186/1745-6215-16-S2-O72

Trial Steering Committees in randomised controlled trials: A survey of registered clinical trials units to establish current practice and experiences (Journal article)

Conroy, E. J., Harman, N. L., Lane, J. A., Lewis, S. C., Murray, G., Norrie, J., . . . Gamble, C. (2015). Trial Steering Committees in randomised controlled trials: A survey of registered clinical trials units to establish current practice and experiences. CLINICAL TRIALS, 12(6), 664-676. doi:10.1177/1740774515589959

DOI: 10.1177/1740774515589959

Reported reasons for missing data and the interplay with trial setting (Poster)

Kearney, A., Bacon, N., Rosala-Hallas, A., Daykin, A., Heawood, A., Lane, A., . . . Gamble, C. (2015). Reported reasons for missing data and the interplay with trial setting. Poster session presented at the meeting of 3rd International Clinical Trials Methodology Conference. Glasgow UK.

The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial (Journal article)

Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Gillard, H., Vinten, J., . . . Weber, D. C. (2015). The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial. TRIALS, 16. doi:10.1186/s13063-015-1040-3

DOI: 10.1186/s13063-015-1040-3

Deferred Consent for Randomized Controlled Trials in Emergency Care Settings (Journal article)

Harron, K., Woolfall, K., Dwan, K., Gamble, C., Mok, Q., Ramnarayan, P., & Gilbert, R. (2015). Deferred Consent for Randomized Controlled Trials in Emergency Care Settings. PEDIATRICS, 136(5), E1316-E1322. doi:10.1542/peds.2015-0512

DOI: 10.1542/peds.2015-0512

How parents and practitioners experience research without prior consent (deferred consent) for emergency research involving children with life threatening conditions: a mixed method study (Journal article)

Woolfall, K., Frith, L., Gamble, C., Gilbert, R., Mok, Q., & Young, B. (2015). How parents and practitioners experience research without prior consent (deferred consent) for emergency research involving children with life threatening conditions: a mixed method study. BMJ Open, 5(9). doi:10.1136/bmjopen-2015-008522

DOI: 10.1136/bmjopen-2015-008522

An evidence base to optimise methods for involving patient and public contributors in clinical trials: a mixed-methods study (Journal article)

Gamble, C., Dudley, L., Allam, A., Bell, P., Buck, D., Goodare, H., . . . Young, B. (2015). An evidence base to optimise methods for involving patient and public contributors in clinical trials: a mixed-methods study. Health Services and Delivery Research, 3(39). doi:10.3310/hsdr03390

DOI: 10.3310/hsdr03390

What Difference Does Patient and Public Involvement Make and What Are Its Pathways to Impact? Qualitative Study of Patients and Researchers from a Cohort of Randomised Clinical Trials (Journal article)

Dudley, L., Gamble, C., Preston, J., Buck, D., The EPIC Patient Advisory Group., Hanley, B., . . . Young, B. (2015). What Difference Does Patient and Public Involvement Make and What Are Its Pathways to Impact? Qualitative Study of Patients and Researchers from a Cohort of Randomised Clinical Trials. PLOS ONE, 10(6). doi:10.1371/journal.pone.0128817

DOI: 10.1371/journal.pone.0128817

Making randomised trials more efficient: report of the first meeting to discuss the Trial Forge platform (Journal article)

Treweek, S., Altman, D. G., Bower, P., Campbell, M., Chalmers, I., Cotton, S., . . . Clarke, M. (2015). Making randomised trials more efficient: report of the first meeting to discuss the Trial Forge platform. TRIALS, 16. doi:10.1186/s13063-015-0776-0

DOI: 10.1186/s13063-015-0776-0

A little more conversation please? Qualitative study of researchers’ and patients’ interview accounts of training for patient and public involvement in clinical trials (Journal article)

Dudley, L., Gamble, C., Allam, A., Bell, P., Buck, D., Goodare, H., . . . Young, B. (2015). A little more conversation please? Qualitative study of researchers’ and patients’ interview accounts of training for patient and public involvement in clinical trials. Trials, 16. doi:10.1186/s13063-015-0667-4

DOI: 10.1186/s13063-015-0667-4

E-health data to support and enhance randomised controlled trials in the United Kingdom (Journal article)

Harron, K., Gamble, C., & Gilbert, R. (2015). E-health data to support and enhance randomised controlled trials in the United Kingdom. CLINICAL TRIALS, 12(2), 86-88. doi:10.1177/1740774514562030

DOI: 10.1177/1740774514562030

Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections (Journal article)

Blair, J., Gregory, J. W., Hughes, D., Ridyard, C. H., Gamble, C., Mckay, A., . . . Peak, M. (2015). Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections. TRIALS, 16. doi:10.1186/s13063-015-0658-5

DOI: 10.1186/s13063-015-0658-5

Quality-of-life outcomes of initiating treatment with standard and newer antiepileptic drugs in adults with new-onset epilepsy: Findings from the SANAD trial (Journal article)

Jacoby, A., Sudell, M., Smith, C. T., Crossley, J., Marson, A. G., & Baker, G. A. (2015). Quality-of-life outcomes of initiating treatment with standard and newer antiepileptic drugs in adults with new-onset epilepsy: Findings from the SANAD trial. EPILEPSIA, 56(3), 460-472. doi:10.1111/epi.12913

DOI: 10.1111/epi.12913

The natural history of conducting and reporting clinical trials: interviews with trialists (Journal article)

Smyth, R., Jacoby, A., Altman, D. G., Gamble, C., & Williamson, P. (2015). The natural history of conducting and reporting clinical trials: interviews with trialists. Trials, 16. doi:10.1186/s13063-014-0536-6

DOI: 10.1186/s13063-014-0536-6

A review of the description of patient withdrawal in trial protocols and patient information sheets (PIS) (Journal article)

Development of an online resource for recruitment research in clinical trials (ORRCA) (Journal article)

Harman, N., Treweek, S., Clarke, M., Williamson, P., Bower, P., & Gamble, C. (2015). Development of an online resource for recruitment research in clinical trials (ORRCA). Trials, 16(Suppl 2), P98.

Development of guidance for statistical analysis plans (SAPs) for clinical trials (Journal article)

Enhancing public involvement in trial oversight committees through qualitative research with eight trials facing challenges (Journal article)

Exploring the role and functionality of trial steering committees (Journal article)

Harman, N., Conroy, E., Lewis, S., Murray, G., Norrie, J., Sydes, M., . . . Gamble, C. (2015). Exploring the role and functionality of trial steering committees. Trials, 16(Suppl 2), P189.

Optimising the design of internal pilot work to inform efficient randomised controlled trials: issues to consider when developing progression criteria (Journal article)

Pragmatic approaches to mitigating missing data and research priorities to assess the effectiveness of interventions (Journal article)

Realising the potential of patient and public involvement to make a difference: what can trial teams do? (Journal article)

Young, B., Dudley, L., Williamson, P., & Gamble, C. (2015). Realising the potential of patient and public involvement to make a difference: what can trial teams do?. Trials, 16(Suppl 2), O93.

Reported reasons for missing data and the interplay with trial setting (Journal article)

Kearney, A., Bacon, N., Rosala-Hallas, A., Daykin, A., Heawood, A., Lane, A., . . . Gamble, C. (2015). Reported reasons for missing data and the interplay with trial setting. Trials, 16(Suppl 2), P101.

Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature (Poster)

Conroy, E. J., Arch, B., Lewis, S., Lane, A., Sydes, M. R., Norrie, J., . . . Gamble, C. (2015). Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature. Poster session presented at the meeting of Unknown Conference. Retrieved from https://www.webofscience.com/

DOI: 10.1186/1745-6215-16-S2-P177

Selective reporting in clinical trials - an examination of discrepancy rates in pre-specified and reported outcomes in articles submitted to the BMJ (Journal article)

2014

From plans to actions in patient and public involvement: qualitative study of documented plans and the accounts of researchers and patients sampled from a cohort of clinical trials (Journal article)

Buck, D., Gamble, C., Dudley, L., Preston, J., Hanley, B., Williamson, P., . . . The EPIC Patient Advisory Group. (2014). From plans to actions in patient and public involvement: qualitative study of documented plans and the accounts of researchers and patients sampled from a cohort of clinical trials. BMJ Open, 4(12). doi:10.1136/bmjopen-2014-006400

DOI: 10.1136/bmjopen-2014-006400

Selective reporting bias of harm outcomes within studies: findings from a cohort of systematic reviews (Journal article)

Saini, P., Loke, Y. K., Gamble, C., Altman, D. G., Williamson, P., & Kirkham, J. (2014). Selective reporting bias of harm outcomes within studies: findings from a cohort of systematic reviews. BMJ: British Medical Journal, 349(7985). doi:10.1136/bmj.g6501

DOI: 10.1136/bmj.g6501

Interventions to improve recruitment and retention in clinical trials: a survey and workshop to assess current practice and future priorities (Journal article)

Bower, P., Brueton, V., Gamble, C., Treweek, S., Smith, C. T., Young, B., & Williamson, P. (2014). Interventions to improve recruitment and retention in clinical trials: a survey and workshop to assess current practice and future priorities. TRIALS, 15. doi:10.1186/1745-6215-15-399

DOI: 10.1186/1745-6215-15-399

Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays (Journal article)

Kearney, A., McKay, A., Hickey, H., Balabanova, S., Marson, A. G., Gamble, C., & Williamson, P. (2014). Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays. BMJ OPEN, 4(9). doi:10.1136/bmjopen-2014-005874

DOI: 10.1136/bmjopen-2014-005874

Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays (Journal article)

DOI: 10.1136/bmjopen-2014-005874

Patient and public involvement in the early stages of clinical trial development: a systematic cohort investigation (Journal article)

Gamble, C., Dudley, L., Allam, A., Bell, P., Goodare, H., Hanley, B., . . . Young, B. (2014). Patient and public involvement in the early stages of clinical trial development: a systematic cohort investigation. BMJ Open, 4(7). doi:10.1136/bmjopen-2014-005234

DOI: 10.1136/bmjopen-2014-005234

Doing challenging research studies in a patient centred way: qualitative study to inform a randomised controlled trial in the paediatric emergency care setting (Journal article)

Woolfall, K., Young, B., Frith, L., Appleton, R., Iyer, A., Messahel, S., . . . Gamble, B. (2014). Doing challenging research studies in a patient centred way: qualitative study to inform a randomised controlled trial in the paediatric emergency care setting. BMJ Open, 4(e005045), 11 pages. doi:10.1136/bmjopen-2014-005045

DOI: 10.1136/bmjopen-2014-005045

Risk-proportionate clinical trial monitoring: an example approach from a non-commercial trials unit (Journal article)

Smith, C. T., Williamson, P., Jones, A., Smyth, A., Hewer, S. L., & Gamble, C. (2014). Risk-proportionate clinical trial monitoring: an example approach from a non-commercial trials unit. TRIALS, 15. doi:10.1186/1745-6215-15-127

DOI: 10.1186/1745-6215-15-127

The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol (Journal article)

Jenkinson, M. D., Gamble, C., Hartley, J. C., Hickey, H., Hughes, D., Blundell, M., . . . Mallucci, C. L. (2014). The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol. TRIALS, 15. doi:10.1186/1745-6215-15-4

DOI: 10.1186/1745-6215-15-4

Effect of thyroxine on brain microstructure in extremely premature babies: magnetic resonance imaging findings in the TIPIT study. (Journal article)

Ng, S. M., Turner, M., Gamble, C., Didi, M., Victor, S., Atkinson, J., . . . Weindling, A. M. (2014). Effect of thyroxine on brain microstructure in extremely premature babies: magnetic resonance imaging findings in the TIPIT study.. Pediatric Radiology, 44, 987-996. doi:10.1007/s00247-014-2911-6

DOI: 10.1007/s00247-014-2911-6

Evidence for the selective reporting of analyses and discrepancies in clinical trials: a systematic review of cohort studies of clinical trials (Journal article)

Dwan, K., Altman, D. G., Clarke, M., Gamble, C., Higgins, J. P. T., Sterne, J. A. C., . . . Kirkham, J. J. (n.d.). Evidence for the selective reporting of analyses and discrepancies in clinical trials: a systematic review of cohort studies of clinical trials. PLoS Medicine, 11(6). doi:10.1371/journal.pmed.1001666

DOI: 10.1371/journal.pmed.1001666

Prospective multicentre randomised, double-blind, equivalence study comparing clonidine and midazolam as intravenous sedative agents in critically ill children: the SLEEPS (Safety profiLe, Efficacy and Equivalence in Paediatric intensive care Sedation) study (Journal article)

Wolf, A., McKay, A., Spowart, C., Granville, H., Boland, A., Petrou, S., . . . Gamble, C. (2014). Prospective multicentre randomised, double-blind, equivalence study comparing clonidine and midazolam as intravenous sedative agents in critically ill children: the SLEEPS (Safety profiLe, Efficacy and Equivalence in Paediatric intensive care Sedation) study. Health Technology Assessment, 18(71), 1-212. doi:10.3310/hta18710

DOI: 10.3310/hta18710

2013

CENTRAL VENOUS CATHETERS Impregnated central venous catheters should be readily used to reduce risk of bloodstream infection (Journal article)

Gilbert, R., Harron, K., Mok, Q., & Gamble, C. (2013). CENTRAL VENOUS CATHETERS Impregnated central venous catheters should be readily used to reduce risk of bloodstream infection. BMJ-BRITISH MEDICAL JOURNAL, 347. doi:10.1136/bmj.f7169

DOI: 10.1136/bmj.f7169

How experience makes a difference: practitioners' views on the use of deferred consent in paediatric and neonatal emergency care trials (Journal article)

Woolfall, K., Frith, L., Gamble, C., & Young, B. (2013). How experience makes a difference: practitioners' views on the use of deferred consent in paediatric and neonatal emergency care trials. BMC MEDICAL ETHICS, 14. doi:10.1186/1472-6939-14-45

DOI: 10.1186/1472-6939-14-45

Reporting of harms data in RCTs: a systematic review of empirical assessments against the CONSORT harms extension (Journal article)

Hodkinson, A., Kirkham, J. J., Tudur-Smith, C., & Gamble, C. (2013). Reporting of harms data in RCTs: a systematic review of empirical assessments against the CONSORT harms extension. BMJ Open, 3(9). doi:10.1136/bmjopen-2013-003436

DOI: 10.1136/bmjopen-2013-003436

An explanatory randomised placebo controlled trial of levothyroxine supplementation for babies born <28 weeks' gestation: results of the TIPIT trial (Journal article)

Ng, S. M., Turner, M. A., Gamble, C., Didi, M., Victor, S., Manning, D., . . . Weindling, A. M. (2013). An explanatory randomised placebo controlled trial of levothyroxine supplementation for babies born <28 weeks' gestation: results of the TIPIT trial. TRIALS, 14. doi:10.1186/1745-6215-14-211

DOI: 10.1186/1745-6215-14-211

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias - An Updated Review (Journal article)

Dwan, K., Gamble, C., Williamson, P. R., & Kirkham, J. J. (2013). Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias - An Updated Review. PLOS ONE, 8(7). doi:10.1371/journal.pone.0066844

DOI: 10.1371/journal.pone.0066844

Selective reporting of outcomes in randomised controlled trials in systematic reviews of cystic fibrosis (Journal article)

Dwan, K., Kirkham, J. J., Williamson, P. R., & Gamble, C. (2013). Selective reporting of outcomes in randomised controlled trials in systematic reviews of cystic fibrosis. BMJ OPEN, 3(6). doi:10.1136/bmjopen-2013-002709

DOI: 10.1136/bmjopen-2013-002709

The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials (Journal article)

Jones, A. P., Conroy, E., Williamson, P. R., Clarke, M., & Gamble, C. (2013). The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials. BMC MEDICAL RESEARCH METHODOLOGY, 13. doi:10.1186/1471-2288-13-50

DOI: 10.1186/1471-2288-13-50

The Role of Systematic Reviews in Pharmacovigilance Planning and Clinical Trials Authorisation Application: Example from the SLEEPS Trial (Journal article)

Gamble, C., Wolf, A., Sinha, I., Spowart, C., & Williamson, P. (2013). The Role of Systematic Reviews in Pharmacovigilance Planning and Clinical Trials Authorisation Application: Example from the SLEEPS Trial. PLOS ONE, 8(3). doi:10.1371/journal.pone.0051787

DOI: 10.1371/journal.pone.0051787

New European Union regulation of clinical trials is conflicting on deferred consent in emergency situations (Journal article)

Gamble, C., Woolfall, K., Williamson, P., Appleton, R., & Young, B. (2013). New European Union regulation of clinical trials is conflicting on deferred consent in emergency situations. BMJ-BRITISH MEDICAL JOURNAL, 346. doi:10.1136/bmj.f667

DOI: 10.1136/bmj.f667

A mapping and gapping analysis of patient and public involvement in a clinical trials unit (Journal article)

Bagley, H., Williamson, P., & Gamble, C. (2013). A mapping and gapping analysis of patient and public involvement in a clinical trials unit. Trials, 14(Suppl 1), P93. doi:10.1186/1745-6215-14-s1-p93

DOI: 10.1186/1745-6215-14-s1-p93

An ethnographic study of group decision making to understand and improve how trial steering committees contribute to trial conduct (Journal article)

Daykin, A., Heawood, A., Lane, A., Macefield, R., Gamble, C., McCann, S., . . . Sydes, M. R. (2013). An ethnographic study of group decision making to understand and improve how trial steering committees contribute to trial conduct. Trials, 14(Suppl 1), O79. doi:10.1186/1745-6215-14-s1-o79

DOI: 10.1186/1745-6215-14-s1-o79

Evidence base for patient and public involvement in clinical trials (EPIC) (Journal article)

Gamble, C., Dudley, L., & Newman, J. (2013). Evidence base for patient and public involvement in clinical trials (EPIC). Trials, 14(Suppl 1), O34. doi:10.1186/1745-6215-14-s1-o34

DOI: 10.1186/1745-6215-14-s1-o34

Guidance to detect, evaluate and prevent the problem of selective reporting in trial publications (Journal article)

Dwan, K., Williamson, P. R., Gamble, C., Higgins, J., Sterne, J., Altman, D. G., . . . Kirkham, J. J. (2013). Guidance to detect, evaluate and prevent the problem of selective reporting in trial publications. Trials, 14(Suppl 1), O91. doi:10.1186/1745-6215-14-s1-o91

DOI: 10.1186/1745-6215-14-s1-o91

How experience makes a difference: practitioners' views on deferred consent in paediatric and neonatal emergency care trials (Journal article)

Woolfall, K., Frith, L., Gamble, C., & Young, B. (2013). How experience makes a difference: practitioners' views on deferred consent in paediatric and neonatal emergency care trials. BMC Medical Ethics, 14(45). doi:10.1186/10.1186/1472-6939-14-45

DOI: 10.1186/10.1186/1472-6939-14-45

Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays (Journal article)

Williamson, P., Gamble, C., Kearney, A., & Hickey, H. (2013). Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays. Trials, 14(Suppl 1), O59. doi:10.1186/1745-6215-14-s1-o59

DOI: 10.1186/1745-6215-14-s1-o59

Optimising the design and evaluation of pilot work to inform the main trial: a review of current evidence and consideration of future practices (Journal article)

O'Connell Francischetto, E., Avery, K., Metcalfe, C., Williamson, P., Gamble, C., & Blazeby, J. (2013). Optimising the design and evaluation of pilot work to inform the main trial: a review of current evidence and consideration of future practices. Trials, 14(Suppl 1), O17.

Systematic Review of the Selective Reporting of Analyses (Conference Paper)

Dwan, K., Gable, C., Williamson, P. R., Higgins, J. P., Sterne, J. A., Altman, D. G., . . . Kirkham, J. J. (2013). Systematic Review of the Selective Reporting of Analyses. In Peer Review Congress (pp. 1). Chicago: BMJ.

Systematic Review of the Selective Reporting of Analyses (Conference Paper)

Dwan, K., Gamble, C., Williamson, P. R., Higgins, J. P. T., Sterne, J. A. C., Altman, D. G., . . . Kirkham, J. J. (2013). Systematic Review of the Selective Reporting of Analyses. In The Cochrane Colloquium (pp. 1). Quebec City: Wiley-Blackwell.

The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials (Conference Paper)

Jones, A., Conroy, E., Williamson, P., Clarke, M., & Gamble, C. (2013). The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials. In Trials Vol. 14 (pp. O92). doi:10.1186/1745-6215-14-s1-o92

DOI: 10.1186/1745-6215-14-s1-o92

Trial steering committees for randomised controlled trials: updating and redeveloping guidance and terms of reference informed by current practice and experience (Conference Paper)

Conroy, E. J., Lewis, S., Lane, A., Sydes, M. R., Norrie, J., Murray, G., . . . Gamble, C. (2013). Trial steering committees for randomised controlled trials: updating and redeveloping guidance and terms of reference informed by current practice and experience. In Trials Vol. 14 (pp. P128). doi:10.1186/1745-6215-14-s1-p128

DOI: 10.1186/1745-6215-14-s1-p128

2012

Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial (Journal article)

Gringras, P., Gamble, C., Jones, A. P., Wiggs, L., Williamson, P. R., Sutcliffe, A., . . . Appleton, R. (2012). Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial. BRITISH MEDICAL JOURNAL, 345. doi:10.1136/bmj.e6664

DOI: 10.1136/bmj.e6664

Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial (Journal article)

DOI: 10.1136/bmj.e6664

The use of MElatonin in children with Neurodevelopmental Disorders and impaired Sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS) (Journal article)

Appleton, R. E., Jones, A. P., Gamble, C., Williamson, P. R., Wiggs, L., Montgomery, P., . . . Gringras, P. (2012). The use of MElatonin in children with Neurodevelopmental Disorders and impaired Sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS). HEALTH TECHNOLOGY ASSESSMENT, 16(40), 1-+. doi:10.3310/hta16400

DOI: 10.3310/hta16400

Making Co-Enrolment Feasible for Randomised Controlled Trials in Paediatric Intensive Care (Journal article)

Harron, K., Lee, T., Ball, T., Mok, Q., Gamble, C., Macrae, D., & Gilbert, R. (2012). Making Co-Enrolment Feasible for Randomised Controlled Trials in Paediatric Intensive Care. PLOS ONE, 7(8). doi:10.1371/journal.pone.0041791

DOI: 10.1371/journal.pone.0041791

Repeated Origin and Loss of Adhesive Toepads in Geckos (Journal article)

Gamble, T., Greenbaum, E., Jackman, T. R., Russell, A. P., & Bauer, A. M. (2012). Repeated Origin and Loss of Adhesive Toepads in Geckos. PLOS ONE, 7(6). doi:10.1371/journal.pone.0039429

DOI: 10.1371/journal.pone.0039429

The use of MElatonin in children with Neuro-developmental Disorders and impaired Sleep; a randomised, double-blind, placebo-controlled, parallel study (MENDS) (Journal article)

Appleton, R. E., Jones, A., Gamble, C., Williamson, P. R., Wiggs, L., Montgomery, P., . . . Gringras, P. (2012). The use of MElatonin in children with Neuro-developmental Disorders and impaired Sleep; a randomised, double-blind, placebo-controlled, parallel study (MENDS). HTA monograph.

What Parents of Children Who Have Received Emergency Care Think about Deferring Consent in Randomised Trials of Emergency Treatments: Postal Survey (Journal article)

Gamble, C., Nadel, S., Snape, D., McKay, A., Hickey, H., Williamson, P., . . . Young, B. (n.d.). What Parents of Children Who Have Received Emergency Care Think about Deferring Consent in Randomised Trials of Emergency Treatments: Postal Survey. PLoS ONE, 7(5), e35982. doi:10.1371/journal.pone.0035982

DOI: 10.1371/journal.pone.0035982

2011

Working length determination in general dental practice: a randomised controlled trial (Journal article)

Jarad, F. D., Albadri, S., Gamble, C., Burnside, G., Fox, K., Ashley, J. R., . . . Preston, A. J. (2011). Working length determination in general dental practice: a randomised controlled trial. BRITISH DENTAL JOURNAL, 211(12), 595-598. doi:10.1038/sj.bdj.2011.1052

DOI: 10.1038/sj.bdj.2011.1052

Working length determination in general dental practice: a randomised controlled trial (Journal article)

Jarad, F. D., Albadri, S., Gamble, C., Burnside, G., Fox, K., Ashley, J. R., . . . Preston, A. J. (2011). Working length determination in general dental practice: a randomised controlled trial. British Dental Journal, 211(12), 595-598. doi:10.1038/sj.bdj.2011.1052

DOI: 10.1038/sj.bdj.2011.1052

DIFFUSION TENSOR IMAGING OF THE INTERNAL CAPSULE AND CORPUS CALLOSUM OF PRETERM INFANTS BORN UNDER 28 WEEKS GESTATION (Journal article)

Atkinson, J. J., Parkes, L. M., Gamble, C., Ng, S. M., Turner, M., Weindling, A. M., . . . Sluming, V. (2011). DIFFUSION TENSOR IMAGING OF THE INTERNAL CAPSULE AND CORPUS CALLOSUM OF PRETERM INFANTS BORN UNDER 28 WEEKS GESTATION. PEDIATRIC RESEARCH, 70, 149. doi:10.1038/pr.2011.374

DOI: 10.1038/pr.2011.374

Consistency between guidelines and reported practice for reducing the risk of catheter-related infection in British paediatric intensive care units (Journal article)

Harron, K., Ramachandra, G., Mok, Q., & Gilbert, R. (2011). Consistency between guidelines and reported practice for reducing the risk of catheter-related infection in British paediatric intensive care units. INTENSIVE CARE MEDICINE, 37(10), 1641-1647. doi:10.1007/s00134-011-2343-9

DOI: 10.1007/s00134-011-2343-9

Comparison of protocols and registry entries to published reports for randomised controlled trials (Journal article)

Dwan, K., Altman, D. G., Cresswell, L., Blundell, M., Gamble, C. L., & Williamson, P. R. (2011). Comparison of protocols and registry entries to published reports for randomised controlled trials. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (1). doi:10.1002/14651858.MR000031.pub2

DOI: 10.1002/14651858.MR000031.pub2

Frequency and reasons for outcome reporting bias in clinical trials: interviews with trialists (Journal article)

Smyth, R. M. D., Kirkham, J. J., Jacoby, A., Altman, D. G., Gamble, C., & Williamson, P. R. (2011). Frequency and reasons for outcome reporting bias in clinical trials: interviews with trialists. BMJ-BRITISH MEDICAL JOURNAL, 342. doi:10.1136/bmj.c7153

DOI: 10.1136/bmj.c7153

Comparison of root canal treatment completed using apex locators versus periapical radiograph for working length determination in general dental practice: A pilot randomised controlled trial. (Journal article)

Jarad, F. D., Gamble, C., Burnside, G., Albadri, S., Fox, K., & Preston, A. J. (2011). Comparison of root canal treatment completed using apex locators versus periapical radiograph for working length determination in general dental practice: A pilot randomised controlled trial.. Br Dent J, 211(12), 595-598.

MENDS: The use of MElatonin in children with Neuro-developmental Disorders and impaired Sleep - a randomised, double-blind, placebo-controlled, parallel trial (Conference Paper)

Appleton, R. E., Jones, A. P., Gamble, C., Williamson, P. R., Wiggs, L., Montgomery, P., . . . the MENDS StudyGroup, O. B. O. (2011). MENDS: The use of MElatonin in children with Neuro-developmental Disorders and impaired Sleep - a randomised, double-blind, placebo-controlled, parallel trial. In RCPCH Annual Conference (pp. 10). Warwick: RCPCH.

Risk-adapted approaches to the management of clinical trials: guidance from the Department of Health (DH)/Medical Research Council(MRC)/Medicines and Healthcare Products Regulatory Agency (MHRA) Clinical Trials Working Group (Journal article)

Meredith, S., Ward, M., Booth, G., Fisher, A., Gamble, C., House, H., & Landray, M. (2011). Risk-adapted approaches to the management of clinical trials: guidance from the Department of Health (DH)/Medical Research Council(MRC)/Medicines and Healthcare Products Regulatory Agency (MHRA) Clinical Trials Working Group. Trials, 12(Suppl 1), A39. doi:10.1186/1745-6215-12-s1-a39

DOI: 10.1186/1745-6215-12-s1-a39

The use of Systematic reviews in the design of randomised controlled trials (Conference Paper)

Jones, A. P., Williamson, P. R., Clarke, M., & Gamble, C. (2011). The use of Systematic reviews in the design of randomised controlled trials. In Clinical Trials Methodology conference Vol. -. -: MRC Network of HUBS for trials methodology Research.

The use of Systematic reviews in the design of randomised controlled trials (Conference Paper)

Jones, A. P., Williamson, P. R., Clarke, M., & Gamble, C. (2011). The use of Systematic reviews in the design of randomised controlled trials. In MRC North West Hub for Trials Methodology Research 'Showcase Meeting' Vol. -. Liverpool: -.

The use of systematic reviews in the design of randomised trials (Performance)

Jones, A. P., Gamble, C., Clarke, M., & Williamson, P. R. (2011). The use of systematic reviews in the design of randomised trials [Undetermined].

DOI: 10.1186/1745-6215-12-s1-a54

The use of systematic reviews in the design of randomised trials (Conference Paper)

Gamble, C., Jones, A. P., & Williamson, P. R. (2011). The use of systematic reviews in the design of randomised trials. In Clinical Trials Methodology Conference (pp. 1). Bristol: Trials Journal.

2010

Indirect Comparisons: A Review of Reporting and Methodological Quality (Journal article)

Donegan, S., Williamson, P., Gamble, C., & Tudur-Smith, C. (2010). Indirect Comparisons: A Review of Reporting and Methodological Quality. PLOS ONE, 5(11). doi:10.1371/journal.pone.0011054

DOI: 10.1371/journal.pone.0011054

FREE THYROXINE LEVELS IN THE INITIAL FOUR WEEKS OF LIFE IN EXTREME PRETERM INFANTS AFFECT BRAIN GROWTH (Conference Paper)

Ng, S. M., Turner, M. A., Didi, M., Gamble, C., Victor, S., Manning, D., . . . Weindling, A. M. (2010). FREE THYROXINE LEVELS IN THE INITIAL FOUR WEEKS OF LIFE IN EXTREME PRETERM INFANTS AFFECT BRAIN GROWTH. In PEDIATRIC RESEARCH Vol. 68 (pp. 206-207). doi:10.1203/00006450-201011001-00401

DOI: 10.1203/00006450-201011001-00401

Assessing the potential for outcome reporting bias in a review: a tutorial (Journal article)

Dwan, K., Gamble, C., Kolamunnage-Dona, R., Mohammed, S., Powell, C., & Williamson, P. R. (2010). Assessing the potential for outcome reporting bias in a review: a tutorial. TRIALS, 11. doi:10.1186/1745-6215-11-52

DOI: 10.1186/1745-6215-11-52

Parent/carer views about deferred consent in trials of emergency treatments in children with life-threatening illness (Journal article)

Nadel, S., Young, B., Gamble, C., Hickey, H., Williamson, P., Snape, D., . . . Glennie, L. (2010). Parent/carer views about deferred consent in trials of emergency treatments in children with life-threatening illness. Archives of Disease in Childhood, 95(Suppl 1), A39.2-A39. doi:10.1136/adc.2010.186338.87

DOI: 10.1136/adc.2010.186338.87

The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews (Journal article)

Kirkham, J. J., Dwan, K. M., Altman, D. G., Gamble, C., Dodd, S., Smyth, R., & Williamson, P. R. (2010). The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews. BMJ-BRITISH MEDICAL JOURNAL, 340. doi:10.1136/bmj.c365

DOI: 10.1136/bmj.c365

A randomized comparative trial of generalized vs targeted physiotherapy in the management of childhood hypermobility (Journal article)

Kemp, S., Roberts, I., Gamble, C., Wilkinson, S., Davidson, J. E., Baildam, E. M., . . . Beresford, M. W. (2010). A randomized comparative trial of generalized vs targeted physiotherapy in the management of childhood hypermobility. RHEUMATOLOGY, 49(2), 315-325. doi:10.1093/rheumatology/kep362

DOI: 10.1093/rheumatology/kep362

Abstracts of the 2010 Joint Colloquium of The Cochrane and Campbell Collaborations (Conference Paper)

Abstracts of the 2010 Joint Colloquium of The Cochrane and Campbell Collaborations (n.d.). In Abstracts of the 2010 Joint Colloquium of The Cochrane and Campbell Collaborations. Wiley. doi:10.1002/14651858.cd000002

DOI: 10.1002/14651858.cd000002

Comparison of protocols and registry entries to published reports for randomised controlled trials (Conference Paper)

Dwan, K., Altman, D. G., Blundell, M., Gamble, C. L., & Williamson, P. R. (n.d.). Comparison of protocols and registry entries to published reports for randomised controlled trials. In K. Dwan (Ed.). John Wiley & Sons, Ltd. doi:10.1002/14651858.mr000031

DOI: 10.1002/14651858.mr000031

Comparison of protocols and registry entries to published reports for randomised controlled trials (Protocol) (Journal article)

Dwan, K., Altman, D. G., Blundell, M., Gamble, C. L., & Williamson, P. R. (2010). Comparison of protocols and registry entries to published reports for randomised controlled trials (Protocol). The Cochrane Library, (10).

Enhanced relapse prevention for bipolar disorder by community mental health teams: cluster feasibility randomised trial (Journal article)

Lobban, F., Taylor, L., Chandler, C., Tyler, E., Kinderman, P., Kolamunnage-Dona, R., . . . Morriss, R. K. (2010). Enhanced relapse prevention for bipolar disorder by community mental health teams: cluster feasibility randomised trial. BRITISH JOURNAL OF PSYCHIATRY, 196(1), 59-63. doi:10.1192/bjp.bp.109.065524

DOI: 10.1192/bjp.bp.109.065524

Longitudinal FT4 levels in the first 4 weeks of life are an independent factor affecting brain growth in extreme preterm babies born (Conference Paper)

Ng, S. M., Turner, M. A., Gamble, C., Didi, M., Newland, P., Victor, S., . . . Weindling, A. M. (2010). Longitudinal FT4 levels in the first 4 weeks of life are an independent factor affecting brain growth in extreme preterm babies born . In British Society for Paediatric Endocrinology and Diabetes (pp. OC1.1). Manchester: BIOScientifica.

2009

Training Staff in Enhanced Relapse Prevention for Bipolar Disorder: Rates of Uptake and Measures of Skill and Confidence (Journal article)

Lobban, F., Taylor, L., Chandler, C., Sellwood, W., Gamble, C., Tyler, E., . . . Morriss, R. (2009). Training Staff in Enhanced Relapse Prevention for Bipolar Disorder: Rates of Uptake and Measures of Skill and Confidence. PSYCHIATRIC SERVICES, 60(5), 702-706. doi:10.1176/ps.2009.60.5.702

DOI: 10.1176/ps.2009.60.5.702

Vaccines for preventing anthrax (Journal article)

Donegan, S., Bellamy, R., & Gamble, C. L. (2009). Vaccines for preventing anthrax. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (2). doi:10.1002/14651858.CD006403.pub2

DOI: 10.1002/14651858.CD006403.pub2

An encouraging assessment of methods to inform priorities for updating systematic reviews (Journal article)

Sutton, A. J., Donegan, S., Takwoingi, Y., Garner, P., Gamble, C., & Donald, A. (2009). An encouraging assessment of methods to inform priorities for updating systematic reviews. JOURNAL OF CLINICAL EPIDEMIOLOGY, 62(3), 241-251. doi:10.1016/j.jclinepi.2008.04.005

DOI: 10.1016/j.jclinepi.2008.04.005

Commentary: Cochrane review on ITNs for preventing malaria in pregnancy. (Journal article)

Yartey, J. (2009). Commentary: Cochrane review on ITNs for preventing malaria in pregnancy.. International journal of epidemiology, 38(1), 35-36. doi:10.1093/ije/dyn272

DOI: 10.1093/ije/dyn272

DIFFUSION TENSOR IMAGING OF THE BRAIN IN INFANTS BORN PREMATURELY: FEASIBILITY AND REPRODUCIBILITY OF MEASUREMENTS IN A CLINICAL SETTING (Conference Paper)

Tietze, A., Atkinson, J., Parkes, L. M., Abernethy, L. J., Gamble, C., Ng, S. M., . . . Weindling, A. M. (2009). DIFFUSION TENSOR IMAGING OF THE BRAIN IN INFANTS BORN PREMATURELY: FEASIBILITY AND REPRODUCIBILITY OF MEASUREMENTS IN A CLINICAL SETTING. In ACTA PAEDIATRICA Vol. 98 (pp. 60). Retrieved from https://www.webofscience.com/

Outcome reporting bias in trials (ORBIT) (Conference Paper)

Kirkham, J. J., Dwan, K., Altman, D., Gamble, C., Dodd, S., Jacoby, A., . . . Williamson, P. R. (2009). Outcome reporting bias in trials (ORBIT). In Cochrane Colloquium (pp. 12). Singapore: Wiley-Blackwell.

The clinical effectiveness of central venous catheters treated with anti-infective agents in preventing catheter-related bloodstream infections: A systematic review (Journal article)

Hockenhull, J. C., Dwan, K. M., Smith, G. W., Gamble, C. L., Boland, A., Walley, T. J., & Dickson, R. C. (2009). The clinical effectiveness of central venous catheters treated with anti-infective agents in preventing catheter-related bloodstream infections: A systematic review. CRITICAL CARE MEDICINE, 37(2), 702-712. doi:10.1097/CCM.0b013e3181958915

DOI: 10.1097/CCM.0b013e3181958915

Training staff in enhanced relapse prevention for bipolar disorder: Rates of uptake and measures of skill and confidence (Journal article)

Lobban, F., Taylor, L., Chandler, C., Sellwood, W., Gamble, C., Tyler, E., . . . Morriss, R. (2009). Training staff in enhanced relapse prevention for bipolar disorder: Rates of uptake and measures of skill and confidence. Psychiatric Services, 60(5), 702-706. doi:10.1176/ps.2009.60.5.702

DOI: 10.1176/ps.2009.60.5.702

2008

Reporting of clinical trials: a review of research funders' guidelines (Journal article)

Dwan, K., Gamble, C., Williamson, P. R., & Altman, D. G. (2008). Reporting of clinical trials: a review of research funders' guidelines. TRIALS, 9. doi:10.1186/1745-6215-9-66

DOI: 10.1186/1745-6215-9-66

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias (Journal article)

Dwan, K., Altman, D. G., Arnaiz, J. A., Bloom, J., Chan, A. -W., Cronin, E., . . . Williamson, P. R. (2008). Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias. PLOS ONE, 3(8). doi:10.1371/journal.pone.0003081

DOI: 10.1371/journal.pone.0003081

TIPIT: A randomised controlled trial of thyroxine in preterm infants under 28 weeks gestation: Magnetic Resonance Imaging and Magnetic Resonance Angiography protocol (Journal article)

Ng, S. M., Turner, M. A., Gamble, C., Didi, M., Victor, S., Malamateniou, C., . . . Weindling, A. M. (2008). TIPIT: A randomised controlled trial of thyroxine in preterm infants under 28 weeks gestation: Magnetic Resonance Imaging and Magnetic Resonance Angiography protocol. BMC PEDIATRICS, 8. doi:10.1186/1471-2431-8-26

DOI: 10.1186/1471-2431-8-26

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation. (Journal article)

Hockenhull, J. C., Dwan, K., Boland, A., Smith, G., Bagust, A., Dündar, Y., . . . Dickson, R. (2008). The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation.. Health technology assessment (Winchester, England), 12(12), iii-154. doi:10.3310/hta12120

DOI: 10.3310/hta12120

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation: Abstract (Journal article)

Hockenhull, J. C., Dwan, K., Boland, A., Smith, G., Bagust, A., Duendar, Y., . . . Dickson, R. (2008). The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation: Abstract. HEALTH TECHNOLOGY ASSESSMENT, 12(12), 1-+. Retrieved from https://www.webofscience.com/

TIPIT: A randomised controlled trial of thyroxine in preterm infants under 28 weeks' gestation (Journal article)

Ng, S. M., Turner, M. A., Gamble, C., Didi, M., Victor, S., & Weindling, A. M. (2008). TIPIT: A randomised controlled trial of thyroxine in preterm infants under 28 weeks' gestation. TRIALS, 9. doi:10.1186/1745-6215-9-17

DOI: 10.1186/1745-6215-9-17

TIPIT: A randomised controlled trial of thyroxine in preterm infants under 28 weeks' gestation. (Journal article)

TIPIT: a randomised controlled trial of thyroxine in preterm infants under 28 weeks gestation: magnetic resonance imaging and magnetic resonance angiography protocol. (Journal article)

Ng, S. M., Turner, M. A., Gamble, C., Didi, M., Victor, S., Malamateniou, C., . . . Weindling, A. M. (2008). TIPIT: a randomised controlled trial of thyroxine in preterm infants under 28 weeks gestation: magnetic resonance imaging and magnetic resonance angiography protocol.. BMC Pediatr., 8(26). Retrieved from http://www.biomedcentral.com/1471-2431/8/26

TIPIT: a randomised controlled trial of thyroxine in preterm infants under 28 weeks gestation: magnetic resonance imaging and magnetic resonance angiography protocol. (Journal article)

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: A systematic review and economic evaluation (Journal article)

Hockenhull, J. C., Dwan, K., Boland, A., Smith, G., Bagust, A., Dündar, Y., . . . Dickson, R. (2008). The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: A systematic review and economic evaluation. Health Technology Assessment, 12(12). doi:10.3310/hta12120

DOI: 10.3310/hta12120

2007

Enhanced relapse prevention for bipolar disorder – ERP trial. A cluster randomised controlled trial to assess the feasibility of training care coordinators to offer enhanced relapse prevention for bipolar disorder (Journal article)

Lobban, F., Gamble, C., Kinderman, P., Taylor, L., Chandler, C., Tyler, E., . . . Morriss, R. K. (2007). Enhanced relapse prevention for bipolar disorder – ERP trial. A cluster randomised controlled trial to assess the feasibility of training care coordinators to offer enhanced relapse prevention for bipolar disorder. BMC Psychiatry, 7(1). doi:10.1186/1471-244x-7-6

DOI: 10.1186/1471-244x-7-6

Vaccines for preventing anthrax (Journal article)

Donegan, S., Bellamy, R., & Gamble, C. L. (n.d.). Vaccines for preventing anthrax. doi:10.1002/14651858.cd006403

DOI: 10.1002/14651858.cd006403

A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. (Journal article)

Marson, A. G., Appleton, R., Baker, G. A., Chadwick, D. W., Doughty, J., Eaton, B., . . . Williamson, P. R. (2007). A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial.. Health technology assessment (Winchester, England), 11(37), iii-134. doi:10.3310/hta11370

DOI: 10.3310/hta11370

Artemether-lumefantrine for treating uncomplicated falciparum malaria (Withdrawn Paper. 2003, art no. CD003125) (Journal article)

Omari, A. A. A., Gamble, C., & Garner, P. (2005). Artemether-lumefantrine for treating uncomplicated falciparum malaria (Withdrawn Paper. 2003, art no. CD003125). COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (4). doi:10.1002/14651858.CD003125.pub2

DOI: 10.1002/14651858.CD003125.pub2

Quality of life outcomes of immediate or delayed treatment of early epilepsy and single seizures (Journal article)

Jacoby, A., Gamble, C., Doughty, J., Marson, A., & Chadwick, D. (2007). Quality of life outcomes of immediate or delayed treatment of early epilepsy and single seizures. NEUROLOGY, 68(15), 1188-1196. doi:10.1212/01.wnl.0000259411.78423.50

DOI: 10.1212/01.wnl.0000259411.78423.50

Application and investigation of a bound for outcome reporting bias (Journal article)

Williamson, P. R., & Gamble, C. (2007). Application and investigation of a bound for outcome reporting bias. TRIALS, 8. doi:10.1186/1745-6215-8-9

DOI: 10.1186/1745-6215-8-9

Insecticide-treated nets for the prevention of malaria in pregnancy: A systematic review of randomised controlled trials (Journal article)

Gamble, C., Ekwaru, P. J., Garner, P., & Kuile, F. O. T. (2007). Insecticide-treated nets for the prevention of malaria in pregnancy: A systematic review of randomised controlled trials. PLOS MEDICINE, 4(3), 506-515. doi:10.1371/journal.pmed.0040107

DOI: 10.1371/journal.pmed.0040107

The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial (Journal article)

Marson, A. G., Al-Kharusi, A. M., Alwaidh, M., Appleton, R., Baker, G. A., Chadwick, D. W., . . . Williamson, P. R. (2007). The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. LANCET, 369(9566), 1000-1015. doi:10.1016/S0140-6736(07)60460-7

DOI: 10.1016/S0140-6736(07)60460-7

The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial (Journal article)

Marson, A. G., Al-Kharusi, A. M., Alwaidh, M., Appleton, R., Baker, G. A., Chadwick, D. W., . . . Williamson, P. R. (2007). The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. LANCET, 369(9566), 1016-1026. doi:10.1016/S0140-6736(07)60461-9

DOI: 10.1016/S0140-6736(07)60461-9

Application and investigation of a bound for outcome reporting bias. (Journal article)

Williamson, P. R., & Gamble, C. (2007). Application and investigation of a bound for outcome reporting bias.. Trials, 8, 9. doi:10.1186/1745-6215-8-9

DOI: 10.1186/1745-6215-8-9

Enhanced relapse prevention for bipolar disorder - ERP trial. A cluster randomised controlled trial to assess the feasibility of training care coordinators to offer enhanced relapse prevention for bipolar disorder (Journal article)

Lobban, F., Gamble, C., Kinderman, P., Taylor, L., Chandler, C., Tyler, E., . . . Morriss, R. K. (2007). Enhanced relapse prevention for bipolar disorder - ERP trial. A cluster randomised controlled trial to assess the feasibility of training care coordinators to offer enhanced relapse prevention for bipolar disorder. BMC PSYCHIATRY, 7. doi:10.1186/1471-244X-7-6

DOI: 10.1186/1471-244X-7-6

A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial (Journal article)

Marson, A. G., Appleton, R., Baker, G. A., Chadwick, D. W., Doughty, J., Eaton, B., . . . Williamson, P. R. (2007). A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. HEALTH TECHNOLOGY ASSESSMENT, 11(37), IX-+. Retrieved from https://www.webofscience.com/

A randomised controlled trial of postoperative radiotherapy following breast-conserving surgery in a minimum-risk older population. The PRIME trial. (Journal article)

Prescott, R. J., Kunkler, I. H., Williams, L. J., King, C. C., Jack, W., van der Pol, M., . . . Cairns, J. (2007). A randomised controlled trial of postoperative radiotherapy following breast-conserving surgery in a minimum-risk older population. The PRIME trial.. Health technology assessment (Winchester, England), 11(31), 1-iv. doi:10.3310/hta11310

DOI: 10.3310/hta11310

Enhanced relapse prevention for bipolar disorder - ERP trial. A cluster randomised controlled trial to assess the feasibility of training care coordinators to offer enhanced relapse prevention for bipolar disorder (Journal article)

Quality of Life Outcomes of Immediate or Delayed Treatment of Early Epilepsy and Single Seizures. (Journal article)

Jacoby, A., Gamble, C., Doughty, J., Marson, A., Chadwick, D., & on behalf of the Medical Research Council MESS Study Group.. (2007). Quality of Life Outcomes of Immediate or Delayed Treatment of Early Epilepsy and Single Seizures.. Neurology, 68, 118-196.

2006

Site-specific skin reactions to amethocaine. (Journal article)

Proudfoot, C., & Gamble, C. (2006). Site-specific skin reactions to amethocaine.. Paediatric nursing, 18(5), 26-28. doi:10.7748/paed2006.06.18.5.26.c1034

DOI: 10.7748/paed2006.06.18.5.26.c1034

A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy (Journal article)

Gamble, C., Williamson, P. R., Chadwick, D. W., & Marson, A. G. (2006). A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy. NEUROLOGY, 66(9), 1310-1317. doi:10.1212/01.wnl.0000210517.03902.6e

DOI: 10.1212/01.wnl.0000210517.03902.6e

Artemether-lumefantrine (four-dose regimen) for treating uncomplicated falciparum malaria (Journal article)

Omari, A. A. A., Gamble, C., & Garner, P. (2006). Artemether-lumefantrine (four-dose regimen) for treating uncomplicated falciparum malaria. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (2). doi:10.1002/14651858.CD005965

DOI: 10.1002/14651858.CD005965

Insecticide-treated nets for preventing malaria in pregnancy (Journal article)

Gamble, C., Ekwaru, J. P., & ter Kuile, F. O. (2006). Insecticide-treated nets for preventing malaria in pregnancy. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (2). doi:10.1002/14651858.CD003755.pub2

DOI: 10.1002/14651858.CD003755.pub2

Lamotrigine versus carbamazepine monotherapy for epilepsy (Journal article)

Gamble, C. L., Williamson, P. R., & Marson, A. G. (2006). Lamotrigine versus carbamazepine monotherapy for epilepsy. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (1). doi:10.1002/14651858.CD001031.pub2

DOI: 10.1002/14651858.CD001031.pub2

Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations (Journal article)

Macfadyen, C. A., Acuin, J. M., & Gamble, C. (2006). Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (1). doi:10.1002/14651858.CD005608

DOI: 10.1002/14651858.CD005608

A meta-analysis of individual patient responses to lamotrigine or carbamazepine (Journal article)

Gamble, C., Williamson, P. R., Chadwick, D. W., & Marson, A. G. (2006). A meta-analysis of individual patient responses to lamotrigine or carbamazepine. Neurology., 66(9), 1310-1317. doi:10.1212/01.wnl.0000210517.03902.6e

DOI: 10.1212/01.wnl.0000210517.03902.6e

A study of site-specific local skin reactions to Amethocaine (Journal article)

Proudfoot, C., & Gamble, C. (2006). A study of site-specific local skin reactions to Amethocaine. Paediatric Nursing, 18, 26-28.

2005

Albendazole for lymphatic filariasis (Journal article)

Critchley, J., Addiss, D., Gamble, C., Garner, P., Gelband, H., & Ejere, H. (2005). Albendazole for lymphatic filariasis. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (4). doi:10.1002/14651858.CD003753.pub3

DOI: 10.1002/14651858.CD003753.pub3

Artemether-lumefantrine (six-dose regimen) for treating uncomplicated falciparum malaria (Journal article)

Omari, A. A. A., Gamble, C., & Garner, P. (2005). Artemether-lumefantrine (six-dose regimen) for treating uncomplicated falciparum malaria. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (4). doi:10.1002/14651858.CD005564

DOI: 10.1002/14651858.CD005564

Topical antibiotics without steroids for chronically discharging ears with underlying eardrum perforations (Journal article)

Macfadyen, C. A., Acuin, J. M., & Gamble, C. (2005). Topical antibiotics without steroids for chronically discharging ears with underlying eardrum perforations. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (4). doi:10.1002/14651858.CD004618.pub2

DOI: 10.1002/14651858.CD004618.pub2

Outcome selection bias in meta-analysis (Journal article)

Williamson, P. R., Gamble, C., Altman, D. G., & Hutton, J. L. (2005). Outcome selection bias in meta-analysis. STATISTICAL METHODS IN MEDICAL RESEARCH, 14(5), 515-524. doi:10.1191/0962280205sm415oa

DOI: 10.1191/0962280205sm415oa

Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial (Journal article)

Marson, A., Jacoby, A., Johnson, A., Kim, L., Gamble, C., & Chadwick, D. (2005). Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial. LANCET, 365(9476), 2007-2013. doi:10.1016/S0140-6736(05)66694-9

DOI: 10.1016/S0140-6736(05)66694-9

Identification and impact of outcome selection bias in meta-analysis (Journal article)

Williamson, P. R., & Gamble, C. (2005). Identification and impact of outcome selection bias in meta-analysis. STATISTICS IN MEDICINE, 24(10), 1547-1561. doi:10.1002/sim.2025

DOI: 10.1002/sim.2025

Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial (Journal article)

Macfadyen, C., Gamble, C., Garner, P., Macharia, I., Mackenzie, I., Mugwe, P., . . . Williamson, P. (2005). Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 10(2), 190-197. doi:10.1111/j.1365-3156.2004.01368.x

DOI: 10.1111/j.1365-3156.2004.01368.x

Albendazole for the control and elimination of lymphatic filariasis: systematic review (Journal article)

Critchley, J., Addiss, D., Ejere, H., Gamble, C., Garner, P., & Gelband, H. (2005). Albendazole for the control and elimination of lymphatic filariasis: systematic review. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 10(9), 818-825. doi:10.1111/j.1365-3156.2005.01458.x

DOI: 10.1111/j.1365-3156.2005.01458.x

Topical quinolone vs. antiseptic for treating chronic suppurative otitis media:: a randomized controlled trial (Journal article)

Macfadyen, C., Gamble, C., Garner, P., Macharia, I., Mackenzie, I., Mugwe, P., . . . Williamson, P. (2005). Topical quinolone vs. antiseptic for treating chronic suppurative otitis media:: a randomized controlled trial. CLINICAL OTOLARYNGOLOGY, 30(2), 193-194. doi:10.1111/j.1365-2273.2005.01012_1.x

DOI: 10.1111/j.1365-2273.2005.01012_1.x

Uncertainty method improved on best-worst case analysis in a binary meta-analysis (Journal article)

Gamble, C., & Hollis, S. (2005). Uncertainty method improved on best-worst case analysis in a binary meta-analysis. JOURNAL OF CLINICAL EPIDEMIOLOGY, 58(6), 579-588. doi:10.1016/j.jclinepi.2004.09.013

DOI: 10.1016/j.jclinepi.2004.09.013

2004

Public knowledge, private grief: A study of public attitudes to epilepsy in the United Kingdom and implications for stigma (Journal article)

Jacoby, A., Gorry, J., Gamble, C., & Baker, T. A. (2004). Public knowledge, private grief: A study of public attitudes to epilepsy in the United Kingdom and implications for stigma. EPILEPSIA, 45(11), 1405-1415. doi:10.1111/j.0013-9580.2004.02904.x

DOI: 10.1111/j.0013-9580.2004.02904.x

Adjusting for publication bias: modelling the selection process (Journal article)

Preston, C., Ashby, D., & Smyth, R. (2004). Adjusting for publication bias: modelling the selection process. JOURNAL OF EVALUATION IN CLINICAL PRACTICE, 10(2), 313-322. doi:10.1111/j.1365-2753.2003.00457.x

DOI: 10.1111/j.1365-2753.2003.00457.x

Artemether-lumefantrine for uncomplicated malaria: a systematic review (Journal article)

Omari, A. A., Gamble, C., & Garner, P. (2004). Artemether-lumefantrine for uncomplicated malaria: a systematic review. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 9(2), 192-199. doi:10.1046/j.1365-3156.2003.01186.x

DOI: 10.1046/j.1365-3156.2003.01186.x

Albendazole for lymphatic filariasis (Cochrane Review) (Journal article)

Julia, C., Henry, E., Paul, G., Carrol, G., & Hellen, G. (2004). Albendazole for lymphatic filariasis (Cochrane Review). The Cochrane Library, (1).

Albendazole for lymphatic filariasis. (Journal article)

Addiss, D., Critchley, J., Ejere, H., Garner, P., Gelband, H., Gamble, C., & International Filariasis Review Group. (2004). Albendazole for lymphatic filariasis.. The Cochrane database of systematic reviews, (1), CD003753. doi:10.1002/14651858.cd003753.pub2

DOI: 10.1002/14651858.cd003753.pub2

2003

Pregnancy outcome in severe placental abruption (Journal article)

Kayani, S. I., Walkinshaw, S. A., & Preston, C. (2003). Pregnancy outcome in severe placental abruption. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 110(7), 679-683. doi:10.1016/S1470-0328(03)02988-4

DOI: 10.1016/S1470-0328(03)02988-4

Pregnancy outcome in severe placental abruption (Journal article)

Kayani, S. I., Walkinshaw, S. A., & Preston, C. (2003). Pregnancy outcome in severe placental abruption. BJOG: An International Journal of Obstetrics & Gynaecology, 110(7), 679-683. doi:10.1046/j.1471-0528.2003.02088.x

DOI: 10.1046/j.1471-0528.2003.02088.x

2002

Zanamivir for the treatment of influenza in adults: a systematic review and economic evaluation. (Journal article)

Burls, A., Clark, W., Stewart, T., Preston, C., Bryan, S., Jefferson, T., & Fry-Smith, A. (2002). Zanamivir for the treatment of influenza in adults: a systematic review and economic evaluation.. Health technology assessment (Winchester, England), 6(9), 1-87. doi:10.3310/hta6090

DOI: 10.3310/hta6090

1998

Time to publication as full reports of abstracts of randomized controlled trials in cystic fibrosis (Journal article)

Cheng, K., Preston, C., Ashby, D., O'Hea, U., & Smyth, R. L. (1998). Time to publication as full reports of abstracts of randomized controlled trials in cystic fibrosis. PEDIATRIC PULMONOLOGY, 26(2), 101-105. doi:3.3.CO;2-C">10.1002/(SICI)1099-0496(199808)26:2<101::AID-PPUL5>3.3.CO;2-C

DOI: 10.1002/(SICI)1099-0496(199808)26:2<101::AID-PPUL5>3.3.CO;2-C

Time to publication of reports of randomised controlled trials in conferences (Journal article)

Cheng, K., Preston, C., Ashby, D., O'Hea, U. M., & Smyth, R. L. (1998). Time to publication of reports of randomised controlled trials in conferences. Pediatric Pulmonology, 26(2), 101-105.