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Prof Jerry Turnbull BSc (Hons), PhD FRSB FRSC

Johnston Professor of Biochemistry Biochemistry

    Research

    Chemical biology, Glycomics and Translational Applications of Heparan Sulphates in Health and Disease

    Chemical biology and glycomics of heparan sulphates (a specialized class of multi-functional glycoproteins) in the nervous system in development and disease. Current topics include: 1. dynamic HS biosynthesis and functions; 2. role of heparan sulphate in stem cell biology; 3. development of innovative technologies for “glycomics” studies on HS structure-activity relationships - saccharide libraries (natural, semi-synthetic and synthetic glycans and mime tics), mass spec sequencing, glycooarrays; 4. the role of HS in neural & neurodegenerative diseases including Alzheimers disease and Kallmanns syndrome; 5. translational studies on drug discovery and biotechnology applications of HS compounds and mimetics in Alzheimers disease, cancer and spinal cord repair. Multi-disciplinary experimental approaches are used including biochemistry (protein expression, carbohydrate analysis), molecular biology (gene cloning & expression, RNA interference), cell biology (cell culture, immunofluorescence) and chemistry (semi-synthetic and synthetic carbohydrates).

    Research Grants
    • Exploring glycosidic neo-epitopes of degenerative granules in aged mice: implications for ageing and dementia -GLYCONEOBRAIN
    • Inhibition of beta-secretase
    • Prodromal inhibitiond of beta-secretase by synthetic heparins
    • Enzymatic heparin production
    • 2014 allocation - Wellcome ISSF non clinical fellowships
    • Interaction of heparan sulfate with the protease beta-secretase: a novel mechanism for regulation of APP processing.
    • Extracellular Modulation of Multiprotein Signalling Complexes: Molecular Regulation of FGFR Signalling by Anosmin & Heparan Sulphate Proteoglycans
    • Integrated Signalling Networks In Muscle Stem Cells: Cell Fate Regulation by Heparan Sulfates (SATCELLOMICS).
    • Evaluation of optimised heparins as novel therapeutics for alzheimers disease.
    • China-UK Partnership to Develop Biotechnology Applications of Novel Heparinoids and Sulfated Polysaccharides
    • Novel oligosaccharide inhibitors of the Alzheimer's beta-secretase enzyme
    • Heparinoid Beta-secretase Inhibitors with Novel Mode of Action: Pilot Development of Leads
    • Chemically modified low molecular weight heparins as potent disruptors of rosetting in severe malaria
    • Identifying intestinal receptors for Crohn's Escherichia coli
    • Exploiting saccharide microarrays: towards glycomic studies of heparan sulphate-protein interactions.
    • Exploiting heparan sulfates for directed neural differentiation of stem cells.
    • CASE studentship: Controlling stem cells with heparan sulfate analogues and polymer scaffolds
    • The Role of Multidrug Transporters in causing Pharmacoresistance in Epilepsy
    • Adel Alghamdi - bench fees
    • “Manipulation of heparan sulphate proteoglycans as a strategy for promoting brain repair"
    • Enhancing the propagation of ES cells by regulation of visceral endoderm differentiation.
    • Chemical intervention in heparan sulphate-dependent growth factor signalling systems using engineered heparin saccharides.
    • Basic technology: glycochips-strategies for high-throughput analysis of the glycome.
    • Developing a stem cell based therapy to replace nephrons lost through reflux nephropathy. EU - PROPOSAL NUMBER 036097-2 KIDSTEM
    • Novel strategies for promoting CNS repair through manipulation of FGF signalling and heparan sulphate proteoglycans
    • Preclinical studies of novel heparan mimetics for prevention and treatment of TSE (HMS AS ANTI PRION DRUGS).
    • Shotgun Functional Glycomics of Heparan Sulphate Saccharides: Generating Diverse Libraries to Decode Biological Selectivity
    • Isolating a heparin-derived sequence to activate endogenous Dnase I agreement
    • Molecular function in post-genome biology (MOLFUN).
    • University of Liverpool Institutional Discipline Bridging.
    • Heparan sulphates as dynamic cell regulators: structure, biosynthesis and mechanisms of action of the neural heparanome.
    • The potential role of soluble plantain fibre and its components in preventing colonisation and invasion of the intestinal mucosa by S.Typhimurium.
    • Microarray Bioassays for Functional Glycome Screening
    • Heparan sulfate and Alzheimer's Disease: Modulation of β-secretase Processing of Amyloid Precursor Protein by Oligosaccharide Inhibitors
    • Altered Heparan Sulfate in Ageing and Dementia: a Potential Axis for Dysregulation of BACE-1 in Alzheimers Disease
    • CIC biomaGUNE studentship
    Research Collaborations

    Prof David Edgar

    Internal

    Stem cell differentiation


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