Photo of Prof Jerry Turnbull

Prof Jerry Turnbull BSc (Hons), PhD FRSB FRSC

Johnston Professor of Biochemistry Biochemistry

    Research

    Chemical biology, Glycomics and Translational Applications of Heparan Sulphates in Health and Disease

    Chemical biology and glycomics of heparan sulphates (a specialized class of multi-functional glycoproteins) in the nervous system in development and disease, with applications for translational drug discovery. Current topics include: 1. dynamic HS biosynthesis and functions; 2. role of heparan sulphate in stem cell biology; 3. development of innovative technologies for “glycomics” studies on HS structure-activity relationships - saccharide libraries (natural, semi-synthetic and synthetic glycans and mime tics), mass spec sequencing, glycooarrays; 4. the role of HS in neural & neurodegenerative diseases including Alzheimers disease and Kallmanns syndrome; 5. translational studies on drug discovery and biotechnology applications of HS compounds and mimetics in Alzheimers disease, cancer and spinal cord repair. Multi-disciplinary experimental approaches are used including biochemistry (protein expression, carbohydrate analysis), molecular biology (gene cloning & expression, RNA interference), cell biology (cell culture, immunofluorescence) and chemistry (semi-synthetic and synthetic carbohydrates).

    Research Group Membership
    Research Grants

    Analysis of Mucin Interactions

    UNILEVER PLC (UK)

    October 2017 - December 2017

    Heparan mimetics as a novel therapeutic for multiple sclerosis

    THE MULTIPLE SCLEROSIS SOCIETY OF GREAT BRITAIN AND NORTHERN IRELAND (UK)

    April 2017 - March 2019

    Polysaccharide analysis

    SHANDONG CHENZHONG BIOPHARMACEUTICAL CO LTD (CHINA)

    November 2016 - March 2017

    Model for Alzheimer's disease

    VICTORIA LINK LIMITED (VICLINK) (NEW ZEALAND)

    April 2016 - July 2016

    Exploring glycosidic neo-epitopes of degenerative granules in aged mice: implications for ageing and dementia -GLYCONEOBRAIN

    EUROPEAN COMMISSION

    September 2017 - August 2019

    Inhibition of beta-secretase

    ALZHEIMER'S RESEARCH (UK)

    November 2015 - August 2016

    Prodromal inhibitiond of beta-secretase by synthetic heparins

    ALZHEIMERS SOCIETY (UK)

    June 2016 - May 2020

    Enzymatic heparin production

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2015 - October 2016

    2014 allocation - Wellcome ISSF non clinical fellowships

    WELLCOME TRUST (UK)

    May 2015 - October 2018

    Sparking Impact

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    June 2013 - July 2014

    Interaction of heparan sulfate with the protease beta-secretase: a novel mechanism for regulation of APP processing.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2004 - December 2007

    Extracellular Modulation of Multiprotein Signalling Complexes: Molecular Regulation of FGFR Signalling by Anosmin & Heparan Sulphate Proteoglycans

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2008 - December 2010

    Evaluation of optimised heparins as novel therapeutics for alzheimers disease.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    May 2006 - August 2007

    China-UK Partnership to Develop Biotechnology Applications of Novel Heparinoids and Sulfated Polysaccharides

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    April 2013 - November 2017

    Novel oligosaccharide inhibitors of the Alzheimer's beta-secretase enzyme

    SOCIETY OF BIOLOGY (UK)

    June 2014 - July 2014

    Heparinoid Beta-secretase Inhibitors with Novel Mode of Action: Pilot Development of Leads

    ALZHEIMER'S RESEARCH (UK)

    November 2012 - December 2013

    Chemically modified low molecular weight heparins as potent disruptors of rosetting in severe malaria

    WELLCOME TRUST (UK)

    October 2010 - September 2011

    Identifying intestinal receptors for Crohn's Escherichia coli

    NAT ASSOC FOR COLITIS & CROHNS DISEASE (UK)

    June 2013 - January 2015

    Exploiting saccharide microarrays: towards glycomic studies of heparan sulphate-protein interactions.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    February 2004 - January 2007

    Exploiting heparan sulfates for directed neural differentiation of stem cells.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2003 - March 2006

    CASE studentship: Controlling stem cells with heparan sulfate analogues and polymer scaffolds

    SPHERITECH LTD (UK)

    September 2009 - September 2012

    The Role of Multidrug Transporters in causing Pharmacoresistance in Epilepsy

    MEDICAL RESEARCH COUNCIL (MRC)

    January 2013 - August 2013

    Adel Alghamdi - bench fees

    ROYAL EMBASSY OF SAUDI ARABIA

    November 2014 - October 2015

    “Manipulation of heparan sulphate proteoglycans as a strategy for promoting brain repair"

    WELLCOME TRUST (UK)

    October 2008 - September 2011

    Enhancing the propagation of ES cells by regulation of visceral endoderm differentiation.

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2004 - September 2007

    Chemical intervention in heparan sulphate-dependent growth factor signalling systems using engineered heparin saccharides.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    February 2006 - March 2009

    Basic technology: glycochips-strategies for high-throughput analysis of the glycome.

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    January 2009 - April 2011

    Developing a stem cell based therapy to replace nephrons lost through reflux nephropathy. EU - PROPOSAL NUMBER 036097-2 KIDSTEM

    EUROPEAN COMMISSION

    September 2006 - August 2010

    Novel strategies for promoting CNS repair through manipulation of FGF signalling and heparan sulphate proteoglycans

    MEDICAL RESEARCH COUNCIL (MRC)

    June 2013 - May 2015

    Preclinical studies of novel heparan mimetics for prevention and treatment of TSE (HMS AS ANTI PRION DRUGS).

    EUROPEAN COMMISSION

    October 2003 - September 2004

    Shotgun Functional Glycomics of Heparan Sulphate Saccharides: Generating Diverse Libraries to Decode Biological Selectivity

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    April 2011 - September 2014

    Isolating a heparin-derived sequence to activate endogenous Dnase I agreement

    CYSTIC FIBROSIS TRUST (UK)

    October 2005 - September 2006

    Molecular function in post-genome biology (MOLFUN).

    EUROPEAN COMMISSION

    October 2006 - September 2010

    University of Liverpool Institutional Discipline Bridging.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2003 - October 2006

    Heparan sulphates as dynamic cell regulators: structure, biosynthesis and mechanisms of action of the neural heparanome.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2003 - September 2006

    The potential role of soluble plantain fibre and its components in preventing colonisation and invasion of the intestinal mucosa by S.Typhimurium.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2009 - December 2012

    Microarray Bioassays for Functional Glycome Screening

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2009 - September 2010

    Heparan sulfate and Alzheimer's Disease: Modulation of β-secretase Processing of Amyloid Precursor Protein by Oligosaccharide Inhibitors

    WELLCOME TRUST (UK)

    June 2006 - July 2006

    Altered Heparan Sulfate in Ageing and Dementia: a Potential Axis for Dysregulation of BACE-1 in Alzheimers Disease

    ALZHEIMER'S RESEARCH (UK)

    October 2013 - September 2016

    CIC biomaGUNE studentship

    CIC BIOMAGUNE (SPAIN)

    January 2012 - December 2015

    Research Collaborations

    Dr Ed Yates

    Project: Novel activities of modified heparins and drug discovery applications
    Internal

    Collaborations on chemically modified heparins

    Dr Dada Pisconti

    Project: Muscle stem cell proteoglycans
    Internal

    Studies on role of HS in muscle stem cell phenotype