Overview
Without an immune system, humans and animals would be vulnerable to overwhelming infections caused by bacteria, viruses, fungi or parasites. Immunology is the study of how the body defends itself against infection. Vaccinology is the science behind developing vaccines that initiate protective immune responses. By pursuing a research degree in Immunology and Vaccinology, you’ll contribute to vital research that enhances our understanding of immune defences and advances vaccine development.
Introduction
The University of Liverpool’s Institute of Infection, Veterinary, and Ecological Sciences (IVES) brings together leading medical, veterinary and basic science researchers from across the Faculty of Health and Life Sciences.
We are one of the few UK institutions to have designed, developed and tested a human vaccine all the way through to clinical trials. Our significant human sample collection supports immunological research, enhancing our understanding of how vaccines work, paving the way for next-generation vaccines.
Research in Immunology and Vaccinology is based in new laboratories at four sites, the Biosciences Building, IC2, the Leahurst campus and the Ronald Ross Building. The Centre for Global Vaccine Research at the University of Liverpool currently works across Europe, Asia, Africa and more recently South America.
Our research spans the breadth of vaccine research from development to implementation and evaluation. The aims of the research are to investigate the nature of the cellular and humoral immune responses to pathogens of human or veterinary importance. It encompasses studies of the immune responses to and vaccination against a range of bacterial, viral and parasitic pathogens. These include:
- SARS-CoV-2
- Influenza
- Salmonella
- Streptococcus pneumoniae
- Chicken metapneumovirus
- Cryptosporidium
- Cytomegalovirus and other herpes viruses
- Cyathostomins
- Fasciola
- Giardia
- HIV
- Japanese encephalitis virus
- Mycobacterium tuberculosis
- Neospora caninum
- Onchocerca
- Toxoplasma
- Leptospira
- Treponema
- Zika virus.
Research topics
Aspects of immunology and vaccinology you could explore on this research degree include:
- The immunological basis of vaccine-induced protective immunity against bacterial and viral pathogens in humans and animals. For example:
- Disease epidemiology and clinical trials
- Vaccine adjuvants
- Microbial ecology
- Antigen discovery and vaccine development
- Pre-clinical assessment models
- Immune correlates of protection.
- Natural immunity to viruses, nature and durability of antibody, B cell and T cell responses, cross-reactivity of adaptive immune responses, studies on correlates of protection
- The use of artificial intelligence and protein engineering to identify and enhance proteins for new or improved vaccines against important spirochaetal diseases affecting animals and humans.