Prof Kevin Park

Professor Molecular and Clinical Pharmacology

    Publications

    2019

    Elucidating the role of mitochondrial dysfunction in drug-induced intrahepatic cholestasis (Conference Paper)

    Penman, S. L., Sharma, P., Park, B. K., Aerts, H., Weaver, R. J., & Chadwick, A. E. (2019). Elucidating the role of mitochondrial dysfunction in drug-induced intrahepatic cholestasis. In TOXICOLOGY LETTERS Vol. 314 (pp. S43-S44). Retrieved from http://gateway.webofknowledge.com/

    Defining the physiological relevance of bile acid induced mitochondrial dysfunction (Conference Paper)

    Penman, S. L., Sharma, P., Park, B. K., Aerts, H., Weaver, R. J., & Chadwick, A. (2019). Defining the physiological relevance of bile acid induced mitochondrial dysfunction. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3043). Retrieved from http://gateway.webofknowledge.com/

    Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity. (Journal article)

    Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., . . . Chadwick, A. E. (2019). Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity.. Current protocols in toxicology, 80(1), e76. doi:10.1002/cptx.76

    DOI: 10.1002/cptx.76

    Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells. (Journal article)

    Penman, S. L., Sharma, P., Aerts, H., Park, B. K., Weaver, R. J., & Chadwick, A. E. (2019). Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells.. Toxicology in vitro : an international journal published in association with BIBRA, 61, 104595. doi:10.1016/j.tiv.2019.104595

    DOI: 10.1016/j.tiv.2019.104595

    Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system. (Journal article)

    Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology (Baltimore, Md.). doi:10.1002/hep.30701

    DOI: 10.1002/hep.30701

    Stem cell models as an in vitro model for predictive toxicology (Journal article)

    Lynch, S., Pridgeon, C. S., Duckworth, C. A., Sharma, P., Park, B. K., & Goldring, C. E. P. (2019). Stem cell models as an in vitro model for predictive toxicology. BIOCHEMICAL JOURNAL, 476, 1149-1158. doi:10.1042/BCJ20170780

    DOI: 10.1042/BCJ20170780

    Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retraction of Vol 127, Pg 2118, 2017) (Journal article)

    Walker, L. E., Frigerio, F., Ravizza, T., Ricci, E., Tse, K., Jenkins, R. E., . . . Pirmohamed, M. (2019). Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retraction of Vol 127, Pg 2118, 2017). JOURNAL OF CLINICAL INVESTIGATION, 129(5), 2166. doi:10.1172/JCI129285

    DOI: 10.1172/JCI129285

    A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction (Journal article)

    Sharkey, J., Ressel, L., Brillant, N., Scarfe, L., Wilm, B., Park, B. K., & Murray, P. (2019). A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction. STEM CELLS INTERNATIONAL. doi:10.1155/2019/7386954

    DOI: 10.1155/2019/7386954

    Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01 (Journal article)

    Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01. ALLERGY, 74(8), 1533-1548. doi:10.1111/all.13769

    DOI: 10.1111/all.13769

    Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers (Journal article)

    Alhilali, K. A., Al-Attar, Z., Gibson, A., Tailor, A., Meng, X., Monshouwer, M., . . . Naisbitt, D. J. (2019). Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers. TOXICOLOGICAL SCIENCES, 168(2), 597-609. doi:10.1093/toxsci/kfz007

    DOI: 10.1093/toxsci/kfz007

    Dose-linearity of the pharmacokinetics of an intravenous [C-14]midazolam microdose in children (Journal article)

    van Groen, B. D., Vaes, W. H., Park, B. K., Krekels, E. H. J., van Duijn, E., Korgvee, L. -T., . . . Turner, M. A. (2019). Dose-linearity of the pharmacokinetics of an intravenous [C-14]midazolam microdose in children. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 85(10), 2332-2340. doi:10.1111/bcp.14047

    DOI: 10.1111/bcp.14047

    2018

    Model-based identification of TNF alpha-induced IKK beta-mediated and I kappa B alpha-mediated regulation of NF kappa B signal transduction as a tool to quantify the impact of drug-induced liver injury compounds (Journal article)

    Oppelt, A., Kaschek, D., Huppelschoten, S., Sison-Young, R., Zhang, F., Buck-Wiese, M., . . . Klingmueuler, U. (2018). Model-based identification of TNF alpha-induced IKK beta-mediated and I kappa B alpha-mediated regulation of NF kappa B signal transduction as a tool to quantify the impact of drug-induced liver injury compounds. NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 4. doi:10.1038/s41540-018-0058-z

    DOI: 10.1038/s41540-018-0058-z

    The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity (Journal article)

    Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., . . . Chadwick, A. E. (2018). The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity. TOXICOLOGY IN VITRO, 53, 136-147. doi:10.1016/j.tiv.2018.08.001

    DOI: 10.1016/j.tiv.2018.08.001

    Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop (Journal article)

    Stacey, G., Andrews, P. W., Asante, C., Barbaric, I., Barry, J., Bisset, L., . . . Williams, D. (2018). Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop. REGENERATIVE MEDICINE, 13(8), 935-944. doi:10.2217/rme-2018-0120

    DOI: 10.2217/rme-2018-0120

    Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration (Journal article)

    Scarfe, L., Taylor, A., Sharkey, J., Harwood, R., Barrow, M., Comenge, J., . . . Wilm, B. (2018). Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration. Stem Cell Research and Therapy. doi:10.1186/s13287-018-1076-x

    DOI: 10.1186/s13287-018-1076-x

    Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury (Journal article)

    Copple, I. M., den Hollander, W., Callegaro, G., Mutter, F. E., Maggs, J. L., Schofield, A. L., . . . Park, B. K. (2019). Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury. ARCHIVES OF TOXICOLOGY, 93(2), 385-399. doi:10.1007/s00204-018-2354-1

    DOI: 10.1007/s00204-018-2354-1

    HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors (Journal article)

    Usui, T., Tailor, A., Faulkner, L., Meng, X., Farrell, J., Daly, A. K., . . . Naisbitt, D. J. (2018). HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 31(10), 1022-1024. doi:10.1021/acs.chemrestox.8b00163

    DOI: 10.1021/acs.chemrestox.8b00163

    Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency (Journal article)

    Toth, B., Jani, M., Beery, E., Heslop, T., Bayliss, M., Kitteringham, N. R., . . . Krajcsi, P. (2018). Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency. TOXICOLOGY IN VITRO, 52, 189-194. doi:10.1016/j.tiv.2018.06.018

    DOI: 10.1016/j.tiv.2018.06.018

    Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo (vol 10, pg 7106, 2016) (Journal article)

    Comenge, J., Fragueiro, O., Sharkey, J., Taylor, A., Held, M., Burton, N. C., . . . Levy, R. (2018). Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo (vol 10, pg 7106, 2016). ACS NANO, 12(8), 8831. doi:10.1021/acsnano.8b05577

    DOI: 10.1021/acsnano.8b05577

    Immune drug-induced liver disease and drugs (Journal article)

    Waddington, J. C., Meng, X., Naisbitt, D. J., & Park, B. K. (2018). Immune drug-induced liver disease and drugs. Current Opinion in Toxicology, 10, 46-53. doi:10.1016/j.cotox.2017.12.006

    DOI: 10.1016/j.cotox.2017.12.006

    Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. (Journal article)

    Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2019). Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.. Oncotarget, 10(6), 685. doi:10.18632/oncotarget.26625

    DOI: 10.18632/oncotarget.26625

    The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. (Journal article)

    Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2018). The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.. Oncotarget, 9(43), 27104-27116. doi:10.18632/oncotarget.25497

    DOI: 10.18632/oncotarget.25497

    TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers. (Journal article)

    Francis, B., Clarke, J. I., Walker, L. E., Brillant, N., Jorgensen, A. L., Park, B. K., . . . Antoine, D. J. (2018). TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.. Journal of hepatology. doi:10.1016/j.jhep.2018.04.024

    DOI: 10.1016/j.jhep.2018.04.024

    Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. (Journal article)

    Bell, C. C., Dankers, A. C. A., Lauschke, V. M., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.. Toxicological sciences : an official journal of the Society of Toxicology, 162(2), 655-666. doi:10.1093/toxsci/kfx289

    DOI: 10.1093/toxsci/kfx289

    Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response (Journal article)

    Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., . . . Vimalachandran, D. (2018). Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. JOURNAL OF PROTEOMICS, 179, 53-60. doi:10.1016/j.jprot.2018.02.030

    DOI: 10.1016/j.jprot.2018.02.030

    Definition of the nature and hapten threshold of the beta-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017) (Journal article)

    Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the beta-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020

    DOI: 10.4049/jimmunol.1800020

    IS AN INTRAVENOUS [14C]MIDAZOLAM MICRODOSE DOSE-LINEAR IN CHILDREN? RESULTS OF A PILOT STUDY. (Conference Paper)

    van Groen, B. D., Park, B. K., Mooij, M. G., Vaes, W., Orgvee, L. -T. K., Maruszak, W., . . . Turner, M. A. (2018). IS AN INTRAVENOUS [14C]MIDAZOLAM MICRODOSE DOSE-LINEAR IN CHILDREN? RESULTS OF A PILOT STUDY.. In CLINICAL PHARMACOLOGY & THERAPEUTICS Vol. 103 (pp. S53). Retrieved from http://gateway.webofknowledge.com/

    The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017) (Journal article)

    Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019

    DOI: 10.4049/jimmunol.1800019

    Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity (Journal article)

    Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030

    DOI: 10.1021/acs.chemrestox.8b00030

    Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study (Journal article)

    Bell, C., Dankers, A., Lauschke, V., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study. Toxicological Sciences. doi:10.1093/toxsci/kfx289

    DOI: 10.1093/toxsci/kfx289

    Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms (Journal article)

    Pridgeon, C. S., Schlott, C., Wong, M. W., Heringa, M. B., Heckel, T., Leedale, J., . . . Goldring, C. E. P. (2018). Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms. ARCHIVES OF TOXICOLOGY, 92(2), 557-569. doi:10.1007/s00204-018-2152-9

    DOI: 10.1007/s00204-018-2152-9

    Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions (Journal article)

    Sullivan, A., Watkinson, J., Waddington, J., Park, B. K., & Naisbitt, D. J. (2018). Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 14(3), 261-274. doi:10.1080/17425255.2018.1441285

    DOI: 10.1080/17425255.2018.1441285

    Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing (Chapter)

    Wong, M. W., Pridgeon, C. S., Schlott, C., Park, B. K., & Goldring, C. E. P. (2018). Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing. In Methods in Pharmacology and Toxicology (pp. 199-212). Springer New York. doi:10.1007/978-1-4939-7677-5_10

    DOI: 10.1007/978-1-4939-7677-5_10

    beta-Lactam hypersensitivity involves expansion of circulating and skin-resident T(H)22 cells (Journal article)

    Sullivan, A., Wang, E., Farrell, J., Whitaker, P., Faulkner, L., Peckham, D., . . . Naisbitt, D. J. (2018). beta-Lactam hypersensitivity involves expansion of circulating and skin-resident T(H)22 cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(1), 235-+. doi:10.1016/j.jaci.2017.01.020

    DOI: 10.1016/j.jaci.2017.01.020

    2017

    MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury. (Journal article)

    Howell, L. S., Ireland, L., Park, B. K., & Goldring, C. E. (2018). MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 18(1), 47-54. doi:10.1080/14737159.2018.1415145

    DOI: 10.1080/14737159.2018.1415145

    Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts (Journal article)

    Amali, M. O., Jenkins, R. E., Meng, X., Faulkner, L., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2017). Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2097-2099. doi:10.1021/acs.chemrestox.7b00291

    DOI: 10.1021/acs.chemrestox.7b00291

    Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity (Journal article)

    Forootan, S. S., Mutter, F. E., Kipar, A., Iwawaki, T., Francis, B., Goldring, C. E., . . . Copple, I. M. (2017). Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-16491-2

    DOI: 10.1038/s41598-017-16491-2

    Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management (Journal article)

    Sutton, P. A., Jithesh, P. V., Jones, R. P., Evans, J. P., Vimalachandran, D., Malik, H. Z., . . . Kitteringham, N. R. (2018). Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management. EJSO, 44(1), 115-121. doi:10.1016/j.ejso.2017.10.211

    DOI: 10.1016/j.ejso.2017.10.211

    Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies (Journal article)

    Dear, J. W., Clarke, J. I., Francis, B., Allen, L., Wraight, J., Shen, J., . . . Antoine, D. J. (2018). Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies. LANCET GASTROENTEROLOGY & HEPATOLOGY, 3(2), 104-113. doi:10.1016/S2468-1253(17)30266-2

    DOI: 10.1016/S2468-1253(17)30266-2

    Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. (Journal article)

    Scarfe, L., Brillant, N., Kumar, J. D., Ali, N., Alrumayh, A., Amali, M., . . . Park, B. K. (2017). Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies.. NPJ Regenerative medicine, 2, 28. doi:10.1038/s41536-017-0029-9

    DOI: 10.1038/s41536-017-0029-9

    Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors (Journal article)

    Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263

    DOI: 10.1021/acs.chemrestox.7b00263

    Kinetic characterization of bile salt transport by human NTCP (SLC10A1) (Journal article)

    Jani, M., Beery, E., Heslop, T., Toth, B., Jagota, B., Kis, E., . . . Weaver, R. J. (2018). Kinetic characterization of bile salt transport by human NTCP (SLC10A1). TOXICOLOGY IN VITRO, 46, 189-193. doi:10.1016/j.tiv.2017.10.012

    DOI: 10.1016/j.tiv.2017.10.012

    Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins (Journal article)

    Rowe, C., Shaeri, M., Large, E., Cornforth, T., Robinson, A., Kostrzewski, T., . . . Hughes, D. (2018). Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins. TOXICOLOGY IN VITRO, 46, 29-38. doi:10.1016/j.tiv.2017.09.012

    DOI: 10.1016/j.tiv.2017.09.012

    Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017) (Journal article)

    Heslop, J. A., Kia, R., Pridgeon, C. S., Sison-Young, R. L., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017). STEM CELLS TRANSLATIONAL MEDICINE, 6(8). Retrieved from http://gateway.webofknowledge.com/

    Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo (Journal article)

    Brillant, N., Elmasry, M., Burton, N. C., Rodriguez, J. M., Sharkey, J. W., Fenwick, S., . . . Antoine, D. J. (2017). Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo. TOXICOLOGY AND APPLIED PHARMACOLOGY, 332, 64-74. doi:10.1016/j.taap.2017.07.019

    DOI: 10.1016/j.taap.2017.07.019

    The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors (Journal article)

    Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2017). The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors. JOURNAL OF IMMUNOLOGY, 199(4), 1223-1237. doi:10.4049/jimmunol.1602029

    DOI: 10.4049/jimmunol.1602029

    Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies (Journal article)

    Clarke, J. I., Forootan, S. S., Lea, J. D., Howell, L. S., Rodriguez, J. M., Kipar, A., . . . Antoine, D. J. (2017). Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies. TOXICOLOGY RESEARCH, 6(4), 406-411. doi:10.1039/c6tx00442c

    DOI: 10.1039/c6tx00442c

    Test systems in Drug Discovery for hazard identification and risk assessment of human Drug-Induced Liver Injury. (Journal article)

    Weaver, R. J., Betts, C., Blomme, E. A. G., Gerets, H. H. J., Gjervig Jensen, K., Hewitt, P. G., . . . Park, B. K. (2017). Test systems in Drug Discovery for hazard identification and risk assessment of human Drug-Induced Liver Injury.. Expert opinion on drug metabolism & toxicology. doi:10.1080/17425255.2017.1341489

    DOI: 10.1080/17425255.2017.1341489

    Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity (Conference Paper)

    Dear, J. W., Clarke, J. I., Francis, B., Philips, L., Wraight, J., Dargan, P. I., . . . Antoine, D. J. (2017). Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity. In CLINICAL TOXICOLOGY Vol. 55 (pp. 468). Retrieved from http://gateway.webofknowledge.com/

    Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retracted article. See vol. 129, pg. 2166, 2019) (Journal article)

    Walker, L. E., Frigerio, F., Ravizza, T., Ricci, E., Tse, K., Jenkins, R. E., . . . Pirmohamed, M. (2017). Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retracted article. See vol. 129, pg. 2166, 2019). JOURNAL OF CLINICAL INVESTIGATION, 127(6), 2118-2132. doi:10.1172/JCI92001

    DOI: 10.1172/JCI92001

    Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients (Journal article)

    Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R. E., Marlot, P. T., Marson, A. G., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 30(7), 1419-1435. doi:10.1021/acs.chemrestox.7b00063

    DOI: 10.1021/acs.chemrestox.7b00063

    Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (Journal article)

    Heslop, J. A., Kia, R., Pridgeon, C. S., Sison-Young, R. L., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells. STEM CELLS TRANSLATIONAL MEDICINE, 6(5), 1321-1331. doi:10.1002/sctm.16-0029

    DOI: 10.1002/sctm.16-0029

    Definition of the Nature and Hapten Threshold of the beta-Lactam Antigen Required for T Cell Activation In Vitro and in Patients (Journal article)

    Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the beta-Lactam Antigen Required for T Cell Activation In Vitro and in Patients. JOURNAL OF IMMUNOLOGY, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209

    DOI: 10.4049/jimmunol.1700209

    Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells (Journal article)

    Ogese, M. O., Faulkner, L., Jenkins, R. E., French, N. S., Copple, I. M., Antoine, D. J., . . . Naisbitt, D. J. (2017). Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. TOXICOLOGICAL SCIENCES, 158(1), 76-89. doi:10.1093/toxsci/kfx069

    DOI: 10.1093/toxsci/kfx069

    Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury (Journal article)

    Carr, D. F., Ayehunie, S., Davies, A., Duckworth, C. A., French, S., Hall, N., . . . Pirmohamed, M. (2017). Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172, 181-194. doi:10.1016/j.pharmthera.2017.01.002

    DOI: 10.1016/j.pharmthera.2017.01.002

    Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo (Journal article)

    Sharkey, J., Lewis, P. J. S., Barrow, M., Alwahsh, S. M., Noble, J., Livingstone, E., . . . Park, B. K. (2017). Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo. CYTOTHERAPY, 19(4), 555-569. doi:10.1016/j.jcyt.2017.01.003

    DOI: 10.1016/j.jcyt.2017.01.003

    Optimising the use of medicines to reduce acute kidney injury in children and babies (Journal article)

    Oni, L., Hawcutt, D. B., Turner, M. A., Beresford, M. W., McWilliam, S., Barton, C., . . . Antoine, D. J. (2017). Optimising the use of medicines to reduce acute kidney injury in children and babies. PHARMACOLOGY & THERAPEUTICS, 174, 55-62. doi:10.1016/j.pharmthera.2017.02.018

    DOI: 10.1016/j.pharmthera.2017.02.018

    Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury (Journal article)

    Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. doi:10.1093/toxsci/kfw218

    DOI: 10.1093/toxsci/kfw218

    Stem Cell-Derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-Induced Liver Injury (Journal article)

    Goldring, C., Antoine, D. J., Bonner, F., Crozier, J., Denning, C., Fontana, R. J., . . . Park, B. K. (2017). Stem Cell-Derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-Induced Liver Injury. HEPATOLOGY, 65(2), 710-721. doi:10.1002/hep.28886

    DOI: 10.1002/hep.28886

    Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells (Journal article)

    Gibson, A., Faulkner, L., Wood, S., Park, B. K., & Naisbitt, D. J. (2017). Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(2), 578-+. doi:10.1016/j.jaci.2016.11.032

    DOI: 10.1016/j.jaci.2016.11.032

    Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways (Journal article)

    Brandi, J., Dando, I., Dalla Pozza, E., Biondani, G., Jenkins, R., Elliott, V., . . . Palmieri, M. (2017). Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways. JOURNAL OF PROTEOMICS, 150, 310-322. doi:10.1016/j.jprot.2016.10.002

    DOI: 10.1016/j.jprot.2016.10.002

    New Approaches to Investigate Drug-Induced Hypersensitivity (Journal article)

    Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333

    DOI: 10.1021/acs.chemrestox.6b00333

    SPIONs for cell labelling and tracking using MRI: magnetite or maghemite? (Journal article)

    Barrow, M., Taylor, A., Fuentes-Caparros, A. M., Sharkey, J., Daniels, L. M., Mandal, P., . . . Adams, D. J. (2017). SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?. BIOMATERIALS SCIENCE, 6(1), 101-106. doi:10.1039/c7bm00515f

    DOI: 10.1039/c7bm00515f

    2016

    A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity (Presentation material)

    Yip, V. L. M., Meng, X., Maggs, J. L., Pertinez, H., Carr, D. F., Marson, A. G., . . . Pirmohamed, M. (2016). A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity. London, UK.

    Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity (Journal article)

    Faulkner, L., Gibson, A., Sullivan, A., Tailor, A., Usui, T., Alfirevic, A., . . . Park, B. K. (2016). Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. TOXICOLOGICAL SCIENCES, 154(2), 416-429. doi:10.1093/toxsci/kfw177

    DOI: 10.1093/toxsci/kfw177

    Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man (Journal article)

    Dragovic, S., Vermeulen, N. P. E., Gerets, H. H., Hewitt, P. G., Ingelman-Sundberg, M., Park, B. K., . . . Weaver, R. J. (2016). Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man. ARCHIVES OF TOXICOLOGY, 90(12), 2979-3003. doi:10.1007/s00204-016-1845-1

    DOI: 10.1007/s00204-016-1845-1

    Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation (Journal article)

    Tailor, A., Waddington, J. C., Meng, X., & Park, B. K. (2016). Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 1912-1935. doi:10.1021/acs.chemrestox.6b00147

    DOI: 10.1021/acs.chemrestox.6b00147

    No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury (Journal article)

    Faulkner, L., Meng, X., Naisbitt, D. J., Spraggs, C. F., & Park, B. K. (2016). No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 2111-2113. doi:10.1021/acs.chemrestox.6b00400

    DOI: 10.1021/acs.chemrestox.6b00400

    Roles of Nrf2 in drug and chemical toxicity (Journal article)

    Clarke, J. L., Murray, J. B., Park, B. K., & Copple, I. M. (2016). Roles of Nrf2 in drug and chemical toxicity. Current Opinion in Toxicology, 1, 104-110. doi:10.1016/j.cotox.2016.10.004

    DOI: 10.1016/j.cotox.2016.10.004

    A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat (Journal article)

    Thulin, P., Hornby, R. J., Auli, M., Nordahl, G., Antoine, D. J., Lewis, P. S., . . . Schuppe-Koistinen, I. (2017). A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat. BIOMARKERS, 22(5), 461-469. doi:10.1080/1354750X.2016.1269131

    DOI: 10.1080/1354750X.2016.1269131

    Detection of drug-responsive B lymphocytes and antidrug IgG in patients with beta-lactam hypersensitivity (Journal article)

    Amali, M. O., Sullivan, A., Jenkins, R. E., Farrell, J., Meng, X., Faulkner, L., . . . Naisbitt, D. J. (2017). Detection of drug-responsive B lymphocytes and antidrug IgG in patients with beta-lactam hypersensitivity. ALLERGY, 72(6), 896-907. doi:10.1111/all.13087

    DOI: 10.1111/all.13087

    A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice (Journal article)

    Lundback, P., Lea, J. D., Sowinska, A., Ottosson, L., Furst, C. M., Steen, J., . . . Harris, H. E. (2016). A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice. HEPATOLOGY, 64(5), 1699-1710. doi:10.1002/hep.28736

    DOI: 10.1002/hep.28736

    Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury (Journal article)

    Usui, T., Whitaker, P., Meng, X., Watson, J., Antoine, D. J., French, N. S., . . . Naisbitt, D. J. (2016). Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(11), 1793-1795. doi:10.1021/acs.chemrestox.6b00393

    DOI: 10.1021/acs.chemrestox.6b00393

    Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation (Journal article)

    Lauschke, V. M., Vorrink, S. U., Moro, S. M. L., Rezayee, F., Nordling, A., Hendriks, D. F. G., . . . Ingelman-Sundberg, M. (2016). Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation. HEPATOLOGY, 64(5), 1743-1756. doi:10.1002/hep.28780

    DOI: 10.1002/hep.28780

    Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients (Journal article)

    Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253

    DOI: 10.1021/acs.chemrestox.6b00253

    Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats (Journal article)

    Richert, L., Baze, A., Parmentier, C., Gerets, H. H. J., Sison-Young, R., Dorau, M., . . . Williams, D. P. (2016). Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats. TOXICOLOGY LETTERS, 258, 207-215. doi:10.1016/j.toxlet.2016.06.1127

    DOI: 10.1016/j.toxlet.2016.06.1127

    MIST AND THE FUTURE (Chapter)

    Park, B. K., & Smith, D. A. (n.d.). MIST AND THE FUTURE. In Metabolite Safety in Drug Development (pp. 305-322). John Wiley & Sons, Inc.. doi:10.1002/9781118949689.ch14

    DOI: 10.1002/9781118949689.ch14

    Co-precipitation of DEAE-dextran coated SPIONs: how synthesis conditions affect particle properties, stem cell labelling and MR contrast (Journal article)

    Barrow, M., Taylor, A., Carrion, J. G., Mandal, P., Park, B. K., Poptani, H., . . . Adams, D. J. (2016). Co-precipitation of DEAE-dextran coated SPIONs: how synthesis conditions affect particle properties, stem cell labelling and MR contrast. CONTRAST MEDIA & MOLECULAR IMAGING, 11(5), 362-370. doi:10.1002/cmmi.1700

    DOI: 10.1002/cmmi.1700

    Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients (Journal article)

    Qin, S., Zhou, Y., Gray, L., Kusebauch, U., McEvoy, L., Antoine, D. J., . . . Hood, L. (2016). Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients. JOURNAL OF PROTEOME RESEARCH, 15(10), 3724-3740. doi:10.1021/acs.jproteome.6b00547

    DOI: 10.1021/acs.jproteome.6b00547

    Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo (Journal article)

    Comenge, J., Fragueiro, O., Sharkey, J., Taylor, A., Held, M., Burton, N. C., . . . Levy, R. (2016). Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo. ACS Nano, 10(7), 7106-7116. doi:10.1021/acsnano.6b03246

    DOI: 10.1021/acsnano.6b03246

    Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease (Journal article)

    Sharkey, J., Scarfe, L., Santeramo, I., Garcia-Finana, M., Park, B. K., Poptani, H., . . . Murray, P. (2016). Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease. EUROPEAN JOURNAL OF PHARMACOLOGY, 790, 74-82. doi:10.1016/j.ejphar.2016.06.056

    DOI: 10.1016/j.ejphar.2016.06.056

    A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity (Journal article)

    Sison-Young, R. L., Lauschke, V. M., Johann, E., Alexandre, E., Antherieu, S., Aerts, H., . . . Park, B. K. (2017). A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. ARCHIVES OF TOXICOLOGY, 91(3), 1385-1400. doi:10.1007/s00204-016-1745-4

    DOI: 10.1007/s00204-016-1745-4

    Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease (Journal article)

    Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., . . . Ingelman-Sundberg, M. (2016). Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. SCIENTIFIC REPORTS, 6. doi:10.1038/srep25187

    DOI: 10.1038/srep25187

    Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile (Journal article)

    Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., . . . Park, B. K. (2017). Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. ARCHIVES OF TOXICOLOGY, 91(1), 439-452. doi:10.1007/s00204-016-1694-y

    DOI: 10.1007/s00204-016-1694-y

    Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites (Journal article)

    Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292

    DOI: 10.1021/acs.jmedchem.5b01292

    From mice to men: Murine models of colorectal cancer for use in translational research (Journal article)

    Evans, J. P., Sutton, P. A., Winiarski, B. K., Fenwick, S. W., Malik, H. Z., Vimalachandran, D., . . . Kitteringham, N. R. (2016). From mice to men: Murine models of colorectal cancer for use in translational research. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 98, 94-105. doi:10.1016/j.critrevonc.2015.10.009

    DOI: 10.1016/j.critrevonc.2015.10.009

    UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis (Journal article)

    Abu-Alainin, W., Gana, T., Liloglou, T., Olayanju, A., Barrera, L. N., Ferguson, R., . . . Costello, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. JOURNAL OF PATHOLOGY, 238(3), 423-433. doi:10.1002/path.4665

    DOI: 10.1002/path.4665

    Application of Pluripotent Stem Cells in Drug-Induced Liver Injury Safety Assessment (Chapter)

    Pridgeon, C. S., Zhang, F., Heslop, J. A., Nugues, C. M. L., Kitteringham, N. R., Park, B. K., & Goldring, C. E. P. (n.d.). Application of Pluripotent Stem Cells in Drug-Induced Liver Injury Safety Assessment. In Drug Discovery Toxicology (pp. 331-345). John Wiley & Sons, Inc. doi:10.1002/9781119053248.ch21

    DOI: 10.1002/9781119053248.ch21

    2015

    CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure (Journal article)

    Stutchfield, B. M., Antoine, D. J., Mackinnon, A. C., Gow, D. J., Bain, C. C., Hawley, C. A., . . . Forbes, S. J. (2015). CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure. GASTROENTEROLOGY, 149(7), 1896-+. doi:10.1053/j.gastro.2015.08.053

    DOI: 10.1053/j.gastro.2015.08.053

    Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney (Journal article)

    Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., . . . Copple, I. M. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. KIDNEY INTERNATIONAL, 88(6), 1261-1273. doi:10.1038/ki.2015.286

    DOI: 10.1038/ki.2015.286

    The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury (Journal article)

    Tailor, A., Faulkner, L., Naisbitt, D. J., & Park, B. K. (2015). The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury. HUMAN & EXPERIMENTAL TOXICOLOGY, 34(12), 1310-1317. doi:10.1177/0960327115606529

    DOI: 10.1177/0960327115606529

    Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus (Journal article)

    Jenkinson, C., Elliott, V. L., Evans, A., Oldfield, L., Jenkins, R. E., O'Brien, D. P., . . . Costello, E. (2016). Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus. CLINICAL CANCER RESEARCH, 22(7), 1734-1743. doi:10.1158/1078-0432.CCR-15-0879

    DOI: 10.1158/1078-0432.CCR-15-0879

    Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis (Journal article)

    Govindappa, K., Sathish, J., Park, K., Kirkham, J., & Pirmohamed, M. (2015). Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 71(11), 1287-1298. doi:10.1007/s00228-015-1921-0

    DOI: 10.1007/s00228-015-1921-0

    Quantification of Drug-Induced Inhibition of Canalicular Cholyl-L-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging (Journal article)

    Barber, J. A., Stahl, S. H., Summers, C., Barrett, G., Park, B. K., Foster, J. R., & Kenna, J. G. (2015). Quantification of Drug-Induced Inhibition of Canalicular Cholyl-L-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging. TOXICOLOGICAL SCIENCES, 148(1), 48-59. doi:10.1093/toxsci/kfv159

    DOI: 10.1093/toxsci/kfv159

    Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury (Journal article)

    Vliegenthart, A. D. B., Shaffer, J. M., Clarke, J. I., Peeters, L. E. J., Caporali, A., Bateman, D. N., . . . Dear, J. W. (2015). Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. SCIENTIFIC REPORTS, 5. doi:10.1038/srep15501

    DOI: 10.1038/srep15501

    In Vitro Priming of Naive T-cells with p-Phenylenediamine and Bandrowski's Base (Journal article)

    Gibson, A., Kim, S. -H., Faulkner, L., Evely, J., Pirmohamed, M., Park, K. B., & Naisbitt, D. J. (2015). In Vitro Priming of Naive T-cells with p-Phenylenediamine and Bandrowski's Base. CHEMICAL RESEARCH IN TOXICOLOGY, 28(10), 2069-2077. doi:10.1021/acs.chemrestox.5b00294

    DOI: 10.1021/acs.chemrestox.5b00294

    DILI: From chemical and metabolism to man (Conference Paper)

    Park, B. K. (2015). DILI: From chemical and metabolism to man. In TOXICOLOGY LETTERS Vol. 238 (pp. S39-S40). doi:10.1016/j.toxlet.2015.08.107

    DOI: 10.1016/j.toxlet.2015.08.107

    CD4+and CD8+T-cells isolated from blood and skin of patients with beta-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17 (Conference Paper)

    Sullivan, A., Faulkner, L., Farrell, J., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2015). CD4+and CD8+T-cells isolated from blood and skin of patients with beta-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17. In ALLERGY Vol. 70 (pp. 25-26). Retrieved from http://gateway.webofknowledge.com/

    Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury (Journal article)

    Kim, S. -H., Saide, K., Farrell, J., Faulkner, L., Tailor, A., Ogese, M., . . . Naisbitt, D. J. (2015). Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury. HEPATOLOGY, 62(3), 887-899. doi:10.1002/hep.27912

    DOI: 10.1002/hep.27912

    Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses (Conference Paper)

    Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from http://gateway.webofknowledge.com/

    Pediatric Microdose and Microtracer Studies Using C-14 in Europe (Journal article)

    Turner, M. A., Mooij, M. G., Vaes, W. H. J., Windhorst, A. D., Hendrikse, N. H., Knibbe, C. A. J., . . . de Wildt, S. N. (2015). Pediatric Microdose and Microtracer Studies Using C-14 in Europe. CLINICAL PHARMACOLOGY & THERAPEUTICS, 98(3), 234-237. doi:10.1002/cpt.163

    DOI: 10.1002/cpt.163

    HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis (Journal article)

    Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546

    DOI: 10.1111/cea.12546

    New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity (Journal article)

    Pirmohamed, M., Ostrov, D. A., & Park, B. K. (2015). New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 236-244. doi:10.1016/j.jaci.2015.06.022

    DOI: 10.1016/j.jaci.2015.06.022

    Parsing interindividual drug variability: an emerging role for systems pharmacology (Journal article)

    Turner, R. M., Park, B. K., & Pirmohamed, M. (2015). Parsing interindividual drug variability: an emerging role for systems pharmacology. WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 7(4), 221-241. doi:10.1002/wsbm.1302

    DOI: 10.1002/wsbm.1302

    The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death (Journal article)

    Kamalian, L., Chadwick, A. E., Bayliss, M., French, N. S., Monshouwer, M., Snoeys, J., & Park, B. K. (2015). The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death. TOXICOLOGY IN VITRO, 29(4), 732-740. doi:10.1016/j.tiv.2015.02.011

    DOI: 10.1016/j.tiv.2015.02.011

    Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study (Journal article)

    Lee, K. C. L., Baker, L. A., Stanzani, G., Alibhai, H., Chang, Y. M., Palacios, C. J., . . . Jalan, R. (2015). Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study. JOURNAL OF HEPATOLOGY, 63(3), 634-642. doi:10.1016/j.jhep.2015.04.020

    DOI: 10.1016/j.jhep.2015.04.020

    Promiscuous T-cell responses to drugs and drug-haptens (Journal article)

    Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036

    DOI: 10.1016/j.jaci.2015.02.036

    Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia (Journal article)

    Eagle, G. L., Zhuang, J., Jenkins, R. E., Till, K. J., Jithesh, P. V., Lin, K., . . . Pettitt, A. R. (2015). Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia. MOLECULAR & CELLULAR PROTEOMICS, 14(4), 933-945. doi:10.1074/mcp.M114.044479

    DOI: 10.1074/mcp.M114.044479

    Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions? (Journal article)

    Sullivan, A., Gibson, A., Park, B. K., & Naisbitt, D. J. (2015). Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 11(3), 357-368. doi:10.1517/17425255.2015.992780

    DOI: 10.1517/17425255.2015.992780

    MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity (Journal article)

    Kia, R., Kelly, L., Sison-Young, R. L. C., Zhang, F., Pridgeon, C. S., Heslop, J. A., . . . Park, B. K. (2015). MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity. TOXICOLOGICAL SCIENCES, 144(1), 173-185. doi:10.1093/toxsci/kfu269

    DOI: 10.1093/toxsci/kfu269

    Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury (Journal article)

    Cross, M. J., Berridge, B. R., Clements, P. J. M., Cove-Smith, L., Force, T. L., Hoffmann, P., . . . Park, B. K. (2015). Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury. BRITISH JOURNAL OF PHARMACOLOGY, 172(4), 957-974. doi:10.1111/bph.12979

    DOI: 10.1111/bph.12979

    Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis (Journal article)

    Garner, C. R., Park, K. B., French, N. S., Earnshaw, C., Schipani, A., Selby, A. M., . . . Turner, M. A. (2015). Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(1), 157-167. doi:10.1111/bcp.12597

    DOI: 10.1111/bcp.12597

    Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin (Journal article)

    Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. CHEMICAL RESEARCH IN TOXICOLOGY, 28(1), 51-58. doi:10.1021/tx500285k

    DOI: 10.1021/tx500285k

    Activation of Flucloxacillin-Specific CD8+T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model (Journal article)

    Nattrass, R., Faulkner, L., Vocanson, M., Antoine, D. J., Kipar, A., Kenna, G., . . . Naisbitt, D. J. (2015). Activation of Flucloxacillin-Specific CD8+T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model. TOXICOLOGICAL SCIENCES, 146(1), 146-156. doi:10.1093/toxsci/kfv077

    DOI: 10.1093/toxsci/kfv077

    Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome (Journal article)

    Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., . . . Park, B. K. (2015). Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. SCIENTIFIC REPORTS, 5. doi:10.1038/srep16423

    DOI: 10.1038/srep16423

    Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis (Journal article)

    Woolbright, B. L., Dorko, K., Antoine, D. J., Clarke, J. I., Gholami, P., Li, F., . . . Jaeschke, H. (2015). Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis. TOXICOLOGY AND APPLIED PHARMACOLOGY, 283(3), 168-177. doi:10.1016/j.taap.2015.01.015

    DOI: 10.1016/j.taap.2015.01.015

    Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2 (Journal article)

    Olayanju, A., Copple, I. M., Bryan, H. K., Edge, G. T., Sison, R. L., Wong, M. W., . . . Park, B. K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. FREE RADICAL BIOLOGY AND MEDICINE, 78, 202-212. doi:10.1016/j.freeradbiomed.2014.11.003

    DOI: 10.1016/j.freeradbiomed.2014.11.003

    Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury (Journal article)

    Antoine, D. J., Sabbisetti, V. S., Francis, B., Jorgensen, A. L., Craig, D. G. N., Simpson, K. J., . . . Dear, J. W. (2015). Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury. HEPATOLOGY, 62(2), 591-599. doi:10.1002/hep.27857

    DOI: 10.1002/hep.27857

    Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication (Journal article)

    Sison-Young, R. L. C., Mitsa, D., Jenkins, R. E., Mottram, D., Alexandre, E., Richert, L., . . . Park, B. K. (2015). Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication. TOXICOLOGICAL SCIENCES, 147(2), 412-424. doi:10.1093/toxsci/kfv136

    DOI: 10.1093/toxsci/kfv136

    Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies (Journal article)

    Heslop, J. A., Hammond, T. G., Santeramo, I., Piella, A. T., Hopp, I., Zhou, J., . . . Park, B. K. (2015). Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. STEM CELLS TRANSLATIONAL MEDICINE, 4(4), 389-400. doi:10.5966/sctm.2014-0110

    DOI: 10.5966/sctm.2014-0110

    Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials (Journal article)

    Sutton, P. A., Jones, R. P., Morrison, F., Goldring, C. E., Park, B. K., Palmer, D. H., . . . Kitteringham, N. R. (2015). Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials. BRITISH JOURNAL OF SURGERY, 102(2), E124-E132. doi:10.1002/bjs.9678

    DOI: 10.1002/bjs.9678

    Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy (Journal article)

    Scarfe, L., Rak-Raszewska, A., Geraci, S., Darssan, D., Sharkey, J., Huang, J., . . . Wilm, B. (2015). Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. SCIENTIFIC REPORTS, 5. doi:10.1038/srep13601

    DOI: 10.1038/srep13601

    Paracetamol (acetaminophen) poisoning. (Journal article)

    Park, B. K., Dear, J. W., & Antoine, D. J. (2015). Paracetamol (acetaminophen) poisoning.. BMJ clinical evidence, 2015.

    Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57:01-restricted CD8(+) T-cell activation (Journal article)

    Naisbitt, D. J., Yang, E. L., Alhaidari, M., Berry, N. G., Lawrenson, A. S., Farrell, J., . . . Park, B. K. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57:01-restricted CD8(+) T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867

    DOI: 10.1097/QAD.0000000000000867

    Understanding and Assessing the Risks of Stem Cell-Based Therapies (Journal article)

    Heslop, J., Hammond, T. G., Santeramo, I., Tort Piella, A., Hopp, I., Zhou, J., . . . Park, B. (2015). Understanding and Assessing the Risks of Stem Cell-Based Therapies. Stem Cells Translational Medicine, 4, 389-400.

    Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure (Journal article)

    Antoine, D. J., Dear, J. W., Goldring, C. E., & Park, B. K. (2015). Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure. HEPATOLOGY, 61(4), 1439-1440. doi:10.1002/hep.27349

    DOI: 10.1002/hep.27349

    Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress (Journal article)

    Mutter, F. E., Park, B. K., & Copple, I. M. (2015). Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress. BIOCHEMICAL SOCIETY TRANSACTIONS, 43, 657-662. doi:10.1042/BST20150044

    DOI: 10.1042/BST20150044

    Where are we now with paracetamol? (Journal article)

    Dear, J. W., Antoine, D. J., & Park, B. K. (2015). Where are we now with paracetamol?. BMJ-BRITISH MEDICAL JOURNAL, 351. doi:10.1136/bmj.h3705

    DOI: 10.1136/bmj.h3705

    2014

    Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase (Journal article)

    Ogese, M. O., Jenkins, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase. CHEMICAL RESEARCH IN TOXICOLOGY, 28(1), 144-154. doi:10.1021/tx500458k

    DOI: 10.1021/tx500458k

    Adverse drug reactions: From man to molecule and back again (Conference Paper)

    Park, B. K. (2014). Adverse drug reactions: From man to molecule and back again. In TOXICOLOGY LETTERS Vol. 229 (pp. S2-S3). doi:10.1016/j.toxlet.2014.07.013

    DOI: 10.1016/j.toxlet.2014.07.013

    Chronic intravenous infusion as a model to investigate mechanisms of toxicity (Conference Paper)

    Norton, A. M., Clarke, J. I., McCarthy, A., Williams, D. P., & Park, B. K. (2014). Chronic intravenous infusion as a model to investigate mechanisms of toxicity. In TOXICOLOGY LETTERS Vol. 229 (pp. S46). doi:10.1016/j.toxlet.2014.06.200

    DOI: 10.1016/j.toxlet.2014.06.200

    Humanized anti-HMGB1 antibody therapy attenuates in vivo acetaminophen-induced liver injury (Conference Paper)

    Lea, J., Lundback, P., Ottosson, L., Sharkey, J., Sowinska, A., Palmblad, K., . . . Antoine, D. (2014). Humanized anti-HMGB1 antibody therapy attenuates in vivo acetaminophen-induced liver injury. In TOXICOLOGY LETTERS Vol. 229 (pp. S69-S70). doi:10.1016/j.toxlet.2014.06.273

    DOI: 10.1016/j.toxlet.2014.06.273

    Investigating the roles of lysosomal iron and reactive oxygen species in the onset of mitochondrial toxicity induced through endoperoxide antimalarial drugs (Conference Paper)

    Firman, J., Cain, K., Park, B. K., MacFarlane, M., & Chadwick, A. (2014). Investigating the roles of lysosomal iron and reactive oxygen species in the onset of mitochondrial toxicity induced through endoperoxide antimalarial drugs. In TOXICOLOGY LETTERS Vol. 229 (pp. S61-S62). doi:10.1016/j.toxlet.2014.06.247

    DOI: 10.1016/j.toxlet.2014.06.247

    Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids (Journal article)

    Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., . . . Park, B. K. (2014). Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. TOXICOLOGICAL SCIENCES, 140(2), 462-469. doi:10.1093/toxsci/kfu080

    DOI: 10.1093/toxsci/kfu080

    The importance of hapten - protein complex formation in the development of drug allergy (Journal article)

    Faulkner, L., Meng, X., Park, B. K., & Naisbitt, D. J. (2014). The importance of hapten - protein complex formation in the development of drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14(4), 293-300. doi:10.1097/ACI.0000000000000078

    DOI: 10.1097/ACI.0000000000000078

    Stimulating macrophages to enhance liver regeneration (Conference Paper)

    Stutchfield, B. M., Mackinnon, A. C., Antoine, D. J., Gow, D. J., Hughes, M., Jenkins, S. J., . . . Forbes, S. J. (2014). Stimulating macrophages to enhance liver regeneration. In BRITISH JOURNAL OF SURGERY Vol. 101 (pp. 14). Retrieved from http://gateway.webofknowledge.com/

    Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers (vol 314, pg 262, 2013) (Journal article)

    Pellegrini, G., Lewis, P. J. S., Palmer, L., Hetzel, U., Goldring, C. E., Park, B. K., . . . Williams, D. P. (2014). Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers (vol 314, pg 262, 2013). TOXICOLOGY, 318, 69-71. doi:10.1016/j.tox.2014.02.005

    DOI: 10.1016/j.tox.2014.02.005

    Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients (Journal article)

    Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 27(4), 524-535. doi:10.1021/tx400406p

    DOI: 10.1021/tx400406p

    Biomarkers Distinguish Apoptotic and Necrotic Cell Death During Hepatic Ischemia/Reperfusion Injury in Mice (Journal article)

    Yang, M., Antoine, D. J., Weemhoff, J. L., Jenkins, R. E., Farhood, A., Park, B. K., & Jaeschke, H. (2014). Biomarkers Distinguish Apoptotic and Necrotic Cell Death During Hepatic Ischemia/Reperfusion Injury in Mice. LIVER TRANSPLANTATION, 20(11), 1372-1382. doi:10.1002/lt.23958

    DOI: 10.1002/lt.23958

    Blood Kidney Injury Molecule-1 Is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD in Type I Diabetes (Journal article)

    Sabbisetti, V. S., Waikar, S. S., Antoine, D. J., Smiles, A., Wang, C., Ravisankar, A., . . . Bonventre, J. V. (2014). Blood Kidney Injury Molecule-1 Is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD in Type I Diabetes. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 25(10), 2177-2186. doi:10.1681/ASN.2013070758

    DOI: 10.1681/ASN.2013070758

    Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis (Journal article)

    Dear, J. W., Antoine, D. J., Starkey-Lewis, P., Goldring, C. E., & Park, B. K. (2014). Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 77(5), 904-905. doi:10.1111/bcp.12214

    DOI: 10.1111/bcp.12214

    HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient (Journal article)

    Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient. CHEMICAL RESEARCH IN TOXICOLOGY, 27(2), 175-177. doi:10.1021/tx400460w

    DOI: 10.1021/tx400460w

    Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications (Journal article)

    Walsh, J., Jenkins, R. E., Wong, M., Olayanju, A., Powell, H., Copple, I., . . . Park, B. K. (2014). Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications. JOURNAL OF PROTEOMICS, 108, 171-187. doi:10.1016/j.jprot.2014.05.007

    DOI: 10.1016/j.jprot.2014.05.007

    Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts (Journal article)

    Thulin, P., Nordahl, G., Gry, M., Yimer, G., Aklillu, E., Makonnen, E., . . . Schuppe-Koistinen, I. (2014). Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts. LIVER INTERNATIONAL, 34(3), 367-378. doi:10.1111/liv.12322

    DOI: 10.1111/liv.12322

    MECHANISTIC BIOMARKERS OF DRUG-INDUCED LIVER AND KIDNEY INJURY (Conference Paper)

    Park, B. K. (2014). MECHANISTIC BIOMARKERS OF DRUG-INDUCED LIVER AND KIDNEY INJURY. In DRUG METABOLISM REVIEWS Vol. 45 (pp. 13-14). Retrieved from http://gateway.webofknowledge.com/

    Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients (Journal article)

    Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079

    DOI: 10.1124/jpet.114.215079

    MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans (Journal article)

    Hornby, R. J., Lewis, P. S., Dear, J., Goldring, C., & Park, B. K. (2014). MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans. EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 7(3), 349-362. doi:10.1586/17512433.2014.904201

    DOI: 10.1586/17512433.2014.904201

    Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22-Secreting T Cells and the Influence of PD-1 on Effector T Cell Function (Journal article)

    Gibson, A., Ogese, M., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. J. (2014). Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22-Secreting T Cells and the Influence of PD-1 on Effector T Cell Function. JOURNAL OF IMMUNOLOGY, 192(6), 2611-2621. doi:10.4049/jimmunol.1302720

    DOI: 10.4049/jimmunol.1302720

    Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method (Journal article)

    Rodrigues, A. V. M., Maggs, J. L., McWilliam, S. J., Pirmohamed, M., Coen, M., Wilson, I. D., . . . Antoine, D. J. (2014). Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method. BIOANALYSIS, 6(7), 919-933. doi:10.4155/BIO.13.350

    DOI: 10.4155/BIO.13.350

    Retro-Orbital Blood Acquisition Facilitates Circulating microRNA Measurement in Zebrafish with Paracetamol Hepatotoxicity (Journal article)

    Vliegenthart, A. D. B., Lewis, P. S., Tucker, C. S., Del Pozo, J., Rider, S., Antoine, D. J., . . . Dear, J. W. (2014). Retro-Orbital Blood Acquisition Facilitates Circulating microRNA Measurement in Zebrafish with Paracetamol Hepatotoxicity. ZEBRAFISH, 11(3), 219-226. doi:10.1089/zeb.2013.0912

    DOI: 10.1089/zeb.2013.0912

    Safety biomarkers for drug-induced liver injury - current status and future perspectives (Journal article)

    Antoine, D. J., Harrill, A. H., Watkins, P. B., & Park, B. K. (2014). Safety biomarkers for drug-induced liver injury - current status and future perspectives. TOXICOLOGY RESEARCH, 3(2), 75-85. doi:10.1039/c3tx50077b

    DOI: 10.1039/c3tx50077b

    T cell responses to drugs and drug metabolites. (Journal article)

    Earnshaw, C. J., Pecaric-Petkovic, T., Park, B. K., & Naisbitt, D. J. (2014). T cell responses to drugs and drug metabolites.. EXS, 104, 137-163. doi:10.1007/978-3-0348-0726-5_10

    DOI: 10.1007/978-3-0348-0726-5_10

    Treatment of paracetamol overdose: room for improvement? (Journal article)

    Park, K., Antoine, D. J., & Pirmohamed, M. (2014). Treatment of paracetamol overdose: room for improvement?. LANCET, 383(9918), 672-674. doi:10.1016/S0140-6736(13)62303-X

    DOI: 10.1016/S0140-6736(13)62303-X

    2013

    Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study (Journal article)

    Jones, R. P., Sutton, P., Greensmith, R. M. D., Santoyo-Castelazo, A., Carr, D. F., Jenkins, R., . . . Kitteringham, N. R. (2013). Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 72(2), 359-368. doi:10.1007/s00280-013-2199-5

    DOI: 10.1007/s00280-013-2199-5

    Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives (Journal article)

    Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. Journal of Allergy and Clinical Immunology, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

    DOI: 10.1016/j.jaci.2013.02.045

    Adherence and variability in warfarin dose requirements: assessment in a prospective cohort (Journal article)

    Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199

    DOI: 10.2217/PGS.12.199

    Are we closer to finding biomarkers for identifying acute drug-induced liver injury? (Journal article)

    Antoine, D. J., Lewis, P. S., Goldring, C. E., & Park, B. K. (2013). Are we closer to finding biomarkers for identifying acute drug-induced liver injury?. Biomarkers in Medicine, 7(3), 383-386. doi:10.2217/bmm.13.42

    DOI: 10.2217/bmm.13.42

    Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population (Journal article)

    Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021

    DOI: 10.1093/cid/cit021

    CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease (Journal article)

    Musumba, C. O., Jorgensen, A., Sutton, L., Van Eker, D., Zhang, E., O'Hara, N., . . . Pirmohamed, M. (2013). CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease. CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(2), 195-203. doi:10.1038/clpt.2012.215

    DOI: 10.1038/clpt.2012.215

    Challenges and approaches for the development of safer immunomodulatory biologics (Journal article)

    Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974

    DOI: 10.1038/nrd3974

    Chemotherapy induced hepatotoxicity in metastatic colorectal cancer: A review of mechanisms and outcomes (Journal article)

    McWhirter, D., Kitteringham, N., Jones, R. P., Malik, H., Park, K., & Palmer, D. (2013). Chemotherapy induced hepatotoxicity in metastatic colorectal cancer: A review of mechanisms and outcomes. Critical Reviews in Oncology/Hematology, 88(2), 404-415. doi:10.1016/j.critrevonc.2013.05.011

    DOI: 10.1016/j.critrevonc.2013.05.011

    Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles (Journal article)

    Elliott, E. -C., Maggs, J. L., Park, B. K., O'Neill, P. M., & Stachulski, A. V. (2013). Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles. Organic & Biomolecular Chemistry, 11(48), 8426. doi:10.1039/c3ob41252k

    DOI: 10.1039/c3ob41252k

    Correlates of Efavirenz Exposure in Chilean Patients Affected With Human Immunodeficiency Virus Reveals a Novel Association With a Polymorphism in the Constitutive Androstane Receptor (Journal article)

    Cortes, C. P., Siccardi, M., Chaikan, A., Owen, A., Zhang, G., & la Porte, C. J. L. (2013). Correlates of Efavirenz Exposure in Chilean Patients Affected With Human Immunodeficiency Virus Reveals a Novel Association With a Polymorphism in the Constitutive Androstane Receptor. THERAPEUTIC DRUG MONITORING, 35(1), 78-83. doi:10.1097/FTD.0b013e318274197e

    DOI: 10.1097/FTD.0b013e318274197e

    Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients (Journal article)

    Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107

    DOI: 10.1021/tx4000107

    Drug-grapefruit juice interactions (Journal article)

    Pirmohamed, M. (2013). Drug-grapefruit juice interactions. BMJ-BRITISH MEDICAL JOURNAL, 346. doi:10.1136/bmj.f1

    DOI: 10.1136/bmj.f1

    Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)

    Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077

    DOI: 10.1002/hep.26077

    Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFN beta interact with the endogenous cytokine and activate complement (Journal article)

    Sethu, S., Govindappa, K., Quinn, P., Wadhwa, M., Stebbings, R., Boggild, M., . . . Sathish, J. (2013). Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFN beta interact with the endogenous cytokine and activate complement. CLINICAL IMMUNOLOGY, 148(2), 177-185. doi:10.1016/j.clim.2013.05.008

    DOI: 10.1016/j.clim.2013.05.008

    Induction of mesenchymal stem cell chondrogenesis by polyacrylate substrates (Journal article)

    Glennon-Alty, L., Williams, R., Dixon, S., & Murray, P. (2013). Induction of mesenchymal stem cell chondrogenesis by polyacrylate substrates. ACTA BIOMATERIALIA, 9(4), 6041-6051. doi:10.1016/j.actbio.2012.12.007

    DOI: 10.1016/j.actbio.2012.12.007

    Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers (Journal article)

    Pellegrini, G., Starkey Lewis, P. J., Palmer, L., Hetzel, U., Goldring, C. E., Park, B. K., . . . Williams, D. P. (2013). Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers. Toxicology, 314(2-3), 262-266. doi:10.1016/j.tox.2013.06.003

    DOI: 10.1016/j.tox.2013.06.003

    Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital (Journal article)

    Antoine, D. J., Dear, J. W., Lewis, P. S., Platt, V., Coyle, J., Masson, M., . . . Park, B. K. (2013). Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology, 58(2), 777-787. doi:10.1002/hep.26294

    DOI: 10.1002/hep.26294

    Nanomedicines for HIV therapy. (Journal article)

    Siccardi, M., Martin, P., McDonald, T. O., Liptrott, N. J., Giardiello, M., Rannard, S., & Owen, A. (2013). Nanomedicines for HIV therapy.. Therapeutic delivery, 4(2), 153-156. doi:10.4155/tde.12.156

    DOI: 10.4155/tde.12.156

    Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling (Journal article)

    Al-Huseini, L. M. A., Aw Yeang, H. X., Sethu, S., Alhumeed, N., Hamdam, J. M., Tingle, Y., . . . Sathish, J. G. (2013). Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling. Journal of Biological Chemistry, 288(31), 22281-22288. doi:10.1074/jbc.M113.483420

    DOI: 10.1074/jbc.M113.483420

    Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells (Journal article)

    Bell, C. C., Castelazo, A. S., Yang, E. L., Maggs, J. L., Jeankins, R. E., Tugwood, J., . . . Park, B. K. (2013). Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells. CHEMICAL RESEARCH IN TOXICOLOGY, 26(7), 1064-1072. doi:10.1021/tx400041v

    DOI: 10.1021/tx400041v

    Paediatric use of mycophenolate mofetil (Journal article)

    Downing, H. J., Pirmohamed, M., Beresford, M. W., & Smyth, R. L. (2013). Paediatric use of mycophenolate mofetil. British Journal of Clinical Pharmacology, 75(1), 45-59. doi:10.1111/j.1365-2125.2012.04305.x

    DOI: 10.1111/j.1365-2125.2012.04305.x

    Pharmacogenetic tests: the need for a level playing field (Journal article)

    Pirmohamed, M., & Hughes, D. A. (2013). Pharmacogenetic tests: the need for a level playing field. NATURE REVIEWS DRUG DISCOVERY, 12(1), 3-4. doi:10.1038/nrd3921

    DOI: 10.1038/nrd3921

    Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity (Journal article)

    Pointon, A., Abi-Gerges, N., Cross, M. J., & Sidaway, J. E. (2013). Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity. Toxicological Sciences, 132(2), 317-326. doi:10.1093/toxsci/kft005

    DOI: 10.1093/toxsci/kft005

    Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice (Journal article)

    Woolbright, B. L., Antoine, D. J., Jenkins, R. E., Bajt, M. L., Park, B. K., & Jaeschke, H. (2013). Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice. Toxicology and Applied Pharmacology, 273(3), 524-531. doi:10.1016/j.taap.2013.09.023

    DOI: 10.1016/j.taap.2013.09.023

    Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation. (Journal article)

    Rowe, C., Gerrard, D. T., Jenkins, R., Berry, A., Durkin, K., Sundstrom, L., . . . Hanley, N. A. (2013). Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation.. Hepatology (Baltimore, Md.), 58(2), 799-809. doi:10.1002/hep.26414

    DOI: 10.1002/hep.26414

    Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (Journal article)

    Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., . . . Hengstler, J. G. (2013). Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. ARCHIVES OF TOXICOLOGY, 87(8), 1315-1530. doi:10.1007/s00204-013-1078-5

    DOI: 10.1007/s00204-013-1078-5

    Role of Nrf2 in protection against acute kidney injury (Journal article)

    Shelton, L. M., Park, B. K., & Copple, I. M. (2013). Role of Nrf2 in protection against acute kidney injury. KIDNEY INTERNATIONAL, 84(6), 1090-1095. doi:10.1038/ki.2013.248

    DOI: 10.1038/ki.2013.248

    Safety pharmacology — Current and emerging concepts (Journal article)

    Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology — Current and emerging concepts. Toxicology and Applied Pharmacology, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039

    DOI: 10.1016/j.taap.2013.04.039

    Simultaneous population pharmacokinetic modelling of atazanavir and ritonavir in HIV-infected adults and assessment of different dose reduction strategies (Journal article)

    Schipani, A., Dickinson, L., Boffito, M., Austin, R., Owen, A., Back, D., . . . Davies, G. (2013). Simultaneous population pharmacokinetic modelling of atazanavir and ritonavir in HIV-infected adults and assessment of different dose reduction strategies. J Acquir Immune Defic Syndr, 62(1), 60-66. doi:10.1097/QAI.0b013e3182737231

    DOI: 10.1097/QAI.0b013e3182737231

    Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet? (Journal article)

    Kia, R., Sison, R. L. C., Heslop, J., Kitteringham, N. R., Hanley, N., Mills, J. S., . . . Goldring, C. E. P. (2013). Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?. British Journal of Clinical Pharmacology, 75(4), 885-896. doi:10.1111/j.1365-2125.2012.04360.x

    DOI: 10.1111/j.1365-2125.2012.04360.x

    T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms (Journal article)

    Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. Chemical Research in Toxicology, 26(5), 759-766. doi:10.1021/tx400060p

    DOI: 10.1021/tx400060p

    TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis (Journal article)

    Nyström, S., Antoine, D. J., Lundbäck, P., Lock, J. G., Nita, A. F., Högstrand, K., . . . Applequist, S. E. (2012). TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis. The EMBO Journal, 32(1), 86-99. doi:10.1038/emboj.2012.328

    DOI: 10.1038/emboj.2012.328

    The Generation, Detection, and Effects of Reactive Drug Metabolites (Journal article)

    Stachulski, A. V., Baillie, T. A., Kevin Park, B., Scott Obach, R., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2013). The Generation, Detection, and Effects of Reactive Drug Metabolites. Medicinal Research Reviews, 33(5), 985-1080. doi:10.1002/med.21273

    DOI: 10.1002/med.21273

    The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation (Journal article)

    Bryan, H. K., Olayanju, A., Goldring, C. E., & Park, B. K. (2013). The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation. Biochemical Pharmacology, 85(6), 705-717. doi:10.1016/j.bcp.2012.11.016

    DOI: 10.1016/j.bcp.2012.11.016

    The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone (Journal article)

    Wright, T., Rea, S. L., Goode, A., Bennett, A. J., Ratajczak, T., Long, J. E., . . . Layfield, R. (2013). The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone. Bone, 52(2), 699-706. doi:10.1016/j.bone.2012.10.023

    DOI: 10.1016/j.bone.2012.10.023

    beta-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis (Journal article)

    Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). beta-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m

    DOI: 10.1021/tx400124m

    2012

    Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation (Journal article)

    Rowe, C., Jenkins, R. E., Kitteringham, N. R., Park, K. B., & Goldring, C. (2012). Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation. Journal of Integrated OMICS, 2(2). doi:10.5584/jiomics.v2i2.102

    DOI: 10.5584/jiomics.v2i2.102

    Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics. (Journal article)

    Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., . . . Park, B. K. (2012). Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.. Pharmacological reports : PR, 64(3), 680-697. doi:10.1016/s1734-1140(12)70863-0

    DOI: 10.1016/s1734-1140(12)70863-0

    Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)

    El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900

    DOI: 10.1124/jpet.111.190900

    Evidence for Metabolic Cleavage of a PEGylated Protein in Vivo Using Multiple Analytical Methodologies (Journal article)

    Elliott, V. L., Edge, G. T., Phelan, M. M., Lian, L. -Y., Webster, R., Finn, R. F., . . . Kitteringham, N. R. (2012). Evidence for Metabolic Cleavage of a PEGylated Protein in Vivo Using Multiple Analytical Methodologies. Molecular Pharmaceutics, 9(5), 1291-1301. doi:10.1021/mp200587m

    DOI: 10.1021/mp200587m

    Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials (Journal article)

    Copple, I. M., Mercer, A. E., Firman, J., Donegan, G., Herpers, B., Wong, M. H. L., . . . Park, B. K. (2012). Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. MOLECULAR MEDICINE, 18(7), 1045-1055. doi:10.2119/molmed.2012.00154

    DOI: 10.2119/molmed.2012.00154

    HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)

    Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.

    Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives (Journal article)

    Elliott, E. -C., Regan, S. L., Maggs, J. L., Bowkett, E. R., Parry, L. J., Williams, D. P., . . . Stachulski, A. V. (2012). Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives. Journal of Medicinal Chemistry, 55(22), 9773-9784. doi:10.1021/jm301013n

    DOI: 10.1021/jm301013n

    Human Pluripotent Stem Cells for Modeling Toxicity (Journal article)

    Sison-Young, R. L. C., Kia, R., Heslop, J., Kelly, L., Rowe, C., Cross, M. J., . . . Goldring, C. E. P. (2012). Human Pluripotent Stem Cells for Modeling Toxicity. Unknown Journal, 207-256. doi:10.1016/b978-0-12-398339-8.00006-9

    DOI: 10.1016/b978-0-12-398339-8.00006-9

    In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers (Journal article)

    Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350

    DOI: 10.1186/gm350

    Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells (Journal article)

    Yeang, H. X. A., Hamdam, J. M., Al-Huseini, L. M. A., Sethu, S., Djouhri, L., Walsh, J., . . . Sathish, J. G. (2012). Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells. Journal of Biological Chemistry, 287(13), 10556-10564. doi:10.1074/jbc.M111.322420

    DOI: 10.1074/jbc.M111.322420

    Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study (Journal article)

    McWilliam, S. J., Antoine, D. J., Sabbisetti, V., Turner, M. A., Farragher, T., Bonventre, J. V., . . . Pirmohamed, M. (2012). Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study. PLOS ONE, 7(8). doi:10.1371/journal.pone.0043809

    DOI: 10.1371/journal.pone.0043809

    Microwave ablation of ex vivo human liver and colorectal liver metastases with a novel 14.5 GHz generator (Journal article)

    Jones, R. P., Kitteringham, N. R., Fenwick, S. W., Poston, G. J., Malik, H. Z., Terlizzo, M., & Ghaneh, P. (2012). Microwave ablation of ex vivo human liver and colorectal liver metastases with a novel 14.5 GHz generator. International Journal of Hyperthermia, 28(1), 43-54.

    Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. (Journal article)

    Antoine, D. J., Jenkins, R. E., Dear, J. W., Williams, D. P., McGill, M. R., McGill, M. R., . . . Park, B. K. (2012). Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.. Journal of hepatology, 56(5), 1070-1079. doi:10.1016/j.jhep.2011.12.019

    DOI: 10.1016/j.jhep.2011.12.019

    Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells (Journal article)

    Daubner, B., Groux-Keller, M., Hausmann, O. V., Kawabata, T., Naisbitt, D. J., Park, B. K., . . . Pichler, W. J. (2012). Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. ALLERGY, 67(1), 58-66. doi:10.1111/j.1398-9995.2011.02720.x

    DOI: 10.1111/j.1398-9995.2011.02720.x

    Serum microRNA Biomarkers for Drug-Induced Liver Injury (Journal article)

    Starkey Lewis, P. J., Merz, M., Couttet, P., Grenet, O., Dear, J., Antoine, D. J., . . . Moggs, J. G. (2012). Serum microRNA Biomarkers for Drug-Induced Liver Injury. Clinical Pharmacology & Therapeutics, 92(3), 291-293. doi:10.1038/clpt.2012.101

    DOI: 10.1038/clpt.2012.101

    The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs (Journal article)

    Faulkner, L., Martinsson, K., Santoyo-Castelazo, A., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., . . . Park, B. K. (2012). The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs. TOXICOLOGICAL SCIENCES, 127(1), 150-158. doi:10.1093/toxsci/kfs080

    DOI: 10.1093/toxsci/kfs080

    The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers (Journal article)

    Harrill, A. H., Roach, J., Fier, I., Eaddy, J. S., Kurtz, C. L., Antoine, D. J., . . . Watkins, P. B. (2012). The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers. Clinical Pharmacology & Therapeutics, 92(2), 214-220. doi:10.1038/clpt.2012.40

    DOI: 10.1038/clpt.2012.40

    Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation (Journal article)

    Xue, M., Rabbani, N., Momiji, H., Imbasi, P., Anwar, M. M., Kitteringham, N., . . . Thornalley, P. J. (2012). Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation. Biochemical Journal, 443(1), 213-222. doi:10.1042/BJ20111648

    DOI: 10.1042/BJ20111648

    Validation of the isolation and quantification of kidney enriched miRNAs for use as biomarkers (Journal article)

    Sharkey, J. W., Antoine, D. J., & Park, B. K. (2012). Validation of the isolation and quantification of kidney enriched miRNAs for use as biomarkers. Biomarkers, 17(3), 231-239. doi:10.3109/1354750X.2012.657246

    DOI: 10.3109/1354750X.2012.657246

    2011

    Assessing the safety of stem cell therapeutics (Journal article)

    Goldring, C., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, K. (2011). Assessing the safety of stem cell therapeutics. Cell Stem Cell, 8(6), 618-628.

    Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury (Journal article)

    Lewis, P. J. S., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury. HEPATOLOGY, 54(5), 1767-1776. doi:10.1002/hep.24538

    DOI: 10.1002/hep.24538

    Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

    Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871

    DOI: 10.1124/jpet.111.183871

    Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity (Journal article)

    Park, B. K., Laverty, H., Srivastava, A., Antoine, D. J., Naisbitt, D., & Williams, D. P. (2011). Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity. Chemico-Biological Interactions, 192(1-2), 30-36. doi:10.1016/j.cbi.2010.09.011

    DOI: 10.1016/j.cbi.2010.09.011

    Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. (Journal article)

    Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.. The Journal of allergy and clinical immunology, 127(6), 1543-51.e3. doi:10.1016/j.jaci.2010.12.1119

    DOI: 10.1016/j.jaci.2010.12.1119

    HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans (Journal article)

    McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperavičiūtė, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med, 364(12), 1134-1143.

    Immune pathomechanism of drug hypersensitivity reactions (Journal article)

    Pichler, W. J., Naisbitt, D. J., & Park, B. K. (2011). Immune pathomechanism of drug hypersensitivity reactions. Journal of Allergy and Clinical Immunology, 127(S3), S74-S81.

    Managing the challenge of chemically reactive metabolites in drug development (Journal article)

    Park, B. K., Boobis, A., Clarke, S., Goldring, C. E. P., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development. NATURE REVIEWS DRUG DISCOVERY, 10(4), 292-306. doi:10.1038/nrd3408

    DOI: 10.1038/nrd3408

    Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis (Journal article)

    Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis. JOURNAL OF IMMUNOLOGY, 187(1), 200-211. doi:10.4049/jimmunol.1100647

    DOI: 10.4049/jimmunol.1100647

    Mdm2 interacts with nme2 (non-metastatic cells 2, protein) and suppresses the ability of nme2 to negatively regulate cell motility (Journal article)

    Polanski, R., Maguire, M., Nield, P. C., Jenkins, R. E., Park, B. K., Krawczynska, K., . . . Boyd, M. T. (2011). Mdm2 interacts with nme2 (non-metastatic cells 2, protein) and suppresses the ability of nme2 to negatively regulate cell motility. Carcinogenesis, 32, 1133-1142.

    Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy (Journal article)

    Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. MOLECULAR CANCER, 10. doi:10.1186/1476-4598-10-37

    DOI: 10.1186/1476-4598-10-37

    Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury (Journal article)

    Williams, C. D., Antoine, D. J., Shaw, P. J., Benson, C., Farhood, A., Williams, D. P., . . . Jaeschke, H. (2011). Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury. Toxicol Appl Pharmacol, 252(3), 289-297.

    The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials (Journal article)

    Mercer, A. E., Copple, I. M., Maggs, J. L., O'Neill, P. M., & Park, B. K. (2011). The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(2), 987-996. doi:10.1074/jbc.M110.144188

    DOI: 10.1074/jbc.M110.144188

    The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors (Journal article)

    Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., . . . Pirmohamed, M. (2012). The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(1), 66-76. doi:10.1111/j.1365-2125.2011.04051.x

    DOI: 10.1111/j.1365-2125.2011.04051.x

    Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways. (Journal article)

    El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways.. Chem Res Toxicol, 24(6), 793.

    ow can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? (Journal article)

    Laverty, H., Benson, C., Cartwright, E., Cross, M., Garland, C., Hammond, T., . . . Valentin, J. (2011). ow can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?. Br J Pharmacol, 163(4), 675-693.

    2010

    Acyl glucuronides: the good, the bad and the ugly (Journal article)

    Regan, S. L., Maggs, J. L., Hammond, T. G., Lambert, C., Williams, D. P., & Park, B. K. (2010). Acyl glucuronides: the good, the bad and the ugly. Biopharmaceutics & Drug Disposition, 31(7), 367-395. doi:10.1002/bdd.720

    DOI: 10.1002/bdd.720

    The potential of cytokines as safety biomarkers for drug-induced liver injury (Journal article)

    Laverty, H. G., Antoine, D. J., Benson, C., Chaponda, M., Williams, D., & Park, B. K. (2010). The potential of cytokines as safety biomarkers for drug-induced liver injury. European Journal of Clinical Pharmacology, 66(10), 961-976. doi:10.1007/s00228-010-0862-x

    DOI: 10.1007/s00228-010-0862-x

    Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer (Journal article)

    Shaw, V. E., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. EXPERT REVIEW OF VACCINES, 9(9), 1007-1016. doi:10.1586/ERV.10.92

    DOI: 10.1586/ERV.10.92

    Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB (Journal article)

    Chia, A. J. L., Goldring, C. E., Kitteringham, N. R., Wong, S. Q., Morgan, P., & Park, B. K. (2010). Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB. Biochemical Pharmacology, 80(3), 410-421. doi:10.1016/j.bcp.2010.04.004

    DOI: 10.1016/j.bcp.2010.04.004

    Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. (Journal article)

    Kitteringham, N. R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R. E., Sison, R., . . . Park, B. K. (2010). Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.. Journal of proteomics, 73(8), 1612-1631. doi:10.1016/j.jprot.2010.03.018

    DOI: 10.1016/j.jprot.2010.03.018

    Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis (Journal article)

    Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Park, B. K., & Naisbitt, D. J. (2010). Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 23(6), 1009-1011. doi:10.1021/tx100151v

    DOI: 10.1021/tx100151v

    Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines (Journal article)

    Chadwick, J., Jones, M., Mercer, A. E., Stocks, P. A., Ward, S. A., Park, B. K., & O'Neill, P. M. (2010). Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines. BIOORGANIC & MEDICINAL CHEMISTRY, 18(7), 2586-2597. doi:10.1016/j.bmc.2010.02.035

    DOI: 10.1016/j.bmc.2010.02.035

    Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein (Journal article)

    Jenkinson, C., Jenkins, R. E., Aleksic, M., Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2010). Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 732-742. doi:10.1038/jid.2009.271

    DOI: 10.1038/jid.2009.271

    Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells (Journal article)

    Antoine, D. J., Srivastava, A., Pirmohamed, M., & Park, B. K. (2010). Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells. BIOCHEMICAL PHARMACOLOGY, 79(4), 647-654. doi:10.1016/j.bcp.2009.09.021

    DOI: 10.1016/j.bcp.2009.09.021

    Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis (Journal article)

    El-Ghaiesh, S., Monshi, M., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2010). Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis. Journal of Cystic Fibrosis, 9(S1), S48.

    Characterization of sulfamethoxazole metabolite-specific T-cell activation in patients with cystic fibrosis (Journal article)

    Elsheikh, A., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2010). Characterization of sulfamethoxazole metabolite-specific T-cell activation in patients with cystic fibrosis. Journal of Cystic Fibrosis, 9(S1), S48.

    DRUG HYPERSENSITIVITY (Chapter)

    Naisbitt, D. J., Park, B. K., & Demoly, P. (2010). DRUG HYPERSENSITIVITY. In S. Holgate (Ed.), Allergy (pp. 200). London: Elsveier.

    Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity. (Journal article)

    Antoine, D. J., Williams, D. P., Kipar, A., Laverty, H., & Park, B. K. (2010). Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity.. Mol Med, 16(11-12), 479-490.

    Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism (Journal article)

    Elsheikh, A., Lavergne, S. N., Castrejon, J. L., Farrell, J., Wang, H., Sathish, J., . . . Naisbitt, D. J. (2010). Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism. JOURNAL OF IMMUNOLOGY, 185(11), 6448-6460. doi:10.4049/jimmunol.1000889

    DOI: 10.4049/jimmunol.1000889

    Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis (Journal article)

    Elsheikh, A., Monshi, M., Castrejon, J., Lavergne, S., Whitaker, P., Pichler, W. J., . . . Naisbitt, D. J. (2010). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis. IMMUNOLOGY, 131, 145-146. Retrieved from http://gateway.webofknowledge.com/

    Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening (Journal article)

    Baxter, M. A., Rowe, C., Alder, J., Harrison, S., Hanley, K. P., Park, B. K., . . . Hanley, N. A. (2010). Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. Stem Cell Research, 5(1), 4-22. doi:10.1016/j.scr.2010.02.002

    DOI: 10.1016/j.scr.2010.02.002

    Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins (Journal article)

    O'Neill, P. M., Amewu, R. K., Nixon, G. L., ElGarah, F. B., Mungthin, M., Chadwick, J., . . . Ward, S. A. (2010). Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(33), 5693-5697. doi:10.1002/anie.201001026

    DOI: 10.1002/anie.201001026

    Immunomodulatory therapies and the risk of opportunistic infections (Journal article)

    Johnson, D. E., Smith, D. A., & Park, B. K. (2010). Immunomodulatory therapies and the risk of opportunistic infections. Current Opinion in Drug Discovery and Development, 13(1), 20-22.

    Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer (Journal article)

    Tweedle, E. M., Khattak, I., Ang, C. W., Nedjadi, T., Jenkins, R., Park, B. K., . . . Costello, E. (2010). Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer. GUT, 59(11), 1501-1510. doi:10.1136/gut.2009.196626

    DOI: 10.1136/gut.2009.196626

    Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives (Journal article)

    Castrejon, J. L., Lavergne, S. N., El-Sheikh, A., Farrell, J., Maggs, J. L., Sabbani, S., . . . Naisbitt, D. J. (2010). Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives. CHEMICAL RESEARCH IN TOXICOLOGY, 23(1), 184-192. doi:10.1021/tx900329b

    DOI: 10.1021/tx900329b

    Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach. (Journal article)

    Rowe, C., Goldring, C. E. P., Kitteringham, N. R., Jenkins, R. E., Lane, B. S., Sanderson, C., . . . Park, B. K. (2010). Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.. Journal of proteome research, 9(5), 2658-2668. doi:10.1021/pr1001687

    DOI: 10.1021/pr1001687

    Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway (Journal article)

    Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., . . . Park, B. K. (2010). Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(22), 16782-16788. doi:10.1074/jbc.M109.096545

    DOI: 10.1074/jbc.M109.096545

    Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (Journal article)

    Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. DRUG METABOLISM AND DISPOSITION, 38(1), 122-132. doi:10.1124/dmd.109.028688

    DOI: 10.1124/dmd.109.028688

    Role of reactive metabolites in drug-induced hepatotoxicity. (Journal article)

    Srivastava, A., Maggs, J. L., Antoine, D. J., Williams, D. P., Smith, D. A., & Park, B. K. (2010). Role of reactive metabolites in drug-induced hepatotoxicity.. Handbook of experimental pharmacology, (196), 165-194. doi:10.1007/978-3-642-00663-0_7

    DOI: 10.1007/978-3-642-00663-0_7

    Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells (Journal article)

    Ang, C. W., Nedjadi, T., Sheikh, A. A., Tweedle, E. M., Tonack, S., Honap, S., . . . Costello, E. (2010). Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. CARCINOGENESIS, 31(9), 1541-1551. doi:10.1093/carcin/bgq137

    DOI: 10.1093/carcin/bgq137

    Stimulation of human T cells with sulfonamides and sulfonamide metabolites (Journal article)

    Castrejon, J. L., Berry, N., El-Ghaiesh, S., Gerber, B., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2010). Stimulation of human T cells with sulfonamides and sulfonamide metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(2), 411-418. doi:10.1016/j.jaci.2009.10.031

    DOI: 10.1016/j.jaci.2009.10.031

    T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays (Journal article)

    Martin, S. F., Esser, P. R., Schmucker, S., Dietz, L., Naisbitt, D. J., Park, B. K., . . . Sallusto, F. (2010). T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. CELLULAR AND MOLECULAR LIFE SCIENCES, 67(24), 4171-4184. doi:10.1007/s00018-010-0495-3

    DOI: 10.1007/s00018-010-0495-3

    The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity. (Journal article)

    Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2010). The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.. Handbook of experimental pharmacology, (196), 233-266. doi:10.1007/978-3-642-00663-0_9

    DOI: 10.1007/978-3-642-00663-0_9

    2009

    "Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells (Journal article)

    Lavergne, S. N., Wang, H., Callan, H. E., Park, B. K., & Naisbitt, D. J. (2009). "Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 331(2), 372-381. doi:10.1124/jpet.109.155374

    DOI: 10.1124/jpet.109.155374

    S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility (Journal article)

    Nedjadi, T., Kitteringham, N., Campbell, F., Jenkins, R. E., Park, B. K., Navarro, P., . . . Costello, E. (2009). S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. BRITISH JOURNAL OF CANCER, 101(7), 1145-1154. doi:10.1038/sj.bjc.6605289

    DOI: 10.1038/sj.bjc.6605289

    A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine (Journal article)

    Jenkinson, C., Jenkins, R. E., Maggs, J. L., Kitteringham, N. R., Aleksic, M., Park, B. K., & Naisbitt, D. J. (2009). A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine. CHEMICAL RESEARCH IN TOXICOLOGY, 22(6), 1172-1180. doi:10.1021/tx900095r

    DOI: 10.1021/tx900095r

    Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo (Journal article)

    Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222

    DOI: 10.1002/prca.200800222

    Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation (Journal article)

    Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2009). Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation. CHEMICAL RESEARCH IN TOXICOLOGY, 22(5), 937-948. doi:10.1021/tx900034r

    DOI: 10.1021/tx900034r

    Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse (Journal article)

    Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse. TOXICOLOGY LETTERS, 185(3), 153-159. doi:10.1016/j.toxlet.2008.12.008

    DOI: 10.1016/j.toxlet.2008.12.008

    Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells (Journal article)

    Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY, 17(3), 1325-1338. doi:10.1016/j.bmc.2008.12.017

    DOI: 10.1016/j.bmc.2008.12.017

    An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype (Conference Paper)

    Curley, P., Kelly, L., Shaw, R., Kitteringham, N., Jenkins, R., Alder, J., . . . Park, K. (2009). An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype. In British Pharmacology Society Winter Meeting. London, UK.

    Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century (Journal article)

    O'Neill, P. M., Park, B. K., Shone, A. E., Maggs, J. L., Roberts, P., Stocks, P. A., . . . Ward, S. A. (2009). Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century. JOURNAL OF MEDICINAL CHEMISTRY, 52(5), 1408-1415. doi:10.1021/jm8012618

    DOI: 10.1021/jm8012618

    Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse. (Journal article)

    Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse.. Toxicol Lett., 185(153-15).

    Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials (Journal article)

    Davis, C. B., Bambal, R., Moorthy, G. S., Hugger, E., Xiang, H., Park, B. K., . . . Ward, S. A. (2009). Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials. Journal of Pharmaceutical Sciences, 98(1), 362-377. doi:10.1002/jps.21469

    DOI: 10.1002/jps.21469

    Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy (Journal article)

    Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347

    DOI: 10.1097/FPC.0b013e3283311347

    Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro (Journal article)

    Liu, X. -P., Goldring, C. E. P., Wang, H. -Y., Copple, I. M., Kitteringham, N. R., & Park, B. K. (2009). Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro. PHYTOMEDICINE, 16(5), 451-455. doi:10.1016/j.phymed.2008.11.001

    DOI: 10.1016/j.phymed.2008.11.001

    Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis (Journal article)

    Mercer, A. E., Regan, S. L., Hirst, C. M., Graham, E. E., Antoine, D. J., Benson, C. A., . . . Park, B. K. (2009). Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis. TOXICOLOGY AND APPLIED PHARMACOLOGY, 239(3), 297-305. doi:10.1016/j.taap.2009.05.027

    DOI: 10.1016/j.taap.2009.05.027

    Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study (Journal article)

    Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5

    DOI: 10.1097/FPC.0b013e3283317ab5

    HLA-B(star)5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin (Journal article)

    Daly, A. K., Donaldson, P. T., Bhatnagar, P., Shen, Y., Pe'er, I., Floratos, A., . . . Consortium, I. S. A. E. (2009). HLA-B(star)5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. NATURE GENETICS, 41(7), 816-U71. doi:10.1038/ng.379

    DOI: 10.1038/ng.379

    High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. (Journal article)

    Antoine, D. J., Williams, D. P., Kipar, A., Jenkins, R. E., Regan, S. L., Sathish, J. G., . . . Park, B. K. (2009). High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.. Toxicological sciences : an official journal of the Society of Toxicology, 112(2), 521-531. doi:10.1093/toxsci/kfp235

    DOI: 10.1093/toxsci/kfp235

    Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals (Journal article)

    Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals. Journal of Investigative Dermatology, 130(1), 161-174. doi:10.1038/jid.2009.187

    DOI: 10.1038/jid.2009.187

    Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics. (Journal article)

    Kitteringham, N. R., Jenkins, R. E., Lane, C. S., Elliott, V. L., & Park, B. K. (2009). Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(13), 1229-1239. doi:10.1016/j.jchromb.2008.11.013

    DOI: 10.1016/j.jchromb.2008.11.013

    Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1 (Journal article)

    Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. TOXICOLOGY AND APPLIED PHARMACOLOGY, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001

    DOI: 10.1016/j.taap.2009.05.001

    Role of reactive metabolites in drug-induced hepatotoxicity (Chapter)

    Srivasta, A., Maggs, J. L., Antoine, D. J., Williams, D. P., Smith, D. A., & Park, B. K. (2009). Role of reactive metabolites in drug-induced hepatotoxicity. In J. Uetrecht (Ed.), Adverse Drug Reactions (pp. 165-194). London: Springer Heidelberg Dordrecht.

    Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4 '-Fluoro and 4 '-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for N-tert-Butyl Isoquine (Journal article)

    O'Neill, P. M., Shone, A. E., Stanford, D., Nixon, G., Asadollahy, E., Park, B. K., . . . Ward, S. A. (2009). Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4 '-Fluoro and 4 '-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for N-tert-Butyl Isoquine. JOURNAL OF MEDICINAL CHEMISTRY, 52(7), 1828-1844. doi:10.1021/jm8012757

    DOI: 10.1021/jm8012757

    TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole (Journal article)

    Alfirevic, A., Vilar, F. J., Alsbou, M., Jawaid, A., Thomson, W., Ollier, W. E. R., . . . Pirmohamed, M. (2009). TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. PHARMACOGENOMICS, 10(4), 531-540. doi:10.2217/PGS.09.6

    DOI: 10.2217/PGS.09.6

    2008

    Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites (Journal article)

    Sanderson, J. P., Hollis, F. J., Maggs, J. L., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2008). Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites. DRUG METABOLISM AND DISPOSITION, 36(12), 2424-2428. doi:10.1124/dmd.108.021246

    DOI: 10.1124/dmd.108.021246

    Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore (Journal article)

    Graham, E. E., Walsh, R. J., Hirst, C. M., Maggs, J. L., Martin, S., Wild, M. J., . . . Park, B. K. (2008). Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore. Journal of Pharmacology and Experimental Therapeutics, 326(2), 657-671. doi:10.1124/jpet.107.135483

    DOI: 10.1124/jpet.107.135483

    The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity (Journal article)

    Lavergne, S. N., Park, B. K., & Naisbitt, D. J. (2008). The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 8(4), 299-307. doi:10.1097/ACI.0b013e3283079c64

    DOI: 10.1097/ACI.0b013e3283079c64

    Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC) (Journal article)

    Liu, X. -P., Goldring, C. E. P., Wang, H. -Y., Copple, I. M., Kitteringharn, N. R., Park, B. K., & Wei, W. (2008). Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC). PHYTOTHERAPY RESEARCH, 22(3), 367-371. doi:10.1002/ptr.2328

    DOI: 10.1002/ptr.2328

    Activation of T-Cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base (Journal article)

    Coulter, E. M., Jenkinson, C., Wu, Y., Farrell, J., Foster, B., Smith, A., . . . Naisbitt, D. J. (2008). Activation of T-Cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(4), 897-905. doi:10.1038/sj.jid.5701071

    DOI: 10.1038/sj.jid.5701071

    Albumin and immunoglobulin depletion of human plasma (Journal article)

    Jenkins, R. E., Kitteringham, N. R., Greenough, C., & Park, B. K. (2008). Albumin and immunoglobulin depletion of human plasma. Methods Mol Biol, 425, 15-25.

    Ethnic variation in drug response: implications for the development and regulation of drugs (Journal article)

    Johnson, D. E., Park, B. K., & Smith, D. A. (2008). Ethnic variation in drug response: implications for the development and regulation of drugs. Current Opinion in Drug Discovery & Development, 11(1), 29-31.

    Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites. (Journal article)

    Jenkins, R. E., Kitteringham, N. R., Goldring, C. E. P., Dowdall, S. M. J., Hamlett, J., Lane, C. S., . . . Park, B. K. (2008). Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.. Proteomics, 8(2), 301-315. doi:10.1002/pmic.200700843

    DOI: 10.1002/pmic.200700843

    Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice (Journal article)

    Randle, L. E., Goldring, C. E. P., Benson, C. A., Metcalfe, P. N., Kitteringham, N. R., Park, B. K., & Williams, D. P. (2008). Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. Toxicology, 243(3), 249-260. doi:10.1016/j.tox.2007.10.011

    DOI: 10.1016/j.tox.2007.10.011

    MDM2 regulates dihydrofolate reductase activity through monoubiquitination (Journal article)

    Maguire, M., Nield, P. C., Devling, T., Jenkins, R. E., Park, B. K., Polanski, R., . . . Boyd, M. T. (2008). MDM2 regulates dihydrofolate reductase activity through monoubiquitination. CANCER RESEARCH, 68(9), 3232-3242. doi:10.1158/0008-5472.CAN-07-5271

    DOI: 10.1158/0008-5472.CAN-07-5271

    The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system (Journal article)

    Copple, I. M., Goldring, C. E., Jenkins, R. E., Chia, A. J. L., Randle, L. E., Hayes, J. D., . . . Park, B. K. (2008). The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. HEPATOLOGY, 48(4), 1292-1301. doi:10.1002/hep.22472

    DOI: 10.1002/hep.22472

    α 1 -Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice (Journal article)

    Randle, L. E., Sathish, J. G., Kitteringham, N. R., Macdonald, I., Williams, D. P., & Park, B. K. (2008). α 1 -Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice. British Journal of Pharmacology, 153(4), 820-830. doi:10.1038/sj.bjp.0707620

    DOI: 10.1038/sj.bjp.0707620

    2007

    Glutathione Transferase π Plays a Critical Role in the Development of Lung Carcinogenesis following Exposure to Tobacco-Related Carcinogens and Urethane (Journal article)

    Ritchie, K. J., Henderson, C. J., Wang, X. J., Vassieva, O., Carrie, D., Farmer, P. B., . . . Wolf, C. R. (2007). Glutathione Transferase π Plays a Critical Role in the Development of Lung Carcinogenesis following Exposure to Tobacco-Related Carcinogens and Urethane. Cancer Research, 67(19), 9248-9257. doi:10.1158/0008-5472.CAN-07-1764

    DOI: 10.1158/0008-5472.CAN-07-1764

    Generation and characterization of antigen-specific CD4(+), CD8(+), and CD4(+)CD8(+) T-cell clones from patients with carbamazopine hypersensitivity (Journal article)

    Wu, Y., Farrell, J., Pirmohmed, M., Park, B. K., & Naisbitt, D. J. (2007). Generation and characterization of antigen-specific CD4(+), CD8(+), and CD4(+)CD8(+) T-cell clones from patients with carbamazopine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(4), 973-981. doi:10.1016/j.jaci.2006.12.617

    DOI: 10.1016/j.jaci.2006.12.617

    Activation of human dendritic cells by p-phenylenediamine (Journal article)

    Coulter, E. M., Farrell, J., Mathews, K. L., Maggs, J. L., Pease, C. K., Lockley, D. J., . . . Naisbitt, D. J. (2007). Activation of human dendritic cells by p-phenylenediamine. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 320(2), 885-892. doi:10.1124/jpet.106.113803

    DOI: 10.1124/jpet.106.113803

    Albumin and immunoglobulin depletion of human plasma. (Chapter)

    Jenkins, R. E., Kitteringham, N. R., Greenough, C., & Park, B. K. (2008). Albumin and immunoglobulin depletion of human plasma.. In Unknown Book (Vol. 425, pp. 15-25). doi:10.1007/978-1-60327-210-0_2

    DOI: 10.1007/978-1-60327-210-0_2

    Biomarkers: The piece de resistance of innovative medicines (Journal article)

    Johnson, D. E., Smith, D. A., & Park, B. K. (2007). Biomarkers: The piece de resistance of innovative medicines. Current Opinion in Drug Discovery & Development, 10(1), 22-24.

    Cyclization of the Acyl Glucuronide Metabolite of a Neutral Endopeptidase Inhibitor to an Electrophilic Glutarimide:  Synthesis, Reactivity, and Mechanistic Analysis (Journal article)

    Meng, X., Maggs, J. L., Pryde, D. C., Planken, S., Jenkins, R. E., Peakman, T. M., . . . Stachulski, A. V. (2007). Cyclization of the Acyl Glucuronide Metabolite of a Neutral Endopeptidase Inhibitor to an Electrophilic Glutarimide:  Synthesis, Reactivity, and Mechanistic Analysis. Journal of Medicinal Chemistry, 50(24), 6165-6176. doi:10.1021/jm0706766

    DOI: 10.1021/jm0706766

    Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene (Journal article)

    Kitteringham, N. R., Palmer, L., Owen, A., Lian, L. -Y., Jenkins, R., Dowdall, S., . . . Goldring, C. E. (2007). Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1240-1247. doi:10.1016/j.bbagen.2007.05.001

    DOI: 10.1016/j.bbagen.2007.05.001

    Drug hypersensitivity reactions in patients with HIV disease. (Journal article)

    Pirmohamed, M., Drummond, N. S., Naisbitt, D. J., & Park, B. K. (2007). Drug hypersensitivity reactions in patients with HIV disease.. Expert review of clinical immunology, 3(3), 395-410. doi:10.1586/1744666x.3.3.395

    DOI: 10.1586/1744666x.3.3.395

    Drugs as haptens, antigens, and immunogens. (Chapter)

    Park, B. K., Sanderson, J. P., & Naisbitt, D. J. (2007). Drugs as haptens, antigens, and immunogens.. In W. J. Pichler (Ed.), Drug Hypersensitivity (pp. 65-67).

    Efficient synthesis of 1β-O-acyl glucuronides via selective acylation of allyl or benzyl d-glucuronate (Journal article)

    Bowkett, E. R., Harding, J. R., Maggs, J. L., Park, B. K., Perrie, J. A., & Stachulski, A. V. (2007). Efficient synthesis of 1β-O-acyl glucuronides via selective acylation of allyl or benzyl d-glucuronate. Tetrahedron, 63(32), 7596-7605. doi:10.1016/j.tet.2007.05.050

    DOI: 10.1016/j.tet.2007.05.050

    Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds (Journal article)

    Mercer, A. E., Maggs, J. L., Sun, X. -M., Cohen, G. M., Chadwick, J., O'Neill, P. M., & Park, B. K. (2007). Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(13), 9372-9382. doi:10.1074/jbc.M610375200

    DOI: 10.1074/jbc.M610375200

    Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway (Journal article)

    Liu, X. -P., Goldring, C. E. P., Copple, I. M., Wang, H. -Y., Wei, W., Kitteringham, N. R., & Park, B. K. (2007). Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway. LIFE SCIENCES, 80(17), 1586-1591. doi:10.1016/j.lfs.2007.01.034

    DOI: 10.1016/j.lfs.2007.01.034

    Immunological principles of T-cell-mediated adverse drug reactions in skin (Journal article)

    Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. EXPERT OPINION ON DRUG SAFETY, 6(2), 109-124. doi:10.1517/14740338.6.2.109

    DOI: 10.1517/14740338.6.2.109

    Investigation of the immunogenicity of diclofenac and diclofenac metabolites (Journal article)

    Naisbitt, D. J., Sanderson, L. S., Meng, X., Stachulski, A. V., Clarke, S. E., & Park, B. K. (2007). Investigation of the immunogenicity of diclofenac and diclofenac metabolites. TOXICOLOGY LETTERS, 168(1), 45-50. doi:10.1016/j.toxlet.2006.10.014

    DOI: 10.1016/j.toxlet.2006.10.014

    Mechanisms of Adverse Drug Reactions (Chapter)

    Pirmohamed, M., & Park, B. K. (n.d.). Mechanisms of Adverse Drug Reactions. In Pharmacovigilance (pp. 85-103). John Wiley & Sons, Ltd. doi:10.1002/9780470059210.ch8

    DOI: 10.1002/9780470059210.ch8

    Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity (Journal article)

    Carr, D. F., Alfirevic, A., Tugwood, J. D., Barratt, B. J., Sherwood, J., Smith, J., . . . Park, B. K. (2007). Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 17(11), 961-972. doi:10.1097/FPC.0b013e3282f00919

    DOI: 10.1097/FPC.0b013e3282f00919

    Sample preparation and pre-fractionation for 2D PAGE (Chapter)

    Jenkins, R. E., Kitteringham, N. R., Greenough, C., & Park, B. K. (2007). Sample preparation and pre-fractionation for 2D PAGE. In A. Posch (Ed.), n/a (pp. 00). Totowa, New Jersey: Humana Press.

    Tacrine-induced liver damage: an analysis of 19 candidate genes (Journal article)

    Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Jawaid, A., Sherwood, J., . . . Pirmohamed, M. (2007). Tacrine-induced liver damage: an analysis of 19 candidate genes. PHARMACOGENETICS AND GENOMICS, 17(12), 1091-1100. doi:10.1097/FPC.0b013e3282f1f12b

    DOI: 10.1097/FPC.0b013e3282f1f12b

    The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore (Journal article)

    Williams, D. P., Antoine, D. J., Butler, P. J., Jones, R., Randle, L., Payne, A., . . . Park, B. K. (2007). The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore. Journal of Pharmacology and Experimental Therapeutics, 322(3), 1208-1220. doi:10.1124/jpet.107.125302

    DOI: 10.1124/jpet.107.125302

    The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity (Journal article)

    Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2008). The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity. TOXICOLOGY, 246(1), 24-33. doi:10.1016/j.tox.2007.10.029

    DOI: 10.1016/j.tox.2007.10.029

    2006

    A medicinal chemistry perspective on 4-aminoquioline antimalarial drugs (Journal article)

    O'Neill, P. M., Ward, S. A., Berry, N. G., Jeyadevan, J. P., Biagini, G. A., Asadollaly, E., . . . Bray, P. G. (2006). A medicinal chemistry perspective on 4-aminoquioline antimalarial drugs. Current topics in medicinal chemistry, 6(5), 479-507.

    Acyl Glucuronides:  Biological Activity, Chemical Reactivity, and Chemical Synthesis (Journal article)

    Stachulski, A. V., Harding, J. R., Lindon, J. C., Maggs, J. L., Park, B. K., & Wilson, I. D. (2006). Acyl Glucuronides:  Biological Activity, Chemical Reactivity, and Chemical Synthesis. Journal of Medicinal Chemistry, 49(24), 6931-6945. doi:10.1021/jm060599z

    DOI: 10.1021/jm060599z

    Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes (Journal article)

    Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005

    DOI: 10.1152/ajpcell.00133.2005

    Drug Hypersnesitivity Meeting, Liverpool, 2006 (Conference Paper)

    Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2006). Drug Hypersnesitivity Meeting, Liverpool, 2006. In 2nd International Drug Hypersnesitivity Meeting Vol. 38 (pp. 59). University Press: University Press.

    Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis (Journal article)

    Drummond, N. S., Vilar, F. J., Naisbitt, D. J., Hanson, A., Woods, A., Park, B. K., & Pirmohamed, M. (2006). Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis. ANTIVIRAL THERAPY, 11(3), 393-395. Retrieved from http://gateway.webofknowledge.com/

    HLA-B locus in Caucasian patients with carbamazepine hypersensitivity (Journal article)

    Alfirevic, A., Jorgensen, A. L., Williamson, P. R., Chadwick, D. W., Park, B. K., & Pirmohamed, M. (2006). HLA-B locus in Caucasian patients with carbamazepine hypersensitivity. PHARMACOGENOMICS, 7(6), 813-818. doi:10.2217/14622416.7.6.813

    DOI: 10.2217/14622416.7.6.813

    Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements (Journal article)

    Owen, A., Goldring, C., Morgan, P., Park, B. K., & Pirmohamed, M. (2006). Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 62(2), 237-242. doi:10.1111/j.1365-2125.2006.02587.x

    DOI: 10.1111/j.1365-2125.2006.02587.x

    Pharmacogenetic and functional analysis of a novel GSTP1 polymorphism (Journal article)

    Palmer, L., Goldring, C., Kitteringham, N., Owen, A., Gilmore, I., & Park, K. (2006). Pharmacogenetic and functional analysis of a novel GSTP1 polymorphism. Drug Metabolism Reviews, 38, 91.

    Pharmacogenetics of Adverse Drug Reactions (Chapter)

    Alfirevic, A., Park, B. K., & Pirmohamed, M. (2006). Pharmacogenetics of Adverse Drug Reactions. In I. Hall, & M. Pirmohamed (Eds.), Textbook of Pharmacogenetics (pp. in press). New York: Marcel Dekker.

    Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements (Journal article)

    Goldring, C., Kitteringham, N., Jenkins, R., Copple, I., Jeannin, J. F., & Park, B. K. (2006). Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements. JOURNAL OF EXPERIMENTAL BIOLOGY, 209(12), 2337-2343. doi:10.1242/jeb.02209

    DOI: 10.1242/jeb.02209

    Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags. (Journal article)

    Jenkins, R. E., Kitteringham, N. R., Hunter, C. L., Webb, S., Hunt, T. J., Elsby, R., . . . Park, B. K. (2006). Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags.. Proteomics, 6(6), 1934-1947. doi:10.1002/pmic.200500432

    DOI: 10.1002/pmic.200500432

    Role of bioactivation in drug-induced hypersensitivity reactions (Journal article)

    Sanderson, J. P., Naisbitt, D. J., & Park, B. K. (2006). Role of bioactivation in drug-induced hypersensitivity reactions. AAPS JOURNAL, 8(1), E55-E64. doi:10.1208/aapsj080107

    DOI: 10.1208/aapsj080107

    Safety of drugs can never be absolute (Journal article)

    Smith, D. A., Johnson, D. E., & Park, B. K. (2006). Safety of drugs can never be absolute. Current Opinion in Drug Discovery & Development, 9(1), 26-28.

    Selection of new chemical entities with decreased potential for adverse drug reactions (Journal article)

    Park, B. K., Dalton-Brown, E., Hirst, C., & Williams, D. P. (2006). Selection of new chemical entities with decreased potential for adverse drug reactions. European Journal of Pharmacology, 549, 1-8.

    Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. (Journal article)

    Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2006). Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster.. Pharmacogenet Geonomics, 16(4), 287-296.

    Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling (Journal article)

    Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. JOURNAL OF IMMUNOLOGY, 178(9), 5533-5542. doi:10.4049/jimmunol.178.9.5533

    DOI: 10.4049/jimmunol.178.9.5533

    The role of covalent binding in drug hypersensitivity (Chapter)

    Sanderson, J. P., Naisbitt, D. J., & Park, B. K. (2006). The role of covalent binding in drug hypersensitivity. In W. J. Pichler (Ed.), Drug Hypersensitivity (pp. 460). Basel: Karger.

    2005

    Characterization of the T-cell response in a patient with phenindione hypersensitivity (Journal article)

    Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Hopkins, J. E., Berry, N. G., Pirmohamed, M., & Park, B. K. (2005). Characterization of the T-cell response in a patient with phenindione hypersensitivity. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 313(3), 1058-1065. doi:10.1124/jpet.105.083758

    DOI: 10.1124/jpet.105.083758

    Drug presentation to T cells (Journal article)

    Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2005). Drug presentation to T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 115(4), 876-877. doi:10.1016/j.jaci.2005.01.011

    DOI: 10.1016/j.jaci.2005.01.011

    Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4 T-cells (Journal article)

    HOPKINS, J., NAISBITT, D., HUMPHREYS, N., DEARMAN, R., KIMBER, I., & PARK, B. (2005). Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4 T-cells. Toxicology, 206(2), 221-231. doi:10.1016/j.tox.2004.08.010

    DOI: 10.1016/j.tox.2004.08.010

    FORMATION AND PROTEIN BINDING OF THE ACYL GLUCURONIDE OF A LEUKOTRIENE B4 ANTAGONIST (SB-209247): RELATION TO SPECIES DIFFERENCES IN HEPATOTOXICITY (Journal article)

    Kenny, J. R. (2004). FORMATION AND PROTEIN BINDING OF THE ACYL GLUCURONIDE OF A LEUKOTRIENE B4 ANTAGONIST (SB-209247): RELATION TO SPECIES DIFFERENCES IN HEPATOTOXICITY. Drug Metabolism and Disposition, 33(2), 271-281. doi:10.1124/dmd.104.001677

    DOI: 10.1124/dmd.104.001677

    Interindividual variation in the expression of the cellular redox sensor Keap1 and its novel splice variants in human lymphocytes (Journal article)

    Abdullah, A., Goldring, C., Owen, A., Kitteringham, N., & Park, K. (2005). Interindividual variation in the expression of the cellular redox sensor Keap1 and its novel splice variants in human lymphocytes. Toxicology, 213(3), 261-262.

    Investigation of toxic metabolites during drug development. (Journal article)

    Park, K., Williams, D. P., Naisbitt, D. J., Kitteringham, N. R., & Pirmohamed, M. (2005). Investigation of toxic metabolites during drug development.. Toxicology and applied pharmacology, 207(2 Suppl), 425-434. doi:10.1016/j.taap.2005.02.029

    DOI: 10.1016/j.taap.2005.02.029

    Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2 (Journal article)

    Kitteringham, N., Abdullah, A., Jenkins, R., Goldring, C., Hayes, J. D., & Park, K. (2005). Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2. Drug Metabolism Reviews, 37, 23.

    Quantitative profiling of cytochromes P450 by isotope coded affinity tagging (Journal article)

    Jenkins, R. E., Kitteringham, N. R., Hunt, T. J., Boucher, B. J., Minkoff, M. S., Elsby, R., . . . Park, B. K. (2005). Quantitative profiling of cytochromes P450 by isotope coded affinity tagging. Toxicology, 213(3), 260-261.

    Relationship between the C3435T and G(2677)T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver (Journal article)

    Owen, A., Goldring, C., Morgan, P., Chadwick, D., Park, B. K., & Pirmohamed, M. (2005). Relationship between the C3435T and G(2677)T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(3), 365-370. doi:10.1111/j.1365-2125.2005.02229.x

    DOI: 10.1111/j.1365-2125.2005.02229.x

    Safety/toxicity threshold concepts in drug discovery and development (Journal article)

    Johnson, D. E., Smith, D. A., & Park, B. K. (2005). Safety/toxicity threshold concepts in drug discovery and development. Current Opinion in Drug Discovery & Development, 8(1), 24-26.

    Selective haptenation of cellular or extracellular protein by chemical allergens: Association with cytokine polarization (Journal article)

    Hopkins, J. E., Naisbitt, D. J., Kitteringham, N. R., Dearman, R. J., Kimber, I., & Park, B. K. (2005). Selective haptenation of cellular or extracellular protein by chemical allergens: Association with cytokine polarization. CHEMICAL RESEARCH IN TOXICOLOGY, 18(2), 375-381. doi:10.1021/tx049688+

    DOI: 10.1021/tx049688+

    The role of metabolic activation in drug-induced hepatotoxicity (Journal article)

    Park, B. K., Kitteringham, N. R., Maggs, J. L., Pirmohamed, M., & Williams, D. P. (2005). The role of metabolic activation in drug-induced hepatotoxicity. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 45, 177-202. doi:10.1146/annurev.pharmtox.45.120403.100058

    DOI: 10.1146/annurev.pharmtox.45.120403.100058

    2004

    A method for the rapid depletion of albumin and immunoglobulin from human plasma (Journal article)

    Greenough, C., Jenkins, R. E., Kitteringham, N. R., Pirmohamed, M., Park, B. K., & Pennington, S. R. (2004). A method for the rapid depletion of albumin and immunoglobulin from human plasma. PROTEOMICS, 4(10), 3107-3111. doi:10.1002/pmic.200300815

    DOI: 10.1002/pmic.200300815

    Activation of hepatic Nrf2in vivo by acetaminophen in CD-1 mice (Journal article)

    Goldring, C. E. P., Kitteringham, N. R., Elsby, R., Randle, L. E., Clement, Y. N., Williams, D. P., . . . Park, B. K. (2004). Activation of hepatic Nrf2in vivo by acetaminophen in CD-1 mice. Hepatology, 39(5), 1267-1276. doi:10.1002/hep.20183

    DOI: 10.1002/hep.20183

    Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients (Journal article)

    Pirmohamed, M., James, S., Meakin, S., Green, C., Scott, A. K., Walley, T. J., . . . Breckenridge, A. M. (2004). Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients. BMJ-BRITISH MEDICAL JOURNAL, 329(7456), 15-19. doi:10.1136/bmj.329.7456.15

    DOI: 10.1136/bmj.329.7456.15

    Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin (Journal article)

    Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry, 47(5), 1290-1298. doi:10.1021/jm030974c

    DOI: 10.1021/jm030974c

    Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity (Journal article)

    Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. PHARMACOGENETICS, 14(6), 335-342. doi:10.1097/00008571-200406000-00002

    DOI: 10.1097/00008571-200406000-00002

    Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac. (Journal article)

    Kenny, J. R., Maggs, J. L., Meng, X., Sinnott, D., Clarke, S. E., Park, B. K., & Stachulski, A. V. (2004). Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.. Journal of medicinal chemistry, 47(11), 2816-2825. doi:10.1021/jm030891w

    DOI: 10.1021/jm030891w

    Time Course Toxicogenomic Profiles in CD-1 Mice after Nontoxic and Nonlethal Hepatotoxic Paracetamol Administration (Journal article)

    Williams, D. P., Garcia-Allan, C., Hanton, G., LeNet, J. L., Provost, J. P., Brain, P., . . . Park, B. K. (2004). Time Course Toxicogenomic Profiles in CD-1 Mice after Nontoxic and Nonlethal Hepatotoxic Paracetamol Administration. Chemical Research in Toxicology, 17(12), 1551-1561. doi:10.1021/tx049846x

    DOI: 10.1021/tx049846x

    Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression (Journal article)

    Singh, D., Alexander, J., Owen, A., Rustom, R., Bone, M., Hammad, A., . . . Pirmohamed, M. (2004). Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression. TRANSPLANTATION, 77(4), 557-561. doi:10.1097/01.TP.0000114594.21317.A5

    DOI: 10.1097/01.TP.0000114594.21317.A5

    2003

    Activation of T cells by carbamazepine and carbamazepine metabolites (Journal article)

    Wu, Y., Sanderson, J. P., Farrell, J., Drummond, N. S., Hanson, A., Bowkett, E., . . . Naisbitt, D. J. (2006). Activation of T cells by carbamazepine and carbamazepine metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 118(1), 233-241. doi:10.1016/j.jaci.2006.03.005

    DOI: 10.1016/j.jaci.2006.03.005

    Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro (Journal article)

    Williams, D. P., O'Donnell, C. J. L., Maggs, J. L., Leeder, J. S., Uetrecht, J., Pirmohamed, M., & Park, B. K. (2003). Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro. CHEMICAL RESEARCH IN TOXICOLOGY, 16(10), 1359-1364. doi:10.1021/tx034035z

    DOI: 10.1021/tx034035z

    Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype and cytokine profile of drug-specific T cell clones (Journal article)

    Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Depta, J. P., Chadwick, D. W., . . . Park, B. K. (2003). Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype and cytokine profile of drug-specific T cell clones. Mol Pharmacol, 63(3), 732-741.

    Idiosyncratic toxicity: the role of toxicophores and bioactivation (Journal article)

    Williams, D. P., & Park, B. K. (2003). Idiosyncratic toxicity: the role of toxicophores and bioactivation. Drug Discovery Today, 8(22), 1044-1050. doi:10.1016/S1359-6446(03)02888-5

    DOI: 10.1016/S1359-6446(03)02888-5

    Immunopharmacology of hypersensitivity reactions to drugs (Journal article)

    Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2003). Immunopharmacology of hypersensitivity reactions to drugs. CURRENT ALLERGY AND ASTHMA REPORTS, 3(1), 22-29. doi:10.1007/s11882-003-0006-9

    DOI: 10.1007/s11882-003-0006-9

    Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S -Transferase Pi (Journal article)

    Elsby, R., Kitteringham, N. R., Goldring, C. E., Lovatt, C. A., Chamberlain, M., Henderson, C. J., . . . Park, B. K. (2003). Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S -Transferase Pi. Journal of Biological Chemistry, 278(25), 22243-22249. doi:10.1074/jbc.M301211200

    DOI: 10.1074/jbc.M301211200

    Isoquine and Related Amodiaquine Analogues:  A New Generation of Improved 4-Aminoquinoline Antimalarials (Journal article)

    O'Neill, P. M., Mukhtar, A., Stocks, P. A., Randle, L. E., Hindley, S., Ward, S. A., . . . Park, B. K. (2003). Isoquine and Related Amodiaquine Analogues:  A New Generation of Improved 4-Aminoquinoline Antimalarials. Journal of Medicinal Chemistry, 46(23), 4933-4945. doi:10.1021/jm030796n

    DOI: 10.1021/jm030796n

    2002

    Anti-malarial compounds (Patent)

    Ward, S. A., O'Neill, P. M., & Park, B. K. (2002). Anti-malarial compounds.

    Are chemically reactive metabolites responsible for adverse reactions to drugs? (Journal article)

    Williams, D. P., Kitteringham, N. R., Naisbitt, D. J., Pirmohamed, M., Smith, D. A., & Park, B. K. (2002). Are chemically reactive metabolites responsible for adverse reactions to drugs?. Curr Drug Metab, 3(4), 351-366.

    TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy (Journal article)

    Maher, B., Alfirevic, A., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2002). TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS, 16(15), 2013-2018. doi:10.1097/00002030-200210180-00005

    DOI: 10.1097/00002030-200210180-00005

    2001

    Efficient Preparations of the β-Glucuronides of Dihydroartemisinin and Structural Confirmation of the Human Glucuronide Metabolite (Journal article)

    O'Neill, P. M., Scheinmann, F., Stachulski, A. V., Maggs, J. L., & Park, B. K. (2001). Efficient Preparations of the β-Glucuronides of Dihydroartemisinin and Structural Confirmation of the Human Glucuronide Metabolite. Journal of Medicinal Chemistry, 44(9), 1467-1470. doi:10.1021/jm001061a

    DOI: 10.1021/jm001061a

    Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+T-cells (Journal article)

    Burkhart, C., Von Greyerz, S., Depta, J. P. H., Naisbitt, D. J., Britschgi, M., Park, K. B., & Pichler, W. J. (2001). Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+T-cells. BRITISH JOURNAL OF PHARMACOLOGY, 132(3), 623-630. doi:10.1038/sj.bjp.0703845

    DOI: 10.1038/sj.bjp.0703845

    TNF alpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients (Journal article)

    Pirmohamed, M., Lin, K., Chadwick, D., & Park, B. K. (2001). TNF alpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients. NEUROLOGY, 56(7), 890-896. doi:10.1212/WNL.56.7.890

    DOI: 10.1212/WNL.56.7.890

    TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis (Other)

    Ahdulrazeg, E. S. M., Alfirevic, A., Gilmore, I. T., Sutton, R., Greenhalf, W., Neoptolemas, J., . . . Pirmohamed, M. (2001). TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis. In Gastroenterology (Vol. 120, Iss. 5, pp. 167). [Paper].

    2000

    4-Aminoquinolines as antimalarials (Patent)

    Raynes, K. J., Ward, S. A., O'Neill, P. M., Stocks, P., & Park, B. K. (2000). 4-Aminoquinolines as antimalarials.

    Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine (Journal article)

    Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Uetrecht, J. P., & Park, B. K. (2000). Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine. MOLECULAR PHARMACOLOGY, 58(1), 207-216. Retrieved from http://gateway.webofknowledge.com/

    Metabolism of lamotrigine to a reactive arene oxide intermediate (Journal article)

    Maggs, J. L., Naisbitt, D. J., Tetty, J. N., Pirmohamed, M., & Park, B. K. (2000). Metabolism of lamotrigine to a reactive arene oxide intermediate. Chemical Research in Toxicology, 11(11), 1075-1081.

    Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection. (Journal article)

    Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G., Pirmohamed, M., & Park, B. K. (2000). Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.. AIDS research and human retroviruses, 16(18), 1926-1938.

    Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4(+) T cells from allergic individuals (Journal article)

    Schnyder, B., Burkhart, C., Schnyder-Frutig, K., von Greyerz, S., Naisbitt, D. J., Pirmohamed, M., . . . Pichler, W. J. (2000). Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4(+) T cells from allergic individuals. JOURNAL OF IMMUNOLOGY, 164(12), 6647-6654. doi:10.4049/jimmunol.164.12.6647

    DOI: 10.4049/jimmunol.164.12.6647