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Molecular Basis of Therapeutic Targeting

Our researchers deal with the identification and study of key biological macromolecules that influence fundamental signalling and regulatory processes of disease relevance, along with changes in response to pathological conditions.

Understanding the underlying control mechanisms is allowing us to identify disease biomarkers and new therapeutic candidates to both monitor and control disease processes, with the potential for future treatment of diseases including cancer, muscular dystrophy and neurodegeneration.

 

Areas of research

This theme deals with the identification and study of key biological macromolecules that influence disease processes, or change in response to pathological conditions.

 

Many diseases arise from problems in how cells communicate:

 

  • Between the cells themselves (central to many neurological diseases, such as Parkinson’s and depression)
  • In the way that they respond to different external conditions (stimuli)
  • In the interactions of the biological molecules (mainly proteins) within cells at local or distal (eg metastatic) sites
  • The broad expertise of the researchers working on this theme helps extract basic knowledge and its therapeutic use in collaboration with clinicians, chemists, and industrial partners
MBTT news - alzheimers

World Alzheimer’s Day: Funding boost for dementia research

A research team led by Dr Jill Madine has been awarded £50,000 to develop pioneering technology that could improve our understanding of Alzheimer’s disease. Read more...

MBTT news - alzheimers walk

Liverpool scientist helps raise dementia awareness at charity walk

The Institute of Integrative Biology's Professor Jerry Turnbull joined 3,000 people this weekend to unite against dementia at a charity walk in the city. Read more...

MBTT news - cell cycle study

£1.5M Wellcome Trust award for cell cycle study

The Institute of Integrative Biology's Professor Sonia Rocha, along with biochemists at the University of Dundee, has been awarded a prestigious Wellcome Trust Collaborative Award in Science of more than £1.5M to study potential disease-causing mechanisms in the cell cycle. Read more...