The Department of Biochemistry at the University of Liverpool is driven by a desire to understand and manipulate biological systems at the level of individual molecules. We also apply global analyses to study the precise and highly evolved relationship between biomolecular structure and function.
The University of Liverpool was home to the first UK Department of Biochemistry, established in 1902. Today we have 26 academic staff and over 100 postdoctoral researchers and postgraduate students.
We are motivated to understand:
- The behaviour of molecules in complex environments
- The structure-function relationships in biological macromolecules
- The processes whereby altered function at the molecular level leads to disease.
Dynamics of biological systems
To understand how biological systems change, we study transient biomolecular interactions. We perform in-depth analysis of ‘omes’, especially, the proteome and metabolome. We also analyse isolated molecules and use analytical, computational and cell biological approaches to understand their structures and their biochemical functions in intact model systems.
Disturbance to normal biochemistry
All disease processes (genetic or environmental) can be traced to biochemical dysfunctions. We are strongly motivated to understand disturbances of normal biochemistry in these processes.
We have studied the disease processes of:
- Muscular dystrophy
- Amyloid‐mediated disease
- Infectious disease.
A component of this research is driving the discovery of new biomarkers for diagnosis and prognosis, providing candidates for biomarker development.
Working with us
We lead the largest concentration of Shared Research Facilities operated through the Technology Directorate, including the Centre for Cell Imaging, the Centre for Proteome Research and the Centre for NMR Metabolomics.
Our staff have been extremely successful in winning infrastructure grants, including four Biotechnology and Biological Sciences Research Council ALERT grants in recent years (for advanced light and mass spectrometry) and were key players in a Medical Research Council grant (led by the Centre for Drug Safety Science) for enabling technologies that will develop mass cytometry, advanced live cell microscopy, and NMR and mass spectrometry metabolomics.
We have extensive opportunities for collaboration with other research groups, joint research funding, shared research students, and international collaborations.