Photo of Dr Hannah Davies

Dr Hannah Davies PhD

Research Associate Health Data Science

Publications

2021

Exploring the potential of rapid evaporative ionization mass spectrometry (Intelligent Knife) for point-of-care testing in aortic surgery (Journal article)

Davies, H. A., Caamano-Gutierrez, E., Sarsby, J., Nawaytou, O., Harky, A., Akhtar, R., . . . Madine, J. (n.d.). Exploring the potential of rapid evaporative ionization mass spectrometry (Intelligent Knife) for point-of-care testing in aortic surgery. European Journal of Cardio-Thoracic Surgery. doi:10.1093/ejcts/ezab166

DOI: 10.1093/ejcts/ezab166

2020

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. (Journal article)

Degenhardt, K., Wagner, J., Skodras, A., Candlish, M., Koppelmann, A. J., Wild, K., . . . Neher, J. J. (2020). Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.2011133117

DOI: 10.1073/pnas.2011133117

Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia. (Journal article)

Migrino, R. Q., Karamanova, N., Truran, S., Serrano, G. E., Davies, H. A., Madine, J., & Beach, T. G. (2020). Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia.. Alzheimer's and Dementia, 12(1), e12072. doi:10.1002/dad2.12072

DOI: 10.1002/dad2.12072

Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction (Journal article)

Younger, S., Jang, H., Davies, H. A., Niemiec, M. J., Garcia, J. G. N., Nussinov, R., . . . Arce, F. T. (2020). Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction. BIOPHYSICAL JOURNAL, 118(11), 2769-2782. doi:10.1016/j.bpj.2020.04.026

DOI: 10.1016/j.bpj.2020.04.026

Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes (Journal article)

Karamanova, N., Truran, S., Serrano, G. E., Beach, T. G., Madine, J., Weissig, V., . . . Migrino, R. Q. (2020). Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes. Journal of the American Heart Association, 9(2). doi:10.1161/JAHA.119.014810

DOI: 10.1161/JAHA.119.014810

2019

Biochemical Characteristics of the Aortic True Lumen Wall, False Lumen Wall and Flap During the Acute Phases of Type A Aortic Dissection in Humans (Conference Paper)

Harky, A., Chim, Y. H., Davies, H. A., Field, M., Nawaytou, O., Akhtar, R., & Madine, J. (2019). Biochemical Characteristics of the Aortic True Lumen Wall, False Lumen Wall and Flap During the Acute Phases of Type A Aortic Dissection in Humans. In CIRCULATION Vol. 140. Retrieved from http://gateway.webofknowledge.com/

Bicuspid valve aortopathy is associated with distinct patterns of matrix degradation (Journal article)

Chim, Y. H., Davies, H., Mason, D., Nawaytou, O., Field, M., Madine, J., & Akhtar, R. (2019). Bicuspid valve aortopathy is associated with distinct patterns of matrix degradation. The Journal of Thoracic and Cardiovascular Surgery, 160(6), E239-E257. doi:10.1016/j.jtcvs.2019.08.094

DOI: 10.1016/j.jtcvs.2019.08.094

Idiopathic degenerative thoracic aneurysms are associated with increased aortic medial amyloid (Journal article)

Davies, H. A., Caamano-Gutierrez, E., Chim, Y. H., Field, M., Nawaytou, O., Ressel, L., . . . Madine, J. (n.d.). Idiopathic degenerative thoracic aneurysms are associated with increased aortic medial amyloid. Amyloid: international journal of experimental and clinical investigation, 26(3), 148-155. doi:10.1080/13506129.2019.1625323

DOI: 10.1080/13506129.2019.1625323

Macro- and Micro-mechanical Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels (Journal article)

Panpho, P., Brendan, G., Chim, Y. H., Davies, H., Field, M., Madine, J., & Akhtar, R. (n.d.). Macro- and Micro-mechanical Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels. Artery Research, 25(1-2), 27-36. doi:10.2991/artres.k.191114.003

DOI: 10.2991/artres.k.191114.003

Quality of Reporting in Human Aortic Tissue Research – A Systematic Review (Journal article)

Chim, Y. -H., Caamaño-Gutiérrez, E., Birla, R., Madine, J., Field, M., Akhtar, R., & Davies, H. A. (n.d.). Quality of Reporting in Human Aortic Tissue Research – A Systematic Review. Artery Research. doi:10.2991/artres.k.191106.003

DOI: 10.2991/artres.k.191106.003

2018

Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia (Journal article)

Migrino, R. Q., Truran, S., Karamanova, N., Davies, H., Madine, J., Reaven, P., & Beach, T. G. (2018). Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia. American Journal of Physiology: Heart and Circulatory Physiology, 315(2), H284-H290. doi:10.1152/ajpheart.00206.2018

DOI: 10.1152/ajpheart.00206.2018

Insights into the Origin of Distinct Medin Fibril Morphologies Induced by Incubation Conditions and Seeding (Journal article)

Davies, H., Lee, C. F., Miller, L., Liu, L., & Madine, J. (2018). Insights into the Origin of Distinct Medin FibrilMorphologies Induced by Incubation Conditionsand Seeding. International Journal of Molecular Sciences, 19(5), 1-15. doi:10.3390/ijms19051357

DOI: 10.3390/ijms19051357

2017

Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation through the Receptor for Advanced Glycation Endproducts (Journal article)

Migrino, M., Davies, H. A., Truran, S., Karamanova, N., Franco, D. A., Beach, T. G., . . . Madine, J. (2017). Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation through the Receptor for Advanced Glycation Endproducts. Cardiovascular Research, 113(11), 1389-1402. doi:10.1093/cvr/cvx135

DOI: 10.1093/cvr/cvx135

Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation Through the Receptor for Advanced Glycation Endproducts (Conference Paper)

Migrino, R. Q., Davies, H., Truran, S., Karamanova, N., Franco, D. A., Serrano, G., . . . Madine, J. (2017). Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation Through the Receptor for Advanced Glycation Endproducts. In FASEB JOURNAL Vol. 31. Retrieved from http://gateway.webofknowledge.com/

Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics (Journal article)

Davies, H. A., Rigden, D. J., Phelan, M. M., & Madine, J. (2017). Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics. Scientific Reports, 7. doi:10.1038/srep45224

DOI: 10.1038/srep45224

2016

HUMAN MICROVASCULAR ENDOTHELIAL DYSFUNCTION INDUCED BY AMYLOIDOGENIC MEDIN PROTEIN (Conference Paper)

Migrino, R. Q., Truran, S., Karamanova, N., Franco, D., Davies, H. A., Burciu, C., & Madine, J. (2016). HUMAN MICROVASCULAR ENDOTHELIAL DYSFUNCTION INDUCED BY AMYLOIDOGENIC MEDIN PROTEIN. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 67 (pp. 2310). doi:10.1016/S0735-1097(16)32311-7

DOI: 10.1016/S0735-1097(16)32311-7

H-1, N-15 and C-13 assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques (Journal article)

Davies, H. A., Phelan, M. M., & Madine, J. (2016). H-1, N-15 and C-13 assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques. BIOMOLECULAR NMR ASSIGNMENTS, 10(1), 75-77. doi:10.1007/s12104-015-9641-z

DOI: 10.1007/s12104-015-9641-z

Nanoliposomes protect against human arteriole endothelial dysfunction induced by beta-amyloid peptide (Journal article)

Truran, S., Weissig, V., Madine, J., Davies, H. A., Guzman-Villanueva, D., Franco, D. A., . . . Migrino, R. Q. (2016). Nanoliposomes protect against human arteriole endothelial dysfunction induced by beta-amyloid peptide. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36(2), 405-412. doi:10.1177/0271678X15610134

DOI: 10.1177/0271678X15610134

2015

Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid (Journal article)

Davies, H., Phelan, M., Wilkinson, M., Migrino, R., Truran, S., Franco, D. A., . . . Madine, J. (2015). Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid. Biophysical Journal, 109(11), 2363-2370. doi:10.1016/j.bpj.2015.10.034

DOI: 10.1016/j.bpj.2015.10.034

Comparison with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid polypeptide medin (Journal article)

Davies, H., Madine, J., & Middleton, D. (2015). Comparison with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid polypeptide medin. The Journal of Biological Chemistry, 290, 7791-7803. doi:10.1074/jbc.M114.602177

DOI: 10.1074/jbc.M114.602177

2014

Expression and purification of the aortic amyloid polypeptide medin (Journal article)

Davies, H. A., Wilkinson, M. C., Gibson, R. P., & Middleton, D. A. (2014). Expression and purification of the aortic amyloid polypeptide medin. PROTEIN EXPRESSION AND PURIFICATION, 98, 32-37. doi:10.1016/j.pep.2014.02.009

DOI: 10.1016/j.pep.2014.02.009

2013

Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity (Journal article)

Madine, J., Davies, H. A., Hughes, E., & Middleton, D. A. (2013). Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity. BIOCHEMISTRY, 52(50), 8984-8992. doi:10.1021/bi401231u

DOI: 10.1021/bi401231u

2012

Fibrils and nanotubes assembled from a modified amyloid-beta peptide fragment differ in the packing of the same beta-sheet building blocks (Journal article)

Madine, J., Davies, H. A., Shaw, C., Hamley, I. W., & Middleton, D. A. (2012). Fibrils and nanotubes assembled from a modified amyloid-beta peptide fragment differ in the packing of the same beta-sheet building blocks. CHEMICAL COMMUNICATIONS, 48(24), 2976-2978. doi:10.1039/c2cc17118j

DOI: 10.1039/c2cc17118j

Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin (Journal article)

Davies, H. A., Madine, J., & Middleton, D. A. (2012). Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin. JOURNAL OF PEPTIDE SCIENCE, 18(1), 65-72. doi:10.1002/psc.1418

DOI: 10.1002/psc.1418

Undated

Expression and characterisation of cardiovascular amyloid proteins (Thesis / Dissertation)

Davies, H. (n.d.). Expression and characterisation of cardiovascular amyloid proteins. (PhD Thesis, University of Liverpool).