I have a long term interest in pneumococcal disease bridging immunology, microbial genomics and prevention of disease. Current activity includes a Gates funded project to characterise the burden of residual vaccine type disease in Malawi following conjugate vaccine introduction in 2011; studies of pneumococcal transmission in high burden areas and the implications for vaccine control including protection of the neonate and young infant; understanding the interaction of the pneumococcus with viral infections, particularly influenza; characterisation of the immune response to pneumococcus in high risk adult groups; and understanding the evolution of the pneumococcus under vaccine pressure.
Vaccine evaluation for efficacy and effectivness.
Having been involved in several vaccine trials and post introductory evaluations of pneumococcal conjugate vaccine and Rotavirus vaccine I have become interested in efficient methods for evaluating new vaccines both in the pre-licensure stage and after introduction to assess effectiveness. Current work is focused on using routine data in the UK to assess rotavirus and influenza virus vaccine effectiveness; and large scale efficient demographic studies to determine vaccine outcomes in resource poor settings.
Group B streptococcal infection.
As a consequence of studies on pneumococcal conjugate vaccines in adults, the move into the use of Group B streptococcal vaccines in pregnant women was relatively straightforward. As well as vaccine trials I am interested in other potential control methods for GBS and understanding the genomic associations with pathogenicity in this bacteria.
- One Health Research Network for the Horn of Africa (HORN)
- The role of immune tolerance and regulation in pneumococcal carriage and invasive disease
- Health priorities in resource-limited settings - Wellcome Trust PhD Block Award
- Preparing a network of primary care providers to study infection in the elderly
- Epidemiology, Prevention, and Treatment of Influenza and Other Respiratory Infections in a Malaria-Endemic Area of Malawi with High HIV Prevalence. (Year 4)
- A phase I study of recombinant poxvirus Zika vaccines
- Epidemiology, Prevention, and Treatment of Influenza and Other Respiratory Infections in a Malaria-Endemic Area of Malawi with High HIV Prevalence. (Year 3)
- Shifts in the metabolic and virulence profiles of Streptococcus pneumoniae following the introduction of conjugatepolysaccharide vaccine in Malawi
- Genomic diversity of Streptococcus pneumoniae serotype 1 across sub-Saharan Africa
- Describing the burden of severe influenza associated illness across local communities in relation to influenza vaccine uptake and socio-economic deprivation
- Impact of an improved stove on reductions in PM2.5 exposure and nasopharyngeal carriage of streptococcus pneumoniae in 6 month old Malawian children.
- Impact of rotavirus vaccination on winter /spring pressures at a large paediatric hospital in the UK: an ecological study.
- Understanding the epidemiology of life threatening invasive Group A Streptococcal infections in Merseyside.
- Estimating the economic burden of acute gastroenteritis in Malawian children
- Impact of national rotavirus vaccination on diarrhoea deaths among infants in rural Malawi
- Epidemiology, Prevention, and Treatment of Influenza and Other Respiratory Infections in a Malaria-Endemic Area of Malawi with High HIV Prevalence.
- Mansoor Alsahag - Bench fees
- The role of influenza in pneumonia in HIV-infected adults in Malawi
- Liverpool - Glasgow Wellcome Trust Centre for Global Health Research.