Photo of Prof Jerry Turnbull

Prof Jerry Turnbull BSc (Hons), PhD FRSB FRSC

Johnston Professor of Biochemistry Biochemistry

    Publications

    Selected Publications

    1. MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival (Journal article - 2014)
    2. Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease (Journal article - 2013)
    3. Differential Sulfation Remodelling of Heparan Sulfate by Extracellular 6-O-Sulfatases Regulates Fibroblast Growth Factor-Induced Boundary Formation by Glial Cells: Implications for Glial Cell Transplantation (Journal article - 2012)
    4. Generating heparan sulfate saccharide libraries for glycomics applications (Journal article - 2010)
    5. Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry (Journal article - 2017)

    2018

    Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy. (Journal article)

    Zubkova, O. V., Ahmed, Y. A., Guimond, S. E., Noble, S. -L., Miller, J. H., Alfred Smith, R. A., . . . Turnbull, J. E. (2018). Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy.. ACS chemical biology. doi:10.1021/acschembio.8b00909

    DOI: 10.1021/acschembio.8b00909

    Enhancing the glycosciences toolkit: new GAGs in the lineup. (Journal article)

    Turnbull, J. E. (2018). Enhancing the glycosciences toolkit: new GAGs in the lineup.. Nature methods, 15(11), 867-868. doi:10.1038/s41592-018-0190-0

    DOI: 10.1038/s41592-018-0190-0

    The Satellite Cell Niche Regulates the Balance between Myoblast Differentiation and Self-Renewal via p53 (Journal article)

    Flamini, V., Ghadiali, R. S., Antczak, P., Rothwell, A., Turnbull, J. E., & Pisconti, A. (2018). The Satellite Cell Niche Regulates the Balance between Myoblast Differentiation and Self-Renewal via p53. STEM CELL REPORTS, 10(3), 970-983. doi:10.1016/j.stemcr.2018.01.007

    DOI: 10.1016/j.stemcr.2018.01.007

    2017

    How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans (Journal article)

    Cartmell, A., Lowe, E. C., Basle, A., Firbank, S. J., Ndeh, D. A., Murray, H., . . . Bolam, D. N. (2017). How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(27), 7037-7042. doi:10.1073/pnas.1704367114

    DOI: 10.1073/pnas.1704367114

    Investigating the Structure-Function Relationships of Heparin By-Products (Thesis / Dissertation)

    Taylor, S. L. (2017, December 20). Investigating the Structure-Function Relationships of Heparin By-Products.

    Label-Free Discovery Array Platform for the Characterization of Glycan Binding Proteins and Glycoproteins (Journal article)

    Gray, C. J., Sanchez-Ruiz, A., Sardzikova, I., Ahmed, Y. A., Miller, R. L., Reyes Martinez, J. E., . . . Flitsch, S. L. (2017). Label-Free Discovery Array Platform for the Characterization of Glycan Binding Proteins and Glycoproteins. ANALYTICAL CHEMISTRY, 89(8), 4444-4451. doi:10.1021/acs.analchem.6b04122

    DOI: 10.1021/acs.analchem.6b04122

    Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface. (Journal article)

    O'Neill, P., Lindsay, S. L., Pantiru, A., Guimond, S. E., Fagoe, N., Verhaagen, J., . . . Barnett, S. C. (2017). Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface.. Glia, 65(1), 19-33. doi:10.1002/glia.23047

    DOI: 10.1002/glia.23047

    Syndecan-3-Mediated Signalling in the Regulation of Myogenesis (Thesis / Dissertation)

    Jones, F. K. (2017, September 28). Syndecan-3-Mediated Signalling in the Regulation of Myogenesis.

    Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry (Journal article)

    Miller, R. L., Guimond, S. E., Prescott, M., Turnbull, J. E., & Karlsson, N. (2017). Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry. ANALYTICAL CHEMISTRY, 89(17), 8942-8950. doi:10.1021/acs.analchem.7b01417

    DOI: 10.1021/acs.analchem.7b01417

    2016

    Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling (Journal article)

    Ghadiali, R. S., Guimond, S. E., Turnbull, J. E., & Pisconti, A. (2017). Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling. MATRIX BIOLOGY, 59, 54-68. doi:10.1016/j.matbio.2016.07.007

    DOI: 10.1016/j.matbio.2016.07.007

    Enrichment of Two Isomeric Heparin Oligosaccharides Exhibiting Different Affinities toward Monocyte Chemoattractant Protein-1 (Journal article)

    Miller, R. L., Dykstra, A. B., Wei, W., Holsclaw, C., Turnbull, J. E., & Leary, J. A. (2016). Enrichment of Two Isomeric Heparin Oligosaccharides Exhibiting Different Affinities toward Monocyte Chemoattractant Protein-1. ANALYTICAL CHEMISTRY, 88(23), 11551-11558. doi:10.1021/acs.analchem.6b02803

    DOI: 10.1021/acs.analchem.6b02803

    Heparin Isomeric Oligosaccharide Separation Using Volatile Salt Strong Anion Exchange Chromatography (Journal article)

    Miller, R. L., Guimond, S. E., Shivkumar, M., Blocksidge, J., Austin, J. A., Leary, J. A., & Turnbull, J. E. (2016). Heparin Isomeric Oligosaccharide Separation Using Volatile Salt Strong Anion Exchange Chromatography. ANALYTICAL CHEMISTRY, 88(23), 11542-11550. doi:10.1021/acs.analchem.6b02801

    DOI: 10.1021/acs.analchem.6b02801

    Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity (Journal article)

    Ahmed, Y. A., Yates, E. A., Moss, D. J., Loeven, M. A., Hussain, S. -A., Hohenester, E., . . . Powell, A. K. (2016). Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity. MOLECULAR BIOSYSTEMS, 12(10), 3166-3175. doi:10.1039/c6mb00432f

    DOI: 10.1039/c6mb00432f

    2015

    2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. (Journal article)

    Chan, W. K., Howe, K., Clegg, J. M., Guimond, S. E., Price, D. J., Turnbull, J. E., & Pratt, T. (2015). 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.. PloS one, 10(6), e0130147. doi:10.1371/journal.pone.0130147

    DOI: 10.1371/journal.pone.0130147

    Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis (Journal article)

    Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409

    DOI: 10.18632/oncotarget.4409

    Composition, sequencing and ion mobility mass spectrometry of heparan sulfate-like octasaccharide isomers differing in glucuronic and iduronic acid content (Journal article)

    Miller, R. L., Wei, W., Schwoerer, R., Zubkova, O. V., Tyler, P. C., Turnbull, J. E., & Leary, J. A. (2015). Composition, sequencing and ion mobility mass spectrometry of heparan sulfate-like octasaccharide isomers differing in glucuronic and iduronic acid content. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 21(3), 245-254. doi:10.1255/ejms.1337

    DOI: 10.1255/ejms.1337

    Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation (Journal article)

    Theodoraki, A., Hu, Y., Poopalasundaram, S., Oosterhof, A., Guimond, S. E., Disterer, P., . . . Bouloux, P. -M. (2015). Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 399(C), 296-310. doi:10.1016/j.mce.2014.09.011

    DOI: 10.1016/j.mce.2014.09.011

    Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding (Journal article)

    Solari, V., Rudd, T. R., Guimond, S. E., Powell, A. K., Turnbull, J. E., & Yates, E. A. (2015). Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. ORGANIC & BIOMOLECULAR CHEMISTRY, 13(21), 6066-6072. doi:10.1039/c5ob00564g

    DOI: 10.1039/c5ob00564g

    Single-entity heparan sulfate glycomimetic clusters for therapeutic applications. (Journal article)

    Tyler, P. C., Guimond, S. E., Turnbull, J. E., & Zubkova, O. V. (2015). Single-entity heparan sulfate glycomimetic clusters for therapeutic applications.. Angewandte Chemie (International ed. in English), 54(9), 2718-2723. doi:10.1002/anie.201410251

    DOI: 10.1002/anie.201410251

    Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions. (Journal article)

    Kalus, I., Rohn, S., Puvirajesinghe, T. M., Guimond, S. E., Eyckerman-Kölln, P. J., Ten Dam, G., . . . Dierks, T. (2015). Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions.. PloS one, 10(10), e0139853. doi:10.1371/journal.pone.0139853

    DOI: 10.1371/journal.pone.0139853

    2014

    Chemical biology of heparan sulfates: from insights to applications in therapeutics and tissue regeneration (Journal article)

    Turnbull, J. E. (2014). Chemical biology of heparan sulfates: from insights to applications in therapeutics and tissue regeneration. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 7. Retrieved from http://gateway.webofknowledge.com/

    Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development. (Journal article)

    Clegg, J. M., Conway, C. D., Howe, K. M., Price, D. J., Mason, J. O., Turnbull, J. E., . . . Pratt, T. (2014). Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(6), 2389-2401. doi:10.1523/JNEUROSCI.3157-13.2014

    DOI: 10.1523/JNEUROSCI.3157-13.2014

    MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival (Journal article)

    Solari, V., Borriello, L., Turcatel, G., Shimada, H., Sposto, R., Fernandez, G. E., . . . DeClerck, Y. A. (2014). MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival. CANCER RESEARCH, 74(21), 5999-6009. doi:10.1158/0008-5472.CAN-13-2513

    DOI: 10.1158/0008-5472.CAN-13-2513

    Nanoscale self-assembled multivalent (SAMul) heparin binders in highly competitive, biologically relevant, aqueous media (Journal article)

    Bromfield, S. M., Posocco, P., Chan, C. W., Calderon, M., Guimond, S. E., Turnbull, J. E., . . . Smith, D. K. (2014). Nanoscale self-assembled multivalent (SAMul) heparin binders in highly competitive, biologically relevant, aqueous media. Chemical Science, 5(4), 1484. doi:10.1039/c4sc00298a

    DOI: 10.1039/c4sc00298a

    Stem cell plasticity and tumorigenesis: regulatory roles of heparan sulphate in the cancer stem cell niche (Conference Paper)

    Baty, R., Pisconti, A., & Turnbull, J. (2014). Stem cell plasticity and tumorigenesis: regulatory roles of heparan sulphate in the cancer stem cell niche. In FEBS JOURNAL Vol. 281 (pp. 781). Retrieved from http://gateway.webofknowledge.com/

    2013

    Compositions for enhancing neural cell transplants (Patent)

    Turnbull, J. (2013). Compositions for enhancing neural cell transplants.

    Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease (Journal article)

    Schwörer, R., Zubkova, O. V., Turnbull, J. E., & Tyler, P. C. (2013). Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease. Chemistry - A European Journal, 19(21), 6817-6823. doi:10.1002/chem.201204519

    DOI: 10.1002/chem.201204519

    2012

    Array-based Functional Screening of Heparin Glycans (Journal article)

    Puvirajesinghe, T. M., Ahmed, Y. A., Powell, A. K., Fernig, D. G., Guimond, S. E., & Turnbull., J. E. (2012). Array-based Functional Screening of Heparin Glycans. Chemistry and Biology, 19, 553-558.

    Compositions for enhancing neural cell transplants (Patent)

    Turnbull, J. (2012). Compositions for enhancing neural cell transplants.

    Differential Sulfation Remodelling of Heparan Sulfate by Extracellular 6-O-Sulfatases Regulates Fibroblast Growth Factor-Induced Boundary Formation by Glial Cells: Implications for Glial Cell Transplantation (Journal article)

    Higginson, J. R., Thompson, S. M., Santos-Silva, A., Guimond, S. E., Turnbull, J. E., & Barnett, S. C. (2012). Differential Sulfation Remodelling of Heparan Sulfate by Extracellular 6-O-Sulfatases Regulates Fibroblast Growth Factor-Induced Boundary Formation by Glial Cells: Implications for Glial Cell Transplantation. Journal of Neuroscience, 32(45), 15902-15912. doi:10.1523/JNEUROSCI.6340-11.2012

    DOI: 10.1523/JNEUROSCI.6340-11.2012

    2011

    Getting the Farm out of Pharma for Heparin Production (Journal article)

    Turnbull, J. E. (2011). Getting the Farm out of Pharma for Heparin Production. Science, 334, 462-463.

    Structure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation? (Journal article)

    Thompson, S. M., Connell, M. G., van Kuppevelt, T. H., Xu, R., Turnbull, J. E., Losty, P. D., . . . Jesudason, E. C. (2011). Structure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation?. BMC developmental biology, 11, 38. doi:10.1186/1471-213X-11-38

    DOI: 10.1186/1471-213X-11-38

    The emerging role of extracellular matrix in signalling (Journal article)

    Kim, S., Turnbull, J. E., & Guimond, S. E. (2011). The emerging role of extracellular matrix in signalling. Journal of Endocrinology, 209(135-15).

    2010

    An expression system for screening of proteins for glycan and protein interactions. (Journal article)

    Otto, D. M. E., Campanero-Rhodes, M. A., Karamanska, R., Powell, A. K., Bovin, N., Turnbull, J. E., . . . Crocker., P. R. (2010). An expression system for screening of proteins for glycan and protein interactions.. Analytical Biochemistry, 411, 261-270.

    Carbohydrate composition analysis of heparin and heparan sulphate derived polymers (Journal article)

    Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Carbohydrate composition analysis of heparin and heparan sulphate derived polymers. Nature Protocols.

    Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships (Journal article)

    Rudd, T. R., Uniewicz, K. A., Ori, A., Guimond, S. E., Skidmore, M. A., Gaudesi, D., . . . Yates, E. A. (2010). Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(23), 5390-5397. doi:10.1039/c0ob00246a

    DOI: 10.1039/c0ob00246a

    Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships (Journal article)

    Rudd, T. R., Uniewicz, K. A., Ori, A., Guimond, S. E., Skidmore, M. A., Gaudesi, D., . . . Yates, E. A. (2010). Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. Organic & Biomolecular Chemistry, 8(23), 5390. doi:10.1039/c0ob00246a

    DOI: 10.1039/c0ob00246a

    Determining the anti-coagulant-independent anti-cancer effects of heparin (Journal article)

    Solari, V., Jesudason, E. C., Turnbull, J. E., & Yates, E. A. (2010). Determining the anti-coagulant-independent anti-cancer effects of heparin. BRITISH JOURNAL OF CANCER, 103(4), 593-594. doi:10.1038/sj.bjc.6605808

    DOI: 10.1038/sj.bjc.6605808

    Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection (Journal article)

    Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection. NATURE PROTOCOLS, 5(12), 1983-1992. doi:10.1038/nprot.2010.145

    DOI: 10.1038/nprot.2010.145

    Generating heparan sulfate saccharide libraries for glycomics applications (Journal article)

    Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics applications. NATURE PROTOCOLS, 5(5), 821-833. doi:10.1038/nprot.2010.17

    DOI: 10.1038/nprot.2010.17

    Generating heparan sulfate saccharide libraries for glycomics applications (Journal article)

    Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics applications. Nature Protocols, 5(5), 821-833. doi:10.1038/nprot.2010.17

    DOI: 10.1038/nprot.2010.17

    Glycomics Profiling of Heparan Sulfate Structure and Activity. (Journal article)

    Turnbull, J. E., Miller, R., Ahmed, Y., Puvirajesinghe, T., & Guimond, S. (2010). Glycomics Profiling of Heparan Sulfate Structure and Activity.. Unknown Journal, 480, 65-85.

    Glycomics Profiling of Heparan Sulfate Structure and Activity. Method in Enzymology (Journal article)

    Turnbull, J. E., Miller, R., Ahmed, Y. A., Puvirajesinghe, T., & Guimond, S. E. (2010). Glycomics Profiling of Heparan Sulfate Structure and Activity. Method in Enzymology. Methods in Enzymology.

    Glycomics: Technologies Taming a Frontier Omics Field (Journal article)

    Turnbull, J. E., & Sasisekharan, R. (2010). Glycomics: Technologies Taming a Frontier Omics Field. Unknown Journal, 14, 4.

    Heparan Sulfate in Lung Morphogenesis: The Elephant in the Room (Journal article)

    Thompson, S. M., Jesudason, E. C., Turnbull, J. E., & Fernig, D. G. (2010). Heparan Sulfate in Lung Morphogenesis: The Elephant in the Room. BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 90(1), 32-44. doi:10.1002/bdrc.20169

    DOI: 10.1002/bdrc.20169

    Heparan sulphate glycomics - towards systems biology strategies. (Journal article)

    Turnbull, J. E. (2010). Heparan sulphate glycomics - towards systems biology strategies.. Unknown Journal, 38, 1356-1360.

    The Heparan Sulfate Motif (GlcNS6S-IdoA2S)(3), Common in Heparin, Has a Strict Topography and Is Involved in Cell Behavior and Disease. (Journal article)

    Smits, N. C., Kurup, S., Rops, A. L., Turnbull, J. E., & al, E. (2010). The Heparan Sulfate Motif (GlcNS6S-IdoA2S)(3), Common in Heparin, Has a Strict Topography and Is Involved in Cell Behavior and Disease.. J. Biol. Chem., 285, 41143-41151.

    2009

    Cations Modulate Polysaccharide Structure To Determine FGF-FGFR Signaling: A Comparison of Signaling and Inhibitory Polysaccharide Interactions with FGF-1 in Solution (Journal article)

    Guimond, S. E., Rudd, T. R., Skidmore, M. A., Ori, A., Gaudesi, D., Cosentino, C., . . . Yates, E. A. (2009). Cations Modulate Polysaccharide Structure To Determine FGF-FGFR Signaling: A Comparison of Signaling and Inhibitory Polysaccharide Interactions with FGF-1 in Solution. BIOCHEMISTRY, 48(22), 4772-4779. doi:10.1021/bi802318z

    DOI: 10.1021/bi802318z

    Fabrication of Carbohydrate Surfaces by Using Nonderivatised Oligosaccharides, and their Application to Measuring the Assembly of Sugar-Protein Complexes (Journal article)

    Popplewell, J. F., Swann, M. J., Ahmed, Y., Turnbull, J. E., & Fernig, D. G. (2009). Fabrication of Carbohydrate Surfaces by Using Nonderivatised Oligosaccharides, and their Application to Measuring the Assembly of Sugar-Protein Complexes. CHEMBIOCHEM, 10(7), 1218-1226. doi:10.1002/cbic.200800696

    DOI: 10.1002/cbic.200800696

    Heparan Sulfate Phage Display Antibodies Identify Distinct Epitopes with Complex Binding Characteristics INSIGHTS INTO PROTEIN BINDING SPECIFICITIES (Journal article)

    Thompson, S. M., Fernig, D. G., Jesudason, E. C., Losty, P. D., van de Westerlo, E. M. A., van Kuppevelt, T. H., & Turnbull, J. E. (2009). Heparan Sulfate Phage Display Antibodies Identify Distinct Epitopes with Complex Binding Characteristics INSIGHTS INTO PROTEIN BINDING SPECIFICITIES. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(51), 35621-35631. doi:10.1074/jbc.M109.009712

    DOI: 10.1074/jbc.M109.009712

    Heparan sulphate saccharide microarrays for high-throughput interrogation of protein binding interactions (Journal article)

    Powell, A., Zhi, Z., & Turnbull, J. E. (2009). Heparan sulphate saccharide microarrays for high-throughput interrogation of protein binding interactions. Methods in Molecular Biology, 534, 313=329.

    Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations. (Journal article)

    Skidmore, M., Atrih, A., Yates, E., & Turnbull, J. E. (2009). Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations.. Methods in molecular biology (Clifton, N.J.), 534, 157-169. doi:10.1007/978-1-59745-022-5_12

    DOI: 10.1007/978-1-59745-022-5_12

    Modular Synthesis of Heparan Sulfate Fragments for Structure-Activity Relationship Studies (Journal article)

    Arungundram, S., Al-Mafraji, K., Asong, J., Leach, F. E., Amster, I. J., Venot, A., . . . Boons, G. J. (2009). Modular Synthesis of Heparan Sulfate Fragments for Structure-Activity Relationship Studies. Unknown Journal, 131, 17394-17405.

    Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies (Journal article)

    Arungundram, S., Al-Mafraji, K., Asong, J., Leach, F. E., Amster, I. J., Venot, A., . . . Boons, G. -J. (2009). Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies. Journal of the American Chemical Society, 131(47), 17394-17405. doi:10.1021/ja907358k

    DOI: 10.1021/ja907358k

    Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1 (Journal article)

    Hu, Y., Guimond, S. E., Travers, P., Cadman, S., Hohenester, E., Turnbull, J. E., . . . Bouloux, P. M. (2009). Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1. Journal of Biological Chemistry.

    Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1. (Journal article)

    Hu, Y., Guimond, S. E., Travers, P., Cadman, S., Hohenester, E., Turnbull, J. E., . . . Bouloux, P. M. (2009). Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.. J Biol Chem, 284(29905-).

    Plasma Polymer surface chemical gradients used to investigate the geometric control of mouse embryonic stem cell pluripotency (Journal article)

    Wells., Turnbull., & al, E. (2009). Plasma Polymer surface chemical gradients used to investigate the geometric control of mouse embryonic stem cell pluripotency. Biomaterials, 30, 1066-1070.

    Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues TOWARD GLYCOMICS PROFILING (Journal article)

    Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M. A., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues TOWARD GLYCOMICS PROFILING. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(38), 25714-25722. doi:10.1074/jbc.M109.032755

    DOI: 10.1074/jbc.M109.032755

    Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling (Journal article)

    Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M. A., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling. Journal of Biological Chemistry.

    Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: towards glycomics profiling. (Journal article)

    Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: towards glycomics profiling.. J Biol Chem, 284, 25714-25722.

    The potential for circular dichroism as an additional facile and sensitive method of monitoring low molecular weight heparins and heparinoids. (Journal article)

    Rudd, T., Skidmore, M., Guimond, S., Holman, J., Turnbull, J. E., Lauder, R., . . . Yates, E. A. (2009). The potential for circular dichroism as an additional facile and sensitive method of monitoring low molecular weight heparins and heparinoids.. Thrombosis and Haemostasis, 102, 874-878.

    The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids (Journal article)

    Rudd, T. R., Skidmore, M. A., Guimond, S. E., Holman, J., Turnbull, J. E., Lauder, R. M., . . . Yates, E. A. (2009). The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. THROMBOSIS AND HAEMOSTASIS, 102(5), 874-878. doi:10.1160/TH08-12-0797

    DOI: 10.1160/TH08-12-0797

    2008

    A Versatile Gold Surface Approach for Fabrication and Interrogation of Glycoarrays (Journal article)

    Zhi, Z., Laurent, N., Powell, A. K., Karamanska , R., Fais , M., Voglmeir, J., . . . Turnbull, J. E. (2008). A Versatile Gold Surface Approach for Fabrication and Interrogation of Glycoarrays. ChemBioChem, 9(10), 1568-1575. doi:10.1002/cbic.200700788

    DOI: 10.1002/cbic.200700788

    Chemometric analysis for comparison of heparan sulphate oligosaccharides (Journal article)

    Puvirajesinghe, T. M., Guimond, S. E., Turnbull, J. E., & Guenneau, S. (2008). Chemometric analysis for comparison of heparan sulphate oligosaccharides. Royal Society Interface (doi: 10.1098/rsif.2008.0483).

    Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities (Journal article)

    Skidmore, M. A., Dumax-Vorzet, A. F., Guimond, S. E., Rudd, T. R., Edwards, E. A., Turnbull, J. E., . . . Yates, E. A. (2008). Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities. JOURNAL OF MEDICINAL CHEMISTRY, 51(5), 1453-1458. doi:10.1021/jm701337t

    DOI: 10.1021/jm701337t

    Engineered heparins: Novel beta-secretase inhibitors as potential Alzheimer's disease therapeutics (Journal article)

    Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2008). Engineered heparins: Novel beta-secretase inhibitors as potential Alzheimer's disease therapeutics. NEURODEGENERATIVE DISEASES, 5(3-4), 197-199. doi:10.1159/000113701

    DOI: 10.1159/000113701

    Extracellular regulation of developmental cell signaling by XtSulf1 (Journal article)

    Freeman, S. D., Moore, W. M., Guiral, E. C., Holme, A. D., Turnbull, J. E., & Pownall, M. E. (2008). Extracellular regulation of developmental cell signaling by XtSulf1. Developmental Biology, 320(2), 436-445. doi:10.1016/j.ydbio.2008.05.554

    DOI: 10.1016/j.ydbio.2008.05.554

    Extracellular regulation of developmental cell signaling by XtSulf1 (Journal article)

    freeman, S. D., Moore, W. M., Guiral, E. C., Holme, A. D., Turnbull, J. E., & Pownall, M. E. (2008). Extracellular regulation of developmental cell signaling by XtSulf1. Developmental Biology, 320(2), 436-445.

    Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques (Journal article)

    Rudd, T. R., Skidmore, M. A., Guimond, S. E., Guerrini, M., Cosentino, C., Edge, R., . . . Yates, E. A. (2008). Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques. CARBOHYDRATE RESEARCH, 343(12), 2184-2193. doi:10.1016/j.carres.2007.12.019

    DOI: 10.1016/j.carres.2007.12.019

    Software Tool for the Structural Determination of Glycosaminoglycans by Mass Spectrometry (Journal article)

    Tissot, B., Ceroni, A., Powell, A. K., Morris, H. R., Yates, E. A., Turnbull, J. E., . . . Haslam, S. M. (2008). Software Tool for the Structural Determination of Glycosaminoglycans by Mass Spectrometry. ANALYTICAL CHEMISTRY, 80(23), 9204-9212. doi:10.1021/ac8013753

    DOI: 10.1021/ac8013753

    Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation (Journal article)

    Patel, V. N., Likar, K. M., Zisman-Rozen, S., Cowherd, S. N., Lassiter, K. S., Sher, I., . . . Hoffman, M. P. (2008). Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(14), 9308-9317. doi:10.1074/jbc.M709995200

    DOI: 10.1074/jbc.M709995200

    The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation (Journal article)

    Skidmore, M. A., Guimond, S. E., Rudd, T. R., Fernig, D. G., Turnbull, J. E., & Yates, E. A. (2008). The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation. CONNECTIVE TISSUE RESEARCH, 49(3-4), 140-144. doi:10.1080/03008200802148595

    DOI: 10.1080/03008200802148595

    2007

    Emerging glycomics technologies (Journal article)

    Turnbull, J. E., & Field, R. A. (2007). Emerging glycomics technologies. Nature Chemical Biology, 3(2), 74-77. doi:10.1038/nchembio0207-74

    DOI: 10.1038/nchembio0207-74

    Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives. (Journal article)

    Rudd, T. R., Guimond, S. E., Skidmore, M. A., Duchesne, L., Guerrini, M., Torri, G., . . . Yates, E. A. (2007). Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives.. Glycobiology, 17(9), 983-993. doi:10.1093/glycob/cwm062

    DOI: 10.1093/glycob/cwm062

    Novel 'phage display antibodies identify distinct heparan sulphate domains in developing mammalian lung. (Journal article)

    Thompson, S., Connell, M. .., Fernig, D. G., Ten Dam, G. B., Van Kuppevelt, T. H., Turnbull, J. E., . . . Losty, P. D. (2007). Novel 'phage display antibodies identify distinct heparan sulphate domains in developing mammalian lung.. Paediatric Surgery International, 23(411-41).

    Sequencing Heparan Sulphate Saccharides (Chapter)

    Turnbull, J. E. (2007). Sequencing Heparan Sulphate Saccharides. In J. Walker, & J. Walker (Eds.), Protein Protocols Handbook (pp. in press). Cambridge: Humana Press.

    Site-specific interactions of copper (II) ions with heparin revealed with complementary (Journal article)

    Rudd, T. R., Skidmore, M. A., Guimond, S. E., Guerrini, M., Cosentino, C., Edge, R., . . . Yates, E. A. (2007). Site-specific interactions of copper (II) ions with heparin revealed with complementary. Carbohydrate Research. Retrieved from doi:10.1016/j.carres.2007.12.0

    Towards GAG glycomics: Analysis of highly sulfated heparins by MALDI-TOF mass spectrometry (Journal article)

    Tissot, B., Gasiunas, N., Powell, A. K., Ahmed, Y., Zhi, Z. -L., Haslam, S. M., . . . Dell, A. (2007). Towards GAG glycomics: Analysis of highly sulfated heparins by MALDI-TOF mass spectrometry. Glycobiology, 17(9), 972-982. doi:10.1093/glycob/cwm072

    DOI: 10.1093/glycob/cwm072

    2006

    A molecular mechanism for the heparan sulfate dependence of Slit-Robo signaling (Journal article)

    Hussain, S. -A., Piper, M., Fukuhara, N., Strochlic, L., Cho, G., Howitt, J. A., . . . Hohenester, E. (2006). A molecular mechanism for the heparan sulfate dependence of Slit-Robo signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(51), 39693-39698. doi:10.1074/jbc.M609384200

    DOI: 10.1074/jbc.M609384200

    Engineered bio-active polysaccharides from heparin (Journal article)

    Guimond, S. E., Turnbull, J. E., & Yates, E. A. (2006). Engineered bio-active polysaccharides from heparin. MACROMOLECULAR BIOSCIENCE, 6(8), 681-686. doi:10.1002/mabi.200600042

    DOI: 10.1002/mabi.200600042

    Fabrication of Carbohydrate Microarrays on Gold Surfaces:  Direct Attachment of Nonderivatized Oligosaccharides to Hydrazide-Modified Self-Assembled Monolayers (Journal article)

    Zhi, Z. -L., Powell, A. K., & Turnbull, J. E. (2006). Fabrication of Carbohydrate Microarrays on Gold Surfaces:  Direct Attachment of Nonderivatized Oligosaccharides to Hydrazide-Modified Self-Assembled Monolayers. Analytical Chemistry, 78(14), 4786-4793. doi:10.1021/ac060084f

    DOI: 10.1021/ac060084f

    Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase, with reduced activity against factor Xa and other proteases (Journal article)

    Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2006). Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase, with reduced activity against factor Xa and other proteases. JOURNAL OF MEDICINAL CHEMISTRY, 49(20), 6129-6132. doi:10.1021/jm051221o

    DOI: 10.1021/jm051221o

    High sensitivity separation and detection of heparan sulfate disaccharides (Journal article)

    Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Atrih, A., Yates, E. A., & Turnbull, J. E. (2006). High sensitivity separation and detection of heparan sulfate disaccharides. JOURNAL OF CHROMATOGRAPHY A, 1135(1), 52-56. doi:10.1016/j.chroma.2006.09.064

    DOI: 10.1016/j.chroma.2006.09.064

    Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex (Journal article)

    Leadbeater, W. E., Gonzalez, A. -M., Logaras, N., Berry, M., Turnbull, J. E., & Logan, A. (2006). Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex. Journal of Neurochemistry, 96(4), 1189-1200. doi:10.1111/j.1471-4159.2005.03632.x

    DOI: 10.1111/j.1471-4159.2005.03632.x

    Synthetic sugars enhance the functional glycomics toolkit (Journal article)

    Turnbull, J. E., & Linhardt, R. J. (2006). Synthetic sugars enhance the functional glycomics toolkit. Nature Chemical Biology, 2(9), 449-450. doi:10.1038/nchembio0906-449

    DOI: 10.1038/nchembio0906-449

    2005

    Functions of heparan sulfate proteoglycans and the Kallman syndrome protein KAL-1 in Caenorhabditis elegans embryogenesis (Journal article)

    Hudson, M. L., Kinnunen, T., Turnbull, J. E., & Chisholm, A. D. (2005). Functions of heparan sulfate proteoglycans and the Kallman syndrome protein KAL-1 in Caenorhabditis elegans embryogenesis. Glycobiology, 15(11), 1189-1190.

    Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans (Journal article)

    Kinnunen, T., Huang, Z., Townsend, J., Gatdula, M. M., Brown, J. R., Esko, J. D., & Turnbull, J. E. (2005). Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans. Proceedings of the National Academy of Sciences, 102(5), 1507-1512. doi:10.1073/pnas.0401591102

    DOI: 10.1073/pnas.0401591102

    Heparan Sulphate-Growth Factor Interactions in Development and Disease (Journal article)

    Guimond, S. E., & Turnbull, J. E. (2005). Heparan Sulphate-Growth Factor Interactions in Development and Disease. Trends in Glycoscience and Glycotechnology, 17(98), 241-253. doi:10.4052/tigg.17.241

    DOI: 10.4052/tigg.17.241

    Heparan sulphate-growth factor interactions in development and disease (Journal article)

    Guimond, S. E., & Turnbull, J. E. (2005). Heparan sulphate-growth factor interactions in development and disease. Trends In Glycoscience And Glycotechnology, 17(98), 241-253.

    Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2 (Journal article)

    West, D. C., Rees, C. G., Duchesne, L., Patey, S. J., Terry, C. J., Turnbull, J. E., . . . Fernig, D. G. (2005). Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(14), 13457-13464. doi:10.1074/jbc.M410924200

    DOI: 10.1074/jbc.M410924200

    Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein (Journal article)

    Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 1116-1118. doi:10.1042/BST0331116

    DOI: 10.1042/BST0331116

    Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein. (Conference Paper)

    Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.. In Biochemical Society transactions Vol. 33 (pp. 1116-1118). doi:10.1042/bst20051116

    DOI: 10.1042/bst20051116

    Separation & sequencing of heparin and HS saccharides. (Journal article)

    Skidmore, M. A., & Turnbull, J. E. (2005). Separation & sequencing of heparin and HS saccharides.. Chemistry and Biology of Heparin and Heparan Sulphate.

    Separation and Sequencing of Heparin and Heparan Sulfate Saccharides (Chapter)

    Skidmore, M. A., & Turnbull, J. E. (2005). Separation and Sequencing of Heparin and Heparan Sulfate Saccharides. In H. G. Garg, R. J. Linhardt, & C. A. Hales (Eds.), Chemistry and Biology of Heparin and Heparan sulfate (pp. 1). New York: Elsevier.

    Synthetic GAG mimetic (RGTA) modified natural GAG species during myogenesis. (Journal article)

    Barbosa, I., Morin, C., Garcia, S., Duchesnay, A., Oudghir, M., Jenniskens, G., . . . Papy-Garcia, D. (2005). Synthetic GAG mimetic (RGTA) modified natural GAG species during myogenesis.. Journal of Cell Science, 118(1), 253-264. doi:10.1242/jcs.01607

    DOI: 10.1242/jcs.01607

    2004

    Anosmin-1 Modulates Fibroblast Growth Factor Receptor 1 Signaling in Human Gonadotropin-Releasing Hormone Olfactory Neuroblasts through a Heparan Sulfate-Dependent Mechanism (Journal article)

    Gonzalez-Martinez, D. (2004). Anosmin-1 Modulates Fibroblast Growth Factor Receptor 1 Signaling in Human Gonadotropin-Releasing Hormone Olfactory Neuroblasts through a Heparan Sulfate-Dependent Mechanism. Journal of Neuroscience, 24(46), 10384-10392. doi:10.1523/JNEUROSCI.3400-04.2004

    DOI: 10.1523/JNEUROSCI.3400-04.2004

    Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism (Journal article)

    Gonzalez-Martinez, D., Kim, S. H., Hu, Y., Guimond, S., Schofield, J., Winyard, P., . . . Bouloux, P. M. (2004). Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism. The Journal of Neuroscience.

    Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces (Journal article)

    Skidmore, M. A., Patey, S. J., Thanh, N. T. K., Fernig, D. G., Turnbull, J. E., & Yates, E. A. (2004). Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces. CHEMICAL COMMUNICATIONS, (23), 2700-2701. doi:10.1039/b411726c

    DOI: 10.1039/b411726c

    Highly Diverse Heparan Sulfate Analogue Libraries:  Providing Access to Expanded Areas of Sequence Space for Bioactivity Screening (Journal article)

    Yates, E. A., Guimond, S. E., & Turnbull, J. E. (2004). Highly Diverse Heparan Sulfate Analogue Libraries:  Providing Access to Expanded Areas of Sequence Space for Bioactivity Screening. Journal of Medicinal Chemistry, 47(1), 277-280. doi:10.1021/jm0309755

    DOI: 10.1021/jm0309755

    Highly diverse heparan sulfate analogue libraries: Providing access to expanded areas of sequence space for bioactivity screening (Journal article)

    Yates, E. A., Guimond, S. E., & Turnbull, J. E. (2004). Highly diverse heparan sulfate analogue libraries: Providing access to expanded areas of sequence space for bioactivity screening. JOURNAL OF MEDICINAL CHEMISTRY, 47(1), 277-280. doi:10.1021/jm0309755

    DOI: 10.1021/jm0309755

    Highly diverse heparan sulfate analogue libraries: a novel resource for bioactivity screening of proteins (Journal article)

    Guimond, S. E., Patey, S. J., Yates, E. A., & Turnbull, J. E. (2004). Highly diverse heparan sulfate analogue libraries: a novel resource for bioactivity screening of proteins. International Journal Of Experimental Pathology, 85(4), A62-A63.

    Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and epxerimental approaches (Journal article)

    Powell, A. K., Yates, E. A., Fernig, D. G., & Turnbull, J. E. (2004). Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and epxerimental approaches. GLYCOBIOLOGY, 14(4), 17R-30R. doi:10.1093/glycob/cwh051

    DOI: 10.1093/glycob/cwh051

    Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces. (Journal article)

    Yates, E. A., Jones, M. O., Clarke, C., Powell, A. K., Johnson, S. R., Porch, A., . . . Turnbull, J. E. (2004). Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces.. Journal Of Materials Chemistry, 13, 2061-2063.

    Proteoglycans Make the Grade-ient (Journal article)

    Guimond, S., & Turnbull, J. E. (2004). Proteoglycans Make the Grade-ient. Molecular Cell, 16(2), 159-160. doi:10.1016/j.molcel.2004.10.008

    DOI: 10.1016/j.molcel.2004.10.008

    Proteoglycans make the grade-ient (Journal article)

    Guimond, S., & Turnbull, J. E. (2004). Proteoglycans make the grade-ient. Molecular Cell, 16(2), 159-160.

    Role of heparan sulfate in embryoid body formation (Journal article)

    Drummond, K. J., Yates, E. A., Murray, P. A., & Turnbull, J. E. (2004). Role of heparan sulfate in embryoid body formation. International Journal Of Experimental Pathology, 85(4), A60-A61.

    Saccharide Libraries and Arrays (Patent)

    Turnbull, J., Yates, E., & Powell, A. (2004). Saccharide Libraries and Arrays.

    Soluble syndecan-1 modulates myeloma growth but not through FGF signalling (Journal article)

    Lovell, R. A., Guimond, S. E., Turnbull, J. E., Moss, P. A. H., & Pratt, G. (2004). Soluble syndecan-1 modulates myeloma growth but not through FGF signalling. British Journal Of Haematology, 125, 9.

    2003

    Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase (Journal article)

    Scholefield, Z., Yates, E. A., Wayne, G., Amour, A., McDowell, W., & Turnbull, J. E. (2003). Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase. JOURNAL OF CELL BIOLOGY, 163(1), 97-107. doi:10.1083/jcb.200303059

    DOI: 10.1083/jcb.200303059

    Heparan sulfate sulfotransferase expression in mice and C. elegans. (Journal article)

    Turnbull, J. E., Drummond, K. J., Huang, Z. B., Kinnunen, T., Murphy, M., Ford-Perriss, M., & Guimond, S. (2003). Heparan sulfate sulfotransferase expression in mice and C. elegans.. Biochemical Society Transactions, 31, 343-348.

    Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans (Conference Paper)

    Turnbull, J., Drummond, K., Huang, Z., Kinnunen, T., Ford-Perriss, M., Murphy, M., & Guimond, S. (2003). Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans. In Biochemical Society Transactions Vol. 31 (pp. 343-348). doi:10.1042/bst0310343

    DOI: 10.1042/bst0310343

    Localisation of specific HS proteoglycans during the proliferative phase of brain development (Journal article)

    Ford-Perriss, M., Turner, K., Guimond, S., Apedaile, A., Haubeck, H. D., Turnbull, J., & Murphy, M. (2003). Localisation of specific HS proteoglycans during the proliferative phase of brain development. Developmental Dynamics.

    Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development (Journal article)

    Ford-Perriss, M., Turner, K., Guimond, S., Apedaile, A., Haubeck, H. -D., Turnbull, J., & Murphy, M. (2003). Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Developmental Dynamics, 227(2), 170-184. doi:10.1002/dvdy.10298

    DOI: 10.1002/dvdy.10298

    Structural determinants of heparan sulphate modulation of GDNF signalling (Journal article)

    Davies, J. A., Yates, E. A., & Turnbull, J. E. (2003). Structural determinants of heparan sulphate modulation of GDNF signalling. GROWTH FACTORS, 21(3-4), 109-119. doi:10.1080/08977190310001621005

    DOI: 10.1080/08977190310001621005

    2002

    Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate - Implications for dynamic assembly of a ternary signaling complex (Journal article)

    Powell, A. K., Fernig, D. G., & Turnbull, J. E. (2002). Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate - Implications for dynamic assembly of a ternary signaling complex. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(32), 28554-28563. doi:10.1074/jbc.M111754200

    DOI: 10.1074/jbc.M111754200

    Identification of the Heparan Sulfate Binding Sites in the Cellular Prion Protein (Journal article)

    Warner, R. G., Hundt, C., Weiss, S., & Turnbull, J. E. (2002). Identification of the Heparan Sulfate Binding Sites in the Cellular Prion Protein. Journal of Biological Chemistry, 277(21), 18421-18430. doi:10.1074/jbc.M110406200

    DOI: 10.1074/jbc.M110406200

    Sequencing Heparan Sulphate Saccharides. In: Protein Protocols Handbook. (Journal article)

    Turnbull, J. E. (2002). Sequencing Heparan Sulphate Saccharides. In: Protein Protocols Handbook.. Unknown Journal, 893-904.

    Specific Heparan Sulfate Structures involved in Retinal Axon Targeting. (Journal article)

    Irie, A., Yates, E. A., Turnbull, J. E., & Holt, C. E. (2002). Specific Heparan Sulfate Structures involved in Retinal Axon Targeting.. Development, 129(1), 61-70.

    Variant Heparan Sulfates Synthesised in Developing Mouse Brain Differentially Regulate FGF Signaling (Journal article)

    Ford-Perriss, M., Guimond, S. E., Greferath, U., Kita, M., Grobe, K., Habuchi, H., . . . Turnbull, J. E. (2002). Variant Heparan Sulfates Synthesised in Developing Mouse Brain Differentially Regulate FGF Signaling. Glycobiology.

    Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling (Journal article)

    Ford-Perriss, M., Guimond, S. E., Greferath, U., Kita, M., Grobe, K., Habuchi, H., . . . Turnbull, J. E. (2002). Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling. Glycobiology, 12(11), 721-727. doi:10.1093/glycob/cwf072

    DOI: 10.1093/glycob/cwf072

    2001

    A rise from obscurity - proteoglycans come into focus (Journal article)

    Turnbull, J. E. (2001). A rise from obscurity - proteoglycans come into focus. Nature Cell Biology, 3, E214.

    Analytical and preparative anion-exchange HPLC of GAG saccharides. In: Proteoglycan Protocols. (Journal article)

    Turnbull, J. E. (2001). Analytical and preparative anion-exchange HPLC of GAG saccharides. In: Proteoglycan Protocols.. Meth. Mol. Biol., 171, 141-148.

    Dynamic Biosynthesis of Heparan Sulphate Sequences in Developing Mouse brain: a potential regulatory mechanism during development. (Journal article)

    Guimond, S. E., Ford-Perriss, M., & Turnbull, J. E. (2001). Dynamic Biosynthesis of Heparan Sulphate Sequences in Developing Mouse brain: a potential regulatory mechanism during development.. Biochemical Society Transactions, 29, 177-181.

    Dynamic biosynthesis of heparan sulphate sequences in developing mouse brain: a potential regulatory mechanism during development (Conference Paper)

    Guimond, S., Turner, K., Kita, M., Ford-Perriss, M., & Turnbull, J. (2001). Dynamic biosynthesis of heparan sulphate sequences in developing mouse brain: a potential regulatory mechanism during development. In Biochemical Society Transactions Vol. 29 (pp. 177-181). doi:10.1042/bst0290177

    DOI: 10.1042/bst0290177

    Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label (Journal article)

    Drummond, K. J., Yates, E. A., & Turnbull, J. E. (2001). Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label. Proteomics, 1(2), 304-310. doi:3.0.CO;2-B">10.1002/1615-9861(200102)1:2<304::AID-PROT304>3.0.CO;2-B

    DOI: 10.1002/1615-9861(200102)1:2<304::AID-PROT304>3.0.CO;2-B

    Heparan sulfate: decoding a dynamic multifunctional cell regulator (Journal article)

    Turnbull, J., Powell, A., & Guimond, S. (2001). Heparan sulfate: decoding a dynamic multifunctional cell regulator. Trends in Cell Biology, 11(2), 75-82. doi:10.1016/S0962-8924(00)01897-3

    DOI: 10.1016/S0962-8924(00)01897-3

    Heparan sulfate: decoding a dynamic multifunctional cell regulator (Journal article)

    Turnbull, J., Powell, A., & Guimond, S. (2001). Heparan sulfate: decoding a dynamic multifunctional cell regulator. Unknown Journal, 11(2), 75-82.

    Infectivity of Chlamydia trachomatis Serovar LGV but Not E Is Dependent on Host Cell Heparan Sulfate (Journal article)

    Taraktchoglou, M., Pacey, A. A., Turnbull, J. E., & Eley, A. (2001). Infectivity of Chlamydia trachomatis Serovar LGV but Not E Is Dependent on Host Cell Heparan Sulfate. Infection and Immunity, 69(2), 968-976. doi:10.1128/IAI.69.2.968-976.2001

    DOI: 10.1128/IAI.69.2.968-976.2001

    Integral Glycan Sequencing ofClycosaminoglycan Saccharides. In: Proteoglycan Protocols. (Journal article)

    Turnbull, J. E. (2001). Integral Glycan Sequencing ofClycosaminoglycan Saccharides. In: Proteoglycan Protocols.. Meth. Mol. Biol., 171, 129-140.

    1999

    Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides (Journal article)

    Guimond, S. E., & Turnbull, J. E. (1999). Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides. Current Biology.

    Undated

    Culture conditions govern mouse embryonic stem cell behaviour: dependence on heparan sulfate and optimisation of synthetic polymer substrates (Thesis / Dissertation)

    Williams, C. (n.d.). Culture conditions govern mouse embryonic stem cell behaviour: dependence on heparan sulfate and optimisation of synthetic polymer substrates. (PhD Thesis, University of Liverpool).
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