Photo of Prof Lu-Yun Lian

Prof Lu-Yun Lian B.Sc.(Hons); Ph.D, MBA

Professor of Structural Biology Biochemistry

    Publications

    2020

    Cyclophilin D binds to the acidic C-terminus region of alpha-Synuclein and affects its aggregation characteristics (Journal article)

    Torpey, J., Madine, J., Wood, A., & Lian, L. -Y. (2020). Cyclophilin D binds to the acidic C-terminus region of alpha-Synuclein and affects its aggregation characteristics. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-66200-9

    DOI: 10.1038/s41598-020-66200-9

    Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure (Journal article)

    Sindrewicz, P., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2020). Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 523(2), 336-341. doi:10.1016/j.bbrc.2019.12.054

    DOI: 10.1016/j.bbrc.2019.12.054

    2019

    Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions (Journal article)

    Sindrewicz, P., Li, X., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2019). Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-47658-8

    DOI: 10.1038/s41598-019-47658-8

    2018

    1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints (Journal article)

    Anderson, J., Chokesuwattanaskul, S., Phelan, M., Welting, T., Lian, L. Y., Peffers, M., & Wright, H. L. (2018). 1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints. Journal of Proteome Research, 17(11), 3780-3790. doi:10.1021/acs.jproteome.8b00455

    DOI: 10.1021/acs.jproteome.8b00455

    Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils. (Journal article)

    Zhan, B., Arumugam, S., Kennedy, M. W., Tricoche, N., Lian, L. -Y., Asojo, O. A., . . . Klei, T. R. (2018). Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.. PLoS neglected tropical diseases, 12(10), e0006772. doi:10.1371/journal.pntd.0006772

    DOI: 10.1371/journal.pntd.0006772

    Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction (Journal article)

    Spencer, C. S., Yunta, C., de Lima, G. P. G., Hemmings, K., Lian, L. -Y., Lycett, G., & Paine, M. J. (2018). Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 98, 25-33. doi:10.1016/j.ibmb.2018.04.010

    DOI: 10.1016/j.ibmb.2018.04.010

    2017

    Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia (Journal article)

    Helassa, N., Antonyuk, S. V., Lian, L. -Y., Haynes, L. P., & Burgoyne, R. D. (2017). Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Human molecular genetics, 26(13), 2426-2435. doi:10.1093/hmg/ddx133

    DOI: 10.1093/hmg/ddx133

    Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor. (Journal article)

    Humbert, M. V., Awanye, A. M., Lian, L. -Y., Derrick, J. P., & Christodoulides, M. (2017). Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor.. PLoS pathogens, 13(6). doi:10.1371/journal.ppat.1006448

    DOI: 10.1371/journal.ppat.1006448

    2016

    Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch (Journal article)

    Patel, P., Prescott, G. R., Burgoyne, R. D., Lian, L. -Y., & Morgan, A. (2016). Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch. STRUCTURE, 24(8), 1380-1386. doi:10.1016/j.str.2016.06.009

    DOI: 10.1016/j.str.2016.06.009

    Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis (Journal article)

    Sindrewicz, P., Lian, L. -Y., & Yu, L. -G. (2016). Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis. FRONTIERS IN ONCOLOGY, 6. doi:10.3389/fonc.2016.00079

    DOI: 10.3389/fonc.2016.00079

    Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis (Journal article)

    Shore, E. R., Awais, M., Kershaw, N. M., Gibson, R. R., Pandalanen, S., Latawiec, D., . . . Sutton, R. (2016). Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis. JOURNAL OF MEDICINAL CHEMISTRY, 59(06), 2596-2611. doi:10.1021/acs.jmedchem.5b01801

    DOI: 10.1021/acs.jmedchem.5b01801

    NMR Metabolomics: A Comparison of the Suitability of Various Commonly used National Health Service Blood Collection Tubes (Journal article)

    Margaret Phelan, M., & Lian, L. -Y. (2016). NMR Metabolomics: A Comparison of the Suitability of Various Commonly used National Health Service Blood Collection Tubes. Current Metabolomics, 4(1), 78-81. doi:10.2174/2213235x03666151006220726

    DOI: 10.2174/2213235x03666151006220726

    2015

    Small Molecule Inhibitors of Cyclophilin D to Protect Mitochondrial Function as a Possible Treatment for Acute Pancreatitis (Journal article)

    Awais, M., Shore, E., Gibson, R., Javed, M. A., Wen, L., Latawiec, D., . . . Sutton, R. (2015). Small Molecule Inhibitors of Cyclophilin D to Protect Mitochondrial Function as a Possible Treatment for Acute Pancreatitis. PANCREAS, 44(8), 1360. Retrieved from http://gateway.webofknowledge.com/

    Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis (Journal article)

    Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409

    DOI: 10.18632/oncotarget.4409

    Neuronal Calcium Sensor-1 binds the D2 dopamine receptor and G-protein-coupled receptor kinase 1 (GRK1) peptides using different modes of interactions (Journal article)

    Pandalaneni, S., Karuppiah, V., Saleem, M., Haynes, L., Burgoyne, B., Mayans, O., . . . Lian, L. -Y. (2015). Neuronal Calcium Sensor-1 binds the D2 dopamine receptor andG-protein-coupled receptor kinase 1 (GRK1) peptides using different modes of interactions. The Journal of Biological Chemistry, 290(30), 18744-18756. doi:10.1074/jbc.M114.627059

    DOI: 10.1074/jbc.M114.627059

    Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions (Journal article)

    Bach, A., Pedersen, S. W., Dorr, L. A., Vallon, G., Ripoche, I., Ducki, S., & Lian, L. -Y. (2015). Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Scientific reports, 5. doi:10.1038/srep12157

    DOI: 10.1038/srep12157

    2014

    The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin (Journal article)

    Phelan, M. M., McLean, L., Armstrong, S. D., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2014). The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin. PLoS One, 9(10). doi:10.1371/journal.pone.0108415

    DOI: 10.1371/journal.pone.0108415

    Demonstration of Binding of Neuronal Calcium Sensor-1 to the Ca(v)2.1 P/Q-Type Calcium Channel (Journal article)

    Lian, L. -Y., Pandalaneni, S. R., Todd, P. A. C., Martin, V. M., Burgoyne, R. D., & Haynes, L. P. (2014). Demonstration of Binding of Neuronal Calcium Sensor-1 to the Ca(v)2.1 P/Q-Type Calcium Channel. BIOCHEMISTRY, 53(38), 6052-6062. doi:10.1021/bi500568v

    DOI: 10.1021/bi500568v

    Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling (Journal article)

    Phelan, M. M., McLean, L., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2014). Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 866-872. doi:10.1042/BST20140082

    DOI: 10.1042/BST20140082

    Trifluoroibuprofen Inhibits alpha-Methylacyl Coenzyme A Racemase (AMACR/P504S), Reduces Cancer Cell Proliferation and Inhibits in vivo Tumor Growth in Aggressive Prostate Cancer Models (Journal article)

    Festuccia, C., Gravina, G. L., Mancini, A., Muzi, P., Di Cesare, E., Kirk, R., . . . Carnell, A. J. (2014). Trifluoroibuprofen Inhibits alpha-Methylacyl Coenzyme A Racemase (AMACR/P504S), Reduces Cancer Cell Proliferation and Inhibits in vivo Tumor Growth in Aggressive Prostate Cancer Models. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 14(7), 1031-1041. doi:10.2174/1871520614666140327152607

    DOI: 10.2174/1871520614666140327152607

    2013

    Development of Small Molecule Inhibitors of Cyclophilin D for Treatment of Severe Acute Pancreatitis (Journal article)

    Awais, M., Javed, M. A., Wen, L., Gibson, R., Shore, E., Kershaw, N., . . . Sutton, R. (2013). Development of Small Molecule Inhibitors of Cyclophilin D for Treatment of Severe Acute Pancreatitis. PANCREAS, 42(8), 1338. Retrieved from http://gateway.webofknowledge.com/

    Structure-Based Design of PDZ Ligands as Inhibitors of 5-HT2A Receptor/PSD-95 PDZ1 Domain Interaction Possessing Anti-hyperalgesic Activity (Journal article)

    Vogrig, A., Dorr, L., Bouzidi, N., Boucherle, B., Wattiez, A. -S., Cassier, E., . . . Ducki, S. (2013). Structure-Based Design of PDZ Ligands as Inhibitors of 5-HT2A Receptor/PSD-95 PDZ1 Domain Interaction Possessing Anti-hyperalgesic Activity. ACS Chemical Biology, 8(10), 2209-2216. doi:10.1021/cb400308u

    DOI: 10.1021/cb400308u

    Inhibition of Human alpha-Methylacyl CoA Racemase (AMACR): a Target for Prostate Cancer (Journal article)

    Carnell, A. J., Kirk, R., Smith, M., McKenna, S., Lian, L. -Y., & Gibson, R. (2013). Inhibition of Human alpha-Methylacyl CoA Racemase (AMACR): a Target for Prostate Cancer. CHEMMEDCHEM, 8(10), 1643-1647. doi:10.1002/cmdc.201300179

    DOI: 10.1002/cmdc.201300179

    Metastasis-Promoting Anterior Gradient 2 Protein Has a Dimeric Thioredoxin Fold Structure and a Role in Cell Adhesion (Journal article)

    Patel, P., Clarke, C., Barraclough, D. L., Jowitt, T. A., Rudland, P. S., Barraclough, R., & Lian, L. -Y. (2013). Metastasis-Promoting Anterior Gradient 2 Protein Has a Dimeric Thioredoxin Fold Structure and a Role in Cell Adhesion. JOURNAL OF MOLECULAR BIOLOGY, 425(5), 929-943. doi:10.1016/j.jmb.2012.12.009

    DOI: 10.1016/j.jmb.2012.12.009

    Cooperative Catalysis through Noncovalent Interactions (Journal article)

    Tang, W., Johnston, S., Iggo, J. A., Berry, N. G., Phelan, M., Lian, L., . . . Xiao, J. (2013). Cooperative Catalysis through Noncovalent Interactions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(6), 1668-1672. doi:10.1002/anie.201208774

    DOI: 10.1002/anie.201208774

    A report of 2 new cases of MODY2 and review of the literature: Implications in the search for type 2 Diabetes drugs (Journal article)

    Shammas, C., Neodeous, V., Phelan, M. M., Lian, L. Y., Skordis, N., & Phylactou, L. A. (2013). A report of 2 new cases of MODY2 and review of the literature: Implications in the search for type 2 Diabetes drugs. METABOLISM-CLINICAL AND EXPERIMENTAL, 62(11), 1535-1542.

    Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents (Journal article)

    Bouzidi, N., Deokar, H., Vogrig, A., Boucherle, B., Ripoche, I., Abrunhosa-Thomas, I., . . . Ducki, S. (2013). Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents. Bioorganic and Medicinal Chemistry Letts, 23, 2624-2627.

    NMR studies of weak protein-protein interactions (Journal article)

    Lian, L. Y. (2013). NMR studies of weak protein-protein interactions. Progess in NMR Spectr, 71, 59-72.

    2012

    Solution NMR Structure of the Ca2+-bound N-terminal Domain of CaBP7 A REGULATOR OF GOLGI TRAFFICKING (Journal article)

    McCue, H. V., Patel, P., Herbert, A. P., Lian, L. -Y., Burgoyne, R. D., & Haynes, L. P. (2012). Solution NMR Structure of the Ca2+-bound N-terminal Domain of CaBP7 A REGULATOR OF GOLGI TRAFFICKING. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(45). doi:10.1074/jbc.M112.402289

    DOI: 10.1074/jbc.M112.402289

    NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast (Journal article)

    Herbert, A. P., Riesen, M., Bloxam, L., Kosmidou, E., Wareing, B. M., Johnson, J. R., . . . Morgan, A. (2012). NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast. PLOS ONE, 7(7). doi:10.1371/journal.pone.0041975

    DOI: 10.1371/journal.pone.0041975

    Splice variant PRKC-zeta-(PrC) is a novel biomarker of human prostate cancer (Journal article)

    Yao, S., Ireland, S. J., Bee, A., Beesley, C., Forootan, S. S., Dodson, A., . . . Foster, C. S. (2012). Splice variant PRKC-zeta-(PrC) is a novel biomarker of human prostate cancer. BRITISH JOURNAL OF CANCER, 107(2), 388-399. doi:10.1038/bjc.2012.162

    DOI: 10.1038/bjc.2012.162

    Asymmetric Mode of Ca2+-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling (Journal article)

    Elliott, P. R., Irvine, A. F., Jung, H. S., Tozawa, K., Pastok, M. W., Picone, R., . . . Barsukov, I. L. (2012). Asymmetric Mode of Ca2+-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling. STRUCTURE, 20(4), 654-666. doi:10.1016/j.str.2012.02.002

    DOI: 10.1016/j.str.2012.02.002

    The structure and selectivity of the SR protein SRSF2 RRM domain with RNA (Journal article)

    Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2012). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA. Nucleic Acids Research, 40(7), 3232-3244. doi:10.1093/nar/gkr1164

    DOI: 10.1093/nar/gkr1164

    Conformational Characterization of Synapse-Associated Protein 97 by Nuclear Magnetic Resonance and Small-Angle X-ray Scattering Shows Compact and Elongated Forms (Journal article)

    Tully, M. D., Grossmann, J. G., Phelan, M., Pandelaneni, S., Leyland, M., & Lian, L. -Y. (2012). Conformational Characterization of Synapse-Associated Protein 97 by Nuclear Magnetic Resonance and Small-Angle X-ray Scattering Shows Compact and Elongated Forms. Biochemistry, 51(4), 899-908. doi:10.1021/bi201178v

    DOI: 10.1021/bi201178v

    Solution NMR Structure of the Ca2+-Bound N-Terminal Domain of Calcium Binding Protein 7 (CaBP7): A regulator of Golgi trafficking (Journal article)

    McCue, H. V., Patel, P., Herbert, A. P., Lian, L. -Y., Burgoyne, R. D., & Haynes, L. P. (2012). Solution NMR Structure of the Ca2+-Bound N-Terminal Domain of Calcium Binding Protein 7 (CaBP7): A regulator of Golgi trafficking. J.Biol. Chem., 45 DOI.

    Structure and Assembly of a Trans-Periplasmic Channel for Type IV Pili in Neisseria meningitidis (Journal article)

    Berry, J. -L., Phelan, M. M., Collins, R. F., Adomavicius, T., Tønjum, T., Frye, S. A., . . . Derrick, J. P. (n.d.). Structure and Assembly of a Trans-Periplasmic Channel for Type IV Pili in Neisseria meningitidis. PLoS Pathogens, 8(9), e1002923. doi:10.1371/journal.ppat.1002923

    DOI: 10.1371/journal.ppat.1002923

    2011

    Characterisation of the Interaction of the C-Terminus of the Dopamine D2 Receptor with Neuronal Calcium Sensor-1 (Journal article)

    Lian, L. -Y., Pandalaneni, S. R., Patel, P., McCue, H. V., Haynes, L. P., & Burgoyne, R. D. (2011). Characterisation of the Interaction of the C-Terminus of the Dopamine D2 Receptor with Neuronal Calcium Sensor-1. PLOS ONE, 6(11). doi:10.1371/journal.pone.0027779

    DOI: 10.1371/journal.pone.0027779

    NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95 (Journal article)

    Vogrig, A., Boucherle, B., Deokar, H., Thomas, I., Ripoche, I., Lian, L. -Y., & Ducki, S. (2011). NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95. Bioorganic & Medicinal Chemistry Letters, 21(11), 3349-3353. doi:10.1016/j.bmcl.2011.04.011

    DOI: 10.1016/j.bmcl.2011.04.011

    Biochemical Comparison of Anopheles gambiae and Human NADPH P450 Reductases Reveals Different 2'-5'-ADP and FMN Binding Traits (Journal article)

    Lian, L. -Y., Widdowson, P., McLaughlin, L. A., & Paine, M. J. I. (n.d.). Biochemical Comparison of Anopheles gambiae and Human NADPH P450 Reductases Reveals Different 2'-5'-ADP and FMN Binding Traits. PLoS ONE, 6(5), e20574. doi:10.1371/journal.pone.0020574

    DOI: 10.1371/journal.pone.0020574

    Characterisation of the Interaction of the C-Terminus of the Dopamine D2 Receptor with Neuronal Calcium Sensor-1 (Journal article)

    Lian, L. Y., Pandalaneni, S. R., Patel, P., McCue, H. V., Haynes, L. P., & Burgoyne, R. D. (2011). Characterisation of the Interaction of the C-Terminus of the Dopamine D2 Receptor with Neuronal Calcium Sensor-1. PLoS ONE, 6(11), e27779. doi:10.1371/journal.pone.0027779PONE-D-11-17757

    DOI: 10.1371/journal.pone.0027779PONE-D-11-17757

    Protein NMR Spectroscopy: Practical Techniques and Applications (Book)

    Roberts, G., & Lian, L. -Y. (Eds.) (2011). Protein NMR Spectroscopy: Practical Techniques and Applications. New Jersey: Wiley-Blackwell.

    Protein NMR Spectroscopy: Principal Techniques and Applications (Book)

    Lian, L. Y., & Roberts, G. C. K. (2011). Protein NMR Spectroscopy: Principal Techniques and Applications. L. Y. Lian, & G. C. K. Roberts (Eds.), London: Chichester.

    The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing (Journal article)

    Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. BIOMOLECULAR NMR ASSIGNMENTS, 5, 7-10.

    The structure and selectivity of the SR protein SRSF2 RRM domain with RNA. (Journal article)

    Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.. Nucleic Acids Research.

    2010

    1H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein. (Journal article)

    Phelan, M. M., McLean, L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2010). 1H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein.. Biomolecular NMR assignments, 4(2), 239-241. doi:10.1007/s12104-010-9253-6

    DOI: 10.1007/s12104-010-9253-6

    Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010) (Journal article)

    Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010). DRUG METABOLISM AND DISPOSITION, 38(7), 1259. doi:10.1124/dmd.38.7.1259

    DOI: 10.1124/dmd.38.7.1259

    Structural and Functional Deficits in a Neuronal Calcium Sensor-1 Mutant Identified in a Case of Autistic Spectrum Disorder (Journal article)

    Handley, M. T. W., Lian, L. -Y., Haynes, L. P., & Burgoyne, R. D. (2010). Structural and Functional Deficits in a Neuronal Calcium Sensor-1 Mutant Identified in a Case of Autistic Spectrum Disorder. PLOS ONE, 5(5). doi:10.1371/journal.pone.0010534

    DOI: 10.1371/journal.pone.0010534

    PRKC-? Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention. (Journal article)

    Yao, S., Bee, A., Brewer, D., Dodson, A., Beesley, C., Ke, Y., . . . Foster, C. S. (2010). PRKC-? Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.. Genes & cancer, 1(5), 444-464. doi:10.1177/1947601910376079

    DOI: 10.1177/1947601910376079

    (1)H, (15)N and (13)C resonance assignment of darcin, a mouse major urinary protein (Journal article)

    Phelan, M. M., McLean, L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. Y. (2010). (1)H, (15)N and (13)C resonance assignment of darcin, a mouse major urinary protein. BIOMOLECULAR NMR ASSIGNMENTS, 4, 239-241.

    H-1, N-15 and C-13 resonance assignment of darcin, a mouse major urinary protein (Journal article)

    Phelan, M. M., McLean, L. L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2010). H-1, N-15 and C-13 resonance assignment of darcin, a mouse major urinary protein. BIOMOLECULAR NMR ASSIGNMENTS, 4, 239-241.

    Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (Journal article)

    Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. DRUG METABOLISM AND DISPOSITION, 38, 122-132.

    Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (Journal article)

    Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. DRUG METABOLISM AND DISPOSITION, 38(1), 122-132. doi:10.1124/dmd.109.028688

    DOI: 10.1124/dmd.109.028688

    2009

    Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine (Journal article)

    Srivastava, A., Williams, D. P., Maggs, J. L., Lian, L. Y., Gardner, I., Chaponda, M., . . . Park, B. K. (2009). Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 68(2), 276-277. Retrieved from http://gateway.webofknowledge.com/

    Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans (Journal article)

    Johnson, J. R., Ferdek, P., Lian, L. -Y., Barclay, J. W., Burgoyne, R. D., & Morgan, A. (2009). Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans. BIOCHEMICAL JOURNAL, 418, 73-80. doi:10.1042/BJ20081956

    DOI: 10.1042/BJ20081956

    Glycerol: An unexpected major metabolite of energy metabolism by the human malaria parasite (Journal article)

    Lian, L. -Y., Al-Helal, M., Roslaini, A., Fisher, N., Bray, P. G., Ward, S. A., & Biagini, G. A. (2009). Glycerol: An unexpected major metabolite of energy metabolism by the human malaria parasite. Malaria Journal, 8(1), 38. doi:10.1186/1475-2875-8-38

    DOI: 10.1186/1475-2875-8-38

    2008

    S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding (Journal article)

    Palmer, Z. J., Duncan, R. R., Johnson, J. R., Lian, L. -Y., Mello, L. V., Booth, D., . . . Morgan, A. (2008). S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding. BIOCHEMICAL JOURNAL, 413, 479-491. doi:10.1042/BJ20080069

    DOI: 10.1042/BJ20080069

    Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP (Journal article)

    Hautbergue, G. M., Hung, M. -L., Golovanov, A. P., Lian, L. -Y., & Wilson, S. A. (2008). Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP. Proceedings of the National Academy of Sciences, 105(13), 5154-5159. doi:10.1073/pnas.0709167105

    DOI: 10.1073/pnas.0709167105

    Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues (Journal article)

    Jack, E. R., Madine, J., Lian, L. -Y., & Middleton, D. A. (2008). Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues. MOLECULAR MEMBRANE BIOLOGY, 25(1), 14-22. doi:10.1080/09687680701494007

    DOI: 10.1080/09687680701494007

    2007

    Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1 (Journal article)

    Goult, B. T., Rapley, J. D., Dart, C., Kitmitto, A., Grossmann, J. G., Leyland, M. L., & Lian, L. -Y. (2007). Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1. BIOCHEMISTRY, 46(49), 14117-14128. doi:10.1021/bi701257z

    DOI: 10.1021/bi701257z

    Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene (Journal article)

    Kitteringham, N. R., Palmer, L., Owen, A., Lian, L. -Y., Jenkins, R., Dowdall, S., . . . Goldring, C. E. (2007). Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1240-1247. doi:10.1016/j.bbagen.2007.05.001

    DOI: 10.1016/j.bbagen.2007.05.001

    Apo calmodulin binding to the L-type voltage-gated calcium channel Cav1.2 IQ peptide (Journal article)

    Lian, L. -Y., Myatt, D., & Kitmitto, A. (2007). Apo calmodulin binding to the L-type voltage-gated calcium channel Cav1.2 IQ peptide. Biochemical and Biophysical Research Communications, 353(3), 565-570. doi:10.1016/j.bbrc.2006.12.070

    DOI: 10.1016/j.bbrc.2006.12.070

    Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression (Journal article)

    Kedzierska, B., Lian, L. -Y., & Hayes, F. (n.d.). Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression. Nucleic Acids Research, 35(1), 325-339. doi:10.1093/nar/gkl1028

    DOI: 10.1093/nar/gkl1028

    2006

    Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8 (Journal article)

    Hargous, Y., Hautbergue, G. M., Tintaru, A. M., Skrisovska, L., Golovanov, A. P., Stevenin, J., . . . Allain, F. H. -T. (2006). Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. The EMBO Journal, 25(21), 5126-5137. doi:10.1038/sj.emboj.7601385

    DOI: 10.1038/sj.emboj.7601385

    The Solution Structure of a Domain from the Neisseria meningitidis Lipoprotein PilP Reveals a New ß-Sandwich Fold (Journal article)

    Golovanov, A. P., Balasingham, S., Tzitzilonis, C., Goult, B. T., Lian, L. -Y., Homberset, H., . . . Derrick, J. P. (2006). The Solution Structure of a Domain from the Neisseria meningitidis Lipoprotein PilP Reveals a New ß-Sandwich Fold. Journal of Molecular Biology, 364(2), 186-195. doi:10.1016/j.jmb.2006.08.078

    DOI: 10.1016/j.jmb.2006.08.078

    Assignment of 1H, 13C, and 15N resonances for the REF2-I (1-155) mRNA export factor (Journal article)

    Golovanov, A. P., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2006). Assignment of 1H, 13C, and 15N resonances for the REF2-I (1-155) mRNA export factor. J. Biom. NMR., in press.

    The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA (Journal article)

    Golovanov, A. P., Hautbergue, G. M., Tintaru, A. M., Lian, L. -Y., & Wilson, S. A. (n.d.). The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA. RNA, 12(11), 1933-1948. doi:10.1261/rna.212106

    DOI: 10.1261/rna.212106

    2005

    The Unstructured N-terminal Tail of ParG Modulates Assembly of a Quaternary Nucleoprotein Complex in Transcription Repression (Journal article)

    Carmelo, E., Barillà, D., Golovanov, A. P., Lian, L. -Y., Derome, A., & Hayes, F. (2005). The Unstructured N-terminal Tail of ParG Modulates Assembly of a Quaternary Nucleoprotein Complex in Transcription Repression. Journal of Biological Chemistry, 280(31), 28683-28691. doi:10.1074/jbc.m501173200

    DOI: 10.1074/jbc.m501173200

    Distinct Domains of Small Tims Involved in Subunit Interaction and Substrate Recognition (Journal article)

    Vergnolle, M. A. S., Baud, C., Golovanov, A. P., Alcock, F., Luciano, P., Lian, L. -Y., & Tokatlidis, K. (2005). Distinct Domains of Small Tims Involved in Subunit Interaction and Substrate Recognition. Journal of Molecular Biology, 351(4), 839-849. doi:10.1016/j.jmb.2005.06.010

    DOI: 10.1016/j.jmb.2005.06.010

    2004

    Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle (Journal article)

    Papagrigoriou, E., Gingras, A. R., Barsukov, I. L., Bate, N., Fillingham, I. J., Patel, B., . . . Emsley, J. (2004). Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. The EMBO Journal, 23(15), 2942-2951. doi:10.1038/sj.emboj.7600285

    DOI: 10.1038/sj.emboj.7600285

    A Simple Method for Improving Protein Solubility and Long-Term Stability (Journal article)

    Golovanov, A. P., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2004). A Simple Method for Improving Protein Solubility and Long-Term Stability. Journal of the American Chemical Society, 126(29), 8933-8939. doi:10.1021/ja049297h

    DOI: 10.1021/ja049297h

    Kinetic and structural characterization of a product complex of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Escherichia coli (Journal article)

    GARÇON, A., BERMINGHAM, A., LIAN, L. -Y., & DERRICK, J. P. (2004). Kinetic and structural characterization of a product complex of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Escherichia coli. Biochemical Journal, 380(3), 867-873. doi:10.1042/bj20031850

    DOI: 10.1042/bj20031850

    Solution Structure of the Two-Iron Rubredoxin ofPseudomonas oleovoransDetermined by NMR Spectroscopy and Solution X-ray Scattering and Interactions with Rubredoxin Reductase†,‡ (Journal article)

    Perry, A., Tambyrajah, W., Grossmann, J. G., Lian, L. -Y., & Scrutton, N. S. (2004). Solution Structure of the Two-Iron Rubredoxin ofPseudomonas oleovoransDetermined by NMR Spectroscopy and Solution X-ray Scattering and Interactions with Rubredoxin Reductase†,‡. Biochemistry, 43(11), 3167-3182. doi:10.1021/bi035817u

    DOI: 10.1021/bi035817u

    Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands (Journal article)

    DAY, C. L., PUTHALAKATH, H., SKEA, G., STRASSER, A., BARSUKOV, I., LIAN, L. -Y., . . . HINDS, M. G. (2004). Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochemical Journal, 377(3), 597-605. doi:10.1042/bj20031251

    DOI: 10.1042/bj20031251

    2003

    Real-Time Chemical-Shift Scaling in High-Resolution NMR Spectroscopy (Journal article)

    Morris, G. A., Jerome, N. P., & Lian, L. -Y. (2003). Real-Time Chemical-Shift Scaling in High-Resolution NMR Spectroscopy. Angewandte Chemie International Edition, 42(7), 823-825. doi:10.1002/anie.200390220

    DOI: 10.1002/anie.200390220

    ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure (Journal article)

    Golovanov, A. P., Barillà, D., Golovanova, M., Hayes, F., & Lian, L. -Y. (n.d.). ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure. Molecular Microbiology, 50(4), 1141-1153. doi:10.1046/j.1365-2958.2003.03750.x

    DOI: 10.1046/j.1365-2958.2003.03750.x

    2001

    Role of the Conserved Phenylalanine 181 of NADPH-Cytochrome P450 Oxidoreductase in FMN Binding and Catalytic Activity† (Journal article)

    Paine, M. J. I., Ayivor, S., Munro, A., Tsan, P., Lian, L. -Y., Roberts, G. C. K., & Wolf, C. R. (2001). Role of the Conserved Phenylalanine 181 of NADPH-Cytochrome P450 Oxidoreductase in FMN Binding and Catalytic Activity†. Biochemistry, 40(45), 13439-13447. doi:10.1021/bi011147l

    DOI: 10.1021/bi011147l

    Labelling approaches for protein structural studies by solution-state and solid-state NMR (Journal article)

    Lian, L. -Y., & Middleton, D. A. (2001). Labelling approaches for protein structural studies by solution-state and solid-state NMR. Progress in Nuclear Magnetic Resonance Spectroscopy, 39(3), 171-190. doi:10.1016/s0079-6565(01)00034-6

    DOI: 10.1016/s0079-6565(01)00034-6

    Labelling approaches for protein structural studies by solution state and solid state NMR (Journal article)

    Lian, L. Y., & Middleton, D. A. (2001). Labelling approaches for protein structural studies by solution state and solid state NMR. Progress in Nuclear Magentic Resonance Spectroscopy, 39(3), 171-190.