Prof Andrea Jorgensen PhD MSc BA ATT ATII

Senior Lecturer, Biostatistics Biostatistics

    Publications

    Selected Publications

    1. A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article - 2013)
    2. Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis (Journal article - 2012)
    3. Integration of genetic, clinical, and INR data to refine warfarin dosing (Journal article - 2010)
    4. Improving the evidence base in pharmacogenetic studies: warfarin as an example (Thesis / Dissertation - 2010)
    5. Methodological quality of pharmacogenetic studies: Issues of concern (Journal article - 2008)

    2019

    Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials (Journal article)

    Johnson, D., Hughes, D., Pirmohamed, M., & Jorgensen, A. (2019). Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials. JOURNAL OF PERSONALIZED MEDICINE, 9(3). doi:10.3390/jpm9030042

    DOI: 10.3390/jpm9030042

    Genetic testing for prevention of severe drug-induced skin rash (Journal article)

    Alfirevic, A., Pirmohamed, M., Marinovic, B., Harcourt-Smith, L., Jorgensen, A. L., & Cooper, T. E. (2019). Genetic testing for prevention of severe drug-induced skin rash. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (7). doi:10.1002/14651858.CD010891.pub2

    DOI: 10.1002/14651858.CD010891.pub2

    Protocol for the development of the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline: checklist of items for reporting pharmacogenetic studies (Journal article)

    Richardson, M., Kirkham, J. J., Dwan, K. M., Sloan, D. J., Davies, G., & Jorgensen, A. (2019). Protocol for the development of the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline: checklist of items for reporting pharmacogenetic studies. BMJ OPEN, 9(7). doi:10.1136/bmjopen-2019-030212

    DOI: 10.1136/bmjopen-2019-030212

    Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (Journal article)

    Carr, D. F., Wang, C. -W., Bellon, T., Ressel, L., Nwikue, G., Shrivastava, V., . . . Pirmohamed, M. (2019). Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. BRITISH JOURNAL OF DERMATOLOGY, 181(1), 166-174. doi:10.1111/bjd.17610

    DOI: 10.1111/bjd.17610

    Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study (Journal article)

    Jorgensen, A. L., Prince, C., Fitzgerald, G., Hanson, A., Downing, J., Reynolds, J., . . . Pirmohamed, M. (2019). Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study. BMC MEDICINE, 17. doi:10.1186/s12916-019-1308-7

    DOI: 10.1186/s12916-019-1308-7

    A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine. (Journal article)

    Berghuis, B., Stapleton, C., Sonsma, A. C. M., Hulst, J., de Haan, G. -J., Lindhout, D., . . . McCormack, M. (2019). A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.. Epilepsia open, 4(1), 102-109. doi:10.1002/epi4.12297

    DOI: 10.1002/epi4.12297

    NAT2 variants and toxicity related to anti-tuberculosis agents: a systematic review and meta-analysis (Journal article)

    Richardson, M., Kirkham, J., Dwan, K., Sloan, D. J., Davies, G., & Jorgensen, A. L. (2019). NAT2 variants and toxicity related to anti-tuberculosis agents: a systematic review and meta-analysis. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 23(3), 293-+. doi:10.5588/ijtld.18.0324

    DOI: 10.5588/ijtld.18.0324

    Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin (Journal article)

    Navaratnam, K., Abreu, P., Clarke, H., Jorgensen, A., Alfirevic, A., & Alfirevic, Z. (2019). Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 32(2), 179-187. doi:10.1080/14767058.2017.1373760

    DOI: 10.1080/14767058.2017.1373760

    Association of variants within the GST and other genes with anti-tubercular agents related toxicity: a systematic review and meta-analysis (Journal article)

    Richardson, M., Kirkham, J., Dwan, K., Sloan, D., Davies, G., & Jorgensen, A. (2019). Association of variants within the GST and other genes with anti-tubercular agents related toxicity: a systematic review and meta-analysis. doi:10.1101/515817

    DOI: 10.1101/515817

    2018

    Growing international evidence for urinary biomarker panels identifying lupus nephritis in children - verification within the South African Paediatric Lupus Cohort (Journal article)

    Smith, E. M. D., Lewandowski, L. B., Jorgensen, A. L., Phuti, A., Nourse, P., Scott, C., & Beresford, M. W. (2018). Growing international evidence for urinary biomarker panels identifying lupus nephritis in children - verification within the South African Paediatric Lupus Cohort. LUPUS, 27(14), 2190-2199. doi:10.1177/0961203318808376

    DOI: 10.1177/0961203318808376

    CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis. (Journal article)

    Richardson, M., Kirkham, J., Dwan, K., Sloan, D. J., Davies, G., & Jorgensen, A. L. (2018). CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis.. Systematic reviews, 7(1), 204. doi:10.1186/s13643-018-0861-z

    DOI: 10.1186/s13643-018-0861-z

    Clinical predictors of active LN development in children - evidence from the UK JSLE Cohort Study (Journal article)

    Smith, E. M. D., Yin, P., Jorgensen, A. L., & Beresford, M. W. (2018). Clinical predictors of active LN development in children - evidence from the UK JSLE Cohort Study. LUPUS, 27(13), 2020-2028. doi:10.1177/0961203318801526

    DOI: 10.1177/0961203318801526

    Development of reporting guidelines for pharmacogenetic studies to facilitate evidence synthesis (Conference Paper)

    Richardson, M., Kirkham, J., Dwan, K., Sloan, D., Davies, G., & Jorgensen, A. (2018). Development of reporting guidelines for pharmacogenetic studies to facilitate evidence synthesis. In GENETIC EPIDEMIOLOGY Vol. 42 (pp. 727). Retrieved from http://gateway.webofknowledge.com/

    joineRML: a joint model and software package for time-to-event and multivariate longitudinal outcomes (Journal article)

    Hickey, G. L., Philipson, P., Jorgensen, A., & Kolamunnage-Dona, R. (2018). joineRML: a joint model and software package for time-to-event and multivariate longitudinal outcomes. BMC MEDICAL RESEARCH METHODOLOGY, 18. doi:10.1186/s12874-018-0502-1

    DOI: 10.1186/s12874-018-0502-1

    Correction: Antoniou, M.; et al. Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review. J. Pers. Med. 2017, 7, 1. (Journal article)

    Antoniou, M., Kolamunnage-Dona, R., & Jorgensen, A. L. (2018). Correction: Antoniou, M.; et al. Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review. J. Pers. Med. 2017, 7, 1.. Journal of personalized medicine, 8(2). doi:10.3390/jpm8020017

    DOI: 10.3390/jpm8020017

    Correction: Antoniou, M.; et al. Fixed and Adaptive Parallel Subgroup-Specific Design for Survival Outcomes: Power and Sample Size. J. Pers. Med. 2017, 7, 19. (Journal article)

    Antoniou, M., Jorgensen, A. L., & Kolamunnage-Dona, R. (2018). Correction: Antoniou, M.; et al. Fixed and Adaptive Parallel Subgroup-Specific Design for Survival Outcomes: Power and Sample Size. J. Pers. Med. 2017, 7, 19.. Journal of personalized medicine, 8(2). doi:10.3390/jpm8020018

    DOI: 10.3390/jpm8020018

    TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers. (Journal article)

    Francis, B., Clarke, J. I., Walker, L. E., Brillant, N., Jorgensen, A. L., Park, B. K., . . . Antoine, D. J. (2018). TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.. Journal of hepatology. doi:10.1016/j.jhep.2018.04.024

    DOI: 10.1016/j.jhep.2018.04.024

    Joint Models of Longitudinal and Time-to-Event Data with More Than One Event Time Outcome: A Review (Journal article)

    Hickey, G. L., Philipson, P., Jorgensen, A., & Kolamunnage-Dona, R. (2018). Joint Models of Longitudinal and Time-to-Event Data with More Than One Event Time Outcome: A Review. INTERNATIONAL JOURNAL OF BIOSTATISTICS, 14(1). doi:10.1515/ijb-2017-0047

    DOI: 10.1515/ijb-2017-0047

    Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin (Journal article)

    McWilliam, S. J., Antoine, D. J., Jorgensen, A. L., Smyth, R. L., & Pirmohamed, M. (2018). Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-23466-4

    DOI: 10.1038/s41598-018-23466-4

    Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study (Journal article)

    Hawcutt, D. B., Francis, B., Carr, D. F., Jorgensen, A. L., Yin, P., Wallin, N., . . . Pirmohamed, M. (2018). Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. LANCET RESPIRATORY MEDICINE, 6(6), 442-450. doi:10.1016/S2213-2600(18)30058-4

    DOI: 10.1016/S2213-2600(18)30058-4

    Clinical predictors of proteinuric remission following an LN flare - evidence from the UK JSLE cohort study (Journal article)

    Smith, E. M. D., Yin, P., Jorgensen, A. L., Beresford, M. W., & Grp, U. K. J. S. L. E. S. (2018). Clinical predictors of proteinuric remission following an LN flare - evidence from the UK JSLE cohort study. PEDIATRIC RHEUMATOLOGY, 16. doi:10.1186/s12969-018-0230-4

    DOI: 10.1186/s12969-018-0230-4

    Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia (Journal article)

    Navaratnam, K., Alfirevic, A., Jorgensen, A., & Alfirevic, Z. (2018). Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 221, 144-150. doi:10.1016/j.ejogrb.2017.12.052

    DOI: 10.1016/j.ejogrb.2017.12.052

    2017

    A comparison of joint models for longitudinal and competing risks data, with application to an epilepsy drug randomized controlled trial (Journal article)

    Hickey, G. L., Philipson, P., Jorgensen, A., & Kolamunnage-Dona, R. (2018). A comparison of joint models for longitudinal and competing risks data, with application to an epilepsy drug randomized controlled trial. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY, 181(4), 1105-1123. doi:10.1111/rssa.12348

    DOI: 10.1111/rssa.12348

    Fixed and Adaptive Parallel Subgroup-Specific Design for Survival Outcomes: Power and Sample Size. (Journal article)

    Antoniou, M., Jorgensen, A. L., & Kolamunnage-Dona, R. (2017). Fixed and Adaptive Parallel Subgroup-Specific Design for Survival Outcomes: Power and Sample Size.. Journal of personalized medicine, 7(4). doi:10.3390/jpm7040019

    DOI: 10.3390/jpm7040019

    GWAS FOR EARLY REMISSION IN NEWLY DIAGNOSED FOCAL EPILEPSY (Conference Paper)

    Auce, P., Francis, B., Langley, S. R., Jorgensen, A., Marson, A. G., Sills, G. J., & Consortium, E. (2017). GWAS FOR EARLY REMISSION IN NEWLY DIAGNOSED FOCAL EPILEPSY. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 88 (pp. A22). doi:10.1136/jnnp-2017-ABN.73

    DOI: 10.1136/jnnp-2017-ABN.73

    The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis (Journal article)

    Cliff, J., Jorgensen, A. L., Lord, R., Azam, F., Cossar, L., Carr, D. F., & Pirmohamed, M. (2017). The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 120, 127-140. doi:10.1016/j.critrevonc.2017.09.009

    DOI: 10.1016/j.critrevonc.2017.09.009

    Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies (Journal article)

    Dear, J. W., Clarke, J. I., Francis, B., Allen, L., Wraight, J., Shen, J., . . . Antoine, D. J. (2018). Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies. LANCET GASTROENTEROLOGY & HEPATOLOGY, 3(2), 104-113. doi:10.1016/S2468-1253(17)30266-2

    DOI: 10.1016/S2468-1253(17)30266-2

    Development and Application of Methodology for the Analysis of Rare Genetic Variants with Time to Event Outcomes Using SurvivalGWAS_RV (Conference Paper)

    Syed, H., Jorgensen, A. L., & Morris, A. P. (2017). Development and Application of Methodology for the Analysis of Rare Genetic Variants with Time to Event Outcomes Using SurvivalGWAS_RV. In GENETIC EPIDEMIOLOGY Vol. 41 (pp. 685-686). Retrieved from http://gateway.webofknowledge.com/

    Overview of Systematic Reviews of Therapeutic Ranges: Establishing the Threshold of Increased Drug Toxicity (Conference Paper)

    Moss, J., Cooney, L., Golder, S., Loke, Y., Jorgensen, A., Sinha, I., & Hawcutt, D. (2017). Overview of Systematic Reviews of Therapeutic Ranges: Establishing the Threshold of Increased Drug Toxicity. In DRUG SAFETY Vol. 40 (pp. 985). Retrieved from http://gateway.webofknowledge.com/

    Influence of genetic variants on toxicity to anti-tubercular agents: a systematic review and meta-analysis (protocol). (Journal article)

    Richardson, M., Kirkham, J., Dwan, K., Sloan, D., Davies, G., & Jorgensen, A. (2017). Influence of genetic variants on toxicity to anti-tubercular agents: a systematic review and meta-analysis (protocol).. Systematic reviews, 6(1), 142. doi:10.1186/s13643-017-0533-4

    DOI: 10.1186/s13643-017-0533-4

    Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy (Journal article)

    Berghuis, B., van der Palen, J., de Haan, G. -J., Lindhout, D., Koeleman, B. P. C., Sander, J. W., & Consortium, E. (2017). Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy. EPILEPSIA, 58(7), 1227-1233. doi:10.1111/epi.13777

    DOI: 10.1111/epi.13777

    Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity (Conference Paper)

    Dear, J. W., Clarke, J. I., Francis, B., Philips, L., Wraight, J., Dargan, P. I., . . . Antoine, D. J. (2017). Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity. In CLINICAL TOXICOLOGY Vol. 55 (pp. 468). Retrieved from http://gateway.webofknowledge.com/

    Overview of systematic reviews of therapeutic ranges: methodologies and recommendations for practice (Journal article)

    Cooney, L., Loke, Y. K., Golder, S., Kirkham, J., Jorgensen, A., Sinha, I., & Hawcutt, D. (2017). Overview of systematic reviews of therapeutic ranges: methodologies and recommendations for practice. BMC MEDICAL RESEARCH METHODOLOGY, 17. doi:10.1186/s12874-017-0363-z

    DOI: 10.1186/s12874-017-0363-z

    Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retracted article. See vol. 129, pg. 2166, 2019) (Journal article)

    Walker, L. E., Frigerio, F., Ravizza, T., Ricci, E., Tse, K., Jenkins, R. E., . . . Pirmohamed, M. (2017). Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retracted article. See vol. 129, pg. 2166, 2019). JOURNAL OF CLINICAL INVESTIGATION, 127(6), 2118-2132. doi:10.1172/JCI92001

    DOI: 10.1172/JCI92001

    TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity (Journal article)

    Thiesen, S., Yin, P., Jorgensen, A. L., Zhang, J. E., Manzo, V., McEvoy, L., . . . Pirmohamed, M. (2017). TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity. PHARMACOGENETICS AND GENOMICS, 27(6), 213-222. doi:10.1097/FPC.0000000000000281

    DOI: 10.1097/FPC.0000000000000281

    Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response (Journal article)

    Zhang, J. E., Klein, K., Jorgensen, A. L., Francis, B., Alfirevic, A., Bourgeois, S., . . . Pirmohamed, M. (2017). Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00323

    DOI: 10.3389/fphar.2017.00323

    SurvivalGWAS_SV: software for the analysis of genome-wide association studies of imputed genotypes with "time-to-event" outcomes (Journal article)

    Syed, H., Jorgensen, A. L., & Morris, A. P. (2017). SurvivalGWAS_SV: software for the analysis of genome-wide association studies of imputed genotypes with "time-to-event" outcomes. BMC BIOINFORMATICS, 18. doi:10.1186/s12859-017-1683-z

    DOI: 10.1186/s12859-017-1683-z

    Biomarker-guided clinical trial designs: sample size calculations with survival endpoints (Conference Paper)

    Antoniou, M., Kolamunnage-Dona, R., & Jorgensen, A. L. (2017). Biomarker-guided clinical trial designs: sample size calculations with survival endpoints. In TRIALS Vol. 18. Retrieved from http://gateway.webofknowledge.com/

    Do classic blood biomarkers of JSLE identify active lupus nephritis? Evidence from the UK JSLE Cohort Study (Journal article)

    Smith, E. M. D., Jorgensen, A. L., Beresford, M. W., & Grp, U. K. J. S. L. E. S. (2017). Do classic blood biomarkers of JSLE identify active lupus nephritis? Evidence from the UK JSLE Cohort Study. LUPUS, 26(11), 1212-1217. doi:10.1177/0961203317702253

    DOI: 10.1177/0961203317702253

    International validation of a urinary biomarker panel for identification of active lupus nephritis in children (Journal article)

    Smith, E. M. D., Jorgensen, A. L., Midgley, A., Oni, L., Goilav, B., Putterman, C., . . . Beresford, M. W. (2017). International validation of a urinary biomarker panel for identification of active lupus nephritis in children. PEDIATRIC NEPHROLOGY, 32(2), 283-295. doi:10.1007/s00467-016-3485-3

    DOI: 10.1007/s00467-016-3485-3

    Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review. (Journal article)

    Antoniou, M., Kolamunnage-Dona, R., & Jorgensen, A. L. (2017). Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review.. Journal of personalized medicine, 7(1). doi:10.3390/jpm7010001

    DOI: 10.3390/jpm7010001

    2016

    Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome (Journal article)

    Turner, R. M., Yin, P., Hanson, A., FitzGerald, R., Morris, A. P., Stables, R. H., . . . Pirmohamed, M. (2017). Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome. JOURNAL OF CLINICAL LIPIDOLOGY, 11(1), 204-214. doi:10.1016/j.jacl.2016.12.007

    DOI: 10.1016/j.jacl.2016.12.007

    SurvivalGWAS_Power: a user friendly tool for power calculations in pharmacogenetic studies with "time to event" outcomes (Journal article)

    Syed, H., Jorgensen, A. L., & Morris, A. P. (2016). SurvivalGWAS_Power: a user friendly tool for power calculations in pharmacogenetic studies with "time to event" outcomes. BMC BIOINFORMATICS, 17. doi:10.1186/s12859-016-1407-9

    DOI: 10.1186/s12859-016-1407-9

    A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease (Journal article)

    Walker, L. E., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2017). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. BIOMARKERS, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003

    DOI: 10.1080/1354750X.2016.1265003

    A Genome-Wide two-Component Mixture Model Expectation-Maximization Algorithm for Time to Event Data (Conference Paper)

    Francis, B., Yin, P., Cook, J., Jorgensen, A., Hutton, J., & Morris, A. (2016). A Genome-Wide two-Component Mixture Model Expectation-Maximization Algorithm for Time to Event Data. In GENETIC EPIDEMIOLOGY Vol. 40 (pp. 637). Retrieved from http://gateway.webofknowledge.com/

    SNP-Treatment Interactions of Cardiovascular Medications and Risk of Acute Coronary Syndrome Recurrence (Conference Paper)

    Yin, P., Jorgensen, A., Morris, A., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2016). SNP-Treatment Interactions of Cardiovascular Medications and Risk of Acute Coronary Syndrome Recurrence. In GENETIC EPIDEMIOLOGY Vol. 40 (pp. 672). Retrieved from http://gateway.webofknowledge.com/

    A candidate gene study for oxaliplatin induced chronic peripheral neuropathy (OICPN) based on a prior genome wide association study (GWAS) (Conference Paper)

    Cliff, J. R., Carr, D. F., Lord, R. H., Jorgensen, A. L., & Pirmohamed, M. (2016). A candidate gene study for oxaliplatin induced chronic peripheral neuropathy (OICPN) based on a prior genome wide association study (GWAS). In ANNALS OF ONCOLOGY Vol. 27. doi:10.1093/annonc/mdw392.54

    DOI: 10.1093/annonc/mdw392.54

    Joint modelling of time-to-event and multivariate longitudinal outcomes: recent developments and issues (Journal article)

    Hickey, G. L., Philipson, P., Jorgensen, A., & Kolamunnage-Dona, R. (2016). Joint modelling of time-to-event and multivariate longitudinal outcomes: recent developments and issues. BMC MEDICAL RESEARCH METHODOLOGY, 16. doi:10.1186/s12874-016-0212-5

    DOI: 10.1186/s12874-016-0212-5

    Joint models of longitudinal and time-to-event data: extensions and recent developments (Poster)

    Hickey, G. L., Sudell, M., Jorgensen, A., Tudur Smith, C., & Kolamunnage-Dona, R. (2016). Joint models of longitudinal and time-to-event data: extensions and recent developments. Poster session presented at the meeting of ITM Research Day 2016. University of Liverpool.

    Joint modelling of longitudinal outcomes and clinical endpoints: JoineR & JoineR-M (Poster)

    Hickey, G. L., Philipson, P., Jorgensen, A., Henderson, R., Diggle, P., Williamson, P., & Kolamunnage-Dona, R. (2016). Joint modelling of longitudinal outcomes and clinical endpoints: JoineR & JoineR-M. Poster session presented at the meeting of MRC Festival of Medical Research. Victoria Gallery and Museum, University of Liverpool.

    Evaluation of methodology for the analysis of 'time-to-event' data in pharmacogenomic genome-wide association studies (Journal article)

    Syed, H., Jorgensen, A. L., & Morris, A. P. (2016). Evaluation of methodology for the analysis of 'time-to-event' data in pharmacogenomic genome-wide association studies. PHARMACOGENOMICS, 17(8), 907-915. doi:10.2217/pgs.16.19

    DOI: 10.2217/pgs.16.19

    Adrenal responses to a low-dose short synacthen test in children with asthma (vol 82, pg 648, 2015) (Journal article)

    Hawcutt, D. B., Jorgensen, A. L., Wallin, N., Thompson, B., Peak, M., Lacy, D., . . . Smyth, R. L. (2016). Adrenal responses to a low-dose short synacthen test in children with asthma (vol 82, pg 648, 2015). CLINICAL ENDOCRINOLOGY, 84(5), 793. doi:10.1111/cen.13069

    DOI: 10.1111/cen.13069

    A methodological review of joint modelling of multivariate time-to-event data and longitudinal outcomes (Poster)

    Hickey, G. L., Philipson, P., Jorgensen, A., & Kolamunnage-Dona, R. (2016). A methodological review of joint modelling of multivariate time-to-event data and longitudinal outcomes. Poster session presented at the meeting of Joint Modeling and Beyond – Meeting and Tutorial on Joint Modeling With Survival, Longitudinal, and Missing Data. Hasselt University, Belgium.

    A Genome-Wide Two-Component Mixture Model Expectation-Maximisation Algorithm for Time to Event Data (Conference Paper)

    Francis, B., Yin, P., Cook, J. P., Jorgensen, A. L., Hutton, J., & Morris, A. P. (2016). A Genome-Wide Two-Component Mixture Model Expectation-Maximisation Algorithm for Time to Event Data. In HUMAN HEREDITY Vol. 81 (pp. 212-213). Retrieved from http://gateway.webofknowledge.com/

    A multi-factorial analysis of response to warfarin in a UK prospective cohort (Journal article)

    Bourgeois, S., Jorgensen, A., Zhang, E. J., Hanson, A., Gillman, M. S., Bumpstead, S., . . . Pirmohamed, M. (2016). A multi-factorial analysis of response to warfarin in a UK prospective cohort. GENOME MEDICINE, 8. doi:10.1186/s13073-015-0255-y

    DOI: 10.1186/s13073-015-0255-y

    Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review (Journal article)

    Antoniou, M., Jorgensen, A. L., & Kolamunnage-Dona, R. (2016). Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review. PLOS ONE, 11(2). doi:10.1371/journal.pone.0149803

    DOI: 10.1371/journal.pone.0149803

    SurvivalGWAS_RV: Software to Test Rare Variant Association with "Time-to-Event" Outcomes (Conference Paper)

    Syed, H., Jorgensen, A. L., & Morris, A. P. (2016). SurvivalGWAS_RV: Software to Test Rare Variant Association with "Time-to-Event" Outcomes. In HUMAN HEREDITY Vol. 81 (pp. 230). Retrieved from http://gateway.webofknowledge.com/

    2015

    Evaluation of methodology for the analysis of "time-toevent" data in pharmacogenetic studies (Conference Paper)

    Syed, H., Jorgensen, A., & Morris, A. P. (2015). Evaluation of methodology for the analysis of "time-toevent" data in pharmacogenetic studies. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 584). Retrieved from http://gateway.webofknowledge.com/

    Pharmacogenetics of Acute Coronary Syndrome (Conference Paper)

    Yin, P., Jorgensen, A., Morris, A. P., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2015). Pharmacogenetics of Acute Coronary Syndrome. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 596). Retrieved from http://gateway.webofknowledge.com/

    Adrenal responses to a low-dose short synacthen test in children with asthma (Journal article)

    Hawcutt, D. B., Jorgensen, A. L., Wallin, N., Thompson, B., Peak, M., Lacy, D., . . . Smyth, R. L. (2015). Adrenal responses to a low-dose short synacthen test in children with asthma. CLINICAL ENDOCRINOLOGY, 82(5), 648-656. doi:10.1111/cen.12655

    DOI: 10.1111/cen.12655

    HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis (Journal article)

    Castro, E. M. C., Carr, D. F., Jorgensen, A. L., Alfirevic, A., & Pirmohamed, M. (2015). HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis. PHARMACOGENETICS AND GENOMICS, 25(4), 186-198. doi:10.1097/FPC.0000000000000124

    DOI: 10.1097/FPC.0000000000000124

    Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury (Journal article)

    Antoine, D. J., Sabbisetti, V. S., Francis, B., Jorgensen, A. L., Craig, D. G. N., Simpson, K. J., . . . Dear, J. W. (2015). Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury. HEPATOLOGY, 62(2), 591-599. doi:10.1002/hep.27857

    DOI: 10.1002/hep.27857

    Evaluating statistical characteristics of biomarker-guided trial designs (Journal article)

    Antoniou, M., Jorgensen, A., & Kolamunnage-Dona, R. (2015). Evaluating statistical characteristics of biomarker-guided trial designs. TRIALS, 16. doi:10.1186/1745-6215-16-S2-O83

    DOI: 10.1186/1745-6215-16-S2-O83

    Genome-Wide Two-Way Competing Risks Approach to Analyse Time to Antiepileptic Drug Withdrawal (Conference Paper)

    Francis, B., Jorgensen, A., Morris, A., Ingason, A., Marson, A., Johnson, M., . . . Consortium, E. (2015). Genome-Wide Two-Way Competing Risks Approach to Analyse Time to Antiepileptic Drug Withdrawal. In HUMAN HEREDITY Vol. 80 (pp. 109-110). Retrieved from http://gateway.webofknowledge.com/

    Powerful Methodology for the Analysis of 'Time-to-Event' Data in Pharmacogenetic Studies (Conference Paper)

    Syed, H., Jorgensen, A., & Morris, A. (2015). Powerful Methodology for the Analysis of 'Time-to-Event' Data in Pharmacogenetic Studies. In HUMAN HEREDITY Vol. 79 (pp. 46-47). Retrieved from http://gateway.webofknowledge.com/

    The Influence of Pharmacogenetics on the Time to Acute Coronary Syndrome Recurrence in a UK Cohort Study (Conference Paper)

    Yin, P., Jorgensen, A., Morris, A., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2015). The Influence of Pharmacogenetics on the Time to Acute Coronary Syndrome Recurrence in a UK Cohort Study. In HUMAN HEREDITY Vol. 80 (pp. 123). Retrieved from http://gateway.webofknowledge.com/

    Two-Component Mixture Modelling Approach Integrating Genetic and Clinical Variables in Analysis of Time to First Seizure in Epilepsy (Conference Paper)

    Francis, B., Jorgensen, A., Morris, A., Marson, A., Johnson, M., Sills, G., & Consortium, E. (2015). Two-Component Mixture Modelling Approach Integrating Genetic and Clinical Variables in Analysis of Time to First Seizure in Epilepsy. In HUMAN HEREDITY Vol. 79 (pp. 34). Retrieved from http://gateway.webofknowledge.com/

    tSNR as Feature Selection Technique in SNP Data Analysis (Conference Paper)

    Hassan, N., Garcia-Finana, M., Czanner, G., & Jorgensen, A. (2015). tSNR as Feature Selection Technique in SNP Data Analysis. In HUMAN HEREDITY Vol. 80 (pp. 112). Retrieved from http://gateway.webofknowledge.com/

    2014

    Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects (Journal article)

    Hawcutt, D. B., Ghani, A. A., Sutton, L., Jorgensen, A., Zhang, E., Murray, M., . . . Pirmohamed, M. (2014). Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects. PHARMACOGENOMICS JOURNAL, 14(6), 542-548. doi:10.1038/tpj.2014.31

    DOI: 10.1038/tpj.2014.31

    WHICH GENETIC PATHWAYS UNDERLIE PHARMACORESISTANT EPILEPSY? (Conference Paper)

    Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, T. (2014). WHICH GENETIC PATHWAYS UNDERLIE PHARMACORESISTANT EPILEPSY?. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 85. doi:10.1136/jnnp-2014-309236.6

    DOI: 10.1136/jnnp-2014-309236.6

    CYP2B6 c.983T > C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations (Journal article)

    Carr, D. F., Chaponda, M., Castro, E. M. C., Jorgensen, A. L., Khoo, S., Van Oosterhout, J. J., . . . Pirmohamed, M. (2014). CYP2B6 c.983T > C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 69(12), 3329-3334. doi:10.1093/jac/dku315

    DOI: 10.1093/jac/dku315

    Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation (Journal article)

    Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., . . . Trialists, F. (2014). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation. HEALTH TECHNOLOGY ASSESSMENT, 18(48), 1-+. doi:10.3310/hta18480

    DOI: 10.3310/hta18480

    IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY (Conference Paper)

    Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY. In EPILEPSIA Vol. 55 (pp. 10). Retrieved from http://gateway.webofknowledge.com/

    Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality (Conference Paper)

    Mirza, N., Sills, G., Jorgensen, A., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality. In JOURNAL OF NEUROLOGY Vol. 261 (pp. S484-S485). Retrieved from http://gateway.webofknowledge.com/

    Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality (Conference Paper)

    Mirza, N., Sills, G., Jorgensen, A., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality. In EUROPEAN JOURNAL OF NEUROLOGY Vol. 21 (pp. 755). Retrieved from http://gateway.webofknowledge.com/

    A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction (Journal article)

    Francis, B., Lane, S., Pirmohamed, M., & Jorgensen, A. (2014). A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction. PLOS ONE, 9(12). doi:10.1371/journal.pone.0114896

    DOI: 10.1371/journal.pone.0114896

    A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy (Journal article)

    Speed, D., Hoggart, C., Petrovski, S., Tachmazidou, I., Coffey, A., Jorgensen, A., . . . Johnson, M. R. (2014). A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. HUMAN MOLECULAR GENETICS, 23(1), 247-258. doi:10.1093/hmg/ddt403

    DOI: 10.1093/hmg/ddt403

    Cervical stitch (cerclage) for preventing preterm birth in multiple pregnancy (Journal article)

    Rafael, T. J., Berghella, V., & Alfirevic, Z. (2014). Cervical stitch (cerclage) for preventing preterm birth in multiple pregnancy. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (9). doi:10.1002/14651858.CD009166.pub2

    DOI: 10.1002/14651858.CD009166.pub2

    Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children (Journal article)

    McWilliam, S. J., Antoine, D. J., Sabbisetti, V., Pearce, R. E., Jorgensen, A. L., Lin, Y., . . . Pirmohamed, M. (2014). Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children. Biomarker Medicine.

    Reference intervals for urinary renal injury biomarkers KIM-1and NGAL in healthy children (Journal article)

    McWilliam, S. J., Antoine, D. J., Sabbisetti, V., Pearce, R. E., Jorgensen, A. L., Lin, Y., . . . Pirmohamed, M. (2014). Reference intervals for urinary renal injury biomarkers KIM-1and NGAL in healthy children. BIOMARKERS IN MEDICINE, 8(10), 1189-1197. doi:10.2217/BMM.14.36

    DOI: 10.2217/BMM.14.36

    2013

    Genetic testing for prevention of severe drug-induced skin rash (Journal article)

    Alfirevic, A., Pirmohamed, M., Marinovic, B., Jorgensen, A. L., & Harcourt-Smith, L. (n.d.). Genetic testing for prevention of severe drug-induced skin rash. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd010891

    DOI: 10.1002/14651858.cd010891

    A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study (Journal article)

    Pirmohamed, M., Burnside, G., Stoddern, J., Prince, C., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study. CIRCULATION, 128(24), 2710-2711. Retrieved from http://gateway.webofknowledge.com/

    The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK (Journal article)

    Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73

    DOI: 10.2217/PGS.13.73

    Systematic review of pharmacogenomics in psoriasis (Conference Paper)

    Foulkes, A. C., Jorgensen, A., Pirmohamed, M., Griffiths, C. E., & Warren, R. B. (2013). Systematic review of pharmacogenomics in psoriasis. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 133 (pp. S88). Retrieved from http://gateway.webofknowledge.com/

    The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia (Journal article)

    Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia. BLOOD, 121(4), 628-637. doi:10.1182/blood-2012-01-405035

    DOI: 10.1182/blood-2012-01-405035

    A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article)

    Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Grp, E. U. -P. A. C. T. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2294-2303. doi:10.1056/NEJMoa1311386

    DOI: 10.1056/NEJMoa1311386

    A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article)

    Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. New England Journal of Medicine, 369(24), 2294-2303. doi:10.1056/nejmoa1311386

    DOI: 10.1056/nejmoa1311386

    A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article)

    Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., & al., E. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. New England Journal of Medicine, (369), 2294-2303.

    A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. (Journal article)

    Speed, D., Hoggart, C., Petrovski, S., Tachmazidou, I., Coffey, A., Jorgensen, A., . . . Johnson, M. R. (2013). A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.. Human Molecular Genetics.

    Adherence and variability in warfarin dose requirements: assessment in a prospective cohort (Journal article)

    Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199

    DOI: 10.2217/PGS.12.199

    Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. (Journal article)

    Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort..

    Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population (Journal article)

    Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021

    DOI: 10.1093/cid/cit021

    Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population. (Journal article)

    Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population..

    CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease (Journal article)

    Musumba, C. O., Jorgensen, A., Sutton, L., Van Eker, D., Zhang, E., O'Hara, N., . . . Pirmohamed, M. (2013). CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease. CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(2), 195-203. doi:10.1038/clpt.2012.215

    DOI: 10.1038/clpt.2012.215

    Institutional profile: the Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. (Journal article)

    Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). Institutional profile: the Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK..

    SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink (Journal article)

    Carr, D. F., O'Meara, H., Jorgensen, A. L., Campbell, J., Hobbs, M., McCann, G., . . . Pirmohamed, M. (2013). SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(6), 695-701. doi:10.1038/clpt.2013.161

    DOI: 10.1038/clpt.2013.161

    SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink (Journal article)

    Carr, D. F., O'Meara, H., Jorgensen, A. L., Campbell, J., Hobbs, M., McCann, G., . . . Pirmohamed, M. (2013). SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink. Clinical Pharmacology and Therapeutics, 94(6), 695-701. doi:10.1038/clpt.2013

    DOI: 10.1038/clpt.2013

    The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia (Journal article)

    Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia. Blood, 121, 628-637.

    2012

    HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review. (Journal article)

    Yip, V., Marson, T., Jorgensen, A., Pirmohamed, M., & Alfirevic, A. (2012). HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.. Clinical Pharmacology and Therapeutics, 92(6), 757-765.

    CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE (Journal article)

    Musumba, C. O., Eker, D. V., Jorgensen, A., Pritchard, D. M., & Pirmohamed, M. (2012). CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE. GUT, 61, A363. doi:10.1136/gutjnl-2012-302514d.165

    DOI: 10.1136/gutjnl-2012-302514d.165

    Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy (Journal article)

    Alfirevic, Z., Stampalija, T., Roberts, D., & Jorgensen, A. L. (2012). Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (4). doi:10.1002/14651858.CD008991.pub2

    DOI: 10.1002/14651858.CD008991.pub2

    HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review (Journal article)

    Yip, V. L., Marson, A. G., Jorgensen, A. L., Pirmohamed, M., & Alfirevic, A. (2012). HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 757-765. doi:10.1038/clpt.2012.189

    DOI: 10.1038/clpt.2012.189

    HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review (Journal article)

    Yip, V. L., Marson, A. G., Jorgensen, A. L., Pirmohamed, M., & Alfirevic, A. (2012). HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review. Clinical Pharmacology and Therapeutics, 92(6), 757-765.

    Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis (Journal article)

    Jorgensen, A. L., FitzGerald, R. J., Oyee, J., Pirmohamed, M., & Williamson, P. R. (2012). Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis. PLOS ONE, 7(8). doi:10.1371/journal.pone.0044064

    DOI: 10.1371/journal.pone.0044064

    Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy (Journal article)

    Horne, B. D., Lenzini, P. A., Wadelius, M., Jorgensen, A. L., Kimmel, S. E., Ridker, P. M., . . . Gage, B. F. (2012). Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy. THROMBOSIS AND HAEMOSTASIS, 107(2), 232-240. doi:10.1160/TH11-06-0388

    DOI: 10.1160/TH11-06-0388

    The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors (Journal article)

    Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., . . . Pirmohamed, M. (2012). The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors. British Journal of Clinical Pharmacology.

    The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hosiptal in the UK between 2005 and 2010 (Journal article)

    Musumba, C., Jorgensen, A., Sutton, L., Van Eker, D., Moorcroft, J., Hopkins, M., . . . Pirmohamed, M. (2012). The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hosiptal in the UK between 2005 and 2010. Alimentary Pharmacology and Therapeutics, 36(1), 48-56.

    The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010 (Journal article)

    Musumba, C., Jorgensen, A., Sutton, L., Van Eker, D., Moorcroft, J., Hopkins, M., . . . Pirmohamed, M. (2012). The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(1), 48-56. doi:10.1111/j.1365-2036.2012.05118.x

    DOI: 10.1111/j.1365-2036.2012.05118.x

    VARIATION AT GLCCI1: ASSOCIATION WITH INCREASED STEROID DOSE BUT NOT ADRENAL SUPPRESSION IN ASTHMATIC CHILDREN (Journal article)

    Thompson, B., Hawcutt, D. B., Carr, D. F., Jorgensen, A. L., Smyth, R. L., & Pirmohamed, M. (2012). VARIATION AT GLCCI1: ASSOCIATION WITH INCREASED STEROID DOSE BUT NOT ADRENAL SUPPRESSION IN ASTHMATIC CHILDREN. THORAX, 67, A17. doi:10.1136/thoraxjnl-2012-202678.037

    DOI: 10.1136/thoraxjnl-2012-202678.037

    2011

    CHANGING TRENDS IN PEPTIC ULCER DISEASE: THE RISE OF NSAID-INDUCED AND FALL OF H PYLORI-INDUCED ULCERS (Conference Paper)

    Musumba, C. O., Van Eker, D., Jorgensen, A., Pritchard, M., & Pirmohamed, M. (2011). CHANGING TRENDS IN PEPTIC ULCER DISEASE: THE RISE OF NSAID-INDUCED AND FALL OF H PYLORI-INDUCED ULCERS. In GUT Vol. 60. doi:10.1136/gut.2011.239301.219

    DOI: 10.1136/gut.2011.239301.219

    A Proposal for an Individualized Pharmacogenetics-Based Warfarin Initiation Dose Regimen for Patients Commencing Anticoagulation Therapy (Journal article)

    Avery, P. J., Jorgensen, A., Hamberg, A., Wadelius, M., Pirmohamed, M., Kamali, F., & Grp, E. U. -P. A. C. T. S. (2011). A Proposal for an Individualized Pharmacogenetics-Based Warfarin Initiation Dose Regimen for Patients Commencing Anticoagulation Therapy. CLINICAL PHARMACOLOGY & THERAPEUTICS, 90(5), 701-706. doi:10.1038/clpt.2011.186

    DOI: 10.1038/clpt.2011.186

    Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors (Journal article)

    Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. PHARMACOGENETICS AND GENOMICS, 21(5), 297-302. doi:10.1097/FPC.0b013e3283441b95

    DOI: 10.1097/FPC.0b013e3283441b95

    Risk modeling strategies for pharmacogenetic studies (Journal article)

    Jorgensen, A. L., & Pirmohamed, M. (2011). Risk modeling strategies for pharmacogenetic studies. PHARMACOGENOMICS, 12(3), 397-410. doi:10.2217/PGS.10.198

    DOI: 10.2217/PGS.10.198

    The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors (Journal article)

    Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., . . . Pirmohamed, M. (2012). The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(1), 66-76. doi:10.1111/j.1365-2125.2011.04051.x

    DOI: 10.1111/j.1365-2125.2011.04051.x

    2010

    CYP4F2 genotype-phenotype correlation in human liver (Conference Paper)

    Zhang, J. E., Jorgensen, A., Kline, K., Alfirevic, A., Zanger, U., & Pirmohamed, M. (2010). CYP4F2 genotype-phenotype correlation in human liver. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297-298). Retrieved from http://gateway.webofknowledge.com/

    Carbamazepine-induced hypersensitivity in Caucasians and genetic variability in the major histocompatibility complex (Conference Paper)

    Alfirevic, A., Bourgeois, S., Jorgensen, A., Steen, K., Weetman, D., Park, B. K., . . . Pirmohamed, M. (2010). Carbamazepine-induced hypersensitivity in Caucasians and genetic variability in the major histocompatibility complex. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 298). Retrieved from http://gateway.webofknowledge.com/

    Proposal of a pharmacogenetic-based dosing algorithm for the induction of warfarin anticoagulation therapy in patients with thromboembolic disease (Conference Paper)

    Avery, P., Pirmohamed, M., Jorgensen, A., & Kamali, F. (2010). Proposal of a pharmacogenetic-based dosing algorithm for the induction of warfarin anticoagulation therapy in patients with thromboembolic disease. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 291). Retrieved from http://gateway.webofknowledge.com/

    Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses (Journal article)

    Fleeman, N., Dundar, Y., Dickson, R., Jorgensen, A., Pushpakom, S., McLeod, C., . . . Walley, T. (2011). Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses. PHARMACOGENOMICS JOURNAL, 11(1), 1-14. doi:10.1038/tpj.2010.73

    DOI: 10.1038/tpj.2010.73

    Improving the evidence base in pharmacogenetic studies: warfarin as an example (Thesis / Dissertation)

    Jorgensen, A. L. (2010). Improving the evidence base in pharmacogenetic studies: warfarin as an example. (PhD Thesis, University of Liverpool).

    Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing (Journal article)

    Lenzini, P., Wadelius, M., Kimmel, S., Anderson, J. L., Jorgensen, A. L., Pirmohamed, M., . . . Gage, B. F. (2010). Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 87(5), 572-578. doi:10.1038/clpt.2010.13

    DOI: 10.1038/clpt.2010.13

    Integration of genetic, clinical, and INR data to refine warfarin dosing (Journal article)

    Lenzini, P., Wadelius, M., Kimmel, S., Anderson, J. L., Jorgensen, A. L., Pirmohamed, M., & al., E. (2010). Integration of genetic, clinical, and INR data to refine warfarin dosing. Unknown Journal, 87(5), 572-578.

    Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. (Journal article)

    Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2010). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.. Pharmacogenetics and Genomics, 21(5), 297-302.

    The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation (Journal article)

    Fleeman, N., McLeod, C., Bagust, A., Beale, S., Boland, A., Dundar, Y., . . . Dickson, R. (2010). The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation. HEALTH TECHNOLOGY ASSESSMENT, 14(3), 1-+. doi:10.3310/hta14030

    DOI: 10.3310/hta14030

    Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups (Journal article)

    Limdi, N. A., Wadelius, M., Cavallari, L., Eriksson, N., Crawford, D. C., Lee, M. -T. M., . . . Cons, I. W. P. (2010). Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups. BLOOD, 115(18), 3827-3834. doi:10.1182/blood-2009-12-255992

    DOI: 10.1182/blood-2009-12-255992

    2009

    Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (vol 360, pg 753, 2009) (Journal article)

    Klein, T. E., Altman, R. B., Eriksson, N., Gage, B. F., Kimmel, S. E., Lee, M. T. M., . . . Shin, J. G. (2009). Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (vol 360, pg 753, 2009). NEW ENGLAND JOURNAL OF MEDICINE, 361(16), 1613. Retrieved from http://gateway.webofknowledge.com/

    IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS (Journal article)

    Hughes, D. A., Al-Zubiedi, S., Hanson, A., Jorgensen, A., & Pirmohamed, M. (2009). IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS. VALUE IN HEALTH, 12(3), A3-A4. doi:10.1016/S1098-3015(10)73081-3

    DOI: 10.1016/S1098-3015(10)73081-3

    Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy (Journal article)

    Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347

    DOI: 10.1097/FPC.0b013e3283311347

    Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (Journal article)

    Klein, T. E., Altman, R. B., Eriksson, N., Gage, B. F., Kimmel, S. E., Lee, M. -T. M., . . . Cons, I. W. P. (2009). Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data. NEW ENGLAND JOURNAL OF MEDICINE, 360(8), 753-764. Retrieved from http://gateway.webofknowledge.com/

    Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study (Journal article)

    Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5

    DOI: 10.1097/FPC.0b013e3283317ab5

    Systematic Review of Pharmacogenetic Warfarin Dosing (Journal article)

    van Schie, R. M. F., Jorgensen, A. L., de Boer, A., Maitland-van der Zee, A. -H., & Grp, E. U. -P. A. C. T. S. (2009). Systematic Review of Pharmacogenetic Warfarin Dosing. JOURNAL OF GENERAL INTERNAL MEDICINE, 24(10), 1171. doi:10.1007/s11606-009-1083-9

    DOI: 10.1007/s11606-009-1083-9

    2008

    A randomized controlled clinical trial of 2295 ultrasound-guided embryo transfers (Journal article)

    Drakeley, A. J., Jorgensen, A., Sklavounos, J., Aust, T., Gazvani, R., Williamson, P., & Kingsland, C. R. (2008). A randomized controlled clinical trial of 2295 ultrasound-guided embryo transfers. HUMAN REPRODUCTION, 23(5), 1101-1106. doi:10.1093/humrep/den064

    DOI: 10.1093/humrep/den064

    Cervical stitch (cerclage) for preventing pregnancy loss: individual patient data meta-analysis - Author's reply (Journal article)

    Jorgensen, A. L., Alfirevic, Z., Smith, C. T., & Williamson, P. R. (2008). Cervical stitch (cerclage) for preventing pregnancy loss: individual patient data meta-analysis - Author's reply. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 115(6), 798-799. doi:10.1111/j.1471-0528.2008.01689.x

    DOI: 10.1111/j.1471-0528.2008.01689.x

    Methodological quality of pharmacogenetic studies: Issues of concern (Journal article)

    Jorgensen, A. L., & Williamson, P. R. (2008). Methodological quality of pharmacogenetic studies: Issues of concern. STATISTICS IN MEDICINE, 27(30), 6547-6569. doi:10.1002/sim.3420

    DOI: 10.1002/sim.3420

    Pharmacogenetics and pharmacogenomics: adverse drug reactions. (Journal article)

    Jorgensen, A., & Alfirevic, A. (2008). Pharmacogenetics and pharmacogenomics: adverse drug reactions.. Pharmacogenomics, 9(10), 1397-1401. doi:10.2217/14622416.9.10.1397

    DOI: 10.2217/14622416.9.10.1397

    Warfarin pharmacogenetics: ready for clinical implementation? (Journal article)

    Jorgensen, A. L. (2008). Warfarin pharmacogenetics: ready for clinical implementation?. JOURNAL OF PHARMACY AND PHARMACOLOGY, 60, A66-A67. Retrieved from http://gateway.webofknowledge.com/

    2007

    Cervical stitch (cerclage) for preventing pregnancy loss: Individual patient data meta-analysis (Journal article)

    Jorgensen, A. L., Alfirevic, Z., Smith, C. T., Williamson, P. R., & Grp, I. M. -A. (2007). Cervical stitch (cerclage) for preventing pregnancy loss: Individual patient data meta-analysis. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 114(12), 1460-1476. doi:10.1111/j.1471-0528.2007.01515.x

    DOI: 10.1111/j.1471-0528.2007.01515.x

    The association between polymorphisms in RLIP76 and drug response in epilepsy (Journal article)

    Leschziner, G. D., Jorgensen, A. L., Andrews, T., Williamson, P. R., Marson, A. G., Coffey, A. J., . . . Pirmohamed, M. (2007). The association between polymorphisms in RLIP76 and drug response in epilepsy. PHARMACOGENOMICS, 8(12), 1715-1722. doi:10.2217/14622416.8.12.1715

    DOI: 10.2217/14622416.8.12.1715

    2006

    ABCB1 polymorphisms and haplotype previously associated with drug resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective epilepsy cohort (Conference Paper)

    Leschziner, G., Jorgensen, A., Andrew, T., Middleditch, C., Pirmohamed, M., Williamson, P., . . . Johnson, M. R. (2006). ABCB1 polymorphisms and haplotype previously associated with drug resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective epilepsy cohort. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 77 (pp. 1394). Retrieved from http://gateway.webofknowledge.com/

    ACB1 polymorphisms and haplotype previously associated with drug-resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective cohort (Conference Paper)

    Leschziner, G. D., Jorgensen, A., Andrew, T., Middleditch, C., Pirmohamed, M., Marson, T., . . . Johnson, M. R. (2006). ACB1 polymorphisms and haplotype previously associated with drug-resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective cohort. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 84). Retrieved from http://gateway.webofknowledge.com/

    Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study (Journal article)

    Leschziner, G., Jorgensen, A. L., Andrew, T., Pirmohaomed, M., Williamson, P. R., Marson, A. G., . . . Johnson, M. R. (2006). Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study. LANCET NEUROLOGY, 5(8), 668-676. doi:10.1016/S1474-4422(06)70500-2

    DOI: 10.1016/S1474-4422(06)70500-2

    HLA-B locus in Caucasian patients with carbamazepine hypersensitivity (Journal article)

    Alfirevic, A., Jorgensen, A. L., Williamson, P. R., Chadwick, D. W., Park, B. K., & Pirmohamed, M. (2006). HLA-B locus in Caucasian patients with carbamazepine hypersensitivity. PHARMACOGENOMICS, 7(6), 813-818. doi:10.2217/14622416.7.6.813

    DOI: 10.2217/14622416.7.6.813

    2005

    Individual patient data meta-analysis : Cervical stitch (cerclage) for preventing pregnancy loss in women. (Journal article)

    Tudur-Smith, C., Jorgensen, A. L., Alfirevic, Z., & Williamson, P. R. (2005). Individual patient data meta-analysis : Cervical stitch (cerclage) for preventing pregnancy loss in women.. BMC pregnancy and childbirth, 5(1), 5. doi:10.1186/1471-2393-5-5

    DOI: 10.1186/1471-2393-5-5