I am interested in how the fundamental mechanisms that maintain neuronal function are affected by neurological disorders and by ageing. To this end, we use a range of approaches from in vitro protein biochemistry through to in vivo studies using simple model organisms.
Current projects in my lab focus on:
(1) revealing how mutations in conserved neuronal genes lead to epilepsy and neurodegeneration;
(2) using nematode worms to identify potential new drug therapies for neurological diseases;
(3) understanding how chaperone proteins maintain cellular function during ageing.
Funding for current research comes from MRC and the Wellcome Trust.