Integrative Genomics of Ageing
Although our work integrates different strategies, its focal point is developing and applying experimental and computational methods that help bridge the gap between genotype and phenotype, a major challenge of the post-genome era, and help decipher the human genome and how it regulates complex processes like ageing. Ongoing projects involve cellular models and stem cells, systems biology of ageing, genetics of caloric restriction, cancer genomics, comparative and evolutionary genomics, and biology of long-lived organisms. Please see our lab website for further details and publications/reprints. The databases and computational resources we develop are also available online.
- Data-Driven Discovery of Novel Correlations Between Genes and Ageing-Related Changes in Humans
- Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing
- Sequencing the genome of the longest-lived mammal to identify longevity assurance mechanisms
- Identifying novel caloric restriction mimetic drugs in worms
- Using massive-scale mRNA sequencing to unravel the mechanisms of ageing and its modulation by diet
- Modelling Human Ageing: Development and Interrogating an Integrated Model of Ageing to Identify Casual Relationships Between Hormonal Changes and Gene Expression Changes.
- Establishment and functional characterization of a large DNA fragment resource from the long-lived naked mole-rat for comparison with mice
- Development of web tools for the integration and visualization of age-related changes at various biological levels
- Uncovering the Mechanisms of Cryoprotectant Toxicity
- Developing online databases and bioinformatics tools for the biology of ageing
- Identification and functional characterization of genes associated with cellular biomarkers of longevity - LONGENES
- GeneFriends: An online tool to unravel transcriptional regulation in mammals