Molecular Basis of Therapeutic Targeting

Before illness or disease can be diagnosed and treated, a wealth of fundamental knowledge must be gained that explains the molecular changes that occur within the affected biological system. With such knowledge, new areas of biomedical research can be discovered. This will improve our ability to identify disease-affected patients and to prevent, treat, and ultimately cure disease

Areas of research

The theme of molecular basis of therapeutic targeting deals with the identification and study of key biological macromolecules that influence disease processes, or change in response to pathological conditions. By understanding the underlying causes of a disease, the outcome can often be manipulated to control disease symptoms and/or eradicate the disease.

Many diseases arise from problems in how cells communicate:

  • Between the cells themselves (central to many neurological diseases, such as Parkinson’s and depression)
  • In the way that they respond to different external conditions (stimuli)
  • In the interactions of the biological molecules (mainly proteins) within cells at local or distal (eg metastatic) sites.

The broad expertise of the researchers working on this theme helps extract basic knowledge and its therapeutic use in collaboration with clinicians, chemists, and industrial partners.

Theme lead

Professor Claire Eyers